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The map label for this gene is cobL [H]

Identifier: 169629281

GI number: 169629281

Start: 2209762

End: 2211036

Strand: Direct

Name: cobL [H]

Synonym: MAB_2195

Alternate gene names: 169629281

Gene position: 2209762-2211036 (Clockwise)

Preceding gene: 169629280

Following gene: 169629282

Centisome position: 43.61

GC content: 64.39

Gene sequence:

>1275_bases
ATGGCGCAGGATGCCGCGATGAGCCCGTCGGGCGAAGAGCATGGAGCACCGATGAGCCCGTCGGGCCACGAGCCTGAAGC
ACCGACGGGCCGGATCACCGTGGTCGGGATAGGCGCCGACGGTGTTGATGGGCTGTCGGCGCGTTCCCGCCGTGAATTAC
ACCGAGCGTCAGTAATTTTCGGTTCCCTGCGCCAGCTGGAGCTGCTAGCCGAAGAATCCCTGGTGGCCGAATGCCGGGTG
TGGCCCTCGCCGCTGTTGCCCGCGTTGCCCACCATGTTCGATGGTCTTGGTGATGTTCACGTGCTCGCGAGCGGTGACCC
CATGCTGCACGGCATCGGTACCACACTCACCCGGCTGTTCGGTGCGCAGCGGGTCGATGTCCATCCGCACATATCCAGCG
TGTCGTTGGCCTGTTCCCGCATGGGATGGGCCGTAAACGATATCGAGATCATCAGCCTGGTGAACGCACCCGCCCGTTCG
GCCCGCAGATTCGGTGGGCGCGCAGTGGTGTTGAGTCGCAACGCCGGAACGCCGCGGGAGCTGGCGCAGACCCTATCGGA
GTCCGGCCTGGGTGATTCGCGTTTGACGGTATGGGAGCAGTTGGGCGGCGCGGGCGAGCACTCGTTCGGAGGTGTCGCCC
GGAGCTGGGATCACCCGCTCGGCGATGCCTTGAATGTTATTGCCGTCGAATATGTTCCGGCAGAAGAAGTGGCCATCCTG
CCGTTGGTTGCCGGCCTGCCCGAGAGTGTGTTCGAGCACGACGGTCAGATCACCAAGCACGAGATTCGGGCGGTTACCCT
GGCGGCACTGGGGCCACGGCCCGGCCAGCGGCTCTGGGACGTCGGTGCGGGATCGGGCAGTATTGCGGTTGAATGGTCGC
GCAGCGGCACCGGCTGTAGCGCCTCGGCCTTTGAGATCGAGCCGTCACGGCGGGCCTCCATCGCCGCCAATGCGACGAAA
TTCGGCGTCGATATCGATGTATTCGGCGCGGCCCCGGACGATTTCGAACAGGCTGTCGCTCCGGATGTGATCTTCGTGGG
TGGCGGCGTGACCCAGCCGGGTCTGCTGGAGGCATGCTGGGAACGGCTGCCGATCGGGGGCCGGATGGTTGTCAACGCTG
TTACCGCGGAATCCGAAGCGTTGTTGCTGCGATGGTATTGCCGCTATGGGGGAGAGTTGCGCAGGTATCGTGTCGAAGAC
GCCGCCCCGCTCGGAGGCTTCACCAGTTGGAGATCTCGTCTGCCCGTAGTTCAGTGGAGCACCGAAAAATCATGA

Upstream 100 bases:

>100_bases
CAGCGACGGTGCGGGCGTTGCGCGGCGGAAAGCGCACGGTGTGGATACCCCGGCCGCTGGGTGCGCTCGCCTTCGTCATG
CGGTGGGTACCGTCGTCGGT

Downstream 100 bases:

>100_bases
CCGTCTATTTCATCGGTGCCGGACCGGGCGCGGCCGACCTCATCACGGTGCGTGGACAGCGGATCCTGCGGCAGTGCTCT
GTGTGTCTGTATGCGGGATC

Product: precorrin-6Y C5,15-methyltransferase CobL

Products: NA

Alternate protein names: Precorrin-6 methyltransferase; Precorrin-6Y methylase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSRRELHRASVIFGSLRQLELLAEESLVAECRV
WPSPLLPALPTMFDGLGDVHVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSRMGWAVNDIEIISLVNAPARS
ARRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWEQLGGAGEHSFGGVARSWDHPLGDALNVIAVEYVPAEEVAIL
PLVAGLPESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSGTGCSASAFEIEPSRRASIAANATK
FGVDIDVFGAAPDDFEQAVAPDVIFVGGGVTQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRYRVED
AAPLGGFTSWRSRLPVVQWSTEKS

Sequences:

>Translated_424_residues
MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSRRELHRASVIFGSLRQLELLAEESLVAECRV
WPSPLLPALPTMFDGLGDVHVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSRMGWAVNDIEIISLVNAPARS
ARRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWEQLGGAGEHSFGGVARSWDHPLGDALNVIAVEYVPAEEVAIL
PLVAGLPESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSGTGCSASAFEIEPSRRASIAANATK
FGVDIDVFGAAPDDFEQAVAPDVIFVGGGVTQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRYRVED
AAPLGGFTSWRSRLPVVQWSTEKS
>Mature_423_residues
AQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSRRELHRASVIFGSLRQLELLAEESLVAECRVW
PSPLLPALPTMFDGLGDVHVLASGDPMLHGIGTTLTRLFGAQRVDVHPHISSVSLACSRMGWAVNDIEIISLVNAPARSA
RRFGGRAVVLSRNAGTPRELAQTLSESGLGDSRLTVWEQLGGAGEHSFGGVARSWDHPLGDALNVIAVEYVPAEEVAILP
LVAGLPESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSGTGCSASAFEIEPSRRASIAANATKF
GVDIDVFGAAPDDFEQAVAPDVIFVGGGVTQPGLLEACWERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRYRVEDA
APLGGFTSWRSRLPVVQWSTEKS

Specific function: Catalyzes the methylation of both C-5 and C-15 in precorrin-6Y to form precorrin-8X [H]

COG id: COG2242

COG function: function code H; Precorrin-6B methylase 2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR012818
- InterPro:   IPR014008
- InterPro:   IPR006365 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.132 [H]

Molecular weight: Translated: 44953; Mature: 44822

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSRRELHRASVIF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
GSLRQLELLAEESLVAECRVWPSPLLPALPTMFDGLGDVHVLASGDPMLHGIGTTLTRLF
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHH
GAQRVDVHPHISSVSLACSRMGWAVNDIEIISLVNAPARSARRFGGRAVVLSRNAGTPRE
CCCEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCEEEEEECCCCCHHH
LAQTLSESGLGDSRLTVWEQLGGAGEHSFGGVARSWDHPLGDALNVIAVEYVPAEEVAIL
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEE
PLVAGLPESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSGTGCS
HHHHCCCHHHHHCCCCEEHHHHEEEEEEECCCCCCCCEEECCCCCCCEEEEECCCCCCCC
ASAFEIEPSRRASIAANATKFGVDIDVFGAAPDDFEQAVAPDVIFVGGGVTQPGLLEACW
CCEEEECCCCCCEEECCCEEECCEEEEECCCCCHHHHHCCCCEEEECCCCCCCHHHHHHH
ERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRYRVEDAAPLGGFTSWRSRLPVVQWS
HHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHCCCEEEEC
TEKS
CCCC
>Mature Secondary Structure 
AQDAAMSPSGEEHGAPMSPSGHEPEAPTGRITVVGIGADGVDGLSARSRRELHRASVIF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
GSLRQLELLAEESLVAECRVWPSPLLPALPTMFDGLGDVHVLASGDPMLHGIGTTLTRLF
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHH
GAQRVDVHPHISSVSLACSRMGWAVNDIEIISLVNAPARSARRFGGRAVVLSRNAGTPRE
CCCEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCEEEEEECCCCCHHH
LAQTLSESGLGDSRLTVWEQLGGAGEHSFGGVARSWDHPLGDALNVIAVEYVPAEEVAIL
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEE
PLVAGLPESVFEHDGQITKHEIRAVTLAALGPRPGQRLWDVGAGSGSIAVEWSRSGTGCS
HHHHCCCHHHHHCCCCEEHHHHEEEEEEECCCCCCCCEEECCCCCCCEEEEECCCCCCCC
ASAFEIEPSRRASIAANATKFGVDIDVFGAAPDDFEQAVAPDVIFVGGGVTQPGLLEACW
CCEEEECCCCCCEEECCCEEECCEEEEECCCCCHHHHHCCCCEEEECCCCCCCHHHHHHH
ERLPIGGRMVVNAVTAESEALLLRWYCRYGGELRRYRVEDAAPLGGFTSWRSRLPVVQWS
HHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHCCCEEEEC
TEKS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]