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The map label for this gene is lrhA [H]

Identifier: 167622276

GI number: 167622276

Start: 399578

End: 400465

Strand: Reverse

Name: lrhA [H]

Synonym: Shal_0335

Alternate gene names: 167622276

Gene position: 400465-399578 (Counterclockwise)

Preceding gene: 167622278

Following gene: 167622271

Centisome position: 7.66

GC content: 44.93

Gene sequence:

>888_bases
ATGTTAAAAATTGAACTATTAGAAAGCTTTATTGCGGTAGTTGAATGCGGAAACCTGTCAAAGGCTGCGGAGAAACTTTG
CCGAACTCAATCTACGATAAGCTTGCAGATCAAGAAGTTAGAAGAGAGCGTTGGCAAACCTTTGTTACTTAGAGATAACA
AAGGCGTCACAATGACAGATGCAGGAAAGACGCTACTCAACTATGCCTATAAGATGCTACAGCTCAGTTCACAAGCTATT
GATGAGCTAAAAGATTGTCAAAATCGTGAAGTCATACGCCTTGGGGTACCGACTGACTATATCAATCGTTATTTAGGTAG
CTTCTTATTAGAGTTTATTCGCGAATTTACCTGTATCGAATTAGTCATCGATACCGATGTCAGTGGCAACCTCTACAAAC
GGCTACATAACGGCGAATTTGATGTGATTGTCGCGACACACTGGCAAACGCCAGCGGCAGGTCATGGCGAATTACTGTTT
GAACGACGTTTTCATTGGGTGGCAGCCAAAGGTGGCAGCGCCCATAAACGCGAAACTGTACCTATGGCGCTGTATCCAGA
GAATTGCCCGATCCGTGCTCAGGTTTTTGCCAATCACCAGATCTCGATGCGCCCGATGAGTGTATTACTATCGACGCCAT
CGCCAACGGCCATGTGTATGGCGGTGGAAAATGACTTAGTGATCGCGCCAATTGCCGAGTTTCGTATTAACGATAAGATG
CAGATCATCGATCCTATCGAGCACAACATTCCGCCACTGCCCAGCTTTAATGAGTCGCTCTATATCAACCCAGAGACTCA
AACGGCAGCGACTAACCAGTTAATCAATTTGATCAAGGCTAACGTGCAAGGACTAGGTGAAGTTAATAAAGCACAAATGC
TTGGCTAA

Upstream 100 bases:

>100_bases
ACAATCAATATTATTTAAGTTCACATTCATAAGGTAGCAGCCTAGTCCCATCACGGGTATTGAGTAATACTGATAGCATC
ATGAATAAACTCAATAGCCC

Downstream 100 bases:

>100_bases
TTGCGTTAATAAAAGAGGCTAAGCTAGAAAACAAGCCTCCATAAAAACGCGTGATTGAAACTAAAAAAGCCAACCTTTTA
GGTTGGCATTTCTTTTAGCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLKIELLESFIAVVECGNLSKAAEKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTMTDAGKTLLNYAYKMLQLSSQAI
DELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIELVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLF
ERRFHWVAAKGGSAHKRETVPMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
QIIDPIEHNIPPLPSFNESLYINPETQTAATNQLINLIKANVQGLGEVNKAQMLG

Sequences:

>Translated_295_residues
MLKIELLESFIAVVECGNLSKAAEKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTMTDAGKTLLNYAYKMLQLSSQAI
DELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIELVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLF
ERRFHWVAAKGGSAHKRETVPMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
QIIDPIEHNIPPLPSFNESLYINPETQTAATNQLINLIKANVQGLGEVNKAQMLG
>Mature_295_residues
MLKIELLESFIAVVECGNLSKAAEKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTMTDAGKTLLNYAYKMLQLSSQAI
DELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIELVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLF
ERRFHWVAAKGGSAHKRETVPMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
QIIDPIEHNIPPLPSFNESLYINPETQTAATNQLINLIKANVQGLGEVNKAQMLG

Specific function: Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788626, Length=279, Percent_Identity=27.5985663082437, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786713, Length=88, Percent_Identity=44.3181818181818, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI157672245, Length=139, Percent_Identity=30.9352517985612, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788887, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790262, Length=146, Percent_Identity=26.7123287671233, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787806, Length=136, Percent_Identity=26.4705882352941, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790208, Length=148, Percent_Identity=29.0540540540541, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787601, Length=152, Percent_Identity=25, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32996; Mature: 32996

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIELLESFIAVVECGNLSKAAEKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTMTD
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEC
AGKTLLNYAYKMLQLSSQAIDELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCEEEE
LVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLFERRFHWVAAKGGSAHKRETV
EEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHEEEEEEEEECCCCCCCCCCC
PMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
CEEECCCCCCEEEEEEECCEEEECEEEEEEECCCCCEEEEEECCCEEEEEHHHHEECCCE
QIIDPIEHNIPPLPSFNESLYINPETQTAATNQLINLIKANVQGLGEVNKAQMLG
EEECHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure
MLKIELLESFIAVVECGNLSKAAEKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTMTD
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEC
AGKTLLNYAYKMLQLSSQAIDELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCEEEE
LVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLFERRFHWVAAKGGSAHKRETV
EEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHEEEEEEEEECCCCCCCCCCC
PMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
CEEECCCCCCEEEEEEECCEEEECEEEEEEECCCCCEEEEEECCCEEEEEHHHHEECCCE
QIIDPIEHNIPPLPSFNESLYINPETQTAATNQLINLIKANVQGLGEVNKAQMLG
EEECHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]