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The map label for this gene is alkK [H]

Identifier: 169629166

GI number: 169629166

Start: 2079985

End: 2081604

Strand: Direct

Name: alkK [H]

Synonym: MAB_2080

Alternate gene names: 169629166

Gene position: 2079985-2081604 (Clockwise)

Preceding gene: 169629165

Following gene: 169629167

Centisome position: 41.05

GC content: 60.68

Gene sequence:

>1620_bases
ATGCAAAATGTTCCGCTCACGGTGTCGGCGATCGTCCAGCATGCGGCAGCCATACACGGTGACAGCGAGGTCGTCACTCC
GACCGGAAATGGATATCGGAGAACGCCTTACCGCATTGTGCTGGCGCGAGTGGCTCGCCTTGCCAATGCGCTGCGCAGTC
TTGGCGTCACGGCAGACCAACGCGTGGCCACCTTCCAGTGGAGCAACCAGGAACATCTGGAGGCCTACTGTGCGATTCCC
TCCATGGGCGCGGTCCTGCACACGCTCAACATTCGTTTGGCCCCAGAGCAACTGGCGTACATCGCCAACCACGCGAGCGA
TCAGATCGTCCTAGTCGACGCTTCGGTTGCCCCGTTGTTGGCGCGCGCGCTCCCAGCGATGGCGTCGGTGCACACCGTCA
TCGTCACCGGAGAGGGCGACCTTGCCCCGCTACAGGGATGCGGGAAGACCGTTCTGCGTTACGAGGAAGTGCTTGCCGGC
CAGGAAGAATCATTTGACTGGCCTCGGCTCGACGAGCTGTCCGCCGCGGCCATGTGTTATACGAGCGGCACCACCGGAGA
TCCCAAAGGCGTCGTCTACAGCCACCGTTCGACGTACCTTCACTCCCTGACCGCCTGCACAGCTAACGCTTTGTCAGTCA
GCGAGGCCGACCGTGTGCTGGCCATCGTCCCAATGTTTCACGCCAATGCGTGGGGGCTTATCTACGCAGCGTTGATGTCC
GGTGCGGATCTGGTGCTGCCTGACCGCTATCTCCAAGCCGAACCGTTGGTGTCGATCATCGAAGACACCAGGCCGACCGT
GGCCGGTGCAGTGCCGACGATCTGGAACGATGTCGACCGATATCTGGATTCGCACCCTGAGCGGGACATTTCTTCGCTAC
GGCTGGTCGCGTGCGGGGGATCTGCTGTTCCGCTTTCCTTGATGCGGGCATTCGAAGAGAAGTACAACGTGCCCATTGTG
CAGGCCTGGGGTATGACCGAAACCTCTCCGTTGGCGACCGTTGCACGTCCGGCTCACAGAGCCGACGCGACGCGACGATG
GGAGATGCGCGCATCCCAGGGCCGGCCGATCTGCGGTGTCGAAATCCGGTTGCGGGATGACGACGGGAAAGATGTGCCGT
GGGACGGGCAATCAGTCGGGGAAATCCAGGCGCGCGGTCCTTGGATCACCGGGTCCTATTTCGGAGACAACGATACGGAG
AAGTTCGACGAAGGATGGCTGCGTACCGGTGATGTGGGCAAGATCGACGCCGAGGGCTATCTGACCCTGACCGACCGCTC
GAAAGACGTCATCAAGTCAGGTGGCGAATGGATCTCCTCGGTGGAGCTGGAAAACACGCTGATCGGCCACCCTGCCGTGT
ACGAAGCGGCGGTAGTCGGCGTCGCGGACGATAAATGGCAGGAAAGGCCGTTGGCGCTTGTCGTCGTCCACCCCGGAACC
GACGTTGACATTGACCAACTCCGATCGTTTCTTGCGGACAAAGTCGCCAAATGGTGGATTCCTGAGCGATGGAGCTTCGT
GTCCGATATTCCGAGAACGAGCGTCGGAAAGTACGACAAAAAGGCCATCCGTGCCCGCCACTCTGCCGGCGAATACCTCA
TCGAAATCGAAACGTCATAA

Upstream 100 bases:

>100_bases
TCCTGCAAGCACTGAGAACGCATTACGGCACATTCATCGATCAGCCGAACAGCCGTCCCGACCTCTTCGCCTGAAAGGGC
ACTACACGATGCAAAGCACA

Downstream 100 bases:

>100_bases
CGTCGAATCCCAGGAATTCCAACAGTCGGAAGGTAATCATGTCCTCACCAATCTCTCCCTGGATGAATGCCGAATTACTC
GAGCTTCGTGACCTCGCTGC

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MQNVPLTVSAIVQHAAAIHGDSEVVTPTGNGYRRTPYRIVLARVARLANALRSLGVTADQRVATFQWSNQEHLEAYCAIP
SMGAVLHTLNIRLAPEQLAYIANHASDQIVLVDASVAPLLARALPAMASVHTVIVTGEGDLAPLQGCGKTVLRYEEVLAG
QEESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANALSVSEADRVLAIVPMFHANAWGLIYAALMS
GADLVLPDRYLQAEPLVSIIEDTRPTVAGAVPTIWNDVDRYLDSHPERDISSLRLVACGGSAVPLSLMRAFEEKYNVPIV
QAWGMTETSPLATVARPAHRADATRRWEMRASQGRPICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTE
KFDEGWLRTGDVGKIDAEGYLTLTDRSKDVIKSGGEWISSVELENTLIGHPAVYEAAVVGVADDKWQERPLALVVVHPGT
DVDIDQLRSFLADKVAKWWIPERWSFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS

Sequences:

>Translated_539_residues
MQNVPLTVSAIVQHAAAIHGDSEVVTPTGNGYRRTPYRIVLARVARLANALRSLGVTADQRVATFQWSNQEHLEAYCAIP
SMGAVLHTLNIRLAPEQLAYIANHASDQIVLVDASVAPLLARALPAMASVHTVIVTGEGDLAPLQGCGKTVLRYEEVLAG
QEESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANALSVSEADRVLAIVPMFHANAWGLIYAALMS
GADLVLPDRYLQAEPLVSIIEDTRPTVAGAVPTIWNDVDRYLDSHPERDISSLRLVACGGSAVPLSLMRAFEEKYNVPIV
QAWGMTETSPLATVARPAHRADATRRWEMRASQGRPICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTE
KFDEGWLRTGDVGKIDAEGYLTLTDRSKDVIKSGGEWISSVELENTLIGHPAVYEAAVVGVADDKWQERPLALVVVHPGT
DVDIDQLRSFLADKVAKWWIPERWSFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
>Mature_539_residues
MQNVPLTVSAIVQHAAAIHGDSEVVTPTGNGYRRTPYRIVLARVARLANALRSLGVTADQRVATFQWSNQEHLEAYCAIP
SMGAVLHTLNIRLAPEQLAYIANHASDQIVLVDASVAPLLARALPAMASVHTVIVTGEGDLAPLQGCGKTVLRYEEVLAG
QEESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANALSVSEADRVLAIVPMFHANAWGLIYAALMS
GADLVLPDRYLQAEPLVSIIEDTRPTVAGAVPTIWNDVDRYLDSHPERDISSLRLVACGGSAVPLSLMRAFEEKYNVPIV
QAWGMTETSPLATVARPAHRADATRRWEMRASQGRPICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTE
KFDEGWLRTGDVGKIDAEGYLTLTDRSKDVIKSGGEWISSVELENTLIGHPAVYEAAVVGVADDKWQERPLALVVVHPGT
DVDIDQLRSFLADKVAKWWIPERWSFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=354, Percent_Identity=29.6610169491525, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI187761345, Length=398, Percent_Identity=27.3869346733668, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI187761343, Length=398, Percent_Identity=27.3869346733668, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI28416953, Length=522, Percent_Identity=25.4789272030651, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI38505220, Length=392, Percent_Identity=25.5102040816327, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI42544132, Length=462, Percent_Identity=21.6450216450216, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI42794754, Length=508, Percent_Identity=21.6535433070866, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI42794752, Length=508, Percent_Identity=21.6535433070866, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI122937307, Length=469, Percent_Identity=22.3880597014925, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI115511026, Length=376, Percent_Identity=25.531914893617, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI13375727, Length=573, Percent_Identity=21.6404886561955, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI58082049, Length=376, Percent_Identity=25.2659574468085, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=361, Percent_Identity=32.6869806094183, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI221142682, Length=518, Percent_Identity=27.2200772200772, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1788107, Length=499, Percent_Identity=26.0521042084168, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786810, Length=359, Percent_Identity=30.08356545961, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788595, Length=491, Percent_Identity=26.4765784114053, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789201, Length=380, Percent_Identity=23.9473684210526, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1790505, Length=537, Percent_Identity=24.5810055865922, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=511, Percent_Identity=26.614481409002, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17531443, Length=446, Percent_Identity=28.0269058295964, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=372, Percent_Identity=27.6881720430108, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17557194, Length=536, Percent_Identity=24.4402985074627, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=357, Percent_Identity=27.4509803921569, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17538037, Length=531, Percent_Identity=24.105461393597, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560140, Length=441, Percent_Identity=23.3560090702948, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17560308, Length=569, Percent_Identity=23.725834797891, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=552, Percent_Identity=24.0942028985507, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71994694, Length=552, Percent_Identity=24.0942028985507, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=552, Percent_Identity=24.0942028985507, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=362, Percent_Identity=28.7292817679558, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71996755, Length=386, Percent_Identity=26.1658031088083, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI115534440, Length=524, Percent_Identity=21.7557251908397, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17556552, Length=449, Percent_Identity=23.6080178173719, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=409, Percent_Identity=24.4498777506112, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71982997, Length=409, Percent_Identity=24.4498777506112, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=357, Percent_Identity=29.4117647058824, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323182, Length=546, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319264, Length=542, Percent_Identity=23.0627306273063, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24581924, Length=554, Percent_Identity=25.812274368231, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI18859661, Length=395, Percent_Identity=26.3291139240506, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21355181, Length=524, Percent_Identity=24.618320610687, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24648255, Length=504, Percent_Identity=24.6031746031746, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356947, Length=489, Percent_Identity=23.1083844580777, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648260, Length=368, Percent_Identity=25.5434782608696, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653035, Length=357, Percent_Identity=23.5294117647059, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24648253, Length=501, Percent_Identity=23.5528942115768, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI19922652, Length=369, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656500, Length=512, Percent_Identity=23.4375, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355225, Length=561, Percent_Identity=23.1729055258467, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161076582, Length=335, Percent_Identity=23.8805970149254, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281365686, Length=242, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356441, Length=498, Percent_Identity=22.4899598393574, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221329755, Length=386, Percent_Identity=21.7616580310881, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648257, Length=503, Percent_Identity=22.6640159045726, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20130357, Length=489, Percent_Identity=21.4723926380368, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648676, Length=404, Percent_Identity=25, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358303, Length=359, Percent_Identity=24.2339832869081, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 58902; Mature: 58902

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNVPLTVSAIVQHAAAIHGDSEVVTPTGNGYRRTPYRIVLARVARLANALRSLGVTADQ
CCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
RVATFQWSNQEHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVDASVAPLL
EEEEEECCCHHHHHHEECCCCHHHEEEHEEEEECHHHHHHHHHCCCCEEEEEECCHHHHH
ARALPAMASVHTVIVTGEGDLAPLQGCGKTVLRYEEVLAGQEESFDWPRLDELSAAAMCY
HHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHEEEE
TSGTTGDPKGVVYSHRSTYLHSLTACTANALSVSEADRVLAIVPMFHANAWGLIYAALMS
ECCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHC
GADLVLPDRYLQAEPLVSIIEDTRPTVAGAVPTIWNDVDRYLDSHPERDISSLRLVACGG
CCCEECCCCHHCHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECC
SAVPLSLMRAFEEKYNVPIVQAWGMTETSPLATVARPAHRADATRRWEMRASQGRPICGV
CCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHCCHHHHCCHHHHHHHHCCCCCEEEE
EIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEKFDEGWLRTGDVGKIDAEGY
EEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCCCHHHCCCCCCCCCCEECCCCE
LTLTDRSKDVIKSGGEWISSVELENTLIGHPAVYEAAVVGVADDKWQERPLALVVVHPGT
EEEECCCHHHHHCCCHHHHHEEHHHEECCCCHHHHEEEEECCCCCCCCCCEEEEEECCCC
DVDIDQLRSFLADKVAKWWIPERWSFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
CCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MQNVPLTVSAIVQHAAAIHGDSEVVTPTGNGYRRTPYRIVLARVARLANALRSLGVTADQ
CCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
RVATFQWSNQEHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVDASVAPLL
EEEEEECCCHHHHHHEECCCCHHHEEEHEEEEECHHHHHHHHHCCCCEEEEEECCHHHHH
ARALPAMASVHTVIVTGEGDLAPLQGCGKTVLRYEEVLAGQEESFDWPRLDELSAAAMCY
HHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHEEEE
TSGTTGDPKGVVYSHRSTYLHSLTACTANALSVSEADRVLAIVPMFHANAWGLIYAALMS
ECCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHC
GADLVLPDRYLQAEPLVSIIEDTRPTVAGAVPTIWNDVDRYLDSHPERDISSLRLVACGG
CCCEECCCCHHCHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECC
SAVPLSLMRAFEEKYNVPIVQAWGMTETSPLATVARPAHRADATRRWEMRASQGRPICGV
CCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHCCHHHHCCHHHHHHHHCCCCCEEEE
EIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEKFDEGWLRTGDVGKIDAEGY
EEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCCCHHHCCCCCCCCCCEECCCCE
LTLTDRSKDVIKSGGEWISSVELENTLIGHPAVYEAAVVGVADDKWQERPLALVVVHPGT
EEEECCCHHHHHCCCHHHHHEEHHHEECCCCHHHHEEEEECCCCCCCCCCEEEEEECCCC
DVDIDQLRSFLADKVAKWWIPERWSFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
CCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]