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The map label for this gene is gyrA [H]

Identifier: 170077448

GI number: 170077448

Start: 851586

End: 854111

Strand: Reverse

Name: gyrA [H]

Synonym: SYNPCC7002_A0826

Alternate gene names: 170077448

Gene position: 854111-851586 (Counterclockwise)

Preceding gene: 170077449

Following gene: 170077444

Centisome position: 28.39

GC content: 53.13

Gene sequence:

>2526_bases
ATGTCACGCTCGTACCTAGAGTACGCCATGAGTGTGATTGTGGGGCGGGCGTTACCCGATGCACGGGATGGCTTAAAACC
CGTACACCGTCGTATTTTGTATGCGATGTATGAATTGGGTTTGACCCCAGATCGCCCTTTCCGGAAATGTGCCCGGGTCG
TGGGGGAAGTCCTCGGTAAATATCACCCCCACGGGGATACAGCGGTCTATGATGCCCTGGTGCGCATGGCCCAAGATTTT
TCCATGCGAGACCCGCTGATCAATGGCCACGGTAATTTTGGCTCCATTGATAACGACCCAGCGGCGGCCATGCGTTACAC
CGAATGTCGGCTCCAGTCTTTAGCGACCAACGCCCTGCTGCGGGATATCGAATCAGAAACCGTTGATTTTGCGGATAACT
TCGATGGCTCTCAACAGGAACCCGTTGTTCTCCCTTCTCGGATTCCCCAGCTTTTGGTGAATGGTTCTTCGGGGATTGCG
GTGGGGATGGCGACCAATATCCCGCCCCATAATCTTGGGGAAATTATTGATGGGGTGACGGCACTCATCCATAACCCTGA
GATCACGATCAAAGAATTAATGCAATTTATTCCGGCCCCTGATTTTCCGACGGGGGCACAGATTCTCGGTCGTTCGGGGA
TTAAAGATGCCTACATGACGGGTCGGGGTTCGATCACCATGCGGGGAGTCGCAGAAATTGAAACGCTCCGCCAAAATGGC
CGGGAAAAAGAAGCAATTATCGTCACCCAACTGCCCTACCAGACCAACAAAGCGGCGCTGATCGAACGCATTGCCGATAT
GGTCAACGACAAGAAAATTGATGGCATCTCTGATATCCGCGATGAAAGCGATCGCCAAGGGATGCGGATTGTCATCGAAC
TCAAGCGCGATGCTTATCCCCGTGTTGTTTTAAATAATCTGTATAAACACACGCCTCTCCAGGCCAATTTTGGCGCGAAT
ATGCTGGCCCTGGTGAACGGCGAACCCCAACTGCTCAATCTGAAGCAATTCCTCCAGGTATTCTTGGATTTCCGGGTGGA
AGTGATTACCCGGCGCACCCGCTATGAACTGCGCAAGGCCCAGGAACGGGATCACATTCTCCAGGGATTACTCATTGCCC
TCGATAATCTCGATGCGGTGATTCACTTAATTCGTCAGGCAGCGGATACGGCGATCGCCCGTCAAGGGTTAATGGACGGC
TACAACCTCAGCCAAGCCCAGGCCGACGCCATTTTACAGATGCAATTGCGTCGCCTCACGGCCCTAGAAGCGGACAAAAT
CGAAGCAGAACACCAGGATCTCTTGCTGAAGATTACGGATCTCGAAGATATTTTGGCGCGTCGGGAACGGGTTTACGCGA
TTATCGAAGCAGAGCTCACCGAAATTAAGACTATCCACCAGAGCGATCGCCGCACAGAATTGGTCTTGGATGACGGCGAT
CTCCAGGATATTGACCTAATTGCCAATGAGCAAGCAGCTATTTTGCTCACCGAACAGGGCTATATCAAACGCATGCCTGT
GGCCACCTTTGACGCCCAAAACCGCGCCACTCGCGGCAAAGCCGCCACCAAAATGAAGGAAGACGATGGCGTCGATCACT
TCCTCACCTGCTGCGATCACGACCATGTGCTGTTCTTTACGGAGCGCGGCGTCGTTTATTCTCTAAGCGCTTACCAAATT
CCCCAGAGTTCCCGCACGGCCAGAGGTTTACCAGCCATTCAACTGCTCCCCATCCCGAAGGATGAAAAAATTACAGCGAT
GCTGGCAGTGAGTGAGTTTACCGAAGATGAATACCTCGTCATGCTCACCCAGAACGGCTACATCAAAAAAACCGCCCTGT
CTGCCTTTGCCAAAATTCGCTCGAACGGTCTAATTGCCATTTCCCTCGAAGATGGCGATGAACTCCGTTGGGTACGCCTC
GCGCGACAGGAGGACAGCATCATTGTGGCCAGTAGTGAAGGGATGGCGATCCACTTCCAGGCTGACCATAACCAGTTACG
TCCCTTGGGCCGTTCTACGAGAGGCGTGCGGGCGATGAAACTCAAATCCGACGATGACAAATTGGTAAGTATGGATATTG
TGTCGTCTCAAATTACGGCGGCGATCGCCGCTGCGGATACAGCAGAAGACGAAGACGATAACGAAGAAGTCACCGAAAAT
GTTGACCAGGGGCCTTGGGTGATTGCCGTAACCACAAAAGGCTTCGGCAAGCGGGTGCCCGTGGGACGATTCCGCCTGCA
AAACCGCGCGGGGGTCGGTCTCCGGGCGATTAAATTCAAATCTAAGGCAGATCGGTTGGCTTCCCTGAGAATTGTCAATC
CCGAAGATGAGCTGATGCTCGTCACGGGGCGCGGCATTATGATCCGTCAAGCAGTGGAATCCATCTCGCTCCAGTCCCGC
AGTGCCACCGGAGTCAGGGTACAACGCCTCGATGGGGATGATGCAATTGTGGCAGTGGCCCTAGTACCGCCCCCAGCAGA
AGAAGACGGTTTAGAAACTGTGGATATGACTGCTGAAGAAGAATAA

Upstream 100 bases:

>100_bases
CGTCTTTTTCTCTGGTTTTTAACCTTTTTTGACCTAGCGGAGCCGAAATCCTATGACCTCCCCCCAGGAGCGCATTATTC
CCACCGATTTAAGCAATGAA

Downstream 100 bases:

>100_bases
ACTCTCCTTTAGTAACACTTCTCTAGCTTCCCTAGAGGAAAGAATTTTGTGGAGCTCGCCAACACACCGGCAACTGTTTC
CCCTCTTGAGAGGGGTCAGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 841; Mature: 840

Protein sequence:

>841_residues
MSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDF
SMRDPLINGHGNFGSIDNDPAAAMRYTECRLQSLATNALLRDIESETVDFADNFDGSQQEPVVLPSRIPQLLVNGSSGIA
VGMATNIPPHNLGEIIDGVTALIHNPEITIKELMQFIPAPDFPTGAQILGRSGIKDAYMTGRGSITMRGVAEIETLRQNG
REKEAIIVTQLPYQTNKAALIERIADMVNDKKIDGISDIRDESDRQGMRIVIELKRDAYPRVVLNNLYKHTPLQANFGAN
MLALVNGEPQLLNLKQFLQVFLDFRVEVITRRTRYELRKAQERDHILQGLLIALDNLDAVIHLIRQAADTAIARQGLMDG
YNLSQAQADAILQMQLRRLTALEADKIEAEHQDLLLKITDLEDILARRERVYAIIEAELTEIKTIHQSDRRTELVLDDGD
LQDIDLIANEQAAILLTEQGYIKRMPVATFDAQNRATRGKAATKMKEDDGVDHFLTCCDHDHVLFFTERGVVYSLSAYQI
PQSSRTARGLPAIQLLPIPKDEKITAMLAVSEFTEDEYLVMLTQNGYIKKTALSAFAKIRSNGLIAISLEDGDELRWVRL
ARQEDSIIVASSEGMAIHFQADHNQLRPLGRSTRGVRAMKLKSDDDKLVSMDIVSSQITAAIAAADTAEDEDDNEEVTEN
VDQGPWVIAVTTKGFGKRVPVGRFRLQNRAGVGLRAIKFKSKADRLASLRIVNPEDELMLVTGRGIMIRQAVESISLQSR
SATGVRVQRLDGDDAIVAVALVPPPAEEDGLETVDMTAEEE

Sequences:

>Translated_841_residues
MSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDF
SMRDPLINGHGNFGSIDNDPAAAMRYTECRLQSLATNALLRDIESETVDFADNFDGSQQEPVVLPSRIPQLLVNGSSGIA
VGMATNIPPHNLGEIIDGVTALIHNPEITIKELMQFIPAPDFPTGAQILGRSGIKDAYMTGRGSITMRGVAEIETLRQNG
REKEAIIVTQLPYQTNKAALIERIADMVNDKKIDGISDIRDESDRQGMRIVIELKRDAYPRVVLNNLYKHTPLQANFGAN
MLALVNGEPQLLNLKQFLQVFLDFRVEVITRRTRYELRKAQERDHILQGLLIALDNLDAVIHLIRQAADTAIARQGLMDG
YNLSQAQADAILQMQLRRLTALEADKIEAEHQDLLLKITDLEDILARRERVYAIIEAELTEIKTIHQSDRRTELVLDDGD
LQDIDLIANEQAAILLTEQGYIKRMPVATFDAQNRATRGKAATKMKEDDGVDHFLTCCDHDHVLFFTERGVVYSLSAYQI
PQSSRTARGLPAIQLLPIPKDEKITAMLAVSEFTEDEYLVMLTQNGYIKKTALSAFAKIRSNGLIAISLEDGDELRWVRL
ARQEDSIIVASSEGMAIHFQADHNQLRPLGRSTRGVRAMKLKSDDDKLVSMDIVSSQITAAIAAADTAEDEDDNEEVTEN
VDQGPWVIAVTTKGFGKRVPVGRFRLQNRAGVGLRAIKFKSKADRLASLRIVNPEDELMLVTGRGIMIRQAVESISLQSR
SATGVRVQRLDGDDAIVAVALVPPPAEEDGLETVDMTAEEE
>Mature_840_residues
SRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFS
MRDPLINGHGNFGSIDNDPAAAMRYTECRLQSLATNALLRDIESETVDFADNFDGSQQEPVVLPSRIPQLLVNGSSGIAV
GMATNIPPHNLGEIIDGVTALIHNPEITIKELMQFIPAPDFPTGAQILGRSGIKDAYMTGRGSITMRGVAEIETLRQNGR
EKEAIIVTQLPYQTNKAALIERIADMVNDKKIDGISDIRDESDRQGMRIVIELKRDAYPRVVLNNLYKHTPLQANFGANM
LALVNGEPQLLNLKQFLQVFLDFRVEVITRRTRYELRKAQERDHILQGLLIALDNLDAVIHLIRQAADTAIARQGLMDGY
NLSQAQADAILQMQLRRLTALEADKIEAEHQDLLLKITDLEDILARRERVYAIIEAELTEIKTIHQSDRRTELVLDDGDL
QDIDLIANEQAAILLTEQGYIKRMPVATFDAQNRATRGKAATKMKEDDGVDHFLTCCDHDHVLFFTERGVVYSLSAYQIP
QSSRTARGLPAIQLLPIPKDEKITAMLAVSEFTEDEYLVMLTQNGYIKKTALSAFAKIRSNGLIAISLEDGDELRWVRLA
RQEDSIIVASSEGMAIHFQADHNQLRPLGRSTRGVRAMKLKSDDDKLVSMDIVSSQITAAIAAADTAEDEDDNEEVTENV
DQGPWVIAVTTKGFGKRVPVGRFRLQNRAGVGLRAIKFKSKADRLASLRIVNPEDELMLVTGRGIMIRQAVESISLQSRS
ATGVRVQRLDGDDAIVAVALVPPPAEEDGLETVDMTAEEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=362, Percent_Identity=24.8618784530387, Blast_Score=77, Evalue=1e-13,
Organism=Homo sapiens, GI19913406, Length=356, Percent_Identity=24.7191011235955, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1788562, Length=874, Percent_Identity=45.4233409610984, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=616, Percent_Identity=38.474025974026, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324241, Length=366, Percent_Identity=25.4098360655738, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17136538, Length=299, Percent_Identity=24.7491638795987, Blast_Score=70, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93481; Mature: 93350

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGK
CCCHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
YHPHGDTAVYDALVRMAQDFSMRDPLINGHGNFGSIDNDPAAAMRYTECRLQSLATNALL
CCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RDIESETVDFADNFDGSQQEPVVLPSRIPQLLVNGSSGIAVGMATNIPPHNLGEIIDGVT
HHHHHHHCCHHCCCCCCCCCCEECHHHCCHHEECCCCCEEEEEECCCCCCHHHHHHHHHH
ALIHNPEITIKELMQFIPAPDFPTGAQILGRSGIKDAYMTGRGSITMRGVAEIETLRQNG
HHHCCCCCCHHHHHHHCCCCCCCCCHHHHCCCCCCHHHCCCCCCEEECHHHHHHHHHHCC
REKEAIIVTQLPYQTNKAALIERIADMVNDKKIDGISDIRDESDRQGMRIVIELKRDAYP
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCH
RVVLNNLYKHTPLQANFGANMLALVNGEPQLLNLKQFLQVFLDFRVEVITRRTRYELRKA
HHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
QERDHILQGLLIALDNLDAVIHLIRQAADTAIARQGLMDGYNLSQAQADAILQMQLRRLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ALEADKIEAEHQDLLLKITDLEDILARRERVYAIIEAELTEIKTIHQSDRRTELVLDDGD
HHHHHHHCCCCCCEEEEEECHHHHHHHHHHEEEEEHHHHHHHHHHHCCCCCEEEEECCCC
LQDIDLIANEQAAILLTEQGYIKRMPVATFDAQNRATRGKAATKMKEDDGVDHFLTCCDH
CCCEEEEECCCEEEEEECCCCEEECCEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHCCC
DHVLFFTERGVVYSLSAYQIPQSSRTARGLPAIQLLPIPKDEKITAMLAVSEFTEDEYLV
CCEEEEECCCEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHCCCCCEEE
MLTQNGYIKKTALSAFAKIRSNGLIAISLEDGDELRWVRLARQEDSIIVASSEGMAIHFQ
EEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEEE
ADHNQLRPLGRSTRGVRAMKLKSDDDKLVSMDIVSSQITAAIAAADTAEDEDDNEEVTEN
CCCCCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHC
VDQGPWVIAVTTKGFGKRVPVGRFRLQNRAGVGLRAIKFKSKADRLASLRIVNPEDELML
CCCCCEEEEEECCCCCCCCCCHHEEECCCCCCCEEEEEEHHHHCCEEEEEEECCCCCEEE
VTGRGIMIRQAVESISLQSRSATGVRVQRLDGDDAIVAVALVPPPAEEDGLETVDMTAEE
EECCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCCEECCCCCC
E
C
>Mature Secondary Structure 
SRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGK
CCHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
YHPHGDTAVYDALVRMAQDFSMRDPLINGHGNFGSIDNDPAAAMRYTECRLQSLATNALL
CCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RDIESETVDFADNFDGSQQEPVVLPSRIPQLLVNGSSGIAVGMATNIPPHNLGEIIDGVT
HHHHHHHCCHHCCCCCCCCCCEECHHHCCHHEECCCCCEEEEEECCCCCCHHHHHHHHHH
ALIHNPEITIKELMQFIPAPDFPTGAQILGRSGIKDAYMTGRGSITMRGVAEIETLRQNG
HHHCCCCCCHHHHHHHCCCCCCCCCHHHHCCCCCCHHHCCCCCCEEECHHHHHHHHHHCC
REKEAIIVTQLPYQTNKAALIERIADMVNDKKIDGISDIRDESDRQGMRIVIELKRDAYP
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCH
RVVLNNLYKHTPLQANFGANMLALVNGEPQLLNLKQFLQVFLDFRVEVITRRTRYELRKA
HHHHHHHHHCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
QERDHILQGLLIALDNLDAVIHLIRQAADTAIARQGLMDGYNLSQAQADAILQMQLRRLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ALEADKIEAEHQDLLLKITDLEDILARRERVYAIIEAELTEIKTIHQSDRRTELVLDDGD
HHHHHHHCCCCCCEEEEEECHHHHHHHHHHEEEEEHHHHHHHHHHHCCCCCEEEEECCCC
LQDIDLIANEQAAILLTEQGYIKRMPVATFDAQNRATRGKAATKMKEDDGVDHFLTCCDH
CCCEEEEECCCEEEEEECCCCEEECCEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHCCC
DHVLFFTERGVVYSLSAYQIPQSSRTARGLPAIQLLPIPKDEKITAMLAVSEFTEDEYLV
CCEEEEECCCEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHCCCCCEEE
MLTQNGYIKKTALSAFAKIRSNGLIAISLEDGDELRWVRLARQEDSIIVASSEGMAIHFQ
EEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEEE
ADHNQLRPLGRSTRGVRAMKLKSDDDKLVSMDIVSSQITAAIAAADTAEDEDDNEEVTEN
CCCCCCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHC
VDQGPWVIAVTTKGFGKRVPVGRFRLQNRAGVGLRAIKFKSKADRLASLRIVNPEDELML
CCCCCEEEEEECCCCCCCCCCHHEEECCCCCCCEEEEEEHHHHCCEEEEEEECCCCCEEE
VTGRGIMIRQAVESISLQSRSATGVRVQRLDGDDAIVAVALVPPPAEEDGLETVDMTAEE
EECCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCCEECCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]