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The map label for this gene is thyX

Identifier: 169824113

GI number: 169824113

Start: 473343

End: 474104

Strand: Direct

Name: thyX

Synonym: FMG_0416

Alternate gene names: 169824113

Gene position: 473343-474104 (Clockwise)

Preceding gene: 169824112

Following gene: 169824114

Centisome position: 26.33

GC content: 36.22

Gene sequence:

>762_bases
ATGAAGGTTAATCTAATTAGATACACTCCAGATGCACAAAAACTTGTCGCATCAAGTGCAAAACTTTGTTATTCAGATAG
TTCTGTCATGGAGATTGAGGAAGGACTAACTGATGAAAATGTAGAAAATTTCATAGATAAATTAATGGGTTTAGGACACA
TGTCTCCGGTTGAACACATTAGTTTTACTTTTGCAATAGAGGGTGTATCTAGAACTTTGACCCACCAATTGGTCAGACAC
AGATTAGCAAGCTACTCGCAAAAATCTCAACGATATGTGAGAGCGAATAATTACGAGTATATTATCCCTCCAAAAATAAA
AAACAATCCCAAGGCTTTAGAAATCTACGAAAGACATATGAAACACACAATCGATGCTTATAACGAACTCACAGAAATTT
TGATACAAGAAGAATACGACAAACTAATCGCAAATGGCATCGATGAGAAGAAAGCGAAAGCAATGTCAGAAAAAAGCTCC
ATTGAAGATGCGAGATATGTATTTTCAAATGCAACTGAGACTAAAATTGTCATGACAATGAATGCCCGTGAATTGTTGCA
TTTCTTCGAAGCAAGATGCTGCCAAAGGGCCCAATGGGAAATAAGAGAAATGGCAACATTAATGCTTATTGAAGCGAAAA
AAGTGTGCCCGCAAATTTTCAAAAAAGCGGGACCAGGTTGTGTTAAAGGAAGTTGTCCAGAAGGAAAGATGACTTGTGGT
AAAATAAAACAAGTTAGAGAATATTTTAATAGCCTTGACTAG

Upstream 100 bases:

>100_bases
AAGACTTCAAAAAAGCAGACGAAATAAGAGATAAACTTTTATCTATGGGAATTGTGTTAAAAGACACCAGAGACGGCGTA
ATATGGGAGAGAAGTAATTA

Downstream 100 bases:

>100_bases
TTAGGAGATATTATGGGAAAGATTGCAATTTTAACAGATTCAGGTAGTGAAATTACACCAAAAATAGCAGAAGAATACGG
CATTGAATTGATGCCACTTC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKVNLIRYTPDAQKLVASSAKLCYSDSSVMEIEEGLTDENVENFIDKLMGLGHMSPVEHISFTFAIEGVSRTLTHQLVRH
RLASYSQKSQRYVRANNYEYIIPPKIKNNPKALEIYERHMKHTIDAYNELTEILIQEEYDKLIANGIDEKKAKAMSEKSS
IEDARYVFSNATETKIVMTMNARELLHFFEARCCQRAQWEIREMATLMLIEAKKVCPQIFKKAGPGCVKGSCPEGKMTCG
KIKQVREYFNSLD

Sequences:

>Translated_253_residues
MKVNLIRYTPDAQKLVASSAKLCYSDSSVMEIEEGLTDENVENFIDKLMGLGHMSPVEHISFTFAIEGVSRTLTHQLVRH
RLASYSQKSQRYVRANNYEYIIPPKIKNNPKALEIYERHMKHTIDAYNELTEILIQEEYDKLIANGIDEKKAKAMSEKSS
IEDARYVFSNATETKIVMTMNARELLHFFEARCCQRAQWEIREMATLMLIEAKKVCPQIFKKAGPGCVKGSCPEGKMTCG
KIKQVREYFNSLD
>Mature_253_residues
MKVNLIRYTPDAQKLVASSAKLCYSDSSVMEIEEGLTDENVENFIDKLMGLGHMSPVEHISFTFAIEGVSRTLTHQLVRH
RLASYSQKSQRYVRANNYEYIIPPKIKNNPKALEIYERHMKHTIDAYNELTEILIQEEYDKLIANGIDEKKAKAMSEKSS
IEDARYVFSNATETKIVMTMNARELLHFFEARCCQRAQWEIREMATLMLIEAKKVCPQIFKKAGPGCVKGSCPEGKMTCG
KIKQVREYFNSLD

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 29047; Mature: 29047

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNLIRYTPDAQKLVASSAKLCYSDSSVMEIEEGLTDENVENFIDKLMGLGHMSPVEHI
CCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHH
SFTFAIEGVSRTLTHQLVRHRLASYSQKSQRYVRANNYEYIIPPKIKNNPKALEIYERHM
EEHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHH
KHTIDAYNELTEILIQEEYDKLIANGIDEKKAKAMSEKSSIEDARYVFSNATETKIVMTM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
NARELLHFFEARCCQRAQWEIREMATLMLIEAKKVCPQIFKKAGPGCVKGSCPEGKMTCG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
KIKQVREYFNSLD
HHHHHHHHHHCCC
>Mature Secondary Structure
MKVNLIRYTPDAQKLVASSAKLCYSDSSVMEIEEGLTDENVENFIDKLMGLGHMSPVEHI
CCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHH
SFTFAIEGVSRTLTHQLVRHRLASYSQKSQRYVRANNYEYIIPPKIKNNPKALEIYERHM
EEHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHH
KHTIDAYNELTEILIQEEYDKLIANGIDEKKAKAMSEKSSIEDARYVFSNATETKIVMTM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
NARELLHFFEARCCQRAQWEIREMATLMLIEAKKVCPQIFKKAGPGCVKGSCPEGKMTCG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
KIKQVREYFNSLD
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]