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The map label for this gene is clpP [H]

Identifier: 170751514

GI number: 170751514

Start: 5457466

End: 5458092

Strand: Direct

Name: clpP [H]

Synonym: Mrad2831_5134

Alternate gene names: 170751514

Gene position: 5457466-5458092 (Clockwise)

Preceding gene: 170751513

Following gene: 170751515

Centisome position: 89.79

GC content: 66.99

Gene sequence:

>627_bases
ATGAGAGATCCGATCGACGTCTACAACAACGCGCTCGTGCCGATGGTCGTCGAGCAGTCGAGCCGCGGCGAGCGCGCCTT
CGACATCTACTCCCGCCTGCTCCGCGAGCGCATCATCTTCCTCACCGGCCCCGTGGAGGATTACGGCGCGTCGCTGATCG
TGGCGCAGCTGCTGTTCCTCGAGGCGGAGAACCCGAAGAAGGAGATCTCCTTCTACATCAACTCCCCCGGCGGCGTGGTC
ACCTCCGGCCTGTCGATCTACGACACGATGCAGTTCATCCGCTGCCCGGTGACGACCCTCTGCGTCGGCCAGGCCGCCTC
GATGGGCTCCCTGCTGCTCACAGCCGGCGAGCCGGGCCACCGCTTCGCCCTGCCGAACGCCCGGATCATGGTCCACCAGC
CGTCCGGCGGCTTCCAGGGCCAGGCGACCGACATCCTGATCCACGCCCGCGAGATCGAGGCGCTGAAGCGGCGCCTGAAC
GAGATCTACGTGAAGCACACCGGGCGCGACTACGACACGATCCACACGGCGCTGGAGCGCGACAACTTCATGACCGCCGA
CGCGGCCAAGGAGTTCGGGCTCATCGACGAGGTGATCGAGAAGCGTCCCGAGCCGGCGGCCGCCTGA

Upstream 100 bases:

>100_bases
CAAGGGTTAGGCGATGGTTAAGCATCGCCGGTGTTCGCTGACATGCCCGGGGCTGCCCTGATTCGCGGCAGCCCCGGGCC
TCACTCCGGGGCAGGACGAG

Downstream 100 bases:

>100_bases
CCGCCCCGCGTCGCCTGACCGCCGCGGCGCGGCCTTGATCCCGCCGCGGCAGCGTGTTTGCATCGAGGTTCGGGCCCTTC
GGTCAAAGGCGCGCAGCACA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRDPIDVYNNALVPMVVEQSSRGERAFDIYSRLLRERIIFLTGPVEDYGASLIVAQLLFLEAENPKKEISFYINSPGGVV
TSGLSIYDTMQFIRCPVTTLCVGQAASMGSLLLTAGEPGHRFALPNARIMVHQPSGGFQGQATDILIHAREIEALKRRLN
EIYVKHTGRDYDTIHTALERDNFMTADAAKEFGLIDEVIEKRPEPAAA

Sequences:

>Translated_208_residues
MRDPIDVYNNALVPMVVEQSSRGERAFDIYSRLLRERIIFLTGPVEDYGASLIVAQLLFLEAENPKKEISFYINSPGGVV
TSGLSIYDTMQFIRCPVTTLCVGQAASMGSLLLTAGEPGHRFALPNARIMVHQPSGGFQGQATDILIHAREIEALKRRLN
EIYVKHTGRDYDTIHTALERDNFMTADAAKEFGLIDEVIEKRPEPAAA
>Mature_208_residues
MRDPIDVYNNALVPMVVEQSSRGERAFDIYSRLLRERIIFLTGPVEDYGASLIVAQLLFLEAENPKKEISFYINSPGGVV
TSGLSIYDTMQFIRCPVTTLCVGQAASMGSLLLTAGEPGHRFALPNARIMVHQPSGGFQGQATDILIHAREIEALKRRLN
EIYVKHTGRDYDTIHTALERDNFMTADAAKEFGLIDEVIEKRPEPAAA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=193, Percent_Identity=62.1761658031088, Blast_Score=258, Evalue=4e-69,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=65.625, Blast_Score=272, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=61.8279569892473, Blast_Score=245, Evalue=1e-65,
Organism=Drosophila melanogaster, GI20129427, Length=199, Percent_Identity=63.3165829145729, Blast_Score=265, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23082; Mature: 23082

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPIDVYNNALVPMVVEQSSRGERAFDIYSRLLRERIIFLTGPVEDYGASLIVAQLLFL
CCCCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
EAENPKKEISFYINSPGGVVTSGLSIYDTMQFIRCPVTTLCVGQAASMGSLLLTAGEPGH
CCCCCCCEEEEEEECCCCEEECCHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCCCCC
RFALPNARIMVHQPSGGFQGQATDILIHAREIEALKRRLNEIYVKHTGRDYDTIHTALER
EEECCCCEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
DNFMTADAAKEFGLIDEVIEKRPEPAAA
CCCCCHHHHHHCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRDPIDVYNNALVPMVVEQSSRGERAFDIYSRLLRERIIFLTGPVEDYGASLIVAQLLFL
CCCCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
EAENPKKEISFYINSPGGVVTSGLSIYDTMQFIRCPVTTLCVGQAASMGSLLLTAGEPGH
CCCCCCCEEEEEEECCCCEEECCHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCCCCC
RFALPNARIMVHQPSGGFQGQATDILIHAREIEALKRRLNEIYVKHTGRDYDTIHTALER
EEECCCCEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
DNFMTADAAKEFGLIDEVIEKRPEPAAA
CCCCCHHHHHHCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA