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The map label for this gene is 170755072

Identifier: 170755072

GI number: 170755072

Start: 1221427

End: 1222935

Strand: Reverse

Name: 170755072

Synonym: CLD_3464

Alternate gene names: NA

Gene position: 1222935-1221427 (Counterclockwise)

Preceding gene: 170755500

Following gene: 170756625

Centisome position: 30.9

GC content: 29.36

Gene sequence:

>1509_bases
ATGGAAATAAAATTCTTAGGAGCAGCTTCTTGTGTAACAGGTTCCTGCCACTTATTAAAAATAAAAGATAAAAATATTCT
TTTAGACTGTGGTGCTTATCAAGGCAAAGACGATGAAGGAGATAGAAATTTTTCTTTTAAATTCGATATTAAAGATATAG
ATTGTGTAATACTCTCTCACGCTCATATAGATCACAGTGGACGAATTCCTTTTTTATATAAACTAGGCTATAGAGGAAAA
GTTATCTCTACTAAAGCTACTGCAGACCTATGCTCCATTATGCTTCCTGACAGCGGTCATATATTAGAATCAGAAGTTGA
ATGGAAAAACAGAAAAAGAATTCGTAGTGGTCTACCTCCTATAGAACCTTTATATACTTTAAAAACAGCTCAAATGAGTA
CATCTCTTTTTGAAGGTTACAATTACGATGAATATATAGAAATATTTTCCAATCTCAAAATAAGATTTTTAGATTCTGGT
CATCTTTTAGGCTCTGCTATAACCGAATTATATATAACTGAAAATGATAAAGAATTTAAAATTGTTTATTCCGGAGATCT
TGGCAATACAAATTTGCCTATACTAAAAGATCCTGTTCAAGTAGATTATGCAGATTATGTGCTAATGGAAACAACCTATG
GAAATAGACTTCATGATAACATAAATTCCCAATTAAAGCAATTGATTCATATCGTAAAAGATACCTTTAAAAAGGGGGGC
AATGTTATTATTCCTTCCTTTGCAGTGGGTAGAACTCAAGAAGTAATATATGCATTAAATAAATATGTGGAAAGCAATAT
ATTAAAAAATATCAAAGTCTACGTAGATAGCCCTTTAGCTTCAGAAGCTACTAAAATATTTAATGAATACACTACAGACT
TTGATGAAGATGCTCAAAAGTTATTAAAGGAAGGTGATAATCCTCTAGAATTTAATGGTCTTTACTTTACTAATTCTCCT
CAAGAATCTATGGAATTAAATAAAATAAAAACTGGTGCTATTATAATATCTGCTAGTGGGATGTGTGAAGCTGGTAGAAT
TCGTCATCATCTGAAACATAATCTTTGGAGAAAAGAATGTTCTATAGTATTTGTAGGTTATCAAGCTGAGGGAACTTTAG
GTCAAAAAATATTAAGCGATGCTAAAAAAATAAAATTATTTGGTGAAGAGATTGCTGTAAATGCTGAAATATATAATCTA
CCATCATTATCTGGTCATGCTGACAAAAATGGGCTATTGAATTGGCTAGAAAGCTTTAAAGAAAAACCTAAGGAAGTTAT
ATTGATCCATGGTGAAAAAGGTTCTAGAGATTATTTTAAAAATCTGTTAATTGAAAAAAACTACAATACTTTTTGTCCTA
ATATAGGTGATATATATTCAAGTGAATTTAAAGGTCAAAGAAAAAGTGTAGTTAAAGATAAAATAACTAATTTATTGAAT
TCCATAGAGGATATAGACTCATTAAATAAAGAAGATTTATTAAACTTGATTAAAAAAGAAATATATTAA

Upstream 100 bases:

>100_bases
AATTATTTATATTATTTTTAAATACATATATATTTTTCAATAAAATAATATTAAAATATTCTTACAAGTATTAATTAATC
ATTAGAACAGGAGGGATCAT

Downstream 100 bases:

>100_bases
AAACAAAACCATTTTATCTATTAAATTTTAAAACTATCTATATATTAAAAAGAAAGAGGCTGTCTCAAAATAGATTTAAA
TTTGTTCTGAGATAGTCTCT

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKKGG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSDAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLESFKEKPKEVILIHGEKGSRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKDKITNLLN
SIEDIDSLNKEDLLNLIKKEIY

Sequences:

>Translated_502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKKGG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSDAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLESFKEKPKEVILIHGEKGSRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKDKITNLLN
SIEDIDSLNKEDLLNLIKKEIY
>Mature_502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKKGG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSDAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLESFKEKPKEVILIHGEKGSRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKDKITNLLN
SIEDIDSLNKEDLLNLIKKEIY

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=448, Percent_Identity=26.3392857142857, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI33300633, Length=480, Percent_Identity=26.0416666666667, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI223555970, Length=330, Percent_Identity=23.6363636363636, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI223555968, Length=264, Percent_Identity=24.6212121212121, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI289191297, Length=264, Percent_Identity=24.6212121212121, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32566029, Length=440, Percent_Identity=27.5, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI32564696, Length=473, Percent_Identity=28.1183932346723, Blast_Score=154, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6323307, Length=511, Percent_Identity=22.5048923679061, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI21358523, Length=472, Percent_Identity=27.5423728813559, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24648013, Length=456, Percent_Identity=26.3157894736842, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 56892; Mature: 56892

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSH
CEEEEEECCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEE
AHIDHSGRIPFLYKLGYRGKVISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPP
EECCCCCCCCEEEEECCCCEEEECHHHHHHHHEECCCCCCEECCHHHHHHHHHHHHCCCC
IEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSGHLLGSAITELYITENDKEFK
CCHHHEEHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHEEEEECCCCEEE
IVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKKGG
EEEECCCCCCCCCEECCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQK
CEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHH
LLKEGDNPLEFNGLYFTNSPQESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKEC
HHHCCCCCEEECCEEEECCCHHHHHHHEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCC
SIVFVGYQAEGTLGQKILSDAKKIKLFGEEIAVNAEIYNLPSLSGHADKNGLLNWLESFK
CEEEEEEECCCCHHHHHHHHHHHEEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHH
EKPKEVILIHGEKGSRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKDKITNLLN
CCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
SIEDIDSLNKEDLLNLIKKEIY
HHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSH
CEEEEEECCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEE
AHIDHSGRIPFLYKLGYRGKVISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPP
EECCCCCCCCEEEEECCCCEEEECHHHHHHHHEECCCCCCEECCHHHHHHHHHHHHCCCC
IEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSGHLLGSAITELYITENDKEFK
CCHHHEEHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHEEEEECCCCEEE
IVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKKGG
EEEECCCCCCCCCEECCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQK
CEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHH
LLKEGDNPLEFNGLYFTNSPQESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKEC
HHHCCCCCEEECCEEEECCCHHHHHHHEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCC
SIVFVGYQAEGTLGQKILSDAKKIKLFGEEIAVNAEIYNLPSLSGHADKNGLLNWLESFK
CEEEEEEECCCCHHHHHHHHHHHEEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHH
EKPKEVILIHGEKGSRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKDKITNLLN
CCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
SIEDIDSLNKEDLLNLIKKEIY
HHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA