Click here to switch to the map view.

The map label for this gene is nuoM [H]

Identifier: 169629232

GI number: 169629232

Start: 2158241

End: 2159848

Strand: Direct

Name: nuoM [H]

Synonym: MAB_2146

Alternate gene names: 169629232

Gene position: 2158241-2159848 (Clockwise)

Preceding gene: 169629231

Following gene: 169629233

Centisome position: 42.59

GC content: 61.82

Gene sequence:

>1608_bases
GTGAGTGCGGTGGGTGCCGTGACAGCGCTATGGCTCATTCCGTTGGTTGGTGCCGCCGCGATATTGGTGCTACCGGCCCA
CCAGCGCACCTTGGCGAAGTACACCGCTCTGGGCACTTCGCTGCTCGTGCTGATCGTCGCCGTCGGGGTGGCAATCGCCT
TCGACCCCGTCGGCCCGCAGTACCAGTTCGTCGAATCGGTGTCCTGGATACCGGCATTCGGAATGAAGTACGCGGTTGGT
CTTGACGGGATCGGCCTCGCCTTGGTGCTGCTGACCACCGGGCTGCTGCCGGTGCTGCTGCTGGCGGGATGGAACGACGG
GGCAGAGGCCCCGGGGTACGGCCACCGGCCGCTGGCGCAGCGCTATATGGCGCTGATGTTGATTGTGGAAGCCATGGTGC
TGCTGTCCTTCTCGGCCCTGGACGTACTGCTGTTCTACATCTTTTTCGAGGCCATGCTCATCCCGATGTACTTCCTGATA
GGTGGATTCGGGAGCACACATTCCGATGTCAAGCAACGCTCCCGCGCGGCGGTGAAGTTCTTGATGTACAACCTGTTCGG
CGGGCTGGTGATGTTGGCGGCCGTGATCGGGCTCTATGTGGTCACGGCCCAGAGTCCGGCCGGTGAACACGGTGGCACAT
TCGATCTGCGTGATATCACCGAAATGGTCGCCACCGGCACGCTCGGTATCGATCCGGGTTTGGCGAAGGCGCTCTTCCTG
GGGTTCATGTTCGCGTTCGCCGTGAAGGCTCCGCTCTGGCCGCTGCACACCTGGCTGCCCGACGCCGCCGTGCATGCCAC
ACCGTCCAGCGCGGTGCTCATGATGGCGGTCGTGGACAAGGTGGGCACGTTCGCGATGCTGCGGTACTGCGTCCAGCTGT
TCCCCGATGCCAGTAGATATTTCACTCCGGTGATCGTCACACTGGCGGTCATCGGCATTGTCTACGGCGCGGTCGTGGCC
ATCGGCCAGACCGATGTGATGCGTTTGATCGCCTATACGTCGATATCGCATTTCGGCTTCATCATCCTGGGTATCTTCGC
GATGACAAGTCAGGGCCAATCGGGCTCGACGCTATACATGGTCAACCACGGCATCTCCACCGCGGCGCTGATGCTGGTCG
CAGGATTTCTGGTCACCCGCAAGGGCTCTCGACTCATCGCGTCCTACGGAGGCGTGCAGAAGGTGGCGCCTGTACTCGCC
GGATCATTTTTGGTGGCAGGTCTGGCCACTCTTTCGCTGCCGGGGCTAGCGCCGTTTATCAGCGAATTCCTGGTCTTGGT
AGGCACTTTCACGCGCTATCCGGTCGCGGCAGCGTGCGCCGTTGTCGCCCTGGTACTGGCGGCCATCTATGTGTTGTGGA
TGTATCAGAGGATGATGACAGGGCCGTTGGCGCCGGGAAACGAAACCATCGGAGATCTTAAGCGCCGTGAGCTCACCGTG
GTGGCGCCGCTGGTCGCGCTTCTGCTGGTATTGGGCATTTATCCCAAACCATTGCTCGACATCGTCAACCCCGCTGTCGA
GCAGACCTTGCGCACCGTCAACGAGAAGGATCCGCCGCCCACCGTGGCCGATATCGCTCTCCGACACGGCGAAGGCGAGC
AGCGATGA

Upstream 100 bases:

>100_bases
GTTGGGTACGGCAGTTGCAGACTGGCCACGTCCGCTCGTACGCGTTGTCCATGTGCGCAGGCGCGGCCGTGGTGGTCGCG
GTGTTGATGGCAGTGAGGTG

Downstream 100 bases:

>100_bases
CCGATATCGGAATTCTTCCTGCTCCCGCGATCGCGTACGGCGCACTCTCTCCCATGCTGATCATGTTCGGGGTGGCGGTG
GTGTCGGTACTGGTGGAGGC

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSAVGAVTALWLIPLVGAAAILVLPAHQRTLAKYTALGTSLLVLIVAVGVAIAFDPVGPQYQFVESVSWIPAFGMKYAVG
LDGIGLALVLLTTGLLPVLLLAGWNDGAEAPGYGHRPLAQRYMALMLIVEAMVLLSFSALDVLLFYIFFEAMLIPMYFLI
GGFGSTHSDVKQRSRAAVKFLMYNLFGGLVMLAAVIGLYVVTAQSPAGEHGGTFDLRDITEMVATGTLGIDPGLAKALFL
GFMFAFAVKAPLWPLHTWLPDAAVHATPSSAVLMMAVVDKVGTFAMLRYCVQLFPDASRYFTPVIVTLAVIGIVYGAVVA
IGQTDVMRLIAYTSISHFGFIILGIFAMTSQGQSGSTLYMVNHGISTAALMLVAGFLVTRKGSRLIASYGGVQKVAPVLA
GSFLVAGLATLSLPGLAPFISEFLVLVGTFTRYPVAAACAVVALVLAAIYVLWMYQRMMTGPLAPGNETIGDLKRRELTV
VAPLVALLLVLGIYPKPLLDIVNPAVEQTLRTVNEKDPPPTVADIALRHGEGEQR

Sequences:

>Translated_535_residues
MSAVGAVTALWLIPLVGAAAILVLPAHQRTLAKYTALGTSLLVLIVAVGVAIAFDPVGPQYQFVESVSWIPAFGMKYAVG
LDGIGLALVLLTTGLLPVLLLAGWNDGAEAPGYGHRPLAQRYMALMLIVEAMVLLSFSALDVLLFYIFFEAMLIPMYFLI
GGFGSTHSDVKQRSRAAVKFLMYNLFGGLVMLAAVIGLYVVTAQSPAGEHGGTFDLRDITEMVATGTLGIDPGLAKALFL
GFMFAFAVKAPLWPLHTWLPDAAVHATPSSAVLMMAVVDKVGTFAMLRYCVQLFPDASRYFTPVIVTLAVIGIVYGAVVA
IGQTDVMRLIAYTSISHFGFIILGIFAMTSQGQSGSTLYMVNHGISTAALMLVAGFLVTRKGSRLIASYGGVQKVAPVLA
GSFLVAGLATLSLPGLAPFISEFLVLVGTFTRYPVAAACAVVALVLAAIYVLWMYQRMMTGPLAPGNETIGDLKRRELTV
VAPLVALLLVLGIYPKPLLDIVNPAVEQTLRTVNEKDPPPTVADIALRHGEGEQR
>Mature_534_residues
SAVGAVTALWLIPLVGAAAILVLPAHQRTLAKYTALGTSLLVLIVAVGVAIAFDPVGPQYQFVESVSWIPAFGMKYAVGL
DGIGLALVLLTTGLLPVLLLAGWNDGAEAPGYGHRPLAQRYMALMLIVEAMVLLSFSALDVLLFYIFFEAMLIPMYFLIG
GFGSTHSDVKQRSRAAVKFLMYNLFGGLVMLAAVIGLYVVTAQSPAGEHGGTFDLRDITEMVATGTLGIDPGLAKALFLG
FMFAFAVKAPLWPLHTWLPDAAVHATPSSAVLMMAVVDKVGTFAMLRYCVQLFPDASRYFTPVIVTLAVIGIVYGAVVAI
GQTDVMRLIAYTSISHFGFIILGIFAMTSQGQSGSTLYMVNHGISTAALMLVAGFLVTRKGSRLIASYGGVQKVAPVLAG
SFLVAGLATLSLPGLAPFISEFLVLVGTFTRYPVAAACAVVALVLAAIYVLWMYQRMMTGPLAPGNETIGDLKRRELTVV
APLVALLLVLGIYPKPLLDIVNPAVEQTLRTVNEKDPPPTVADIALRHGEGEQR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=383, Percent_Identity=28.1984334203655, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI251831117, Length=401, Percent_Identity=23.4413965087282, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788613, Length=451, Percent_Identity=37.2505543237251, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1788827, Length=320, Percent_Identity=26.25, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788829, Length=348, Percent_Identity=30.4597701149425, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788831, Length=422, Percent_Identity=23.4597156398104, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788614, Length=502, Percent_Identity=25.6972111553785, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693160, Length=267, Percent_Identity=26.5917602996255, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI2367154, Length=225, Percent_Identity=28.8888888888889, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56805; Mature: 56674

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS00673 V8_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVGAVTALWLIPLVGAAAILVLPAHQRTLAKYTALGTSLLVLIVAVGVAIAFDPVGPQ
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YQFVESVSWIPAFGMKYAVGLDGIGLALVLLTTGLLPVLLLAGWNDGAEAPGYGHRPLAQ
HHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
RYMALMLIVEAMVLLSFSALDVLLFYIFFEAMLIPMYFLIGGFGSTHSDVKQRSRAAVKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LMYNLFGGLVMLAAVIGLYVVTAQSPAGEHGGTFDLRDITEMVATGTLGIDPGLAKALFL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
GFMFAFAVKAPLWPLHTWLPDAAVHATPSSAVLMMAVVDKVGTFAMLRYCVQLFPDASRY
HHHHHHHHHCCCCHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FTPVIVTLAVIGIVYGAVVAIGQTDVMRLIAYTSISHFGFIILGIFAMTSQGQSGSTLYM
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VNHGISTAALMLVAGFLVTRKGSRLIASYGGVQKVAPVLAGSFLVAGLATLSLPGLAPFI
EECCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SEFLVLVGTFTRYPVAAACAVVALVLAAIYVLWMYQRMMTGPLAPGNETIGDLKRRELTV
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
VAPLVALLLVLGIYPKPLLDIVNPAVEQTLRTVNEKDPPPTVADIALRHGEGEQR
HHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAVGAVTALWLIPLVGAAAILVLPAHQRTLAKYTALGTSLLVLIVAVGVAIAFDPVGPQ
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC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HHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]