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The map label for this gene is hisN [H]

Identifier: 170748557

GI number: 170748557

Start: 2279582

End: 2280370

Strand: Reverse

Name: hisN [H]

Synonym: Mrad2831_2139

Alternate gene names: 170748557

Gene position: 2280370-2279582 (Counterclockwise)

Preceding gene: 170748558

Following gene: 170748556

Centisome position: 37.52

GC content: 73.89

Gene sequence:

>789_bases
ATGAGCGTCGTCGAACTCGGCCGGTTCATGGACGACCTCGCGGACGCGTCCGGGAAGGCGATCCTGCCGTTCTTCCGCGC
CCAGTTCGGCCTGGACGACAAGGCCCGCGGCGGGGCGCCGTTCGATCCGGTCACCGAGGCCGACCGGGCCGCCGAGGTCG
TCCTCCGGGCGATGATCGGCCAGACCTTCCCGGGCCACGGCATCCTCGGCGAGGAGTTCGGCGCGGAGCGCACCGACGCC
GAGTGCGTCTGGGTCCTCGACCCGATCGACGGCACCCGCGCCTTCATCGGCGGCCTGCCGACCTGGGGCACCCTGATCGG
GCTGACCCGCAACGGCGTGCCGGTGCGGGGGATGATGCACCAGCCCTACCTCGCGGAGCGGTTCACCGGGGACGGGCGCA
GCGCCAAGCTCCGCGCGCCGGCGGGCGAGCGGACCCTGCGCACCCGCCGCTGCGGAGACCTCGCCCAGGCCATCCTGGCC
ACGACGGATCCCCGCCTGTTCGCGGCCGGAGACGAGGCCGAGCGCTTCCGGGCACTGGAAGGCCAGGTGCGGATGTCCCG
CTACGGCGCCGATTGCTACGCCTACTGCATGCTGGCGGCCGGCCAGATCGACCTCGTGGTCGAGGCCGGTCTGAAGCCCT
ACGACATCGTCGCGCTGATCCCGATCGTCGAGGGGGCCGGGGGACGGGTCACGGCCTGGGACGGCGGCTCCGCCGCCGGC
GGCGGCCGCGTGATCGCGGCCGGCGACCCGCGGCTGCACGAGGCCGCGCTCAAGGTTCTGAACCCGTGA

Upstream 100 bases:

>100_bases
TGCGCGGGGGCGAGGGCTTGACGGGCAGGGGCGCGCGCCGGTTTCGTCGGAACGGGCCGGTTGGCCGCGCGGCCTTCGGG
CGGAACAGGGGACGGAACGG

Downstream 100 bases:

>100_bases
CGCGCGGCCGTCTCCAGTCCGTCCGCCGCGAAGGTTCGTCCGCGTGCTGCTGAACGCGCTGATCCTGGTCACGGCCCTGG
TGCCGCACGCCGAGGCCGGC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSVVELGRFMDDLADASGKAILPFFRAQFGLDDKARGGAPFDPVTEADRAAEVVLRAMIGQTFPGHGILGEEFGAERTDA
ECVWVLDPIDGTRAFIGGLPTWGTLIGLTRNGVPVRGMMHQPYLAERFTGDGRSAKLRAPAGERTLRTRRCGDLAQAILA
TTDPRLFAAGDEAERFRALEGQVRMSRYGADCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGRVTAWDGGSAAG
GGRVIAAGDPRLHEAALKVLNP

Sequences:

>Translated_262_residues
MSVVELGRFMDDLADASGKAILPFFRAQFGLDDKARGGAPFDPVTEADRAAEVVLRAMIGQTFPGHGILGEEFGAERTDA
ECVWVLDPIDGTRAFIGGLPTWGTLIGLTRNGVPVRGMMHQPYLAERFTGDGRSAKLRAPAGERTLRTRRCGDLAQAILA
TTDPRLFAAGDEAERFRALEGQVRMSRYGADCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGRVTAWDGGSAAG
GGRVIAAGDPRLHEAALKVLNP
>Mature_261_residues
SVVELGRFMDDLADASGKAILPFFRAQFGLDDKARGGAPFDPVTEADRAAEVVLRAMIGQTFPGHGILGEEFGAERTDAE
CVWVLDPIDGTRAFIGGLPTWGTLIGLTRNGVPVRGMMHQPYLAERFTGDGRSAKLRAPAGERTLRTRRCGDLAQAILAT
TDPRLFAAGDEAERFRALEGQVRMSRYGADCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGRVTAWDGGSAAGG
GRVIAAGDPRLHEAALKVLNP

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=223, Percent_Identity=35.4260089686099, Blast_Score=97, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI193202570, Length=201, Percent_Identity=29.8507462686567, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193202572, Length=206, Percent_Identity=28.6407766990291, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24664922, Length=207, Percent_Identity=32.3671497584541, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357329, Length=241, Percent_Identity=29.8755186721992, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357957, Length=245, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24664926, Length=215, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664918, Length=248, Percent_Identity=28.2258064516129, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27830; Mature: 27699

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVELGRFMDDLADASGKAILPFFRAQFGLDDKARGGAPFDPVTEADRAAEVVLRAMIG
CCHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
QTFPGHGILGEEFGAERTDAECVWVLDPIDGTRAFIGGLPTWGTLIGLTRNGVPVRGMMH
CCCCCCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHCCCCCHHHHEEECCCCCCCCCCCC
QPYLAERFTGDGRSAKLRAPAGERTLRTRRCGDLAQAILATTDPRLFAAGDEAERFRALE
CCHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
GQVRMSRYGADCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGRVTAWDGGSAAG
HHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEEEECCCCEEEEECCCCCCC
GGRVIAAGDPRLHEAALKVLNP
CCEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SVVELGRFMDDLADASGKAILPFFRAQFGLDDKARGGAPFDPVTEADRAAEVVLRAMIG
CHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
QTFPGHGILGEEFGAERTDAECVWVLDPIDGTRAFIGGLPTWGTLIGLTRNGVPVRGMMH
CCCCCCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHCCCCCHHHHEEECCCCCCCCCCCC
QPYLAERFTGDGRSAKLRAPAGERTLRTRRCGDLAQAILATTDPRLFAAGDEAERFRALE
CCHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
GQVRMSRYGADCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGRVTAWDGGSAAG
HHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEEEECCCCEEEEECCCCCCC
GGRVIAAGDPRLHEAALKVLNP
CCEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]