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The map label for this gene is frmA [H]

Identifier: 170024796

GI number: 170024796

Start: 2823802

End: 2824941

Strand: Direct

Name: frmA [H]

Synonym: YPK_2571

Alternate gene names: 170024796

Gene position: 2823802-2824941 (Clockwise)

Preceding gene: 170024795

Following gene: 170024797

Centisome position: 60.22

GC content: 51.49

Gene sequence:

>1140_bases
ATGGAGATGATTAAAACCCGCGCCGCTGTCGCATGGGGGCCAAACCAGCCACTGTCCGTTGAAGAAGTTGATTTGATGCC
ACCACAGAAAGGCGAAGTGTTAGTGCGGATTGTCGCCAGTGGCGTTTGTCACACTGACGCTTATACCCTTTCGGGGGCCG
ATCCTGAAGGCGTATTCCCGACCATTTTAGGTCATGAAGGCGGTGGAATTGTTGAAGCCATTGGCGAAGGTGTCACCAGT
GTTGCCGTAGGGGACCACGTTATTCCGCTGTACACACCAGAGTGTGGCGAGTGCAAGTACTGCCGCTCCGGTAAAACCAA
CCTGTGCCAGGCAATCCGCAGCACTCAGGGTAAAGGTTTGATGCCCGATGGTACCACCCGCTTCTCTAAAAATGGTCAAC
CCATCTTCCACTACATGGGGACGTCAACCTTCTCCGAACTGACCGTTGTACCGGAAATATCACTCGCGAAAATCAATAAA
GAAGCCCCGTTGGAAGAAGTATGCCTGCTGGGCTGCGGCGTCACCACTGGGATGGGTGCGGTGATGAATACCGCAAAAGT
TAAACCAGGTGATACCGTCGCAATCTTCGGCCTTGGCGGTATCGGTTTATCGGCGGTGATTGGTGCACAGATGGCGGGGG
CGAGCCGAATTATTGGGATCGATCTCAATACCAGCAAATTCGAGCTGGCCCGCAAATTGGGCGCGACAGACCTGATCAAT
CCGAAAGACTATGATAAACCTATCCAGGAAGTGATCGTTGAACTGACCGACGGCGGTGTAGATTTCTCATTTGAATGCAT
TGGTAACGTCAATGTCATGCGTTCAGCATTAGAGTGCTGCCATAAAGGTTGGGGAGAGTCGGTGATTATTGGTGTCGCCG
GTGCCGGTGAAGAAATTTCAACCCGCCCGTTCCAATTGGTTACGGGCCGCGTATGGCGGGGTTCTGCATTTGGTGGCGTC
AAAGGCCGCTCAGAATTGCCGGGCATTGTGCAGCAATATTTGGACGGTAAATTCGCGTTGAACGACTTCATTACCCACAC
AATGGCGCTGGATCAAATCAACGAAGCCTTTGATTTAATGCACGAGGGTAAATCTATCCGCAGTGTAATCCATTTTAATC
ACTCTTCCGAAAGCAAATAA

Upstream 100 bases:

>100_bases
TGACTGGGGTGAGCAAGGACAGTTAACCCCCCCAGCACCTTGAAGGGCGACGGGTAGATTTATATAACACTCATTACACT
GAAGCTATAGGAGCAACACC

Downstream 100 bases:

>100_bases
AGCAAGGAGGCAGACAAAACGTGAATACGTCACTTGAACTTCTCGAAGAGCATCGGATGTTTGGCGGCTGGCAACAGCGC
TACCGCCATGCTGCCAGCAG

Product: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFPTILGHEGGGIVEAIGEGVTS
VAVGDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGLMPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINK
EAPLEEVCLLGCGVTTGMGAVMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEISTRPFQLVTGRVWRGSAFGGV
KGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLMHEGKSIRSVIHFNHSSESK

Sequences:

>Translated_379_residues
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFPTILGHEGGGIVEAIGEGVTS
VAVGDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGLMPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINK
EAPLEEVCLLGCGVTTGMGAVMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEISTRPFQLVTGRVWRGSAFGGV
KGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLMHEGKSIRSVIHFNHSSESK
>Mature_379_residues
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFPTILGHEGGGIVEAIGEGVTS
VAVGDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGLMPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINK
EAPLEEVCLLGCGVTTGMGAVMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEISTRPFQLVTGRVWRGSAFGGV
KGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLMHEGKSIRSVIHFNHSSESK

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=63.9566395663957, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=51.4824797843666, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=51.4666666666667, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=49.8652291105121, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=49.8659517426273, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=50.4043126684636, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=50.2688172043011, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=48.780487804878, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=49.0358126721763, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=70.7317073170732, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=26.8421052631579, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790045, Length=365, Percent_Identity=25.7534246575342, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=25.4237288135593, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87081918, Length=354, Percent_Identity=29.9435028248588, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786825, Length=274, Percent_Identity=27.007299270073, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788075, Length=369, Percent_Identity=24.9322493224932, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=374, Percent_Identity=26.7379679144385, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI226510992, Length=351, Percent_Identity=21.6524216524217, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=58.9333333333333, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=58.6206896551724, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=58.8921282798834, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17562584, Length=369, Percent_Identity=29.5392953929539, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=369, Percent_Identity=25.7452574525745, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=365, Percent_Identity=29.041095890411, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=380, Percent_Identity=26.0526315789474, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=58.7601078167116, Blast_Score=472, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=31.4079422382672, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=359, Percent_Identity=28.6908077994429, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=377, Percent_Identity=28.6472148541114, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=28.6173633440514, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=300, Percent_Identity=28.3333333333333, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=26.7924528301887, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=365, Percent_Identity=26.3013698630137, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=365, Percent_Identity=26.3013698630137, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=276, Percent_Identity=24.2753623188406, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=62.7345844504021, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI17137530, Length=349, Percent_Identity=26.9340974212034, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737897, Length=271, Percent_Identity=27.3062730627306, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40218; Mature: 40218

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFP
CCCHHCCEEEEECCCCCCCCCEEECCCCCCCCHHHEEHHCCCCCCCCEEECCCCCCCCCC
TILGHEGGGIVEAIGEGVTSVAVGDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGL
EEECCCCCCHHHHHHCCHHEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCC
MPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINKEAPLEEVCLLGCGVTTGMGA
CCCCCCCCCCCCCEEEEECCCCCHHHEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHHHH
VMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
HHHCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCC
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEIS
CCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
TRPFQLVTGRVWRGSAFGGVKGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLM
CCCEEEEECEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
HEGKSIRSVIHFNHSSESK
HCCHHHHHHEEECCCCCCC
>Mature Secondary Structure
MEMIKTRAAVAWGPNQPLSVEEVDLMPPQKGEVLVRIVASGVCHTDAYTLSGADPEGVFP
CCCHHCCEEEEECCCCCCCCCEEECCCCCCCCHHHEEHHCCCCCCCCEEECCCCCCCCCC
TILGHEGGGIVEAIGEGVTSVAVGDHVIPLYTPECGECKYCRSGKTNLCQAIRSTQGKGL
EEECCCCCCHHHHHHCCHHEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCC
MPDGTTRFSKNGQPIFHYMGTSTFSELTVVPEISLAKINKEAPLEEVCLLGCGVTTGMGA
CCCCCCCCCCCCCEEEEECCCCCHHHEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHHHH
VMNTAKVKPGDTVAIFGLGGIGLSAVIGAQMAGASRIIGIDLNTSKFELARKLGATDLIN
HHHCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCC
PKDYDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGEEIS
CCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
TRPFQLVTGRVWRGSAFGGVKGRSELPGIVQQYLDGKFALNDFITHTMALDQINEAFDLM
CCCEEEEECEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
HEGKSIRSVIHFNHSSESK
HCCHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]