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The map label for this gene is cpxR [H]

Identifier: 167622279

GI number: 167622279

Start: 402620

End: 403303

Strand: Reverse

Name: cpxR [H]

Synonym: Shal_0338

Alternate gene names: 167622279

Gene position: 403303-402620 (Counterclockwise)

Preceding gene: 167622282

Following gene: 167622278

Centisome position: 7.72

GC content: 47.95

Gene sequence:

>684_bases
ATGAGCCGTATATTGTTGATAGATGATGACTTAGGTCTATCTGAGCTGCTTGCACAGCTGCTAGAGCTTGAAGGCTTTGA
GCTAACACTGGCCCATGATGGTCAGTCGGGACTCGATCTTGCTATCGAGCAACAATTCGATCTTATCTTGCTCGATGTGA
TGCTGCCTAAGCTCAATGGTTTTGAAGTGTTACGTGCACTCCGTAGCAAGAAACAAACACCGGTACTAATGCTGACAGCC
CGTGGCGATGAAATCGATCGCGTCGTGGGGTTAGAGATTGGCGCCGATGATTACCTACCTAAGCCTTTTAATGATAGAGA
ACTGGTGGCGCGTATTCGTGCCATTATCCGTCGCACACATAGCCAAGCAAACGAAACACCGCTATCGACACGTCAGTACG
GTGATATAAATTTAGATCCTGCCCGTCAAGAAGTGCACTGCCAAGATCAGCTCATCATCCTCACTGGCACCGAGTTTAGC
TTACTGTTTGAGCTGGTCAAAAGTGCCGGAGAGCTTGCAAGCAAAGAAGTATTAAGCGAAAAGGTGCTGGGTAAAAAACT
GATGCCCTTCGATCGCAGCTTAGACATGCACCTTTCTAATTTACGCAAGAAAATGCCTGAACGCGATGACGGCCGCCCAC
GAGTAAAGACGATTCGTGGCAAAGGCTACATCTGGTTACCCTAA

Upstream 100 bases:

>100_bases
CCACCAATGACTGTGGATCTTTACTTAGCATTACACTCCTAAACTGCAATTGACATCAAAAAGGGTATACTCACAGTAAG
AGTACATTAGAAGGGTAATT

Downstream 100 bases:

>100_bases
ATGCAGCTGAGAAAAAATCCCAACAATATATTCGTTAAACTGCTACTGGGCTTCTGGCTCTGTAGCTCGCTGATTATTAC
CCTGGTAGGCTTACTTCCTC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSRILLIDDDLGLSELLAQLLELEGFELTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNGFEVLRALRSKKQTPVLMLTA
RGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTHSQANETPLSTRQYGDINLDPARQEVHCQDQLIILTGTEFS
LLFELVKSAGELASKEVLSEKVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP

Sequences:

>Translated_227_residues
MSRILLIDDDLGLSELLAQLLELEGFELTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNGFEVLRALRSKKQTPVLMLTA
RGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTHSQANETPLSTRQYGDINLDPARQEVHCQDQLIILTGTEFS
LLFELVKSAGELASKEVLSEKVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP
>Mature_226_residues
SRILLIDDDLGLSELLAQLLELEGFELTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNGFEVLRALRSKKQTPVLMLTAR
GDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTHSQANETPLSTRQYGDINLDPARQEVHCQDQLIILTGTEFSL
LFELVKSAGELASKEVLSEKVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=56.140350877193, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=40.343347639485, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=38.5650224215247, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=38.0090497737557, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=38.8392857142857, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=35.3711790393013, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=36.1607142857143, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=36.283185840708, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=35.2678571428571, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=32.4561403508772, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=34.2342342342342, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.936170212766, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787229, Length=211, Percent_Identity=31.2796208530806, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=29.0178571428571, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790437, Length=186, Percent_Identity=30.6451612903226, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=34.8623853211009, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790299, Length=148, Percent_Identity=30.4054054054054, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25710; Mature: 25579

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRILLIDDDLGLSELLAQLLELEGFELTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNG
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCCEEEHHHCCCCH
FEVLRALRSKKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTH
HHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
SQANETPLSTRQYGDINLDPARQEVHCQDQLIILTGTEFSLLFELVKSAGELASKEVLSE
HHCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
KVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP
HHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECC
>Mature Secondary Structure 
SRILLIDDDLGLSELLAQLLELEGFELTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNG
CEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCCEEEHHHCCCCH
FEVLRALRSKKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTH
HHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
SQANETPLSTRQYGDINLDPARQEVHCQDQLIILTGTEFSLLFELVKSAGELASKEVLSE
HHCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
KVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP
HHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]