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The map label for this gene is lysN [H]

Identifier: 170024486

GI number: 170024486

Start: 2508008

End: 2509192

Strand: Reverse

Name: lysN [H]

Synonym: YPK_2257

Alternate gene names: 170024486

Gene position: 2509192-2508008 (Counterclockwise)

Preceding gene: 170024488

Following gene: 170024483

Centisome position: 53.51

GC content: 47.43

Gene sequence:

>1185_bases
ATGAATAAAATTATAACGGATCAGCGTCACCAATTTTCCTCACGAGTGAATGACCTTCACCCGTCGCCAATTAGGGAAAT
ACTGTCTGTCATTGATCGTCCGGGAATGATCTCGTTTGCCGGCGGATTACCCGCAGTAGAAAGTTTTCCTCATATGAGCC
TTGAGGGAATGCCGCAGCCGATGCTGCAATATGGCGCGAGTGAAGGGGAGCTGGAATTACGTCAACAGATTGCTCAAAAT
TTGTGTGAGCGAGGTTTATCCTGTACTGAGGAACAAGTCCTGATTATTTCAGGCTCACAGCAGGGCATTGATCTGGTCGC
TAAGTTGTTTATTGACGAGGGAACCCCCGTCGCCGTTGAATCGCCTACCTACCTACCTACCTACCTACCTACCTATCTGG
CTGCGTTACAGGTATTCCGTTTTTTCGGTGCTCAATTTGTGGCTTATGATTCAACTCAGCCTGATATCGACAAGCTTCGC
ACCGAAAAACCTGCTTTTGCTTATACTATTCCGACCTTCCAGAATCCAAGCGGTCACTGCCTTGATACTGAACAACGAGA
GTTACTGGCGAAGACATGTGATGACATTATGTTACCGCTCTTTGAAGATGACCCGTACCATGACTTGGTTTATGACCCTT
GTGAGCGTAAGCCAGTGTGTGCTTCATTACAGCGAGCTTCGTGGATTTACCAAGGATCTTTTTCTAAAAGTTTATCCCCG
GCGCTGCGTTTGGGCTATCTTGTCGCATCTTCAGAATTGATTCCCTATTTGACACGTTTAAAACAAGCCGCAGATTTGCA
CAGCAGCCGGATCAGCCAATGGTTAGTGTTACAGCAGTTGCGTAGCCCTAGGCATACTGAGCATATGCATGAACTGGCAG
CCTATTATCGAACTCGCCGTGATGCGTTTGAAATCTCCCTACAACGCCATTTTGGCTCTCTTGCGACGTGGAAAAAACCG
GCTGGAGGGCTGTTCTTCTGGTTAACCCTTAATCGCTGCATAGATACTCGTCAACTCTTGCCTAAAGCGCTGGCAAGCAA
TATTGCATTTATGCCCGGAGAGTCGTTCCTCCCTCATTCATCTGAAGGCTGCGGTCAGTTACGGCTTAATTTTAGCCATG
CGACGGAAGAACAAGCGGATGTAGGGCTGAAAATATTAGCGGGTTTAGTGCAGGAACATGCATAA

Upstream 100 bases:

>100_bases
GTTAGCAATAGGGTAGAAAGTGAAATTATGTTGACGTAATGAACAGCGCATTTTACTTTCCATAAATGCCAAATTGGTTG
ACCTTTGTGGAAGAACTGCA

Downstream 100 bases:

>100_bases
GATGGGCTATCGGTGAATCTCATTGACTCATTAATTGAAGACGCTGAATGAATCGAAATAAATTTCAGATGGACCGAGTA
ACGAAAGCTGCCAACGCACA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPHMSLEGMPQPMLQYGASEGELELRQQIAQN
LCERGLSCTEEQVLIISGSQQGIDLVAKLFIDEGTPVAVESPTYLPTYLPTYLAALQVFRFFGAQFVAYDSTQPDIDKLR
TEKPAFAYTIPTFQNPSGHCLDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLSP
ALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTRRDAFEISLQRHFGSLATWKKP
AGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPHSSEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA

Sequences:

>Translated_394_residues
MNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPHMSLEGMPQPMLQYGASEGELELRQQIAQN
LCERGLSCTEEQVLIISGSQQGIDLVAKLFIDEGTPVAVESPTYLPTYLPTYLAALQVFRFFGAQFVAYDSTQPDIDKLR
TEKPAFAYTIPTFQNPSGHCLDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLSP
ALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTRRDAFEISLQRHFGSLATWKKP
AGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPHSSEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA
>Mature_394_residues
MNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPHMSLEGMPQPMLQYGASEGELELRQQIAQN
LCERGLSCTEEQVLIISGSQQGIDLVAKLFIDEGTPVAVESPTYLPTYLPTYLAALQVFRFFGAQFVAYDSTQPDIDKLR
TEKPAFAYTIPTFQNPSGHCLDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLSP
ALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTRRDAFEISLQRHFGSLATWKKP
AGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPHSSEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=418, Percent_Identity=28.4688995215311, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI33469970, Length=418, Percent_Identity=28.4688995215311, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1787710, Length=384, Percent_Identity=25.5208333333333, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1790797, Length=292, Percent_Identity=23.972602739726, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 44313; Mature: 44313

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPHMSLEGMPQP
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHCCCCCCCCCCCH
MLQYGASEGELELRQQIAQNLCERGLSCTEEQVLIISGSQQGIDLVAKLFIDEGTPVAVE
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEC
SPTYLPTYLPTYLAALQVFRFFGAQFVAYDSTQPDIDKLRTEKPAFAYTIPTFQNPSGHC
CCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCCCC
LDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLSP
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCH
ALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DAFEISLQRHFGSLATWKKPAGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPHS
HHHHHHHHHHHCHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCEEECCCCCCCCCC
SEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKIITDQRHQFSSRVNDLHPSPIREILSVIDRPGMISFAGGLPAVESFPHMSLEGMPQP
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHCCCCCCCCCCCH
MLQYGASEGELELRQQIAQNLCERGLSCTEEQVLIISGSQQGIDLVAKLFIDEGTPVAVE
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEC
SPTYLPTYLPTYLAALQVFRFFGAQFVAYDSTQPDIDKLRTEKPAFAYTIPTFQNPSGHC
CCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCCCC
LDTEQRELLAKTCDDIMLPLFEDDPYHDLVYDPCERKPVCASLQRASWIYQGSFSKSLSP
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCH
ALRLGYLVASSELIPYLTRLKQAADLHSSRISQWLVLQQLRSPRHTEHMHELAAYYRTRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DAFEISLQRHFGSLATWKKPAGGLFFWLTLNRCIDTRQLLPKALASNIAFMPGESFLPHS
HHHHHHHHHHHCHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCEEECCCCCCCCCC
SEGCGQLRLNFSHATEEQADVGLKILAGLVQEHA
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA