Definition Yersinia pseudotuberculosis YPIII chromosome, complete genome.
Accession NC_010465
Length 4,689,441

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The map label for this gene is metL [H]

Identifier: 170026301

GI number: 170026301

Start: 4524556

End: 4526991

Strand: Reverse

Name: metL [H]

Synonym: YPK_4094

Alternate gene names: 170026301

Gene position: 4526991-4524556 (Counterclockwise)

Preceding gene: 170026302

Following gene: 170026300

Centisome position: 96.54

GC content: 52.59

Gene sequence:

>2436_bases
ATGAATGCAACAGCGGTAGCAGCGGCGGCAACGGGCCGTCAACTGCATAAATTTGGTGGCAGTAGCCTTGCGGATGTGAA
GTGTTATCTACGGGTGGCTAATATTATGGCCAACTACAGTCACCCCGGCGATCTCATGGTGGTGTCTGCTGCCGGGAGCA
CGACAAACCAGTTGATCAGTTGGTTGAAACTCAGTCAAAACGACCGTCTTTCTGCTCATCAGGTACAGCAAAGTCTGCGT
CGTTATCAACACGATCTGATCAATGGCTTATTGCCTCCAGAAATGGCAGAGCCATTAATCAGTGAGTTTATTCATGATTT
AGAGCGCCTGGCGGGCTTGCTGGATAATAAAATTGATGATGTGATTTATGCTGAAGTGGTTGGTCATGGTGAAATTTGGT
CAGCCCGCTTGATGTCTGCGCTACTGAATAAGTTGGATATGGATGCCGTCTGGCTTGACGCCCGCCGTTTCCTACGTGCA
GAGCGTGCAGCGCAACCACAAATTGATGAAAGCCGCTCTTATCCGTTACTGCAACAATTAATGGCCCAACACCCTCACCA
GCGTTTGGTGGTGACTGGTTTTATCTCGCGCAATGAGGCGGGTGAAACGGTCTTGCTTGGCCGTAATGGCAGTGACTATT
CGGCGACGCAGGTCGGGGCATTGGCCGGGGCCGAGCGTGTCACCATCTGGAGTGATGTTGCCGGGGTGTACAGTGCCGAT
CCACGTAAAGTGAAGGACGCTTGCCTGCTACCATTATTGCGGTTGGATGAAGCCAGTGAACTGGCCCGCCTGGCAGCACC
GGTGTTACATACCCGCACATTACAACCGGTTTCTGGTAGTGACATCGATTTGCAATTACGTTGCAGTTATCAGCCGGAGC
AGGGGTCAACCCGTATTGAACGTGTGCTGGCTTCGGGATTGGGTGCCAAGATAGTGACCAGCCACGATGATGTTTGCCTG
ATTGAATTGCAGATTGCCAGTCACCATGATTTCTCGTTGGCGCAGAAAGAGATCGATCTACTGCTCAAACGTGCGCAAAT
CAAACCACTGGCGACCGGTATTCACCCAGATCGTAACCTGCTGCAACTTTGCTATACCTCAGAAGTGGTTAACAGCGCCT
TACGGGTGTTGGAAGATGCCGCTCTGCCGGGGAAACTCTCTCTGCGCGAAGGGCTGGCATTGGTCGCACTGGTGGGGGCG
GGTGTGAGCAAGAACCCACTTCACAGTCACCGTTTCTACCAACAACTGAAAGATCAGCCAGTTGAGTTTGTCTGGCAGGC
CGAAGACGGTATCAGTATGGTGGCCGTCCTGCGTCTTGGGCCGACTGAGCACCTGATTCAAGGGTTGCACCAGTCGTTGT
TCCGGGCGGAAAAACGTATTGGTCTGATGCTGTTTGGCAAAGGCAACATTGGTGCTCGCTGGTTGGAGCTGTTTGCCCGT
GAGCAGAAAAGTCTTTCGGCCCGCAGTGGTTTTGAATTTGTGCTAGCCGGGGTGGTCGATAGCCGCCGTAGTCTGCTGAG
TTACGATGGTTTGGATGCCAGCCGGACGCTGGCATTTTACAACGATGAAGCCAAAGAACAGGATGAAGAATCCCTGTTCT
TGTGGATGCGTGCCCACCCGTTTGACGACCTGGTGGTGTTGGATGTGACCGCCAGCCCGTCACTTGCAGAACAATATCTG
GATTTTGCCAGTTATGGTTTCCACGTTATCAGCGCGAACAAATTAGCGGGGGCTTCAAGCAGCAATAATTACCGCCAAAT
CCGCGATGCGTTTGCGAAAACTGGCCGCCACTGGTTGTATAACGCCACGGTAGGCGCGGGGTTACCGGTTAACCATACGG
TGCGCGATCTGCGTGACAGTGGCGACAGTATTTTAGCGATCAGCGGTATTTTCTCTGGCACGCTGTCTTGGTTATTCCTG
CAATTTGATGGCTCAGTACCTTTTACCGAGCTGGTAGACCAAGCCTGGCAGCAAGGTTTGACCGAGCCTGATCCAAGGGT
TGATCTCTCTGGTCAGGATGTAATGCGTAAGTTGGTGATTTTAGCCCGTGAAGCGGGTTACGACATCGAACCGAATCAGG
TGCGGGTGGAGTCGTTGGTGCCTGCTGGCGCAGAGAGTGGGTCGGTTGATCAATTCTTTGAAAACGGCGAGGCATTAAAT
CAGCAAATGATTCAGCGTTTAGAAGCCGCGAAGGAGATGGGCTTGGTATTACGCTACGTGGCACGCTTTGATGCTAATGG
TAAGGCGCGGGTGGGCGTTGAAGCGGTACGTACCGATCATCCGTTGGCTTCTTTGCTACCGTGCGATAATGTTTTTGCTA
TTGAGAGCCGCTGGTATCGCGATAATCCGTTGGTGATTCGCGGCCCAGGCGCTGGCCGTGATGTGACCGCTGGGGCGATT
CAATCTGATTTAAACCGCCTATCACAACTGTTGTAA

Upstream 100 bases:

>100_bases
TTACTGATAGTTTGTTGCGTATTTCCGTGGGTATTGAAGACAGTGAAGATTTGATTGCTGATTTGGACCACGCGTTCCAA
TTGGCAGTAACGAGGTAAGC

Downstream 100 bases:

>100_bases
TCCGCTGTTATTCGCCTCTTCTGTTCTGCGCAGGAGAGGCGCATCCCCCGTTACTCGCCAATATGAATTTTTCACGCATT
GCGTGTGAATATTAATCATC

Product: bifunctional aspartate kinase II/homoserine dehydrogenase II

Products: NA

Alternate protein names: Aspartokinase II/homoserine dehydrogenase II; AKII-HDII; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 811; Mature: 811

Protein sequence:

>811_residues
MNATAVAAAATGRQLHKFGGSSLADVKCYLRVANIMANYSHPGDLMVVSAAGSTTNQLISWLKLSQNDRLSAHQVQQSLR
RYQHDLINGLLPPEMAEPLISEFIHDLERLAGLLDNKIDDVIYAEVVGHGEIWSARLMSALLNKLDMDAVWLDARRFLRA
ERAAQPQIDESRSYPLLQQLMAQHPHQRLVVTGFISRNEAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD
PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIERVLASGLGAKIVTSHDDVCL
IELQIASHHDFSLAQKEIDLLLKRAQIKPLATGIHPDRNLLQLCYTSEVVNSALRVLEDAALPGKLSLREGLALVALVGA
GVSKNPLHSHRFYQQLKDQPVEFVWQAEDGISMVAVLRLGPTEHLIQGLHQSLFRAEKRIGLMLFGKGNIGARWLELFAR
EQKSLSARSGFEFVLAGVVDSRRSLLSYDGLDASRTLAFYNDEAKEQDEESLFLWMRAHPFDDLVVLDVTASPSLAEQYL
DFASYGFHVISANKLAGASSSNNYRQIRDAFAKTGRHWLYNATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFL
QFDGSVPFTELVDQAWQQGLTEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAESGSVDQFFENGEALN
QQMIQRLEAAKEMGLVLRYVARFDANGKARVGVEAVRTDHPLASLLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAI
QSDLNRLSQLL

Sequences:

>Translated_811_residues
MNATAVAAAATGRQLHKFGGSSLADVKCYLRVANIMANYSHPGDLMVVSAAGSTTNQLISWLKLSQNDRLSAHQVQQSLR
RYQHDLINGLLPPEMAEPLISEFIHDLERLAGLLDNKIDDVIYAEVVGHGEIWSARLMSALLNKLDMDAVWLDARRFLRA
ERAAQPQIDESRSYPLLQQLMAQHPHQRLVVTGFISRNEAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD
PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIERVLASGLGAKIVTSHDDVCL
IELQIASHHDFSLAQKEIDLLLKRAQIKPLATGIHPDRNLLQLCYTSEVVNSALRVLEDAALPGKLSLREGLALVALVGA
GVSKNPLHSHRFYQQLKDQPVEFVWQAEDGISMVAVLRLGPTEHLIQGLHQSLFRAEKRIGLMLFGKGNIGARWLELFAR
EQKSLSARSGFEFVLAGVVDSRRSLLSYDGLDASRTLAFYNDEAKEQDEESLFLWMRAHPFDDLVVLDVTASPSLAEQYL
DFASYGFHVISANKLAGASSSNNYRQIRDAFAKTGRHWLYNATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFL
QFDGSVPFTELVDQAWQQGLTEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAESGSVDQFFENGEALN
QQMIQRLEAAKEMGLVLRYVARFDANGKARVGVEAVRTDHPLASLLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAI
QSDLNRLSQLL
>Mature_811_residues
MNATAVAAAATGRQLHKFGGSSLADVKCYLRVANIMANYSHPGDLMVVSAAGSTTNQLISWLKLSQNDRLSAHQVQQSLR
RYQHDLINGLLPPEMAEPLISEFIHDLERLAGLLDNKIDDVIYAEVVGHGEIWSARLMSALLNKLDMDAVWLDARRFLRA
ERAAQPQIDESRSYPLLQQLMAQHPHQRLVVTGFISRNEAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD
PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIERVLASGLGAKIVTSHDDVCL
IELQIASHHDFSLAQKEIDLLLKRAQIKPLATGIHPDRNLLQLCYTSEVVNSALRVLEDAALPGKLSLREGLALVALVGA
GVSKNPLHSHRFYQQLKDQPVEFVWQAEDGISMVAVLRLGPTEHLIQGLHQSLFRAEKRIGLMLFGKGNIGARWLELFAR
EQKSLSARSGFEFVLAGVVDSRRSLLSYDGLDASRTLAFYNDEAKEQDEESLFLWMRAHPFDDLVVLDVTASPSLAEQYL
DFASYGFHVISANKLAGASSSNNYRQIRDAFAKTGRHWLYNATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFL
QFDGSVPFTELVDQAWQQGLTEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAESGSVDQFFENGEALN
QQMIQRLEAAKEMGLVLRYVARFDANGKARVGVEAVRTDHPLASLLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAI
QSDLNRLSQLL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=804, Percent_Identity=83.955223880597, Blast_Score=1402, Evalue=0.0,
Organism=Escherichia coli, GI1786183, Length=821, Percent_Identity=30.816077953715, Blast_Score=331, Evalue=1e-91,
Organism=Escherichia coli, GI1790455, Length=462, Percent_Identity=27.2727272727273, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322599, Length=345, Percent_Identity=32.463768115942, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320893, Length=502, Percent_Identity=22.9083665338645, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 89308; Mature: 89308

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATAVAAAATGRQLHKFGGSSLADVKCYLRVANIMANYSHPGDLMVVSAAGSTTNQLIS
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHH
WLKLSQNDRLSAHQVQQSLRRYQHDLINGLLPPEMAEPLISEFIHDLERLAGLLDNKIDD
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VIYAEVVGHGEIWSARLMSALLNKLDMDAVWLDARRFLRAERAAQPQIDESRSYPLLQQL
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
MAQHPHQRLVVTGFISRNEAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD
HHHCCCCEEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEHHHHHHHCCCC
PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIE
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHH
RVLASGLGAKIVTSHDDVCLIELQIASHHDFSLAQKEIDLLLKRAQIKPLATGIHPDRNL
HHHHHCCCCEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCHHH
LQLCYTSEVVNSALRVLEDAALPGKLSLREGLALVALVGAGVSKNPLHSHRFYQQLKDQP
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHEEHHHCCCCCCCCCHHHHHHHHHCCCC
VEFVWQAEDGISMVAVLRLGPTEHLIQGLHQSLFRAEKRIGLMLFGKGNIGARWLELFAR
EEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
EQKSLSARSGFEFVLAGVVDSRRSLLSYDGLDASRTLAFYNDEAKEQDEESLFLWMRAHP
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCC
FDDLVVLDVTASPSLAEQYLDFASYGFHVISANKLAGASSSNNYRQIRDAFAKTGRHWLY
CCCEEEEEECCCHHHHHHHHHHHHCCEEEEECCHHCCCCCCCCHHHHHHHHHHCCCCEEE
NATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGL
EECCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHEEEEEEEECCCCCHHHHHHHHHHCCC
TEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAESGSVDQFFENGEALN
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCCCCCCHHHHHHCHHHHH
QQMIQRLEAAKEMGLVLRYVARFDANGKARVGVEAVRTDHPLASLLPCDNVFAIESRWYR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHCCCCHHHHCCCCCEEEECCCEEC
DNPLVIRGPGAGRDVTAGAIQSDLNRLSQLL
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNATAVAAAATGRQLHKFGGSSLADVKCYLRVANIMANYSHPGDLMVVSAAGSTTNQLIS
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHH
WLKLSQNDRLSAHQVQQSLRRYQHDLINGLLPPEMAEPLISEFIHDLERLAGLLDNKIDD
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VIYAEVVGHGEIWSARLMSALLNKLDMDAVWLDARRFLRAERAAQPQIDESRSYPLLQQL
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
MAQHPHQRLVVTGFISRNEAGETVLLGRNGSDYSATQVGALAGAERVTIWSDVAGVYSAD
HHHCCCCEEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEHHHHHHHCCCC
PRKVKDACLLPLLRLDEASELARLAAPVLHTRTLQPVSGSDIDLQLRCSYQPEQGSTRIE
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHH
RVLASGLGAKIVTSHDDVCLIELQIASHHDFSLAQKEIDLLLKRAQIKPLATGIHPDRNL
HHHHHCCCCEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCHHH
LQLCYTSEVVNSALRVLEDAALPGKLSLREGLALVALVGAGVSKNPLHSHRFYQQLKDQP
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHEEHHHCCCCCCCCCHHHHHHHHHCCCC
VEFVWQAEDGISMVAVLRLGPTEHLIQGLHQSLFRAEKRIGLMLFGKGNIGARWLELFAR
EEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
EQKSLSARSGFEFVLAGVVDSRRSLLSYDGLDASRTLAFYNDEAKEQDEESLFLWMRAHP
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCC
FDDLVVLDVTASPSLAEQYLDFASYGFHVISANKLAGASSSNNYRQIRDAFAKTGRHWLY
CCCEEEEEECCCHHHHHHHHHHHHCCEEEEECCHHCCCCCCCCHHHHHHHHHHCCCCEEE
NATVGAGLPVNHTVRDLRDSGDSILAISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGL
EECCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHEEEEEEEECCCCCHHHHHHHHHHCCC
TEPDPRVDLSGQDVMRKLVILAREAGYDIEPNQVRVESLVPAGAESGSVDQFFENGEALN
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCCCCCCHHHHHHCHHHHH
QQMIQRLEAAKEMGLVLRYVARFDANGKARVGVEAVRTDHPLASLLPCDNVFAIESRWYR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHCCCCHHHHCCCCCEEEECCCEEC
DNPLVIRGPGAGRDVTAGAIQSDLNRLSQLL
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6298218; 8346018; 9278503 [H]