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The map label for this gene is cysS

Identifier: 169824112

GI number: 169824112

Start: 471955

End: 473343

Strand: Direct

Name: cysS

Synonym: FMG_0415

Alternate gene names: 169824112

Gene position: 471955-473343 (Clockwise)

Preceding gene: 169824111

Following gene: 169824113

Centisome position: 26.26

GC content: 32.33

Gene sequence:

>1389_bases
ATGAAGTTATACAATACACTGACACGAAAAAAGGAAGAATTCAAACCAATTAAAGAAAAAAATGTCGGTATATACGTATG
TGGCCCTACTGTTTATAATTATATTCACGTTGGAAATGCAAGACCGATAGTGGTATTTGATACTTTGAGAAGATATTTTA
TTTACAAAGGATATAATGTTAAATTTGTAAGCAACTTCACTGATATCGACGACAAAATTATCAATAAAGCAAAAGACGAA
AATATAGATTTTAGAGAAATAACTAAGAAATACATTCAAGCTTACTTGGACAATGTATCGGGACTTAATTTCGACGAAGA
TGACACTATTCATCCAAAAGCTACTGAATATATCGACGAAATGATTAAATTTGTAAAAACTTTGGAAGACAAAGGTGCAG
CATATAATGTCGATGGCAATGTGTATTTTGATATCACAAAAGCAAAAGACTACGGAAAATTATCCAAGAAAAATATAGAT
GATTTGCGTGCTGGTGCTAGAATTGATGTCAACAGCGAAAAGAAAAATCCGATGGATTTTGCTTTGTGGAAGAAGAGAAA
AGAAGAGAGTGAACCTGCTTGGGAAAGTCCATGGGGAATGGGAAGACCTGGTTGGCATTTGGAATGTTCTGTAATGAGCA
AAACAATTTTGGGTGACACTATTGATATTCACGCTGGTGGTGAAGATTTGCAATTCCCACATCACGAAAATGAAATCGCA
CAATCAGAAACATGCACTGGAGCTCACTTTGCAAACTATTGGCTACACAACTCAATGATAACTGTAGACAAGGAAAAAAT
GAGCAAATCAAAAAATAATTTCTTCTTGTTAAAAGATATTGAAAAAGAATTTGATTTGGAAGTTATCAGATTGTGGTTGT
TATCTGTTCACTACAGAAATCCGATTGATTTCAGCCACGACACGTTAGTAGCTACGAAAAATTCTCTTGATAGATTGTAT
ACTGCTAAGAAATTCTTAAATAGAATTTTGGAAAACTCTTCTGAAAAAGAAGAAAAAGATGATAATATAAAAACATTCAG
AGAAAAATTTGAACAAGCTATGGATGATGACATCAACACAGCTGATGCGATTAGCGTATTATTCGATTTCATTAAATATA
TCAACAAAAATTACGATGAAAATACATCGAAAAATATCTTGCTTGACGCTAAGAAATTGATGGATGATATTTCTTATGTT
TTGGGAATTTTATTCAAAGAAGATGACGATGATTTGGATTCTGAAATAGAAGAATTAATAGAACAAAGAAATGCTGCAAG
AAAAGAAAAAGACTTCAAAAAAGCAGACGAAATAAGAGATAAACTTTTATCTATGGGAATTGTGTTAAAAGACACCAGAG
ACGGCGTAATATGGGAGAGAAGTAATTAA

Upstream 100 bases:

>100_bases
GTAATGTTCACGGACCAGACTTGGATTCTATTATGGTAGTTTTAGGAAAACAAGAAGTTTTAGATAGGATTAACAAAGCT
TTAAATAGATAGGAGAAGAT

Downstream 100 bases:

>100_bases
TGAAGGTTAATCTAATTAGATACACTCCAGATGCACAAAAACTTGTCGCATCAAGTGCAAAACTTTGTTATTCAGATAGT
TCTGTCATGGAGATTGAGGA

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKLYNTLTRKKEEFKPIKEKNVGIYVCGPTVYNYIHVGNARPIVVFDTLRRYFIYKGYNVKFVSNFTDIDDKIINKAKDE
NIDFREITKKYIQAYLDNVSGLNFDEDDTIHPKATEYIDEMIKFVKTLEDKGAAYNVDGNVYFDITKAKDYGKLSKKNID
DLRAGARIDVNSEKKNPMDFALWKKRKEESEPAWESPWGMGRPGWHLECSVMSKTILGDTIDIHAGGEDLQFPHHENEIA
QSETCTGAHFANYWLHNSMITVDKEKMSKSKNNFFLLKDIEKEFDLEVIRLWLLSVHYRNPIDFSHDTLVATKNSLDRLY
TAKKFLNRILENSSEKEEKDDNIKTFREKFEQAMDDDINTADAISVLFDFIKYINKNYDENTSKNILLDAKKLMDDISYV
LGILFKEDDDDLDSEIEELIEQRNAARKEKDFKKADEIRDKLLSMGIVLKDTRDGVIWERSN

Sequences:

>Translated_462_residues
MKLYNTLTRKKEEFKPIKEKNVGIYVCGPTVYNYIHVGNARPIVVFDTLRRYFIYKGYNVKFVSNFTDIDDKIINKAKDE
NIDFREITKKYIQAYLDNVSGLNFDEDDTIHPKATEYIDEMIKFVKTLEDKGAAYNVDGNVYFDITKAKDYGKLSKKNID
DLRAGARIDVNSEKKNPMDFALWKKRKEESEPAWESPWGMGRPGWHLECSVMSKTILGDTIDIHAGGEDLQFPHHENEIA
QSETCTGAHFANYWLHNSMITVDKEKMSKSKNNFFLLKDIEKEFDLEVIRLWLLSVHYRNPIDFSHDTLVATKNSLDRLY
TAKKFLNRILENSSEKEEKDDNIKTFREKFEQAMDDDINTADAISVLFDFIKYINKNYDENTSKNILLDAKKLMDDISYV
LGILFKEDDDDLDSEIEELIEQRNAARKEKDFKKADEIRDKLLSMGIVLKDTRDGVIWERSN
>Mature_462_residues
MKLYNTLTRKKEEFKPIKEKNVGIYVCGPTVYNYIHVGNARPIVVFDTLRRYFIYKGYNVKFVSNFTDIDDKIINKAKDE
NIDFREITKKYIQAYLDNVSGLNFDEDDTIHPKATEYIDEMIKFVKTLEDKGAAYNVDGNVYFDITKAKDYGKLSKKNID
DLRAGARIDVNSEKKNPMDFALWKKRKEESEPAWESPWGMGRPGWHLECSVMSKTILGDTIDIHAGGEDLQFPHHENEIA
QSETCTGAHFANYWLHNSMITVDKEKMSKSKNNFFLLKDIEKEFDLEVIRLWLLSVHYRNPIDFSHDTLVATKNSLDRLY
TAKKFLNRILENSSEKEEKDDNIKTFREKFEQAMDDDINTADAISVLFDFIKYINKNYDENTSKNILLDAKKLMDDISYV
LGILFKEDDDDLDSEIEELIEQRNAARKEKDFKKADEIRDKLLSMGIVLKDTRDGVIWERSN

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=388, Percent_Identity=34.020618556701, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI21269877, Length=285, Percent_Identity=36.4912280701754, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI10835051, Length=285, Percent_Identity=36.4912280701754, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI303304987, Length=285, Percent_Identity=36.4912280701754, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI62240992, Length=285, Percent_Identity=36.4912280701754, Blast_Score=179, Evalue=7e-45,
Organism=Escherichia coli, GI1786737, Length=471, Percent_Identity=44.7983014861996, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17509797, Length=247, Percent_Identity=38.0566801619433, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17509795, Length=247, Percent_Identity=38.0566801619433, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324082, Length=346, Percent_Identity=34.971098265896, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI19922218, Length=507, Percent_Identity=30.7692307692308, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI19922364, Length=368, Percent_Identity=29.8913043478261, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_FINM2 (B0S0W3)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691723.1
- ProteinModelPortal:   B0S0W3
- GeneID:   6019816
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0415
- HOGENOM:   HBG327651
- OMA:   DFDALNM
- ProtClustDB:   PRK00260
- BioCyc:   FMAG334413:FMG_0415-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 53941; Mature: 53941

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 269-269

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNTLTRKKEEFKPIKEKNVGIYVCGPTVYNYIHVGNARPIVVFDTLRRYFIYKGYNV
CCHHHHHHHHHHHCCCHHHCCCEEEEECHHHEEEEEECCCCCEEEHHHHHHHHEECCCCE
KFVSNFTDIDDKIINKAKDENIDFREITKKYIQAYLDNVSGLNFDEDDTIHPKATEYIDE
EEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
MIKFVKTLEDKGAAYNVDGNVYFDITKAKDYGKLSKKNIDDLRAGARIDVNSEKKNPMDF
HHHHHHHHHHCCCEEECCCEEEEEEECCCCCCCHHHCCHHHHHCCCEEECCCCCCCCHHH
ALWKKRKEESEPAWESPWGMGRPGWHLECSVMSKTILGDTIDIHAGGEDLQFPHHENEIA
HHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHH
QSETCTGAHFANYWLHNSMITVDKEKMSKSKNNFFLLKDIEKEFDLEVIRLWLLSVHYRN
HCCCCCCHHHHHHHHHCCEEEEEHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
PIDFSHDTLVATKNSLDRLYTAKKFLNRILENSSEKEEKDDNIKTFREKFEQAMDDDINT
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHCCCCCH
ADAISVLFDFIKYINKNYDENTSKNILLDAKKLMDDISYVLGILFKEDDDDLDSEIEELI
HHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EQRNAARKEKDFKKADEIRDKLLSMGIVLKDTRDGVIWERSN
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEECCC
>Mature Secondary Structure
MKLYNTLTRKKEEFKPIKEKNVGIYVCGPTVYNYIHVGNARPIVVFDTLRRYFIYKGYNV
CCHHHHHHHHHHHCCCHHHCCCEEEEECHHHEEEEEECCCCCEEEHHHHHHHHEECCCCE
KFVSNFTDIDDKIINKAKDENIDFREITKKYIQAYLDNVSGLNFDEDDTIHPKATEYIDE
EEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
MIKFVKTLEDKGAAYNVDGNVYFDITKAKDYGKLSKKNIDDLRAGARIDVNSEKKNPMDF
HHHHHHHHHHCCCEEECCCEEEEEEECCCCCCCHHHCCHHHHHCCCEEECCCCCCCCHHH
ALWKKRKEESEPAWESPWGMGRPGWHLECSVMSKTILGDTIDIHAGGEDLQFPHHENEIA
HHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHH
QSETCTGAHFANYWLHNSMITVDKEKMSKSKNNFFLLKDIEKEFDLEVIRLWLLSVHYRN
HCCCCCCHHHHHHHHHCCEEEEEHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
PIDFSHDTLVATKNSLDRLYTAKKFLNRILENSSEKEEKDDNIKTFREKFEQAMDDDINT
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHCCCCCH
ADAISVLFDFIKYINKNYDENTSKNILLDAKKLMDDISYVLGILFKEDDDDLDSEIEELI
HHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EQRNAARKEKDFKKADEIRDKLLSMGIVLKDTRDGVIWERSN
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA