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The map label for this gene is folD [H]

Identifier: 170077511

GI number: 170077511

Start: 919947

End: 920813

Strand: Reverse

Name: folD [H]

Synonym: SYNPCC7002_A0889

Alternate gene names: 170077511

Gene position: 920813-919947 (Counterclockwise)

Preceding gene: 170077512

Following gene: 170077510

Centisome position: 30.61

GC content: 54.9

Gene sequence:

>867_bases
ATGGCACAAATCCTTGACGGCAAAAGCTTTGCCCAAAAAATCCAAGCAAACCTCAAAACCCAAATCGCGGCCCTCACCCC
AAAAATGGGTCGTCCCCCCGGTCTCGCCGTGCTGATGGTTGGGGATAATCCTGCTAGCGCTGCCTATGTCCGTAACAAAG
AACGCGCCTGCGAACGGATTGGCATGGCCTCCTTTGGTAAGCATTTTCCCGCCGATACCACCCAAAGCGAACTTGAAGCT
GTGATCCAAGACCTGAATCAAGATGAGCGAGTTGACGGGATTTTGGTGCAATTGCCGTTACCGCCCCACCTAGATGCCGT
GGGTTTGCTGTTAACCATTGCCCCGGAAAAGGATGCCGATGGGCTGCACCCCTTAAACCTAGGCCATCTTGTACGCTCCG
AACCGGGCCTGCGCAGTTGTACCCCCTACGGCGTAATGGAACTGCTCAAGGAATATCACATCCCCCTCGAAGGGAAAAAA
GCCGTGGTGGTGGGCCGGAGTATTTTGGTAGGGAAACCCATTGCCTTGATGCTTTTAGAAGCAAATGCCACAGTGGCGAT
CGCCCATTCTCGCACCCAAGACCTCGCTGCGGTGACCAGGGAAGCAGATATTCTCGTAGCCGCCATTGGCAGACCAGAAT
TTATTACCGCTGACATGATCAAGCCCGGTGCTGTGGTGATCGATGTGGGCATCAATCGCATCGTCGATACGGCAACGGGT
AAATCGCGCCTGGTGGGAGATGTCGCCTACACAGAGGCCGCCCAAGTCGCCGCCCAGATTACGCCCGTCCCCGGTGGCAT
CGGCCCCATGACCGTAGCAATGCTCCTACAAAATACCTTCAACAGTTACCAAGCTAAGGCGAAGTAA

Upstream 100 bases:

>100_bases
TGCTCCCACGACCCCTTAAATTTGCACCGCTTAGATCCTATCCTCAGCATCAGATCTAAGATAAACTTGGCAACCGAAAT
GCTCAGCATCCCCGACATCC

Downstream 100 bases:

>100_bases
GCATTTATTTTTAGGTACAGATTTGTATGAAATTTTCTCTCCTCCCGGGGGGAGTTTTTTATGGTCTTTAGCGAGGGAAA
TTGCCCAGAGAAATTGACCT

Product: 5,10-methylenetetrahydrofolate dehydrogenase; methenyl tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MAQILDGKSFAQKIQANLKTQIAALTPKMGRPPGLAVLMVGDNPASAAYVRNKERACERIGMASFGKHFPADTTQSELEA
VIQDLNQDERVDGILVQLPLPPHLDAVGLLLTIAPEKDADGLHPLNLGHLVRSEPGLRSCTPYGVMELLKEYHIPLEGKK
AVVVGRSILVGKPIALMLLEANATVAIAHSRTQDLAAVTREADILVAAIGRPEFITADMIKPGAVVIDVGINRIVDTATG
KSRLVGDVAYTEAAQVAAQITPVPGGIGPMTVAMLLQNTFNSYQAKAK

Sequences:

>Translated_288_residues
MAQILDGKSFAQKIQANLKTQIAALTPKMGRPPGLAVLMVGDNPASAAYVRNKERACERIGMASFGKHFPADTTQSELEA
VIQDLNQDERVDGILVQLPLPPHLDAVGLLLTIAPEKDADGLHPLNLGHLVRSEPGLRSCTPYGVMELLKEYHIPLEGKK
AVVVGRSILVGKPIALMLLEANATVAIAHSRTQDLAAVTREADILVAAIGRPEFITADMIKPGAVVIDVGINRIVDTATG
KSRLVGDVAYTEAAQVAAQITPVPGGIGPMTVAMLLQNTFNSYQAKAK
>Mature_287_residues
AQILDGKSFAQKIQANLKTQIAALTPKMGRPPGLAVLMVGDNPASAAYVRNKERACERIGMASFGKHFPADTTQSELEAV
IQDLNQDERVDGILVQLPLPPHLDAVGLLLTIAPEKDADGLHPLNLGHLVRSEPGLRSCTPYGVMELLKEYHIPLEGKKA
VVVGRSILVGKPIALMLLEANATVAIAHSRTQDLAAVTREADILVAAIGRPEFITADMIKPGAVVIDVGINRIVDTATGK
SRLVGDVAYTEAAQVAAQITPVPGGIGPMTVAMLLQNTFNSYQAKAK

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=287, Percent_Identity=46.3414634146341, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI222418558, Length=289, Percent_Identity=46.7128027681661, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI94721354, Length=289, Percent_Identity=44.636678200692, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI36796743, Length=199, Percent_Identity=29.1457286432161, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786741, Length=281, Percent_Identity=46.6192170818505, Blast_Score=261, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17568735, Length=296, Percent_Identity=39.527027027027, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319558, Length=284, Percent_Identity=44.3661971830986, Blast_Score=239, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6321643, Length=291, Percent_Identity=42.6116838487972, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322933, Length=293, Percent_Identity=26.2798634812287, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136816, Length=292, Percent_Identity=46.2328767123288, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI17136818, Length=292, Percent_Identity=46.2328767123288, Blast_Score=246, Evalue=9e-66,
Organism=Drosophila melanogaster, GI62472483, Length=286, Percent_Identity=44.7552447552448, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI45551871, Length=286, Percent_Identity=44.7552447552448, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24645718, Length=286, Percent_Identity=44.7552447552448, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17137370, Length=286, Percent_Identity=44.7552447552448, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 30556; Mature: 30425

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQILDGKSFAQKIQANLKTQIAALTPKMGRPPGLAVLMVGDNPASAAYVRNKERACERI
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHCHHHHHHHH
GMASFGKHFPADTTQSELEAVIQDLNQDERVDGILVQLPLPPHLDAVGLLLTIAPEKDAD
CHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCC
GLHPLNLGHLVRSEPGLRSCTPYGVMELLKEYHIPLEGKKAVVVGRSILVGKPIALMLLE
CCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEECCCEEEEEEE
ANATVAIAHSRTQDLAAVTREADILVAAIGRPEFITADMIKPGAVVIDVGINRIVDTATG
CCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCEEECCCCCCCEEEEECCCHHHHCCCCC
KSRLVGDVAYTEAAQVAAQITPVPGGIGPMTVAMLLQNTFNSYQAKAK
CHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AQILDGKSFAQKIQANLKTQIAALTPKMGRPPGLAVLMVGDNPASAAYVRNKERACERI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHCHHHHHHHH
GMASFGKHFPADTTQSELEAVIQDLNQDERVDGILVQLPLPPHLDAVGLLLTIAPEKDAD
CHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCC
GLHPLNLGHLVRSEPGLRSCTPYGVMELLKEYHIPLEGKKAVVVGRSILVGKPIALMLLE
CCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEECCCEEEEEEE
ANATVAIAHSRTQDLAAVTREADILVAAIGRPEFITADMIKPGAVVIDVGINRIVDTATG
CCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCEEECCCCCCCEEEEECCCHHHHCCCCC
KSRLVGDVAYTEAAQVAAQITPVPGGIGPMTVAMLLQNTFNSYQAKAK
CHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA