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The map label for this gene is argH [H]

Identifier: 170747064

GI number: 170747064

Start: 676020

End: 677510

Strand: Reverse

Name: argH [H]

Synonym: Mrad2831_0630

Alternate gene names: 170747064

Gene position: 677510-676020 (Counterclockwise)

Preceding gene: 170747065

Following gene: 170747063

Centisome position: 11.15

GC content: 74.11

Gene sequence:

>1491_bases
ATGCGGCGCACGATGGTCTGGGTCGCACTGGCGCTGCTGGTGCCCGCGGGGGCTTGCGCCGAGCCGAAGGACAGCTTCGC
CCGGATCGACCAGATCAACCGCGCCTCTCTGGTCATGACGGTGGAGACCGGCATCGTGCCGCGGGCGCTGGGCGCGACCA
TCGCCCGCGCCCTCGACCGGGTCGCCGCCGACGCCGCGAAGCCGGGTGCGGAGCGGCCGGACGACTACCTGCGGATCGAG
CCGCTGATCACCGCCATCGCGGGCGCCGACGCGACCCGGATGCATTCCGGGCGCAGCCGCCAGGACATCATCCCGACGGT
GCTGAAGCTCGAGCAGCGCGACCGCCTCCTGAACCTCGCCAAGGCGCTCGACGAGACCCGGGCGGCCCTGCTGACCGTGG
CCGAGCGCGAGGCCGACACGATCGTCCCGGCCTACACCAACGGCGTGCAGGCCCAGCCGACGACGCTCGGCCACATCTAT
TTGGGCTACGCGGCCGTCCTCGCCCGCGACGCGGACCGTCTCCGGGAGACCTGGGCGCGGCTGAACCTGTCGCCCCTGGG
CGCGGCCGCCCTGGGAACGTCGAGCTTCCCGGTGAACCGCGAGAGGCTGGCGGCGCTGCTCGGCTTCGACGCGCCGGTGG
AGAACAGCTACGATTCCGGCCAGCTCGCGCCGATGGATATGGGGATCGAGCTGACCGGGCTCGCGGCGAACCTCGCCACC
ACGGCCGGCAGCTTCGCGCAGGACCTCTACGCGCAGTACCACCAGACCCGGCCCTGGATCCTGCTGCGGGAGGGCGCGCT
GACCGGGCCCAGCAGCATCATGCCGCAGAAGCGCAACCCCGTCGCGCTCTACAGCCTGCGCATGAAGGCCAGCGACGTCG
TGGGGGCCGCGCAGGCCTTCGTCATCATGGCGCACAACGTCGATTCCGGCATGCCGGACTACAAGCGCAACCAGGCCGAG
CCGCCCGGGCGGACCCTGGCCGAGGCCGCCGAGATGTGCCGGCGCTGGACCCACGTCCTCGACGGGCTGGTCGTCGACCG
GGCGCGCGCCGCCGACGAGGTCGCGGCGGACTATTCCACCACCACCGAGCTCGCCGACACGCTCCAGCGCGAGGCCGACG
TTCCGTTCCGGCTCGGCCACCACTTCGCGTCCGAGCTGGTGAGCTACGGCCGCAGCCACGACCTGCGCCCGGCCGACCTG
CCCTTCCCGGAGGTGCGGCGCATCTACGCCGAGGCCGCGGCGGGGTCGGGGCTGACGCCGGACCTGCCCCTCGACGAGGC
CCGCTTCCGGGCGGCTCTCTCGGCCCGCGGCATGATCGACGCCGCGAAGGGCCTCGGCGGTCCGCAGCCCGCGGAGGTCC
GGCGGATGCTGGGCGCCGCGCAGACGCGGCTGCGGACCGACCGCGACTGGCTCGACGCCCGCCGCACGGGCCTGGCCGAC
GCCCGGGCGCGGCTCGACGCCGCCTTCGCGGCCCTGACGCGCGAGCCCTGA

Upstream 100 bases:

>100_bases
CCGTCGCCTGAGCCGCCGCAAACGCCCGCATTATACAGTTGTGAATAGGAAGGCGGGCCGCGACGGGTCTATCAGGACCG
AGACGGCAGGGAGCGGCTCG

Downstream 100 bases:

>100_bases
GCCCGGCGCGGGGGCGCCGTGCCGAAACTCTGCCGTGACAGGGCCAATATTGCGGTATAGCGCGCGCCTGACGCCTGCCG
GCTGAAGCGGGCCTCTCCCG

Product: fumarate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MRRTMVWVALALLVPAGACAEPKDSFARIDQINRASLVMTVETGIVPRALGATIARALDRVAADAAKPGAERPDDYLRIE
PLITAIAGADATRMHSGRSRQDIIPTVLKLEQRDRLLNLAKALDETRAALLTVAEREADTIVPAYTNGVQAQPTTLGHIY
LGYAAVLARDADRLRETWARLNLSPLGAAALGTSSFPVNRERLAALLGFDAPVENSYDSGQLAPMDMGIELTGLAANLAT
TAGSFAQDLYAQYHQTRPWILLREGALTGPSSIMPQKRNPVALYSLRMKASDVVGAAQAFVIMAHNVDSGMPDYKRNQAE
PPGRTLAEAAEMCRRWTHVLDGLVVDRARAADEVAADYSTTTELADTLQREADVPFRLGHHFASELVSYGRSHDLRPADL
PFPEVRRIYAEAAAGSGLTPDLPLDEARFRAALSARGMIDAAKGLGGPQPAEVRRMLGAAQTRLRTDRDWLDARRTGLAD
ARARLDAAFAALTREP

Sequences:

>Translated_496_residues
MRRTMVWVALALLVPAGACAEPKDSFARIDQINRASLVMTVETGIVPRALGATIARALDRVAADAAKPGAERPDDYLRIE
PLITAIAGADATRMHSGRSRQDIIPTVLKLEQRDRLLNLAKALDETRAALLTVAEREADTIVPAYTNGVQAQPTTLGHIY
LGYAAVLARDADRLRETWARLNLSPLGAAALGTSSFPVNRERLAALLGFDAPVENSYDSGQLAPMDMGIELTGLAANLAT
TAGSFAQDLYAQYHQTRPWILLREGALTGPSSIMPQKRNPVALYSLRMKASDVVGAAQAFVIMAHNVDSGMPDYKRNQAE
PPGRTLAEAAEMCRRWTHVLDGLVVDRARAADEVAADYSTTTELADTLQREADVPFRLGHHFASELVSYGRSHDLRPADL
PFPEVRRIYAEAAAGSGLTPDLPLDEARFRAALSARGMIDAAKGLGGPQPAEVRRMLGAAQTRLRTDRDWLDARRTGLAD
ARARLDAAFAALTREP
>Mature_496_residues
MRRTMVWVALALLVPAGACAEPKDSFARIDQINRASLVMTVETGIVPRALGATIARALDRVAADAAKPGAERPDDYLRIE
PLITAIAGADATRMHSGRSRQDIIPTVLKLEQRDRLLNLAKALDETRAALLTVAEREADTIVPAYTNGVQAQPTTLGHIY
LGYAAVLARDADRLRETWARLNLSPLGAAALGTSSFPVNRERLAALLGFDAPVENSYDSGQLAPMDMGIELTGLAANLAT
TAGSFAQDLYAQYHQTRPWILLREGALTGPSSIMPQKRNPVALYSLRMKASDVVGAAQAFVIMAHNVDSGMPDYKRNQAE
PPGRTLAEAAEMCRRWTHVLDGLVVDRARAADEVAADYSTTTELADTLQREADVPFRLGHHFASELVSYGRSHDLRPADL
PFPEVRRIYAEAAAGSGLTPDLPLDEARFRAALSARGMIDAAKGLGGPQPAEVRRMLGAAQTRLRTDRDWLDARRTGLAD
ARARLDAAFAALTREP

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=373, Percent_Identity=28.686327077748, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI68303542, Length=373, Percent_Identity=28.686327077748, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI68303547, Length=256, Percent_Identity=33.984375, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI68303549, Length=373, Percent_Identity=26.2734584450402, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1790398, Length=433, Percent_Identity=30.715935334873, Blast_Score=165, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6321806, Length=300, Percent_Identity=33, Blast_Score=126, Evalue=9e-30,
Organism=Drosophila melanogaster, GI221473854, Length=351, Percent_Identity=28.2051282051282, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78706858, Length=351, Percent_Identity=28.2051282051282, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 53653; Mature: 53653

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTMVWVALALLVPAGACAEPKDSFARIDQINRASLVMTVETGIVPRALGATIARALDR
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
VAADAAKPGAERPDDYLRIEPLITAIAGADATRMHSGRSRQDIIPTVLKLEQRDRLLNLA
HHHHHCCCCCCCCCCCEEHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
KALDETRAALLTVAEREADTIVPAYTNGVQAQPTTLGHIYLGYAAVLARDADRLRETWAR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LNLSPLGAAALGTSSFPVNRERLAALLGFDAPVENSYDSGQLAPMDMGIELTGLAANLAT
CCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHH
TAGSFAQDLYAQYHQTRPWILLREGALTGPSSIMPQKRNPVALYSLRMKASDVVGAAQAF
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCCCCEEEEEEHHHHHHHHHHHHEE
VIMAHNVDSGMPDYKRNQAEPPGRTLAEAAEMCRRWTHVLDGLVVDRARAADEVAADYST
EEEEECCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TTELADTLQREADVPFRLGHHFASELVSYGRSHDLRPADLPFPEVRRIYAEAAAGSGLTP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
DLPLDEARFRAALSARGMIDAAKGLGGPQPAEVRRMLGAAQTRLRTDRDWLDARRTGLAD
CCCCHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHH
ARARLDAAFAALTREP
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRTMVWVALALLVPAGACAEPKDSFARIDQINRASLVMTVETGIVPRALGATIARALDR
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
VAADAAKPGAERPDDYLRIEPLITAIAGADATRMHSGRSRQDIIPTVLKLEQRDRLLNLA
HHHHHCCCCCCCCCCCEEHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
KALDETRAALLTVAEREADTIVPAYTNGVQAQPTTLGHIYLGYAAVLARDADRLRETWAR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LNLSPLGAAALGTSSFPVNRERLAALLGFDAPVENSYDSGQLAPMDMGIELTGLAANLAT
CCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHH
TAGSFAQDLYAQYHQTRPWILLREGALTGPSSIMPQKRNPVALYSLRMKASDVVGAAQAF
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCCCCEEEEEEHHHHHHHHHHHHEE
VIMAHNVDSGMPDYKRNQAEPPGRTLAEAAEMCRRWTHVLDGLVVDRARAADEVAADYST
EEEEECCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TTELADTLQREADVPFRLGHHFASELVSYGRSHDLRPADLPFPEVRRIYAEAAAGSGLTP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
DLPLDEARFRAALSARGMIDAAKGLGGPQPAEVRRMLGAAQTRLRTDRDWLDARRTGLAD
CCCCHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHH
ARARLDAAFAALTREP
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA