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The map label for this gene is nuoN

Identifier: 169629233

GI number: 169629233

Start: 2159845

End: 2161461

Strand: Direct

Name: nuoN

Synonym: MAB_2147

Alternate gene names: 169629233

Gene position: 2159845-2161461 (Clockwise)

Preceding gene: 169629232

Following gene: 169629234

Centisome position: 42.62

GC content: 63.39

Gene sequence:

>1617_bases
ATGACCGATATCGGAATTCTTCCTGCTCCCGCGATCGCGTACGGCGCACTCTCTCCCATGCTGATCATGTTCGGGGTGGC
GGTGGTGTCGGTACTGGTGGAGGCGTTCGTTCCGCGGGGACATCGGCTCCGCACCCAATTGGCCCTGGCGACGGTCGGAA
TTCTCGGCGCCTTTGTGGCGGTGGTGGCGCTGAGCGGTTCACATCAGGTCGTCATGAACGGCGCGGTCGCGATCGATGGC
CCGACGCTGTACTTACAGGGGCTCATCTTGGTGGCGTCCGGATTGGCTTTGGTGGTGATGGCACAACGCAGAACAGTCGC
GGCGGTGCCCAGTGCCGTCGGCGCGGGGGCCGGCGGCGGGCTGGACTCCTTTGCCGCGCAGGCGTCCAGCGTGCCCGGAA
GTGAACCGGAGCGGGTATTGAATCGCACCGGTATCACGCAAACGGAGATCTTCCCGCTGACGTTGTTCGCGATCGCGGGC
ATGATGCTGTTTCCGGCCTGTAATGACCTGCTGACGATGTTCGTCGCACTGGAGGTGTTTTCTCTTCCGCTCTACGTGAT
GTGTGCTCTGGCCCGGCGCCGCCGACTGCTGTCCCAGGAATCGGCGCTCAAGTACTTTCTGCTGGGGGCGTTCTCCTCGG
CGTTCTTTCTTTTCGGATCGGCGTTTGTGTACGGATACGCGGGGACGGTCGAACTCGACGCCGTCGCGCGTGCCGTCGAT
GCCGATGCGGGGGAACGGTCCTTTCTGCTGCTCGGTGTCGCCATGTTGTCGGTGGGGCTGCTGTTCAAGGTGGGTGCGGT
GCCGTTCCATTTCTGGGTCCCCGACGTGTACCAGGGGGCGCCCACACCGGTGACCGCGTTCATGGCGGCAACCACAAAGA
TCGCGGCATTCGGTGCGCTGCTGCGGGTGCTGTATGTCGCGCTGCCGGGAATCACCACCGATTGGCGGCCGGTGCTATGG
GGGGTGGCCATTGCCACCATGTTGATCGGATCGATCGGTGCGGTGACACAAACCGATGTCAAGCGAATGCTGGCCTACTC
GGCGGTGGCGCATACCGGATTTCTGCTTACCGGCGTAGCCGCCGCCAACGAGCGTGGTGTCTCCTCGACATTGTTCTATT
TGGCGGCATACGGTTTCAGCACTGTAGGGGCGTTCATCATCGCCGGTCTGGTGCGTTCGGGCAACGCAGATGACGGGGCC
GATGGCGATTACAAAGACGACGACGAGGTAACCGATCTGCGGCGGTGGGCCGGGGTCGGTCGGCGAGCGCCGGTGTTGGG
CATTGTGTTCGCGTTGTTTCTGTTGGCGTTCGCCGGAATCCCCTTGACGAGCGGATTCGTGAGCAAGTTCGCTGTTTTCG
AGGCCGCGGCAGCCGGGGGTGCCATGCCTCTGGTGGTGGTGGGCGTGATGTGCAGCGCCATCGCGGCCTACTTTTACGTC
CGCGTCATCGTGGTGATGTTCTTCGCCGACCCGGTCGAGGATTCCGGGGTACTGCGCATTCCGGGTCCCGCGGTGACGGT
GTCGATCGCGGTGAGCGCACTGATCACCGTGCTGCTTGGCGTGGCTCCGCAGCCGCTGCTCGATCTTGTCGAGAATCTCG
CCGACTTCGTCACGTGA

Upstream 100 bases:

>100_bases
TCAACCCCGCTGTCGAGCAGACCTTGCGCACCGTCAACGAGAAGGATCCGCCGCCCACCGTGGCCGATATCGCTCTCCGA
CACGGCGAAGGCGAGCAGCG

Downstream 100 bases:

>100_bases
GCCCAGTCACCCCCCACGGGTGTTCGACACGCCGCGTCGTGTGTCCGACACGCCTTCGAGTCGCGCAGAAAACGGCGTGT
CGGCGCATACCGTGGCCTGG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MTDIGILPAPAIAYGALSPMLIMFGVAVVSVLVEAFVPRGHRLRTQLALATVGILGAFVAVVALSGSHQVVMNGAVAIDG
PTLYLQGLILVASGLALVVMAQRRTVAAVPSAVGAGAGGGLDSFAAQASSVPGSEPERVLNRTGITQTEIFPLTLFAIAG
MMLFPACNDLLTMFVALEVFSLPLYVMCALARRRRLLSQESALKYFLLGAFSSAFFLFGSAFVYGYAGTVELDAVARAVD
ADAGERSFLLLGVAMLSVGLLFKVGAVPFHFWVPDVYQGAPTPVTAFMAATTKIAAFGALLRVLYVALPGITTDWRPVLW
GVAIATMLIGSIGAVTQTDVKRMLAYSAVAHTGFLLTGVAAANERGVSSTLFYLAAYGFSTVGAFIIAGLVRSGNADDGA
DGDYKDDDEVTDLRRWAGVGRRAPVLGIVFALFLLAFAGIPLTSGFVSKFAVFEAAAAGGAMPLVVVGVMCSAIAAYFYV
RVIVVMFFADPVEDSGVLRIPGPAVTVSIAVSALITVLLGVAPQPLLDLVENLADFVT

Sequences:

>Translated_538_residues
MTDIGILPAPAIAYGALSPMLIMFGVAVVSVLVEAFVPRGHRLRTQLALATVGILGAFVAVVALSGSHQVVMNGAVAIDG
PTLYLQGLILVASGLALVVMAQRRTVAAVPSAVGAGAGGGLDSFAAQASSVPGSEPERVLNRTGITQTEIFPLTLFAIAG
MMLFPACNDLLTMFVALEVFSLPLYVMCALARRRRLLSQESALKYFLLGAFSSAFFLFGSAFVYGYAGTVELDAVARAVD
ADAGERSFLLLGVAMLSVGLLFKVGAVPFHFWVPDVYQGAPTPVTAFMAATTKIAAFGALLRVLYVALPGITTDWRPVLW
GVAIATMLIGSIGAVTQTDVKRMLAYSAVAHTGFLLTGVAAANERGVSSTLFYLAAYGFSTVGAFIIAGLVRSGNADDGA
DGDYKDDDEVTDLRRWAGVGRRAPVLGIVFALFLLAFAGIPLTSGFVSKFAVFEAAAAGGAMPLVVVGVMCSAIAAYFYV
RVIVVMFFADPVEDSGVLRIPGPAVTVSIAVSALITVLLGVAPQPLLDLVENLADFVT
>Mature_537_residues
TDIGILPAPAIAYGALSPMLIMFGVAVVSVLVEAFVPRGHRLRTQLALATVGILGAFVAVVALSGSHQVVMNGAVAIDGP
TLYLQGLILVASGLALVVMAQRRTVAAVPSAVGAGAGGGLDSFAAQASSVPGSEPERVLNRTGITQTEIFPLTLFAIAGM
MLFPACNDLLTMFVALEVFSLPLYVMCALARRRRLLSQESALKYFLLGAFSSAFFLFGSAFVYGYAGTVELDAVARAVDA
DAGERSFLLLGVAMLSVGLLFKVGAVPFHFWVPDVYQGAPTPVTAFMAATTKIAAFGALLRVLYVALPGITTDWRPVLWG
VAIATMLIGSIGAVTQTDVKRMLAYSAVAHTGFLLTGVAAANERGVSSTLFYLAAYGFSTVGAFIIAGLVRSGNADDGAD
GDYKDDDEVTDLRRWAGVGRRAPVLGIVFALFLLAFAGIPLTSGFVSKFAVFEAAAAGGAMPLVVVGVMCSAIAAYFYVR
VIVVMFFADPVEDSGVLRIPGPAVTVSIAVSALITVLLGVAPQPLLDLVENLADFVT

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=297, Percent_Identity=23.9057239057239, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI145693160, Length=527, Percent_Identity=32.6375711574953, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788831, Length=334, Percent_Identity=25.4491017964072, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788613, Length=372, Percent_Identity=23.9247311827957, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788614, Length=344, Percent_Identity=25.2906976744186, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788829, Length=273, Percent_Identity=26.3736263736264, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788827, Length=210, Percent_Identity=24.7619047619048, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_MYCA9 (B1MAF7)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001702882.1
- EnsemblBacteria:   EBMYCT00000008448
- GeneID:   5964660
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2147
- GeneTree:   EBGT00050000015714
- HOGENOM:   HBG747830
- OMA:   LMFFSEP
- ProtClustDB:   PRK05777
- BioCyc:   MABS561007:MAB_2147-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 55912; Mature: 55781

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x226fed08)-; HASH(0x22827834)-; HASH(0x2241dcc0)-; HASH(0x217a632c)-; HASH(0x22813b00)-; HASH(0x22cc330c)-; HASH(0x23012064)-; HASH(0x22a36f50)-; HASH(0x230abcc0)-; HASH(0x23467850)-; HASH(0x22d20580)-; HASH(0x234a97e0)-; HASH(0x23478848)-; HASH(0x226c1390)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIGILPAPAIAYGALSPMLIMFGVAVVSVLVEAFVPRGHRLRTQLALATVGILGAFVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VVALSGSHQVVMNGAVAIDGPTLYLQGLILVASGLALVVMAQRRTVAAVPSAVGAGAGGG
HHHCCCCCEEEEECEEEECCHHHHHHHHHHHHCCHHHHHHHHCCHHHHCCHHHCCCCCCC
LDSFAAQASSVPGSEPERVLNRTGITQTEIFPLTLFAIAGMMLFPACNDLLTMFVALEVF
HHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLPLYVMCALARRRRLLSQESALKYFLLGAFSSAFFLFGSAFVYGYAGTVELDAVARAVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHC
ADAGERSFLLLGVAMLSVGLLFKVGAVPFHFWVPDVYQGAPTPVTAFMAATTKIAAFGAL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHH
LRVLYVALPGITTDWRPVLWGVAIATMLIGSIGAVTQTDVKRMLAYSAVAHTGFLLTGVA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AANERGVSSTLFYLAAYGFSTVGAFIIAGLVRSGNADDGADGDYKDDDEVTDLRRWAGVG
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCC
RRAPVLGIVFALFLLAFAGIPLTSGFVSKFAVFEAAAAGGAMPLVVVGVMCSAIAAYFYV
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RVIVVMFFADPVEDSGVLRIPGPAVTVSIAVSALITVLLGVAPQPLLDLVENLADFVT
HHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCH
>Mature Secondary Structure 
TDIGILPAPAIAYGALSPMLIMFGVAVVSVLVEAFVPRGHRLRTQLALATVGILGAFVA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VVALSGSHQVVMNGAVAIDGPTLYLQGLILVASGLALVVMAQRRTVAAVPSAVGAGAGGG
HHHCCCCCEEEEECEEEECCHHHHHHHHHHHHCCHHHHHHHHCCHHHHCCHHHCCCCCCC
LDSFAAQASSVPGSEPERVLNRTGITQTEIFPLTLFAIAGMMLFPACNDLLTMFVALEVF
HHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLPLYVMCALARRRRLLSQESALKYFLLGAFSSAFFLFGSAFVYGYAGTVELDAVARAVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHC
ADAGERSFLLLGVAMLSVGLLFKVGAVPFHFWVPDVYQGAPTPVTAFMAATTKIAAFGAL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHH
LRVLYVALPGITTDWRPVLWGVAIATMLIGSIGAVTQTDVKRMLAYSAVAHTGFLLTGVA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AANERGVSSTLFYLAAYGFSTVGAFIIAGLVRSGNADDGADGDYKDDDEVTDLRRWAGVG
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCC
RRAPVLGIVFALFLLAFAGIPLTSGFVSKFAVFEAAAAGGAMPLVVVGVMCSAIAAYFYV
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RVIVVMFFADPVEDSGVLRIPGPAVTVSIAVSALITVLLGVAPQPLLDLVENLADFVT
HHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA