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The map label for this gene is dxs [C]

Identifier: 167040552

GI number: 167040552

Start: 1934089

End: 1935036

Strand: Reverse

Name: dxs [C]

Synonym: Teth514_1923

Alternate gene names: 167040552

Gene position: 1935036-1934089 (Counterclockwise)

Preceding gene: 167040553

Following gene: 167040551

Centisome position: 78.75

GC content: 35.86

Gene sequence:

>948_bases
ATGAGTGAATTAAAGAAGTCAACCAGAACATCATTTGCTGAGGCAATTGTTGAGCTGGGAGAGAAAAATCCAGATGTTGT
AACTGTTGCAGCGGATTCAGCATCACGATATGGAGATTTTATAAAAAAATTTCCGGAAAGGAGCTTTAATGTTGGCATAG
CAGAACAGACTATGGTAAGTGTAGCTGCTGGAATGGCTCTTTGTGGAAAAATACCTGTTGTCACATCATATGCTAATTTT
TTAGCATTTAGGGCAGCAGAACAAATAAGAGTAGATGTGGCAGGTAGCAAATTAAATGTTAAATTAATAGGAACAGATAC
AGGATTTTCATCAGCGTGGTTGGGCTTTACACATTTAGCACTAGAGGATATGGGAGTGATTCGAGCAATTCCTGGAATAG
TCATAATAGATCCAGCTGATGCAGCAGAAGCTTATGTTGCTACAAAAGCAATATTTGAATACAATGGTCCTGTTTATATG
CGGCTTAGAGGTAGAAAAGAAGAACCGGTAATTTTTTACAAAAAGAAAGATTTTAAAATTGGAAAAGGAGAAATTATAAA
AGAAGGAAAAGATGCTTTAATTATTGCTTGTGGTGGTGCTGTATATGATAGTTTAAAAGCTTCTGAAATTTTGCAGTCAA
GAGGTATAAAAGTAACGCTTGTAAATATGCCTACTGTAAGACCATTAGATGAAGATTTGCTACTGGAGCTTACATCTTCA
GTAGATAATATCATTACTGTTGAACATCACAATACAACGGGTGGACTAGGGAGTGCAGTGGCAGAATTTTTAACTGAAAA
AAGGCCGCAAATTAGACAATTGAGGTTAGGAGTAAAAAATAGATTTGGAACGGCAGGTTCAGAAGATATGTTGAAAAAAG
GGTTTGGGCTAGATGGTGAGACAATAGCTATAAGTATAGAGAATTTTCTTAAAAATAGAACTAAGTGA

Upstream 100 bases:

>100_bases
TTAAAAATTGCTGAAAATAAGGTTGATTGGCACTATAAAGTTCTTTCATATGAACAATACGAGGAATTAAAAAATGAAAT
GTCATTGGAGGAGCTTTATC

Downstream 100 bases:

>100_bases
GGAGGAAAAAATGATGAAGATAATTTTGGGTAGTGATCATTTTGGTTTTGATTTAAAAGAAGTTATTAAAGAACATCTAC
AGTCTAAAGGAATTGCAGTA

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSELKKSTRTSFAEAIVELGEKNPDVVTVAADSASRYGDFIKKFPERSFNVGIAEQTMVSVAAGMALCGKIPVVTSYANF
LAFRAAEQIRVDVAGSKLNVKLIGTDTGFSSAWLGFTHLALEDMGVIRAIPGIVIIDPADAAEAYVATKAIFEYNGPVYM
RLRGRKEEPVIFYKKKDFKIGKGEIIKEGKDALIIACGGAVYDSLKASEILQSRGIKVTLVNMPTVRPLDEDLLLELTSS
VDNIITVEHHNTTGGLGSAVAEFLTEKRPQIRQLRLGVKNRFGTAGSEDMLKKGFGLDGETIAISIENFLKNRTK

Sequences:

>Translated_315_residues
MSELKKSTRTSFAEAIVELGEKNPDVVTVAADSASRYGDFIKKFPERSFNVGIAEQTMVSVAAGMALCGKIPVVTSYANF
LAFRAAEQIRVDVAGSKLNVKLIGTDTGFSSAWLGFTHLALEDMGVIRAIPGIVIIDPADAAEAYVATKAIFEYNGPVYM
RLRGRKEEPVIFYKKKDFKIGKGEIIKEGKDALIIACGGAVYDSLKASEILQSRGIKVTLVNMPTVRPLDEDLLLELTSS
VDNIITVEHHNTTGGLGSAVAEFLTEKRPQIRQLRLGVKNRFGTAGSEDMLKKGFGLDGETIAISIENFLKNRTK
>Mature_314_residues
SELKKSTRTSFAEAIVELGEKNPDVVTVAADSASRYGDFIKKFPERSFNVGIAEQTMVSVAAGMALCGKIPVVTSYANFL
AFRAAEQIRVDVAGSKLNVKLIGTDTGFSSAWLGFTHLALEDMGVIRAIPGIVIIDPADAAEAYVATKAIFEYNGPVYMR
LRGRKEEPVIFYKKKDFKIGKGEIIKEGKDALIIACGGAVYDSLKASEILQSRGIKVTLVNMPTVRPLDEDLLLELTSSV
DNIITVEHHNTTGGLGSAVAEFLTEKRPQIRQLRLGVKNRFGTAGSEDMLKKGFGLDGETIAISIENFLKNRTK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=312, Percent_Identity=30.1282051282051, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI4507521, Length=312, Percent_Identity=30.1282051282051, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI225637463, Length=316, Percent_Identity=30.6962025316456, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI225637461, Length=316, Percent_Identity=30.6962025316456, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI225637459, Length=316, Percent_Identity=30.6962025316456, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI133778974, Length=295, Percent_Identity=30.8474576271186, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786622, Length=302, Percent_Identity=33.112582781457, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17539652, Length=312, Percent_Identity=34.2948717948718, Blast_Score=153, Evalue=9e-38,
Organism=Drosophila melanogaster, GI45551847, Length=314, Percent_Identity=30.2547770700637, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45550715, Length=314, Percent_Identity=30.2547770700637, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24645119, Length=314, Percent_Identity=30.2547770700637, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24666278, Length=267, Percent_Identity=31.8352059925094, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34211; Mature: 34080

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKKSTRTSFAEAIVELGEKNPDVVTVAADSASRYGDFIKKFPERSFNVGIAEQTMVS
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
VAAGMALCGKIPVVTSYANFLAFRAAEQIRVDVAGSKLNVKLIGTDTGFSSAWLGFTHLA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCCCCCHHHHHHHHHH
LEDMGVIRAIPGIVIIDPADAAEAYVATKAIFEYNGPVYMRLRGRKEEPVIFYKKKDFKI
HHHCCHHHHCCCEEEECCCCCHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEECCCCCC
GKGEIIKEGKDALIIACGGAVYDSLKASEILQSRGIKVTLVNMPTVRPLDEDLLLELTSS
CCCHHEECCCCEEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHC
VDNIITVEHHNTTGGLGSAVAEFLTEKRPQIRQLRLGVKNRFGTAGSEDMLKKGFGLDGE
CCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCC
TIAISIENFLKNRTK
EEEEEHHHHHCCCCC
>Mature Secondary Structure 
SELKKSTRTSFAEAIVELGEKNPDVVTVAADSASRYGDFIKKFPERSFNVGIAEQTMVS
CHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
VAAGMALCGKIPVVTSYANFLAFRAAEQIRVDVAGSKLNVKLIGTDTGFSSAWLGFTHLA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCCCCCHHHHHHHHHH
LEDMGVIRAIPGIVIIDPADAAEAYVATKAIFEYNGPVYMRLRGRKEEPVIFYKKKDFKI
HHHCCHHHHCCCEEEECCCCCHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEECCCCCC
GKGEIIKEGKDALIIACGGAVYDSLKASEILQSRGIKVTLVNMPTVRPLDEDLLLELTSS
CCCHHEECCCCEEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHC
VDNIITVEHHNTTGGLGSAVAEFLTEKRPQIRQLRLGVKNRFGTAGSEDMLKKGFGLDGE
CCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCC
TIAISIENFLKNRTK
EEEEEHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]