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The map label for this gene is yeiG [H]

Identifier: 170024797

GI number: 170024797

Start: 2824962

End: 2825804

Strand: Direct

Name: yeiG [H]

Synonym: YPK_2572

Alternate gene names: 170024797

Gene position: 2824962-2825804 (Clockwise)

Preceding gene: 170024796

Following gene: 170024798

Centisome position: 60.24

GC content: 50.77

Gene sequence:

>843_bases
GTGAATACGTCACTTGAACTTCTCGAAGAGCATCGGATGTTTGGCGGCTGGCAACAGCGCTACCGCCATGCTGCCAGCAG
CCTGAATTGTCATATGACCTTCAGTATCTATCTGCCACCGCCACGGGACGATAACCCACCACCAGTCCTTTATTGGCTAT
CGGGCCTAACCTGTAATGATGAGAACTTTACGCTGAAAGCGGGCGCACAGCGGGTTGCTGCAGAACTCGGGCTGGTACTG
GTTATGCCTGATACCAGCCCCCGCGGTGATAATGTTCCCAACGATGACAGCTATGATTTAGGTCAGGGAGCGGGCTTCTA
CCTTAATGCGACGCAGGAGCCGTGGTCTGATCATTTCCAGATGTATGACTATATCAGCCAGGAATTGCCCTCACTGATCC
GCCAACATTTTAGCGTCAGTGAACGGCAATCAATCAGTGGTCATTCAATGGGCGGCCATGGTGCACTGATGCTAGCTCTG
CGTAATCCTCAACAATATCAGTCTGTTTCTGCTTTTGCGCCAATAGTTACCCCATGCCAAGTACCATGGGGCCGAAAAGC
CTTTACCGCTTATCTTGGCAGTGATGAAAACCAATGGCTGCAATATGATAGCTGCCATTTACTGACCCATGCACAGCATC
AGTTGCCTATATTGGTGGATCAGGGGGATGGTGATCAATTTCTTGCCGATCAACTCCAACCGGCAAAATTGGCGGAGCTG
GCGCGCCAGCGAGACTGGCCACTGATGTTGCGTATTCAGCCGGGTTATGATCACAGCTATTTTACCATAGCTACATTTAT
TGAAGATCACCTGCGCTTTCATGCTGCACACCTACAGCCGTAA

Upstream 100 bases:

>100_bases
ACGAAGCCTTTGATTTAATGCACGAGGGTAAATCTATCCGCAGTGTAATCCATTTTAATCACTCTTCCGAAAGCAAATAA
AGCAAGGAGGCAGACAAAAC

Downstream 100 bases:

>100_bases
CATTTGTCATTAGCCTAATTATTACACATAAAACCCCAAGCCCTTTCGAGGGCTTTTTATTCGATAGATAAAACCCCTCA
CATTAAAACCTCGTTTAAGA

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVTPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP

Sequences:

>Translated_280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVTPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
>Mature_280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVTPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=50.7142857142857, Blast_Score=306, Evalue=1e-83,
Organism=Escherichia coli, GI1788477, Length=276, Percent_Identity=73.1884057971015, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=53.8181818181818, Blast_Score=331, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=46.6192170818505, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=43.4343434343434, Blast_Score=237, Evalue=1e-63,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=48.4098939929329, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24648347, Length=281, Percent_Identity=48.3985765124555, Blast_Score=268, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31767; Mature: 31767

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCND
CCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCEEEEECCEEECC
ENFTLKAGAQRVAAELGLVLVMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQ
CCEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLALRNPQQYQSVSAFAPIVTPCQ
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCC
VPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
CCCCCHHEEEEECCCCCCEEEECCEEEEECCCCCCCEEEECCCCCHHHHHCCCHHHHHHH
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
HHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCND
CCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCEEEEECCEEECC
ENFTLKAGAQRVAAELGLVLVMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQ
CCEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLALRNPQQYQSVSAFAPIVTPCQ
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCC
VPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
CCCCCHHEEEEECCCCCCEEEECCEEEEECCCCCCCEEEECCCCCHHHHHCCCHHHHHHH
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
HHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA