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The map label for this gene is alr

Identifier: 170757299

GI number: 170757299

Start: 353434

End: 354648

Strand: Direct

Name: alr

Synonym: CLD_0476

Alternate gene names: 170757299

Gene position: 353434-354648 (Clockwise)

Preceding gene: 170756066

Following gene: 170754659

Centisome position: 8.93

GC content: 29.79

Gene sequence:

>1215_bases
ATGTTTGAACATTCTAGACCTGCATGGATTGAAATAAATTTAGACAATTTAATTCATAATATGAAGGAAATAAGAAGAGT
TGCTAGAAGCAAGGAAATAATAAGTGTAGTTAAAGCAGATGCATATGGACATGGTGCTTTAGAAATAGCCTCCCTTTTGC
TTGAAAACGGAGCCAATAGATTGGCAGTAGCAGTTCTTTCAGAAGCACTAGAATTAAGAAATAGTGGTATTACAGCGCCT
ATTATTATTTTAGGCTACACTCCACTGCGATATGACGAAAGAACAATATGCAATAATGCTGAAACTATAATAAAAAATGA
CTTAGAGGTATCTGTAAGTTCATATAAATATGCGGAGCAATTATCTAAGAAAGCACAACAATTAGGCAAAGATGTAAAAA
TTCATGTAAACATTGATACAGGTATGGGAAGATTAGGATTTTTGCCCACAGAAGAAAATTTAGAAAAAATATATCAAATA
AGTAAACTACCAAATATAATATTTGAAGGCTTGTTTTCTCATTTTTCAACAGTAGATGAAAAAAATAAAGATTATACTAA
TGAACAATTTAAAAAATTCTTAGATTTTTATTATAAACTTAGAGATAAAAATGTGAAAGTTAATATAAAGCATATTGCCA
ATAGTGCTGCTTTAATAGATTTACCTTACACTCATTTAGATGCTGTTCGACCTGGTATAGCTCAATATGGTTATTATCCT
TCATCAGAAGTCAATCATAAAGATATAAATTTAAGACCAATAATGACATTAAAAACAAATATTGTTCTAGTGAAAGACAT
TAAATCAGGACAATCTATCAGTTATGGAAGAAAATTTAGAACAATAAGAAATAGCAAGATAGCTGTTCTTCCAATAGGTT
ATGCCGATGGATATGAAAGAGAATTATCTAATGAAAATAATGTTTATAAAGCTCAAGTTATTGTGAACGGAAGGCGTGCA
CCTATAGTAGGGCGAATAACCATGGATATGTGTATGATTGATGTGACAGATATAGGTGATGTTAAAGTTGGTGACGAAGT
TATATTAATAGGGGAATGTAATGATGAAAGGATTTCAGTAGAAGATATAGCCGATTTATTGAATACCATACCTTATGAAG
TAACAAGCAGAATCAGTAAAAGAATTCCAAGATATTATATAAAAGATGGAAAGATAGTGAAGATATCACAAATAAATAAA
GAAGTAAACAAATAA

Upstream 100 bases:

>100_bases
AATCTCACCATTTATAATTAAGCATTATATTATAATATTGTAAGTTTTTATTTTTAAAATTGTAGCTTTAAGTAAAAATT
TAAAATTTGGAGTGAATTTT

Downstream 100 bases:

>100_bases
TTATAATAATATATTTATTTTGAAATAAAAGGAAATATATTCTGAATCATATAATAAATATAAGTCATGAATTTGTATCT
ATTATATTATGATTCTTTTA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MFEHSRPAWIEINLDNLIHNMKEIRRVARSKEIISVVKADAYGHGALEIASLLLENGANRLAVAVLSEALELRNSGITAP
IIILGYTPLRYDERTICNNAETIIKNDLEVSVSSYKYAEQLSKKAQQLGKDVKIHVNIDTGMGRLGFLPTEENLEKIYQI
SKLPNIIFEGLFSHFSTVDEKNKDYTNEQFKKFLDFYYKLRDKNVKVNIKHIANSAALIDLPYTHLDAVRPGIAQYGYYP
SSEVNHKDINLRPIMTLKTNIVLVKDIKSGQSISYGRKFRTIRNSKIAVLPIGYADGYERELSNENNVYKAQVIVNGRRA
PIVGRITMDMCMIDVTDIGDVKVGDEVILIGECNDERISVEDIADLLNTIPYEVTSRISKRIPRYYIKDGKIVKISQINK
EVNK

Sequences:

>Translated_404_residues
MFEHSRPAWIEINLDNLIHNMKEIRRVARSKEIISVVKADAYGHGALEIASLLLENGANRLAVAVLSEALELRNSGITAP
IIILGYTPLRYDERTICNNAETIIKNDLEVSVSSYKYAEQLSKKAQQLGKDVKIHVNIDTGMGRLGFLPTEENLEKIYQI
SKLPNIIFEGLFSHFSTVDEKNKDYTNEQFKKFLDFYYKLRDKNVKVNIKHIANSAALIDLPYTHLDAVRPGIAQYGYYP
SSEVNHKDINLRPIMTLKTNIVLVKDIKSGQSISYGRKFRTIRNSKIAVLPIGYADGYERELSNENNVYKAQVIVNGRRA
PIVGRITMDMCMIDVTDIGDVKVGDEVILIGECNDERISVEDIADLLNTIPYEVTSRISKRIPRYYIKDGKIVKISQINK
EVNK
>Mature_404_residues
MFEHSRPAWIEINLDNLIHNMKEIRRVARSKEIISVVKADAYGHGALEIASLLLENGANRLAVAVLSEALELRNSGITAP
IIILGYTPLRYDERTICNNAETIIKNDLEVSVSSYKYAEQLSKKAQQLGKDVKIHVNIDTGMGRLGFLPTEENLEKIYQI
SKLPNIIFEGLFSHFSTVDEKNKDYTNEQFKKFLDFYYKLRDKNVKVNIKHIANSAALIDLPYTHLDAVRPGIAQYGYYP
SSEVNHKDINLRPIMTLKTNIVLVKDIKSGQSISYGRKFRTIRNSKIAVLPIGYADGYERELSNENNVYKAQVIVNGRRA
PIVGRITMDMCMIDVTDIGDVKVGDEVILIGECNDERISVEDIADLLNTIPYEVTSRISKRIPRYYIKDGKIVKISQINK
EVNK

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1790487, Length=385, Percent_Identity=33.7662337662338, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1787439, Length=383, Percent_Identity=29.7650130548303, Blast_Score=159, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 45838; Mature: 45838

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1 ; PS00395 ALANINE_RACEMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHSRPAWIEINLDNLIHNMKEIRRVARSKEIISVVKADAYGHGALEIASLLLENGANR
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
LAVAVLSEALELRNSGITAPIIILGYTPLRYDERTICNNAETIIKNDLEVSVSSYKYAEQ
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCCCHHHHCCCCEEEHHHHHHHHH
LSKKAQQLGKDVKIHVNIDTGMGRLGFLPTEENLEKIYQISKLPNIIFEGLFSHFSTVDE
HHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNKDYTNEQFKKFLDFYYKLRDKNVKVNIKHIANSAALIDLPYTHLDAVRPGIAQYGYYP
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCHHHHHHCCCHHHCCCCC
SSEVNHKDINLRPIMTLKTNIVLVKDIKSGQSISYGRKFRTIRNSKIAVLPIGYADGYER
CCCCCCCCCCEEEEEEEEEEEEEEEECCCCCCCCCCHHHHHCCCCEEEEEEECCCCCHHH
ELSNENNVYKAQVIVNGRRAPIVGRITMDMCMIDVTDIGDVKVGDEVILIGECNDERISV
HCCCCCCEEEEEEEECCCCCCEEEEEEEEEEEEEECCCCCEEECCEEEEEECCCCCEEEH
EDIADLLNTIPYEVTSRISKRIPRYYIKDGKIVKISQINKEVNK
HHHHHHHHHCCHHHHHHHHHCCCCEEECCCCEEEEEHHHHHHCC
>Mature Secondary Structure
MFEHSRPAWIEINLDNLIHNMKEIRRVARSKEIISVVKADAYGHGALEIASLLLENGANR
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
LAVAVLSEALELRNSGITAPIIILGYTPLRYDERTICNNAETIIKNDLEVSVSSYKYAEQ
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCCCHHHHCCCCEEEHHHHHHHHH
LSKKAQQLGKDVKIHVNIDTGMGRLGFLPTEENLEKIYQISKLPNIIFEGLFSHFSTVDE
HHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNKDYTNEQFKKFLDFYYKLRDKNVKVNIKHIANSAALIDLPYTHLDAVRPGIAQYGYYP
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCHHHHHHCCCHHHCCCCC
SSEVNHKDINLRPIMTLKTNIVLVKDIKSGQSISYGRKFRTIRNSKIAVLPIGYADGYER
CCCCCCCCCCEEEEEEEEEEEEEEEECCCCCCCCCCHHHHHCCCCEEEEEEECCCCCHHH
ELSNENNVYKAQVIVNGRRAPIVGRITMDMCMIDVTDIGDVKVGDEVILIGECNDERISV
HCCCCCCEEEEEEEECCCCCCEEEEEEEEEEEEEECCCCCEEECCEEEEEECCCCCEEEH
EDIADLLNTIPYEVTSRISKRIPRYYIKDGKIVKISQINKEVNK
HHHHHHHHHCCHHHHHHHHHCCCCEEECCCCEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]