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The map label for this gene is tig

Identifier: 170751513

GI number: 170751513

Start: 5455918

End: 5457339

Strand: Direct

Name: tig

Synonym: Mrad2831_5133

Alternate gene names: 170751513

Gene position: 5455918-5457339 (Clockwise)

Preceding gene: 170751511

Following gene: 170751514

Centisome position: 89.77

GC content: 67.86

Gene sequence:

>1422_bases
ATGCAGGTGACCGAGATCAACGCCCAGGGGCTGAAGCGCGAGTTTCAGGTTCTGCTGGCCGCCCAGGAACTCGAGGAGCG
CCTGACCAACGAGCTGTCCGGCATGAAGGACAAGGTGCAGCTCAAGGGCTTCCGTCCCGGTAAGGTGCCGGTCGCGCACC
TGCGCAAGGTCTACGGCCGCTCCGTGATGGCCGAGGTGGTGCAGAACGCCGTCAACGAGGCGAACCGCCAGATCGTCACC
GATAACGGCCTCAAGCTCGCCCTGGAGCCGCAGGTCGAGTTCCCGACCGACCAGGCCGAGGTCGAGAAGGCGCTGGACGC
CAAGGGCGACCTCGCCTTCAAGGTCGCCCTCGAGGTGATGCCGAGCTTCGAGCTCGCCGACCTCTCCGACGTCAGCCTGA
CCAAGCTCGTCGCCAAGCCGTCGGACGCGGAGGTCGACGAGGCCCTCGACCGCATGGCCGGCCAGAGCCGCCCGTTCACC
GAGCGCGAAGAGGGCGCCGAGGCCCAGAGCGGCGACCGCGTCACGATCGACTTCGTCGGCCGCATCGACGGCGAGGAGTT
CCAGGGCGGCAAGGGCGAGGGCATCGACCTCGAGCTGGGCTCCGGCTCGTTCATCCCGGGCTTCGAGGATCAGCTCGTCG
GCGCCAAGGTCGGCGACAAGCGCCTCGTGAAGGTCACCTTCCCCGAGTCGTACGGGGCCGAGCACCTCGCCGGCAAGGAC
GCCGAGTTCGACGTGACCGTCACGAAGATCCAGGCGGCGGGCGAAGCCAAGATCGACGACGAGTTCGCCAAGTCGATGGG
CATGGAGTCGCTGGAGAAGCTCCGCGAGGCCGTGTCCGAGGCGATCGGCCGGGACTTCGAGGCCGCCTCGCGCCGCCGGC
TCAAGAAGGAGCTCCTCGACGCGCTGGACGGCAAGTACGCCTTCGAGCTGCCCCCGTCGCTGGTGGCGCAGGAATTCGCC
GCGGTGTGGGCGCAGGTCGAGCAGGACCTCAAGACCCGCGGCAAGACCTTCGAGGACGAGGACACCACCGAGGAGAAGGC
CCAGGCCGAGTACCGGAAGATCGCGGAACGGCGCGTCCGTCTCGGTCTCGTGCTTGCGCAGGTCGGCGAGAGCGCCGATA
TCAAGGTCTCGGACGAGGAGGTGAACCAGGCCCTCATCGCCCGGGTCCGGCAGTTCCCGGGCCAGGAGCAGCAGGTCTGG
GACTTCTACCGGAAGAATGCGCAGGCGCTCGCGGAACTCCGCGCGCCCCTGTTCGAGGAGAAGGTCGTCGACCACGTCCT
CGGGCAGGTCAAGCTCGTCGAGGAGCCCGTCTCGAAAGAGGCGCTTTTCGCCGACGAAGATGGCGACGACACGACCGGCG
GGAAGCCGGCAGACAAGGCCGAGGCCAAGGACGAGTCCAAGACCGAAGCCAAGGCCGACTGA

Upstream 100 bases:

>100_bases
ACCCTCCGCCCCGTACCCGACATCTCGGCATCCCGGTCCGCGCGAGCACGACGCCGGCCCGGCCGGCGACCCCAGGTTTC
TTTGAAGAGCGACGACGACG

Downstream 100 bases:

>100_bases
GTCCCGCTCTGTCCCAGGACGGCGGGCAAGGGTTAGGCGATGGTTAAGCATCGCCGGTGTTCGCTGACATGCCCGGGGCT
GCCCTGATTCGCGGCAGCCC

Product: trigger factor

Products: peptidylproline (w =0) [C]

Alternate protein names: TF

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MQVTEINAQGLKREFQVLLAAQELEERLTNELSGMKDKVQLKGFRPGKVPVAHLRKVYGRSVMAEVVQNAVNEANRQIVT
DNGLKLALEPQVEFPTDQAEVEKALDAKGDLAFKVALEVMPSFELADLSDVSLTKLVAKPSDAEVDEALDRMAGQSRPFT
EREEGAEAQSGDRVTIDFVGRIDGEEFQGGKGEGIDLELGSGSFIPGFEDQLVGAKVGDKRLVKVTFPESYGAEHLAGKD
AEFDVTVTKIQAAGEAKIDDEFAKSMGMESLEKLREAVSEAIGRDFEAASRRRLKKELLDALDGKYAFELPPSLVAQEFA
AVWAQVEQDLKTRGKTFEDEDTTEEKAQAEYRKIAERRVRLGLVLAQVGESADIKVSDEEVNQALIARVRQFPGQEQQVW
DFYRKNAQALAELRAPLFEEKVVDHVLGQVKLVEEPVSKEALFADEDGDDTTGGKPADKAEAKDESKTEAKAD

Sequences:

>Translated_473_residues
MQVTEINAQGLKREFQVLLAAQELEERLTNELSGMKDKVQLKGFRPGKVPVAHLRKVYGRSVMAEVVQNAVNEANRQIVT
DNGLKLALEPQVEFPTDQAEVEKALDAKGDLAFKVALEVMPSFELADLSDVSLTKLVAKPSDAEVDEALDRMAGQSRPFT
EREEGAEAQSGDRVTIDFVGRIDGEEFQGGKGEGIDLELGSGSFIPGFEDQLVGAKVGDKRLVKVTFPESYGAEHLAGKD
AEFDVTVTKIQAAGEAKIDDEFAKSMGMESLEKLREAVSEAIGRDFEAASRRRLKKELLDALDGKYAFELPPSLVAQEFA
AVWAQVEQDLKTRGKTFEDEDTTEEKAQAEYRKIAERRVRLGLVLAQVGESADIKVSDEEVNQALIARVRQFPGQEQQVW
DFYRKNAQALAELRAPLFEEKVVDHVLGQVKLVEEPVSKEALFADEDGDDTTGGKPADKAEAKDESKTEAKAD
>Mature_473_residues
MQVTEINAQGLKREFQVLLAAQELEERLTNELSGMKDKVQLKGFRPGKVPVAHLRKVYGRSVMAEVVQNAVNEANRQIVT
DNGLKLALEPQVEFPTDQAEVEKALDAKGDLAFKVALEVMPSFELADLSDVSLTKLVAKPSDAEVDEALDRMAGQSRPFT
EREEGAEAQSGDRVTIDFVGRIDGEEFQGGKGEGIDLELGSGSFIPGFEDQLVGAKVGDKRLVKVTFPESYGAEHLAGKD
AEFDVTVTKIQAAGEAKIDDEFAKSMGMESLEKLREAVSEAIGRDFEAASRRRLKKELLDALDGKYAFELPPSLVAQEFA
AVWAQVEQDLKTRGKTFEDEDTTEEKAQAEYRKIAERRVRLGLVLAQVGESADIKVSDEEVNQALIARVRQFPGQEQQVW
DFYRKNAQALAELRAPLFEEKVVDHVLGQVKLVEEPVSKEALFADEDGDDTTGGKPADKAEAKDESKTEAKAD

Specific function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation

COG id: COG0544

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Escherichia coli, GI1786640, Length=440, Percent_Identity=31.5909090909091, Blast_Score=200, Evalue=1e-52,

Paralogues:

None

Copy number: 1070 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 500 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 340 Molecules/Cell In: Growth-Phase, Mini

Swissprot (AC and ID): TIG_METRJ (B1LV84)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001757773.1
- ProteinModelPortal:   B1LV84
- SMR:   B1LV84
- GeneID:   6141202
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_5133
- HOGENOM:   HBG635105
- OMA:   RFIPGFE
- ProtClustDB:   PRK01490
- HAMAP:   MF_00303
- InterPro:   IPR001179
- InterPro:   IPR005215
- InterPro:   IPR008880
- InterPro:   IPR008881
- Gene3D:   G3DSA:1.10.3120.10
- Gene3D:   G3DSA:3.30.70.1050
- PANTHER:   PTHR10516
- PIRSF:   PIRSF003095
- TIGRFAMs:   TIGR00115

Pfam domain/function: PF00254 FKBP_C; PF05698 Trigger_C; PF05697 Trigger_N; SSF109998 Trigger_fac_C_bac; SSF102735 Trigger_fac_ribosome-bd_bac

EC number: NA

Molecular weight: Translated: 52060; Mature: 52060

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTEINAQGLKREFQVLLAAQELEERLTNELSGMKDKVQLKGFRPGKVPVAHLRKVYGR
CCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCHHHHHHHHHH
SVMAEVVQNAVNEANRQIVTDNGLKLALEPQVEFPTDQAEVEKALDAKGDLAFKVALEVM
HHHHHHHHHHHHHHCCEEEECCCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHC
PSFELADLSDVSLTKLVAKPSDAEVDEALDRMAGQSRPFTEREEGAEAQSGDRVTIDFVG
CCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCEEEEEEEE
RIDGEEFQGGKGEGIDLELGSGSFIPGFEDQLVGAKVGDKRLVKVTFPESYGAEHLAGKD
CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCCHHHCCCC
AEFDVTVTKIQAAGEAKIDDEFAKSMGMESLEKLREAVSEAIGRDFEAASRRRLKKELLD
CCCEEEEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALDGKYAFELPPSLVAQEFAAVWAQVEQDLKTRGKTFEDEDTTEEKAQAEYRKIAERRVR
HHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGLVLAQVGESADIKVSDEEVNQALIARVRQFPGQEQQVWDFYRKNAQALAELRAPLFEE
HHHHHHHCCCCCCCEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KVVDHVLGQVKLVEEPVSKEALFADEDGDDTTGGKPADKAEAKDESKTEAKAD
HHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCHHHCCCCCCHHCCCC
>Mature Secondary Structure
MQVTEINAQGLKREFQVLLAAQELEERLTNELSGMKDKVQLKGFRPGKVPVAHLRKVYGR
CCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCHHHHHHHHHH
SVMAEVVQNAVNEANRQIVTDNGLKLALEPQVEFPTDQAEVEKALDAKGDLAFKVALEVM
HHHHHHHHHHHHHHCCEEEECCCEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHC
PSFELADLSDVSLTKLVAKPSDAEVDEALDRMAGQSRPFTEREEGAEAQSGDRVTIDFVG
CCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCEEEEEEEE
RIDGEEFQGGKGEGIDLELGSGSFIPGFEDQLVGAKVGDKRLVKVTFPESYGAEHLAGKD
CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCCHHHCCCC
AEFDVTVTKIQAAGEAKIDDEFAKSMGMESLEKLREAVSEAIGRDFEAASRRRLKKELLD
CCCEEEEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALDGKYAFELPPSLVAQEFAAVWAQVEQDLKTRGKTFEDEDTTEEKAQAEYRKIAERRVR
HHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGLVLAQVGESADIKVSDEEVNQALIARVRQFPGQEQQVWDFYRKNAQALAELRAPLFEE
HHHHHHHCCCCCCCEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KVVDHVLGQVKLVEEPVSKEALFADEDGDDTTGGKPADKAEAKDESKTEAKAD
HHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: peptidylproline (w =180) [C]

Specific reaction: peptidylproline (w =180) = peptidylproline (w =0) [C]

General reaction: Isomerases; cis-trans-Isomerases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA