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The map label for this gene is mvaD

Identifier: 169832809

GI number: 169832809

Start: 444640

End: 445593

Strand: Direct

Name: mvaD

Synonym: SPH_0489

Alternate gene names: NA

Gene position: 444640-445593 (Clockwise)

Preceding gene: 169834117

Following gene: 169832511

Centisome position: 19.8

GC content: 43.29

Gene sequence:

>954_bases
ATGGATAGAGAGCCTGTAACAGTACGTTCCTACGCAAATATTGCTATTATCAAATATTGGGGAAAGAAAAAAGAAAAAGA
GATGGTGCCTGCTACTAGCAGTATTTCTCTAACTTTGGAAAATATGTATACAGAGACGACCTTGTCGCCTTTACCAGCCA
ATGTAACAGCTGACGAATTTTACATCAATGGTCAGCTACAAAATGAGGTCGAGCATGCCAAGATGAGTAAGATTATTGAC
CGTTATCGTCCAGCTGGTGAGGGCTTTGTCCGTATCGATACTCAAAACAATATGCCTACGGCAGCGGGCCTGTCCTCAAG
TTCTAGTGGTTTGTCCGCCCTGGTCAAGGCTTGTAATGCTTATTTCAAACTTGGATTGGATAGAAGTCAGTTGGCACAGG
AAGCCAAATTTGCCTCAGGCTCTTCTTCTCGGAGTTTTTATGGACCACTAGGAGCCTGGGATAAGGATAGTGGAGAAATT
TACCCTGTAGAGACAGACTTGAAACTAGCTATGATTATGTTGGTGCTAGAGGACAAGAAAAAACCAATCTCTAGCCGTGA
CGGGATGAAACTTTGTGTGGAAACCTCGACGACTTTCGACGACTGGGTTCGTCAGTCTGAGAAGGACTATCAGGATATGC
TGATTTATCTCAAGGAAAATGATTTTGCCAAGATTGGAGAATTAACGGAGAAAAATGCCCTGGCTATGCATGCTACGACA
AAGACTGCTAGTCCAGCCTTTTCTTATCTGACGGATGCCTCTTATGAGGCTATGGACTTTGTTCGCCAGCTTCGTGAGAA
AGGAGAGGCCTGCTACTTTACCATGGATGCTGGTCCCAATGTTAAGGTCTTCTGTCAGGAGAAAGACTTGGAGCATTTAT
CAGAAATTTTCGGTCATCGTTATCGCTTGATTGTGTCAAAAACAAAGGATTTGAGTCAAGATGATTGCTGTTAA

Upstream 100 bases:

>100_bases
GCGGTGGTGGGCTAGGAGGTTGTATCATAGCCTTGGTAACCAATTTGACACACGCACAAGAACTAGCAGAAAGATTAGAA
GAGAAAGGAGCTGTTCAGAC

Downstream 100 bases:

>100_bases
AACTTGCGGAAAACTCTATTGGGCAGGTGAATATGCTATTTTAGAGCCAGGGCAGTTAGCTTTGATAAAGGATATTCCCA
TCTATATGAGGGCTGAGATT

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; Phosphomevalonate Kinase; Ghmp Kinase

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIID
RYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEI
YPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATT
KTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGHRYRLIVSKTKDLSQDDCC

Sequences:

>Translated_317_residues
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIID
RYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEI
YPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATT
KTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGHRYRLIVSKTKDLSQDDCC
>Mature_317_residues
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIID
RYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEI
YPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATT
KTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGHRYRLIVSKTKDLSQDDCC

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=308, Percent_Identity=28.8961038961039, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17537201, Length=315, Percent_Identity=29.2063492063492, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537203, Length=177, Percent_Identity=29.9435028248588, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324371, Length=336, Percent_Identity=30.0595238095238, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28571205, Length=317, Percent_Identity=29.9684542586751, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 35587; Mature: 35587

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEF
CCCCCEEEEECCCEEEEEECCCCCCHHCCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCEE
YINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNA
EECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
YFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKK
HHHCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCC
KPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATT
CCCCCCCCCEEEEECCCCHHHHHHHHCCCHHHEEEEEECCCCHHHHHHHCCCEEEEEECC
KTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGHR
CCCCCHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHHHHHHCCE
YRLIVSKTKDLSQDDCC
EEEEEECCCCCCCCCCC
>Mature Secondary Structure
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEF
CCCCCEEEEECCCEEEEEECCCCCCHHCCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCEE
YINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNA
EECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
YFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKK
HHHCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCC
KPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATT
CCCCCCCCCEEEEECCCCHHHHHHHHCCCHHHEEEEEECCCCHHHHHHHCCCEEEEEECC
KTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGHR
CCCCCHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHHHHHHCCE
YRLIVSKTKDLSQDDCC
EEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA