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The map label for this gene is gltP [H]

Identifier: 167623572

GI number: 167623572

Start: 1969558

End: 1970820

Strand: Direct

Name: gltP [H]

Synonym: Shal_1641

Alternate gene names: 167623572

Gene position: 1969558-1970820 (Clockwise)

Preceding gene: 167623568

Following gene: 167623575

Centisome position: 37.68

GC content: 46.95

Gene sequence:

>1263_bases
GTGTTGAACAAAAAGAAAAAGTTTTATAAGAATATCGGATTCCAAGTAGTTGTAGCTATGGTCCTAGGTGCGATCGTGGG
TATGATGATGGGAGAAGATGCCTCTATCTTCGCTCCGCTAGGAACATTTTTTATCCATTTGATTAAAATGTTGGTGATCC
CTCTAGTCGCAGTTTCAATTATTGCGGGCGCAGCAAGCTTAGGCGCTGGTCCATCGGCAGGTAAAGTCGGTATTGGCACT
ATCAGTTTCTTCATGGCGACCTCTGCTTTGGCTGTGACTTTAGCGCTTGTTATGGGTGAGTTCTTCCAGCCAGGTGTTGG
CATGGACTTCTCACAGCATACTGCGGGTCTCGCTGCGGTAACCGCTGAGCAGGGCGCACTACCTGGTGTGGCTGATACCA
TTATCGGTATGATCCCAACGAACGTGTTCGAGGCGCTAACTGGCGGTAACATTCTGCAAATTTTGGTGTTCTGTATCTTC
TTCGGTATCGCACTGACTAAAGTTAATCCAGAGAGTGCTAAGCCGATTACTTCTGCACTGAATACTATCGTTGAAGCCTT
TATTTGGATGATTAACATCGTGATGTTGATTGCCCCGATTGGTGTGTTTGGCTTGATGGCTGACTCTGTAGGTACCTTTG
GCTTCCAGTCATTGACTGTGGTGTTGAACCTATTCCTAGTTTATGTCGCAGCTATCTTAATCTATGGCTTTATCTTCTTC
CCATTGATGGTGAAGTTCTTCTCTAACGTTCCGGTTGGCAAGTTCCTATCGGCGATGAAGAAGCCGCAAGCATTGGCTAT
GTCTACCGCTTCATCGATGGCTGCGCTGCCAGTTAACATCGAAGTGTGTGAGAAAGAGCTAGGCGTATCTAAGTCGACAG
CCGCGTTTGTATTGCCTTTAGGCGCTACCATTAACATGAGTGGTAACGCGATCTACTACGGTCTAGTAGCGGTATTCTTC
GCTCAGATGTTCAATGTAGAGCTAGGCCTTGCAGCTTACGTTGCAATCATATTCACCTCGACATTGGGCGCGATTGGCCA
AGCGGGTGTTCCAGGTCCATCATTCCTAGTGATTGCGGTATTAGTTGCTGCTGGTATTCCAATTGAAGGCCTACCACTAC
TGTTCGCTCTGGACCGTGTGTTTGACATGATCAGAACAACGCTAAACATTACGGGTGATGCGGTTTGTGCTGTGGTTATC
GATAAGTTTAACCCAGAAACTGAAATCCCAGTGCCAGCTGAGCAGGCTAACGCCAATAGTTAA

Upstream 100 bases:

>100_bases
GTGAATCACATTAATAACCTACACTGGGTGTTATCGTACTTCAAAGAATTAAAGTGGTACTCGTACTACTTAAAAAATAT
AAGTCTGTGATGGAGCTAGG

Downstream 100 bases:

>100_bases
GCCTATTTAGCTAACGTCAGTCGTTAATGCTTAGCCGTTAACTGCTAAGTTAACAATAGAAAGCCCTCTTTATAGAGGGC
TTTTTCGTATTTAAAGGCTA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLNKKKKFYKNIGFQVVVAMVLGAIVGMMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSIIAGAASLGAGPSAGKVGIGT
ISFFMATSALAVTLALVMGEFFQPGVGMDFSQHTAGLAAVTAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIF
FGIALTKVNPESAKPITSALNTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPLGATINMSGNAIYYGLVAVFF
AQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAVLVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVI
DKFNPETEIPVPAEQANANS

Sequences:

>Translated_420_residues
MLNKKKKFYKNIGFQVVVAMVLGAIVGMMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSIIAGAASLGAGPSAGKVGIGT
ISFFMATSALAVTLALVMGEFFQPGVGMDFSQHTAGLAAVTAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIF
FGIALTKVNPESAKPITSALNTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPLGATINMSGNAIYYGLVAVFF
AQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAVLVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVI
DKFNPETEIPVPAEQANANS
>Mature_420_residues
MLNKKKKFYKNIGFQVVVAMVLGAIVGMMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSIIAGAASLGAGPSAGKVGIGT
ISFFMATSALAVTLALVMGEFFQPGVGMDFSQHTAGLAAVTAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIF
FGIALTKVNPESAKPITSALNTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPLGATINMSGNAIYYGLVAVFF
AQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAVLVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVI
DKFNPETEIPVPAEQANANS

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=465, Percent_Identity=26.8817204301075, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI66773030, Length=465, Percent_Identity=28.3870967741935, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI4827012, Length=461, Percent_Identity=26.6811279826464, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI21314632, Length=408, Percent_Identity=29.4117647058824, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI5032093, Length=421, Percent_Identity=28.978622327791, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI223468566, Length=298, Percent_Identity=30.2013422818792, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI40254478, Length=455, Percent_Identity=26.8131868131868, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI223468564, Length=292, Percent_Identity=30.4794520547945, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI194239697, Length=261, Percent_Identity=30.6513409961686, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI262359914, Length=382, Percent_Identity=26.4397905759162, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI301601644, Length=152, Percent_Identity=36.8421052631579, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=33.2530120481928, Blast_Score=227, Evalue=9e-61,
Organism=Escherichia coli, GI1789947, Length=408, Percent_Identity=29.656862745098, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1789473, Length=378, Percent_Identity=28.042328042328, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788024, Length=454, Percent_Identity=25.9911894273128, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=432, Percent_Identity=28.2407407407407, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193206654, Length=416, Percent_Identity=31.0096153846154, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=451, Percent_Identity=27.9379157427938, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71983106, Length=451, Percent_Identity=27.9379157427938, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI193206505, Length=405, Percent_Identity=28.641975308642, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=437, Percent_Identity=27.9176201372998, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=419, Percent_Identity=27.9236276849642, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24583025, Length=409, Percent_Identity=24.2053789731051, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17137668, Length=409, Percent_Identity=24.2053789731051, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24583023, Length=409, Percent_Identity=24.2053789731051, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281360483, Length=476, Percent_Identity=24.5798319327731, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17137666, Length=476, Percent_Identity=24.5798319327731, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281360481, Length=476, Percent_Identity=24.5798319327731, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43863; Mature: 43863

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKKKKFYKNIGFQVVVAMVLGAIVGMMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSI
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGAASLGAGPSAGKVGIGTISFFMATSALAVTLALVMGEFFQPGVGMDFSQHTAGLAAV
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHEE
TAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIFFGIALTKVNPESAKPITSAL
EHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
NTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPL
HHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEC
GATINMSGNAIYYGLVAVFFAQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAV
CCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVIDKFNPETEIPVPAEQANANS
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MLNKKKKFYKNIGFQVVVAMVLGAIVGMMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSI
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGAASLGAGPSAGKVGIGTISFFMATSALAVTLALVMGEFFQPGVGMDFSQHTAGLAAV
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHEE
TAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIFFGIALTKVNPESAKPITSAL
EHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
NTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPL
HHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEC
GATINMSGNAIYYGLVAVFFAQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAV
CCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVIDKFNPETEIPVPAEQANANS
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]