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The map label for this gene is tpiA [H]

Identifier: 170026325

GI number: 170026325

Start: 4551843

End: 4552610

Strand: Direct

Name: tpiA [H]

Synonym: YPK_4118

Alternate gene names: 170026325

Gene position: 4551843-4552610 (Clockwise)

Preceding gene: 170026324

Following gene: 170026327

Centisome position: 97.07

GC content: 48.96

Gene sequence:

>768_bases
ATGCGACATCCATTAGTTATGGGTAACTGGAAGCTGAACGGTAGTACTCATATGGTTAACGAGCTTATCGCTGGCCTGCG
TAAAGAATTGAGCACCGTTGATGGTTGTGGCGTTGCCATTGCCCCACCGGCGATCTATCTAAATCAGGCAAAACATGAGC
TTGCTGGTAGCCGTATTGCTCTGGGTGCTCAAAACGTCGATGTGAACCTCTCCGGCGCATTTACCGGTGAAACATCTGCT
GAAATGCTGAAAGATATCGGTGCGCAATACATTATTATCGGCCACTCTGAGCGCCGTACTTATCACCAAGAAAGTGATGA
ATTGATCGCGAAGAAATTTGGCGTACTGAAAGAGATCGGCTTGATCCCAGTATTGTGTATCGGTGAGTCCGAAGCAGAAA
ACGAAGCGGGCCAAACTGAAGCAGTATGCGCCAAACAACTGGACGCCGTGCTGAATACCCTAGGCGTGAAAGCGTTCGAA
GGTGCGGTTATCGCTTATGAGCCAATCTGGGCTATCGGTACCGGTAAATCAGCAACTCCAGCGCAGGCTCAGGCTGTTCA
CAAATTTATCCGTGACCATATCGCCAAGCAAGACGCAGCAGTTGCAGCACAAGTGATCATTCAGTACGGCGGTTCTGTTA
ACGATAAAAACGCAGCAGAATTGTTCACTCAGCCAGATATTGATGGCGCACTGGTTGGCGGTGCATCACTGAAAGCAGAC
GCTTTCGCAGTTATCGTGAAAGCAGCCGCTAAAGCTAAAAAAGCCTAA

Upstream 100 bases:

>100_bases
AGCCATGACGACTAATCATCTCTATACTGTTGGACAGGTAAACTGCCTGTCAGGCAGTCATTATTATTGACCCTCGCGTT
CCCTAGTTGGAGGAAGAAAC

Downstream 100 bases:

>100_bases
CCCACGCTTTAAGCTAATTCTGGGTACAACACAAAAACCGGCGTAAATAAAAGCGCCGGTTTTTTATACACCCCAGATAA
TTCGAGTAGATTCATCCACT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MRHPLVMGNWKLNGSTHMVNELIAGLRKELSTVDGCGVAIAPPAIYLNQAKHELAGSRIALGAQNVDVNLSGAFTGETSA
EMLKDIGAQYIIIGHSERRTYHQESDELIAKKFGVLKEIGLIPVLCIGESEAENEAGQTEAVCAKQLDAVLNTLGVKAFE
GAVIAYEPIWAIGTGKSATPAQAQAVHKFIRDHIAKQDAAVAAQVIIQYGGSVNDKNAAELFTQPDIDGALVGGASLKAD
AFAVIVKAAAKAKKA

Sequences:

>Translated_255_residues
MRHPLVMGNWKLNGSTHMVNELIAGLRKELSTVDGCGVAIAPPAIYLNQAKHELAGSRIALGAQNVDVNLSGAFTGETSA
EMLKDIGAQYIIIGHSERRTYHQESDELIAKKFGVLKEIGLIPVLCIGESEAENEAGQTEAVCAKQLDAVLNTLGVKAFE
GAVIAYEPIWAIGTGKSATPAQAQAVHKFIRDHIAKQDAAVAAQVIIQYGGSVNDKNAAELFTQPDIDGALVGGASLKAD
AFAVIVKAAAKAKKA
>Mature_255_residues
MRHPLVMGNWKLNGSTHMVNELIAGLRKELSTVDGCGVAIAPPAIYLNQAKHELAGSRIALGAQNVDVNLSGAFTGETSA
EMLKDIGAQYIIIGHSERRTYHQESDELIAKKFGVLKEIGLIPVLCIGESEAENEAGQTEAVCAKQLDAVLNTLGVKAFE
GAVIAYEPIWAIGTGKSATPAQAQAVHKFIRDHIAKQDAAVAAQVIIQYGGSVNDKNAAELFTQPDIDGALVGGASLKAD
AFAVIVKAAAKAKKA

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=245, Percent_Identity=45.7142857142857, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI226529917, Length=245, Percent_Identity=45.7142857142857, Blast_Score=187, Evalue=8e-48,
Organism=Escherichia coli, GI1790353, Length=255, Percent_Identity=82.3529411764706, Blast_Score=429, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17536593, Length=247, Percent_Identity=48.9878542510121, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320255, Length=248, Percent_Identity=44.758064516129, Blast_Score=193, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28572008, Length=253, Percent_Identity=47.0355731225296, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28572006, Length=253, Percent_Identity=47.0355731225296, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28572004, Length=253, Percent_Identity=47.0355731225296, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26794; Mature: 26794

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHPLVMGNWKLNGSTHMVNELIAGLRKELSTVDGCGVAIAPPAIYLNQAKHELAGSRIA
CCCCEEEECEEECCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCEEE
LGAQNVDVNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHQESDELIAKKFGVLKEIG
ECCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
LIPVLCIGESEAENEAGQTEAVCAKQLDAVLNTLGVKAFEGAVIAYEPIWAIGTGKSATP
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCEEEECCEEEEECCCCCCC
AQAQAVHKFIRDHIAKQDAAVAAQVIIQYGGSVNDKNAAELFTQPDIDGALVGGASLKAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEECCCCCCHH
AFAVIVKAAAKAKKA
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MRHPLVMGNWKLNGSTHMVNELIAGLRKELSTVDGCGVAIAPPAIYLNQAKHELAGSRIA
CCCCEEEECEEECCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCEEE
LGAQNVDVNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHQESDELIAKKFGVLKEIG
ECCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
LIPVLCIGESEAENEAGQTEAVCAKQLDAVLNTLGVKAFEGAVIAYEPIWAIGTGKSATP
CEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCEEEECCEEEEECCCCCCC
AQAQAVHKFIRDHIAKQDAAVAAQVIIQYGGSVNDKNAAELFTQPDIDGALVGGASLKAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEECCCCCCHH
AFAVIVKAAAKAKKA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA