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The map label for this gene is mvk [H]

Identifier: 169834117

GI number: 169834117

Start: 443780

End: 444658

Strand: Direct

Name: mvk [H]

Synonym: SPH_0488

Alternate gene names: 169834117

Gene position: 443780-444658 (Clockwise)

Preceding gene: 169833764

Following gene: 169832809

Centisome position: 19.76

GC content: 46.19

Gene sequence:

>879_bases
ATGACAAAAAAAGTTGGTGTCGGTCAGGCACATAGTAAGATAATTTTAATAGGGGAACATGCGGTCGTTTACGGTTATCC
TGCCATTTCCCTGCCTCTTTTGGAGGTGGAGGTGACCTGTAAGGTAGTTCCTGCAGAGAGTCCTTGGCGCCTTTATGAGG
AGGATACCTTGTCCATGGCGGTTTATGCCTCACTGGAGTATTTGGATATCACAGAAGCCTGCATTCGTTGTGAGATTGAC
TCGGCTATCCCTGAGAAACGGGGGATGGGTTCGTCAGCGGCTATCAGCATAGCGGCCATTCGTGCGGTATTTGACTACTA
TCAGGCTGATCTGCCTCATGATGTACTAGAAATCTTGGTCAATCGAGCTGAAATGATTGCCCATATGAATCCTAGTGGTT
TGGATGCTAAGACCTGTCTCAGTGACCAACCTATTCGCTTTATCAAGAACGTAGGATTTACAGAACTTGAGATGGATTTA
TCCGCCTATTTGGTGATTGCCGATACGGGTGTTTATGGTCATACTCGTGAAGCCATCCAAGTGGTTCAAAATAAGGGCAA
GGATGCCCTACCGTTTTTGCATGCCTTGGGAGAATTAACCCAGCAAGCAGAAGTTGCGATTTCACAAAAAGATGCTGAAG
GACTGGGACAAATCCTCAGTCAAGCGCATTTACATTTAAAAGAAATTGGAGTCAGTAGCCCTGAGGCAGACTTTTTGGTT
GAAACGACTCTTAGCCATGGTGCTCTGGGTGCCAAGATGAGCGGTGGTGGGCTAGGAGGTTGTATCATAGCCTTGGTAAC
CAATTTGACACACGCACAAGAACTAGCAGAAAGATTAGAAGAGAAAGGAGCTGTTCAGACATGGATAGAGAGCCTGTAA

Upstream 100 bases:

>100_bases
GAAACAATCGCTTTTTTTGTGAAAATATAATAAAATAGATAGGAAAGAATTAATACTTGTATGAAAAATAAGACGTTTTT
TCGTCTAGTAAAAGGAAAAA

Downstream 100 bases:

>100_bases
CAGTACGTTCCTACGCAAATATTGCTATTATCAAATATTGGGGAAAGAAAAAAGAAAAAGAGATGGTGCCTGCTACTAGC
AGTATTTCTCTAACTTTGGA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMAVYASLEYLDITEACIRCEID
SAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDL
SAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQILSQAHLHLKEIGVSSPEADFLV
ETTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL

Sequences:

>Translated_292_residues
MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMAVYASLEYLDITEACIRCEID
SAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDL
SAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQILSQAHLHLKEIGVSSPEADFLV
ETTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL
>Mature_291_residues
TKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMAVYASLEYLDITEACIRCEIDS
AIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDLS
AYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQILSQAHLHLKEIGVSSPEADFLVE
TTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL

Specific function: Galactose metabolism; first step. [C]

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Drosophila melanogaster, GI78707210, Length=230, Percent_Identity=25.6521739130435, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 31495; Mature: 31363

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMA
CCCCCCCCCCCCEEEEEECCEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHHH
VYASLEYLDITEACIRCEIDSAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILV
HHHHHHHHHHHHHHHHCCCHHCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDLSAYLVIADTGVYGHTREAIQ
HHHHHHHCCCCCCCCHHHHCCCCCHHHHHHCCCEEEEECCEEEEEEEECCCCCCHHHHHH
VVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQILSQAHLHLKEIGVSSPEADFLV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
ETTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL
EEHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure 
TKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWRLYEEDTLSMA
CCCCCCCCCCCEEEEEECCEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHHH
VYASLEYLDITEACIRCEIDSAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILV
HHHHHHHHHHHHHHHHCCCHHCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDLSAYLVIADTGVYGHTREAIQ
HHHHHHHCCCCCCCCHHHHCCCCCHHHHHHCCCEEEEECCEEEEEEEECCCCCCHHHHHH
VVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQILSQAHLHLKEIGVSSPEADFLV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
ETTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL
EEHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10497066 [H]