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The map label for this gene is cpxA [H]

Identifier: 167622278

GI number: 167622278

Start: 401249

End: 402619

Strand: Reverse

Name: cpxA [H]

Synonym: Shal_0337

Alternate gene names: 167622278

Gene position: 402619-401249 (Counterclockwise)

Preceding gene: 167622279

Following gene: 167622276

Centisome position: 7.7

GC content: 46.1

Gene sequence:

>1371_bases
ATGCAGCTGAGAAAAAATCCCAACAATATATTCGTTAAACTGCTACTGGGCTTCTGGCTCTGTAGCTCGCTGATTATTAC
CCTGGTAGGCTTACTTCCTCTGCTGCAGCAAAATCACGATCAATCTGAACTGCCACCCCAGCTTAAACATCTGCTTGAAA
CAGTATCGCAAAAAATTATCAATAATCCCCAAGTGTTAAATAACGATAAAATGAAGCGCTGGGATCGGTTTAAGGAGTTT
AACGGTCGACCGATACGGATTTACCTGGTCGATGAGAATGCTAACGTACTCAATACTCACAAACCCTCTCGGACATTGCG
TCGCTTTATGTTGATCGCCGATGAAGCTGGCAAACCGATAAAACAACAGTTTAGAAATGAACTCATGTTTGGTCCCTATA
GCTTCCACGTTGAAGGTAAAGAGTACAGCTTGTATGGCCGTATTCCAGAGCATCATTCACGGCCCTGGTTCTTCTTTTTT
AGCGATAATAAGATCTTAACCCTCAGTATCGCAATTTTACTATCAGGCCTCTTATGTGGCTTATTTGCTTGGCATTTAGG
TAAGCCGTTGCGCTCACTTAAACGCAGCGCCGACGCACTCGCCGGTGGTGATTTAAGTAGCCGAGTCGATATGGCAACCG
CCCTGCGAAACGATGAAATTGGCCAGCTAGCCCAAGCCTTTAATAGTATGGCTGACTCGGTAGAAGATATGGTCAATAGC
CAACAAAGACTGATCAGCGATATCTCTCATGAGCTACGAACGCCACTGACAAGACTGAAACTGTCTTTGGCACTCAGTCG
TAAAAAGGGTCAAGAAACAGCTGAAACTGAACGTATTGAGTATGAAGCCGACCAACTTGAGCAGATGATTGCCGAGCTGT
TAGAGCTGTCTAGAGTCAAGCTCAATGCTAACGAGACCAAGCGCAACCTCGAGCTTTCCGAAACCTTAAGCCAAGTCTTA
GACGATGCCGATTTCGAGGCTCAGCAGCAACAAAAACAGCTGCATATCGACATTGATGAATCGATTGTTGCACCGCTATA
TCCACGACCTTTATGCCGCGCAGTTGAAAACTTGCTTCGCAATGCGATCCGCTATGCCAACAGCCAAGTCTCAATTCAAG
CCATAGCCACTGCAAGCAATATACAAATTGAGATTATTGATGATGGCCCAGGGATCGCCGACGAGACCGACTTAGAGGCG
ATTTTCGAACCTTTCTACCGCCCACAATCGGCACGAGATAGAGAGTCCGGCGGCTGGGGCTTAGGTCTCGCGATAGCCAG
AGCCGCAATTCAGGCCCATCAAGGCAAGATAACGGCTGAAAATAATCAACATAGTGGTTTAAAAATCACCATCAACTTGC
CTATCCAATAA

Upstream 100 bases:

>100_bases
CATGCACCTTTCTAATTTACGCAAGAAAATGCCTGAACGCGATGACGGCCGCCCACGAGTAAAGACGATTCGTGGCAAAG
GCTACATCTGGTTACCCTAA

Downstream 100 bases:

>100_bases
ATACCATCACTCAACTACGCGGCGTTTGCCGCGGGTTCGAGTCTGGCAAGCCAGTGTGCGTAATCTGCCTGCTTAGGAAT
ACGTTTATCTGAATGCCCCA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MQLRKNPNNIFVKLLLGFWLCSSLIITLVGLLPLLQQNHDQSELPPQLKHLLETVSQKIINNPQVLNNDKMKRWDRFKEF
NGRPIRIYLVDENANVLNTHKPSRTLRRFMLIADEAGKPIKQQFRNELMFGPYSFHVEGKEYSLYGRIPEHHSRPWFFFF
SDNKILTLSIAILLSGLLCGLFAWHLGKPLRSLKRSADALAGGDLSSRVDMATALRNDEIGQLAQAFNSMADSVEDMVNS
QQRLISDISHELRTPLTRLKLSLALSRKKGQETAETERIEYEADQLEQMIAELLELSRVKLNANETKRNLELSETLSQVL
DDADFEAQQQQKQLHIDIDESIVAPLYPRPLCRAVENLLRNAIRYANSQVSIQAIATASNIQIEIIDDGPGIADETDLEA
IFEPFYRPQSARDRESGGWGLGLAIARAAIQAHQGKITAENNQHSGLKITINLPIQ

Sequences:

>Translated_456_residues
MQLRKNPNNIFVKLLLGFWLCSSLIITLVGLLPLLQQNHDQSELPPQLKHLLETVSQKIINNPQVLNNDKMKRWDRFKEF
NGRPIRIYLVDENANVLNTHKPSRTLRRFMLIADEAGKPIKQQFRNELMFGPYSFHVEGKEYSLYGRIPEHHSRPWFFFF
SDNKILTLSIAILLSGLLCGLFAWHLGKPLRSLKRSADALAGGDLSSRVDMATALRNDEIGQLAQAFNSMADSVEDMVNS
QQRLISDISHELRTPLTRLKLSLALSRKKGQETAETERIEYEADQLEQMIAELLELSRVKLNANETKRNLELSETLSQVL
DDADFEAQQQQKQLHIDIDESIVAPLYPRPLCRAVENLLRNAIRYANSQVSIQAIATASNIQIEIIDDGPGIADETDLEA
IFEPFYRPQSARDRESGGWGLGLAIARAAIQAHQGKITAENNQHSGLKITINLPIQ
>Mature_456_residues
MQLRKNPNNIFVKLLLGFWLCSSLIITLVGLLPLLQQNHDQSELPPQLKHLLETVSQKIINNPQVLNNDKMKRWDRFKEF
NGRPIRIYLVDENANVLNTHKPSRTLRRFMLIADEAGKPIKQQFRNELMFGPYSFHVEGKEYSLYGRIPEHHSRPWFFFF
SDNKILTLSIAILLSGLLCGLFAWHLGKPLRSLKRSADALAGGDLSSRVDMATALRNDEIGQLAQAFNSMADSVEDMVNS
QQRLISDISHELRTPLTRLKLSLALSRKKGQETAETERIEYEADQLEQMIAELLELSRVKLNANETKRNLELSETLSQVL
DDADFEAQQQQKQLHIDIDESIVAPLYPRPLCRAVENLLRNAIRYANSQVSIQAIATASNIQIEIIDDGPGIADETDLEA
IFEPFYRPQSARDRESGGWGLGLAIARAAIQAHQGKITAENNQHSGLKITINLPIQ

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=374, Percent_Identity=39.8395721925134, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1787894, Length=331, Percent_Identity=32.6283987915408, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786783, Length=331, Percent_Identity=30.8157099697885, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789808, Length=290, Percent_Identity=28.2758620689655, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=31.25, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=24.0677966101695, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788279, Length=302, Percent_Identity=26.158940397351, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=24.4147157190635, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=260, Percent_Identity=25, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=26.5486725663717, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=351, Percent_Identity=25.3561253561254, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=300, Percent_Identity=24.3333333333333, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790551, Length=278, Percent_Identity=24.1007194244604, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=351, Percent_Identity=24.5014245014245, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=29.2035398230088, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51686; Mature: 51686

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRKNPNNIFVKLLLGFWLCSSLIITLVGLLPLLQQNHDQSELPPQLKHLLETVSQKII
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
NNPQVLNNDKMKRWDRFKEFNGRPIRIYLVDENANVLNTHKPSRTLRRFMLIADEAGKPI
CCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHH
KQQFRNELMFGPYSFHVEGKEYSLYGRIPEHHSRPWFFFFSDNKILTLSIAILLSGLLCG
HHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEECCEEEEHHHHHHHHHHHHH
LFAWHLGKPLRSLKRSADALAGGDLSSRVDMATALRNDEIGQLAQAFNSMADSVEDMVNS
HHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QQRLISDISHELRTPLTRLKLSLALSRKKGQETAETERIEYEADQLEQMIAELLELSRVK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LNANETKRNLELSETLSQVLDDADFEAQQQQKQLHIDIDESIVAPLYPRPLCRAVENLLR
CCCCHHHHCCCHHHHHHHHHCCCCCHHHHHHHHEEECCCHHHHCCCCCCHHHHHHHHHHH
NAIRYANSQVSIQAIATASNIQIEIIDDGPGIADETDLEAIFEPFYRPQSARDRESGGWG
HHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCH
LGLAIARAAIQAHQGKITAENNQHSGLKITINLPIQ
HHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCC
>Mature Secondary Structure
MQLRKNPNNIFVKLLLGFWLCSSLIITLVGLLPLLQQNHDQSELPPQLKHLLETVSQKII
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
NNPQVLNNDKMKRWDRFKEFNGRPIRIYLVDENANVLNTHKPSRTLRRFMLIADEAGKPI
CCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHH
KQQFRNELMFGPYSFHVEGKEYSLYGRIPEHHSRPWFFFFSDNKILTLSIAILLSGLLCG
HHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEECCEEEEHHHHHHHHHHHHH
LFAWHLGKPLRSLKRSADALAGGDLSSRVDMATALRNDEIGQLAQAFNSMADSVEDMVNS
HHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QQRLISDISHELRTPLTRLKLSLALSRKKGQETAETERIEYEADQLEQMIAELLELSRVK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LNANETKRNLELSETLSQVLDDADFEAQQQQKQLHIDIDESIVAPLYPRPLCRAVENLLR
CCCCHHHHCCCHHHHHHHHHCCCCCHHHHHHHHEEECCCHHHHCCCCCCHHHHHHHHHHH
NAIRYANSQVSIQAIATASNIQIEIIDDGPGIADETDLEAIFEPFYRPQSARDRESGGWG
HHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCH
LGLAIARAAIQAHQGKITAENNQHSGLKITINLPIQ
HHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]