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The map label for this gene is nuoL [H]

Identifier: 169629231

GI number: 169629231

Start: 2156379

End: 2158244

Strand: Direct

Name: nuoL [H]

Synonym: MAB_2145

Alternate gene names: 169629231

Gene position: 2156379-2158244 (Clockwise)

Preceding gene: 169629230

Following gene: 169629232

Centisome position: 42.56

GC content: 63.34

Gene sequence:

>1866_bases
GTGACATGGCTCATGCCGGCGCTGCCTCTTGCTGGTGCGGCTGTGCTCCTGCTCGTCGGCCGCCGGGGAGATGCCCGGGG
GCATTTGGTGGGCTGTGCGGCGTCCCTCGGGTCGTTCCTGGTGGCCGTGGTGGCATTCCTCGGCATGCTCGGCAGGGCCG
GGCCCGATCGAGTGATGCACGAGGTGCTTTTCAACTGGGTCCCGGTAGGCGGATTGCACATCGATTTCGGGTTGACCCTC
GATCAACTGTCGGTGTGTTTCGCACTGCTGATCACCGGGGTTGGTTCGCTGATCCATGTTTACTCGATCGGCTACATGGC
ACATGATCCGGACAGGCGACGGTTCTTCGGATATCTGAATCTGTTTCTCGCCGCCATGCTGCTGTTGGTACTCGCCGACA
ACTTCCTTGGTCTGTACCTGGGCTGGGAGGGGGTCGGTCTGGCCTCCTATCTGCTGATCGGTTTTTGGTATCAGAAACCG
TCGGCTGCCGCGGCGGCCAAGAAGGCCTTCATCGTCAACAGGGTCGGTGATATGGGCTTGGCGCTGGCGATGATGCTGAT
GTTCTCGACGTTCGGCTCCGTCGGTTTCGCACAGGTGTTGGGGTCGGCGAGCGCGGCCGGTGAGAGCCGCAATACCGCAA
TCGGATTGGCGCTGTTACTGGCGGCCTGCGGTAAGTCGGCCCAGGTGCCGTTGCAGTCCTGGCTCGGCGACGCGATGGAA
GGGCCCACCCCCGTCTCTGCGCTGATTCATGCGGCGACGATGGTGACCGCGGGTGTCTACCTGATCACCCGCTCCGGGCC
GATTTTCGAACACGCTCCCTACGCCCAAGTGGCGGTGGTGCTGGTGGGCGCCGTCACGCTGCTGTTCGGGGCCATCATCG
GCTGCGCCAAGGACGACATCAAGAAGGCGCTTGCCGCCAGCACCATGTCGCAGATCGGGTACATGGTGCTGGCGGCGGGT
TTGGGCCCCGCGGGCTATGCGGTGGCCATCATGCACCTGCTCACCCACGGGTTCTTCAAGGCTGGGCTGTTCCTCGGCGC
CGGTTCGGTGATGCACGGGATGAACGAGGAAACCGATATGCGTCGTTACGGCGGGTTGCGTGCCGTCATGCCGATCACCT
TCGTCACCTTTGGGCTGGGATATCTTGCCATCATTGGTGTTCCGCCATTCGCCGGCTTTTACTCCAAGGACAAGATCATC
GAGGTCGCTTTCGGTCACGGTGGTGCGGGCGGATTCCTGTTGGGTGCGGCGGCCCTGTCGGGCGCCGGTATCACCGCCTT
CTACATGACCAGGGTCATGCTCCTGACCTTCTTCGGCAAGCGCCGTTGGCACAGGGATGTGCATCCACACGAATCGCCGT
CGGTGATGACATGGCCGATGTTGGTGCTCGCAGTCGGTTCGGTGGCGGCCGGATTCTTGCTGAGCCTTGGTGGGGCACTA
CAGAACTGGTTGGCGCCTGTGGTTGGTATGCATCATGGCGAGCTACCCGTGCCGGGCTGGGTGATCAGTGCCATCACGGT
CGCGGTGGTGCTCTGCGGAGCCGGTATTGCCTACCGGATATATCGCGCGGATGTCCCGGAGACCGCACCACAGGGCTCCA
CCCTCACCGTCGCCGCGCGCCGGGATCTCTACGGAGACGCCTTCAACGAGGCGGTGTTCATGCGTCCTGGCCAACGGCTG
ACTCGGGGCATGGTGCTGGTCGATGACCGTGCGGTCGACGGCATGGTCAACGGTGTGGCTTCAATCCTCGGTGCCGTATC
GGGTTGGGTACGGCAGTTGCAGACTGGCCACGTCCGCTCGTACGCGTTGTCCATGTGCGCAGGCGCGGCCGTGGTGGTCG
CGGTGTTGATGGCAGTGAGGTGGTGA

Upstream 100 bases:

>100_bases
GTGGTGGTGGGGCTGGGAATCATCATGACGATCTTCCGCACCCGCAGGTCGGCCTCGGTCGACGACGCCGATGTGTTGAA
ATTCTAGGAGGGGAGTACTC

Downstream 100 bases:

>100_bases
GTGCGGTGGGTGCCGTGACAGCGCTATGGCTCATTCCGTTGGTTGGTGCCGCCGCGATATTGGTGCTACCGGCCCACCAG
CGCACCTTGGCGAAGTACAC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MTWLMPALPLAGAAVLLLVGRRGDARGHLVGCAASLGSFLVAVVAFLGMLGRAGPDRVMHEVLFNWVPVGGLHIDFGLTL
DQLSVCFALLITGVGSLIHVYSIGYMAHDPDRRRFFGYLNLFLAAMLLLVLADNFLGLYLGWEGVGLASYLLIGFWYQKP
SAAAAAKKAFIVNRVGDMGLALAMMLMFSTFGSVGFAQVLGSASAAGESRNTAIGLALLLAACGKSAQVPLQSWLGDAME
GPTPVSALIHAATMVTAGVYLITRSGPIFEHAPYAQVAVVLVGAVTLLFGAIIGCAKDDIKKALAASTMSQIGYMVLAAG
LGPAGYAVAIMHLLTHGFFKAGLFLGAGSVMHGMNEETDMRRYGGLRAVMPITFVTFGLGYLAIIGVPPFAGFYSKDKII
EVAFGHGGAGGFLLGAAALSGAGITAFYMTRVMLLTFFGKRRWHRDVHPHESPSVMTWPMLVLAVGSVAAGFLLSLGGAL
QNWLAPVVGMHHGELPVPGWVISAITVAVVLCGAGIAYRIYRADVPETAPQGSTLTVAARRDLYGDAFNEAVFMRPGQRL
TRGMVLVDDRAVDGMVNGVASILGAVSGWVRQLQTGHVRSYALSMCAGAAVVVAVLMAVRW

Sequences:

>Translated_621_residues
MTWLMPALPLAGAAVLLLVGRRGDARGHLVGCAASLGSFLVAVVAFLGMLGRAGPDRVMHEVLFNWVPVGGLHIDFGLTL
DQLSVCFALLITGVGSLIHVYSIGYMAHDPDRRRFFGYLNLFLAAMLLLVLADNFLGLYLGWEGVGLASYLLIGFWYQKP
SAAAAAKKAFIVNRVGDMGLALAMMLMFSTFGSVGFAQVLGSASAAGESRNTAIGLALLLAACGKSAQVPLQSWLGDAME
GPTPVSALIHAATMVTAGVYLITRSGPIFEHAPYAQVAVVLVGAVTLLFGAIIGCAKDDIKKALAASTMSQIGYMVLAAG
LGPAGYAVAIMHLLTHGFFKAGLFLGAGSVMHGMNEETDMRRYGGLRAVMPITFVTFGLGYLAIIGVPPFAGFYSKDKII
EVAFGHGGAGGFLLGAAALSGAGITAFYMTRVMLLTFFGKRRWHRDVHPHESPSVMTWPMLVLAVGSVAAGFLLSLGGAL
QNWLAPVVGMHHGELPVPGWVISAITVAVVLCGAGIAYRIYRADVPETAPQGSTLTVAARRDLYGDAFNEAVFMRPGQRL
TRGMVLVDDRAVDGMVNGVASILGAVSGWVRQLQTGHVRSYALSMCAGAAVVVAVLMAVRW
>Mature_620_residues
TWLMPALPLAGAAVLLLVGRRGDARGHLVGCAASLGSFLVAVVAFLGMLGRAGPDRVMHEVLFNWVPVGGLHIDFGLTLD
QLSVCFALLITGVGSLIHVYSIGYMAHDPDRRRFFGYLNLFLAAMLLLVLADNFLGLYLGWEGVGLASYLLIGFWYQKPS
AAAAAKKAFIVNRVGDMGLALAMMLMFSTFGSVGFAQVLGSASAAGESRNTAIGLALLLAACGKSAQVPLQSWLGDAMEG
PTPVSALIHAATMVTAGVYLITRSGPIFEHAPYAQVAVVLVGAVTLLFGAIIGCAKDDIKKALAASTMSQIGYMVLAAGL
GPAGYAVAIMHLLTHGFFKAGLFLGAGSVMHGMNEETDMRRYGGLRAVMPITFVTFGLGYLAIIGVPPFAGFYSKDKIIE
VAFGHGGAGGFLLGAAALSGAGITAFYMTRVMLLTFFGKRRWHRDVHPHESPSVMTWPMLVLAVGSVAAGFLLSLGGALQ
NWLAPVVGMHHGELPVPGWVISAITVAVVLCGAGIAYRIYRADVPETAPQGSTLTVAARRDLYGDAFNEAVFMRPGQRLT
RGMVLVDDRAVDGMVNGVASILGAVSGWVRQLQTGHVRSYALSMCAGAAVVVAVLMAVRW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=417, Percent_Identity=40.0479616306954, Blast_Score=282, Evalue=7e-76,
Organism=Escherichia coli, GI1788614, Length=610, Percent_Identity=39.672131147541, Blast_Score=339, Evalue=4e-94,
Organism=Escherichia coli, GI1788829, Length=409, Percent_Identity=33.7408312958435, Blast_Score=175, Evalue=8e-45,
Organism=Escherichia coli, GI1788831, Length=339, Percent_Identity=29.7935103244838, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788827, Length=628, Percent_Identity=25.9554140127389, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1788613, Length=334, Percent_Identity=27.5449101796407, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI2367154, Length=449, Percent_Identity=23.6080178173719, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI145693160, Length=346, Percent_Identity=26.0115606936416, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 65223; Mature: 65092

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWLMPALPLAGAAVLLLVGRRGDARGHLVGCAASLGSFLVAVVAFLGMLGRAGPDRVMH
CCCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EVLFNWVPVGGLHIDFGLTLDQLSVCFALLITGVGSLIHVYSIGYMAHDPDRRRFFGYLN
HHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LFLAAMLLLVLADNFLGLYLGWEGVGLASYLLIGFWYQKPSAAAAAKKAFIVNRVGDMGL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALAMMLMFSTFGSVGFAQVLGSASAAGESRNTAIGLALLLAACGKSAQVPLQSWLGDAME
HHHHHHHHHHHCCHHHHHHHCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCHHCC
GPTPVSALIHAATMVTAGVYLITRSGPIFEHAPYAQVAVVLVGAVTLLFGAIIGCAKDDI
CCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKALAASTMSQIGYMVLAAGLGPAGYAVAIMHLLTHGFFKAGLFLGAGSVMHGMNEETDM
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHH
RRYGGLRAVMPITFVTFGLGYLAIIGVPPFAGFYSKDKIIEVAFGHGGAGGFLLGAAALS
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHC
GAGITAFYMTRVMLLTFFGKRRWHRDVHPHESPSVMTWPMLVLAVGSVAAGFLLSLGGAL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QNWLAPVVGMHHGELPVPGWVISAITVAVVLCGAGIAYRIYRADVPETAPQGSTLTVAAR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCEEEEEEH
RDLYGDAFNEAVFMRPGQRLTRGMVLVDDRAVDGMVNGVASILGAVSGWVRQLQTGHVRS
HHHCCHHHCCEEEECCCHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
YALSMCAGAAVVVAVLMAVRW
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TWLMPALPLAGAAVLLLVGRRGDARGHLVGCAASLGSFLVAVVAFLGMLGRAGPDRVMH
CCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EVLFNWVPVGGLHIDFGLTLDQLSVCFALLITGVGSLIHVYSIGYMAHDPDRRRFFGYLN
HHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LFLAAMLLLVLADNFLGLYLGWEGVGLASYLLIGFWYQKPSAAAAAKKAFIVNRVGDMGL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALAMMLMFSTFGSVGFAQVLGSASAAGESRNTAIGLALLLAACGKSAQVPLQSWLGDAME
HHHHHHHHHHHCCHHHHHHHCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCHHCC
GPTPVSALIHAATMVTAGVYLITRSGPIFEHAPYAQVAVVLVGAVTLLFGAIIGCAKDDI
CCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKALAASTMSQIGYMVLAAGLGPAGYAVAIMHLLTHGFFKAGLFLGAGSVMHGMNEETDM
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHH
RRYGGLRAVMPITFVTFGLGYLAIIGVPPFAGFYSKDKIIEVAFGHGGAGGFLLGAAALS
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHC
GAGITAFYMTRVMLLTFFGKRRWHRDVHPHESPSVMTWPMLVLAVGSVAAGFLLSLGGAL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QNWLAPVVGMHHGELPVPGWVISAITVAVVLCGAGIAYRIYRADVPETAPQGSTLTVAAR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCEEEEEEH
RDLYGDAFNEAVFMRPGQRLTRGMVLVDDRAVDGMVNGVASILGAVSGWVRQLQTGHVRS
HHHCCHHHCCEEEECCCHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
YALSMCAGAAVVVAVLMAVRW
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]