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Identifier: 16520032

GI number: 16520032

Start: 89135

End: 90145

Strand: Direct

Name: Not Available

Synonym: NGR_a00730

Alternate gene names: 16520032

Gene position: 89135-90145 (Clockwise)

Preceding gene: 16520033

Following gene: 16520031

Centisome position: 16.62

GC content: 63.9

Gene sequence:

>1011_bases
ATGCTGCACACGACCGTAACACAATTGATCGGCCAGACGCCGGTCATGTCGATCGACGTGCCGGGCCGCAACGCCACCTT
GGTTCTGAAGATCGAGAAGAACAATCCCGGCGGCTCGATGAAGGATCGTATGGCTCGCAGCATGGTGATTGCGGCCCTTC
AGGATGGGCGCCTCCCTCCGGGCGGCACGATCGTTGAATCATCGTCGGGAAATACTGGCACGGGGCTGGCGCTCGCAGCG
CTGGAATTCGGGCTGCGCTTCATTGCCGTGGTGGACCACCATGCAGCGCCCGACAAGATCCGCATGATGCGGGCGCTAGG
GGCTGAGATCCGCTATGTCGAAGGCGACTTTCGCGAAGACGAGGTCGCAGTCGTCGAGCGCCAGCGCCTCGCAGCGCAAC
TCGGCGCGCAGCTTCCGGGCGCGCTGTTCATGAACCAGTCCGACAACCCGGCAAATCCGGAAGGCTATACCGGCCTCGTG
GACGAACTGGTTGCCCAGCTTCCCGACGGCATCGACGCCTTTGTCGGCTGCGTCGGGACCGGCGGCTCGATGACCGGAAT
CTCCCAGCGTCTGAAGCGTAACAATCCGGCCGTACGCACTATTGCCGTGGAGCCGGCCGGCTCGATCGTTTTCGGCAAGC
CGGGGCACCCCTATTACCAGTCAGGAACGGGCACGCCCGCCGGCGATGAGGTCGGCAAGGTGCTGGACTATGGCTGCATC
GACGAAGGCGTGCAGGTGACCGATACGCAAGCCTTCGAGACGGCGCGCTACATCGCCCGCCGCAAGGGACTGCTCGTTGG
CGGCTCGACCGGCGGCGCCATCTACAAGGCGCTGGAGTTCATTGGCGCCGGCAAGCTCACCGGCACCGTCGTCACGACGG
TTGCCGATGGCGGCGAGAAATATCTTGGCACGATTTTCGATGAGGAATGGATGGCGAAGCGCCGCCTGCTCGACCCGGCA
ATCGCTGCCCAGTTGGATGGCTGGCTATTCGGAAAGGCGCGGGCAGCATGA

Upstream 100 bases:

>100_bases
AAACGAGTTCCATCGCCATCCCATGCCCGCTCGCTTCTGCGTCATCGAAGACGCCGAAGGGCGGCCCAATCTCGTTCCCG
ACACAATTGGAGAGGTTTAG

Downstream 100 bases:

>100_bases
AGGTGACCATTTGCGGCGCTGGCCGCACCGGACATTTGAATGCGGTCCTTTTCAAGCAGAACCCGGGCATCGATGTTTCG
GTCCTGACCACGTCCGCCAC

Product: cysteine synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLHTTVTQLIGQTPVMSIDVPGRNATLVLKIEKNNPGGSMKDRMARSMVIAALQDGRLPPGGTIVESSSGNTGTGLALAA
LEFGLRFIAVVDHHAAPDKIRMMRALGAEIRYVEGDFREDEVAVVERQRLAAQLGAQLPGALFMNQSDNPANPEGYTGLV
DELVAQLPDGIDAFVGCVGTGGSMTGISQRLKRNNPAVRTIAVEPAGSIVFGKPGHPYYQSGTGTPAGDEVGKVLDYGCI
DEGVQVTDTQAFETARYIARRKGLLVGGSTGGAIYKALEFIGAGKLTGTVVTTVADGGEKYLGTIFDEEWMAKRRLLDPA
IAAQLDGWLFGKARAA

Sequences:

>Translated_336_residues
MLHTTVTQLIGQTPVMSIDVPGRNATLVLKIEKNNPGGSMKDRMARSMVIAALQDGRLPPGGTIVESSSGNTGTGLALAA
LEFGLRFIAVVDHHAAPDKIRMMRALGAEIRYVEGDFREDEVAVVERQRLAAQLGAQLPGALFMNQSDNPANPEGYTGLV
DELVAQLPDGIDAFVGCVGTGGSMTGISQRLKRNNPAVRTIAVEPAGSIVFGKPGHPYYQSGTGTPAGDEVGKVLDYGCI
DEGVQVTDTQAFETARYIARRKGLLVGGSTGGAIYKALEFIGAGKLTGTVVTTVADGGEKYLGTIFDEEWMAKRRLLDPA
IAAQLDGWLFGKARAA
>Mature_336_residues
MLHTTVTQLIGQTPVMSIDVPGRNATLVLKIEKNNPGGSMKDRMARSMVIAALQDGRLPPGGTIVESSSGNTGTGLALAA
LEFGLRFIAVVDHHAAPDKIRMMRALGAEIRYVEGDFREDEVAVVERQRLAAQLGAQLPGALFMNQSDNPANPEGYTGLV
DELVAQLPDGIDAFVGCVGTGGSMTGISQRLKRNNPAVRTIAVEPAGSIVFGKPGHPYYQSGTGTPAGDEVGKVLDYGCI
DEGVQVTDTQAFETARYIARRKGLLVGGSTGGAIYKALEFIGAGKLTGTVVTTVADGGEKYLGTIFDEEWMAKRRLLDPA
IAAQLDGWLFGKARAA

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family

Homologues:

Organism=Homo sapiens, GI295821202, Length=337, Percent_Identity=32.9376854599407, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI295821200, Length=337, Percent_Identity=32.9376854599407, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI4557415, Length=337, Percent_Identity=32.9376854599407, Blast_Score=164, Evalue=8e-41,
Organism=Escherichia coli, GI2367138, Length=316, Percent_Identity=31.6455696202532, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788754, Length=322, Percent_Identity=30.1242236024845, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17535051, Length=311, Percent_Identity=31.8327974276527, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25147552, Length=331, Percent_Identity=33.2326283987915, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=33.2317073170732, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI115535073, Length=303, Percent_Identity=34.3234323432343, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=32.7759197324415, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=32.5581395348837, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71996324, Length=377, Percent_Identity=28.6472148541114, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=32.2368421052632, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32566672, Length=206, Percent_Identity=31.0679611650485, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=348, Percent_Identity=33.9080459770115, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=26.7477203647416, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319788, Length=350, Percent_Identity=24.5714285714286, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24643623, Length=328, Percent_Identity=32.0121951219512, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20129101, Length=328, Percent_Identity=32.0121951219512, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4XP_RHISN (P55708)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_444152.1
- ProteinModelPortal:   P55708
- SMR:   P55708
- GeneID:   962517
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a00730
- HOGENOM:   HBG748215
- ProtClustDB:   CLSK809025
- InterPro:   IPR001216
- InterPro:   IPR001926

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =2.5.1.47

Molecular weight: Translated: 35416; Mature: 35416

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: BINDING 71-71 BINDING 269-269

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHTTVTQLIGQTPVMSIDVPGRNATLVLKIEKNNPGGSMKDRMARSMVIAALQDGRLPP
CCCHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
GGTIVESSSGNTGTGLALAALEFGLRFIAVVDHHAAPDKIRMMRALGAEIRYVEGDFRED
CCEEEECCCCCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCC
EVAVVERQRLAAQLGAQLPGALFMNQSDNPANPEGYTGLVDELVAQLPDGIDAFVGCVGT
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
GGSMTGISQRLKRNNPAVRTIAVEPAGSIVFGKPGHPYYQSGTGTPAGDEVGKVLDYGCI
CCCHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCC
DEGVQVTDTQAFETARYIARRKGLLVGGSTGGAIYKALEFIGAGKLTGTVVTTVADGGEK
CCCCEECCHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCH
YLGTIFDEEWMAKRRLLDPAIAAQLDGWLFGKARAA
HHHHHHHHHHHHHHHHCCHHHHHHHCCEEECCCCCC
>Mature Secondary Structure
MLHTTVTQLIGQTPVMSIDVPGRNATLVLKIEKNNPGGSMKDRMARSMVIAALQDGRLPP
CCCHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
GGTIVESSSGNTGTGLALAALEFGLRFIAVVDHHAAPDKIRMMRALGAEIRYVEGDFRED
CCEEEECCCCCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCC
EVAVVERQRLAAQLGAQLPGALFMNQSDNPANPEGYTGLVDELVAQLPDGIDAFVGCVGT
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
GGSMTGISQRLKRNNPAVRTIAVEPAGSIVFGKPGHPYYQSGTGTPAGDEVGKVLDYGCI
CCCHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCC
DEGVQVTDTQAFETARYIARRKGLLVGGSTGGAIYKALEFIGAGKLTGTVVTTVADGGEK
CCCCEECCHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCH
YLGTIFDEEWMAKRRLLDPAIAAQLDGWLFGKARAA
HHHHHHHHHHHHHHHHCCHHHHHHHCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424