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The map label for this gene is murB [H]

Identifier: 170022585

GI number: 170022585

Start: 349642

End: 350679

Strand: Direct

Name: murB [H]

Synonym: YPK_0326

Alternate gene names: 170022585

Gene position: 349642-350679 (Clockwise)

Preceding gene: 170022584

Following gene: 170022586

Centisome position: 7.46

GC content: 43.64

Gene sequence:

>1038_bases
ATGTCGAATCAGCGTTCCTCTCTAAAACACCTTAATACCTTTGCGCTACCTGCTTATGCAAGCAATGTCATTAGTGCTGG
CTCAGTAGAAACATTAATTGCGGCTTGGCATGAATCAAAAGCCAAGCGACAGCCGGTACTATTACTAGGTGAAGGTAGCA
ATGTGTTATTTATTAAAAATTTCTCTGGGACAGTATTACTCAATAGGATTATGGGGATTACTTCTACCGAAGACAGTGCT
GCTTGGCATTTACATGTCGGTGCTGGGGAAAATTGGCATCAACTGGTATGTCATTCACTGCAAAATAATATGCCGGGGTT
GGAAAATTTAGCGTTAATTCCAGGCTGTGTCGGCTCTGCGCCGATCCAAAATATAGGTGCCTATGGCGTTGAATTAAAAC
AAGTATGTGAATATGTTGATTTACTTGATATGGATAAAGGTACTATTCAGCGTATCTCCGCTGAGGAGTGTCAGTTTGGT
TACCGTGACAGCATTTTTAAACATCGCTATGGGAATGGATTTGCTATCGTATCTGTCGGTATTAAATTGATGAAATCATG
GACTCCAACGCTGGGTTATGGCGACTTAATACATATGGACCCATTAACAGTTACTGCCACAGATATTTTTAACTCTGTCT
GTACAATGCGGCGGAGTAAACTTCCAGACCCAATGGTCACTGGCAATGCCGGGAGTTTCTTCAAAAACCCTGTAGTAAGC
GCAGCAATCGCTGAGGAGATCGTACATTGTTACCCCAATGCTCCTCATTATCTGCAGCCAGATGGGTCAGTAAAACTTGC
AGCAGGTTGGTTGATCGATCAGTGTTCACTTAAGGGGTACCAGATTGGTGGTGCCGCAGTACACCAGCAACAAGCTCTGG
TGCTGATTAACCAGTCAGAAGCGACTGGCCAAGATGTAATACATCTTGCACGTTATATCCGCCAGCAGGTCGCACAGAGA
TTTTCAATCTGGCTAGAACCAGAGGTACGCTTTATTGCTGATAATGGTGAAGTTAATGCTGTGGAGCATTTATCGTGA

Upstream 100 bases:

>100_bases
TCACTACTTTTTCATTATTTACTTGAAATAAAAAATACAAACAGCCCATTACGATCGGTTAGACTAGCGCGAGAGTTATT
TAGAATGAGCATCTAATGTA

Downstream 100 bases:

>100_bases
AAGATATCAGGGTCCCCTTACGGTTAGTCAGTATATTATCTGATGGTTTTTTTCACTCCGGTGAGCAATTGGGTGAAACG
TTAGGCATGAGTCGCGCTGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKNFSGTVLLNRIMGITSTEDSA
AWHLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSAPIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFG
YRDSIFKHRYGNGFAIVSVGIKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVS
AAIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSEATGQDVIHLARYIRQQVAQR
FSIWLEPEVRFIADNGEVNAVEHLS

Sequences:

>Translated_345_residues
MSNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKNFSGTVLLNRIMGITSTEDSA
AWHLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSAPIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFG
YRDSIFKHRYGNGFAIVSVGIKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVS
AAIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSEATGQDVIHLARYIRQQVAQR
FSIWLEPEVRFIADNGEVNAVEHLS
>Mature_344_residues
SNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKNFSGTVLLNRIMGITSTEDSAA
WHLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSAPIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFGY
RDSIFKHRYGNGFAIVSVGIKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVSA
AIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSEATGQDVIHLARYIRQQVAQRF
SIWLEPEVRFIADNGEVNAVEHLS

Specific function: Cell wall formation [H]

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1790407, Length=339, Percent_Identity=61.6519174041298, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C [H]

EC number: =1.1.1.158 [H]

Molecular weight: Translated: 37742; Mature: 37610

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKN
CCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEC
FSGTVLLNRIMGITSTEDSAAWHLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSA
CCCHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCC
PIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFGYRDSIFKHRYGNGFAIVSVG
CHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHCCCCHHHHHHHHCCCCEEEHHHH
IKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVS
HHHHHHCCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHCCCCCEEECCCCCHHHCHHHH
AAIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSE
HHHHHHHHHHCCCCCCEECCCCCEEEEECEEEECCCCCCEEECCHHHCCCCEEEEEECCC
ATGQDVIHLARYIRQQVAQRFSIWLEPEVRFIADNGEVNAVEHLS
CCHHHHHHHHHHHHHHHHHHHCEEECCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SNQRSSLKHLNTFALPAYASNVISAGSVETLIAAWHESKAKRQPVLLLGEGSNVLFIKN
CCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEC
FSGTVLLNRIMGITSTEDSAAWHLHVGAGENWHQLVCHSLQNNMPGLENLALIPGCVGSA
CCCHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCC
PIQNIGAYGVELKQVCEYVDLLDMDKGTIQRISAEECQFGYRDSIFKHRYGNGFAIVSVG
CHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHCCCCHHHHHHHHCCCCEEEHHHH
IKLMKSWTPTLGYGDLIHMDPLTVTATDIFNSVCTMRRSKLPDPMVTGNAGSFFKNPVVS
HHHHHHCCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHCCCCCEEECCCCCHHHCHHHH
AAIAEEIVHCYPNAPHYLQPDGSVKLAAGWLIDQCSLKGYQIGGAAVHQQQALVLINQSE
HHHHHHHHHHCCCCCCEECCCCCEEEEECEEEECCCCCCEEECCHHHCCCCEEEEEECCC
ATGQDVIHLARYIRQQVAQRFSIWLEPEVRFIADNGEVNAVEHLS
CCHHHHHHHHHHHHHHHHHHHCEEECCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]