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Identifier: 16519985

GI number: 16519985

Start: 149218

End: 149784

Strand: Direct

Name: Not Available

Synonym: NGR_a01200

Alternate gene names: NA

Gene position: 149218-149784 (Clockwise)

Preceding gene: 16520009

Following gene: 16519984

Centisome position: 27.83

GC content: 53.26

Gene sequence:

>567_bases
ATGCCTGTGAAAAAAAGAGTCCCTTTCGTTGCCTTTCGCACGCGTGTTCGCGACGAGACAATAGGAGGGCCAAACCCATA
CCGATGGGAAGTCAGGACAACCGAGGATTACTTCAGTGGCAAGCGCGTCGTTCTGTTTTCGCTTCCCGGTGCGTTCACCC
CGACCTGCTCAACTCAGCAATTGCCTGACTTTGAGAGACTTTACGACGAATTCGGGAAGGTAGGAATCGAAGCGGTCTAC
TGCCTGTCAGTTAATGACGCCTTCGTCATGAACGCATGGGGCAAGGCGTTGGGCTTAGAGAAGGTCAGGCTTATCCCGGA
TGGTTCGGGCGAATTCACTCGCAAGATGGGCATGCTGGTTGCAAAGGACAATCTCGGCTTCGGAATGCGCTCGTGGCGCT
ACGCTGCCGTGGTCAATGATAGCGTGGTGGAGCAATGGTTCGAAGAAGAAGGTTTCTCGGACAACTGCGAGTCGGATCCT
TATTGGGCATCTTCTCCGCAGAACATTCTTGAAACGCTGAGGACTTTCGACACCGCACGTCTCGGTCGTGTCCCGATTAA
ATTTTGA

Upstream 100 bases:

>100_bases
CTGTTCGTTGGCCGACGAACTGATTATTTAAGTAACGGTGCTTCGCCAGAGGGTCCAGAGGCGGCGAATGCTCAGTTCTT
TTTTGAAGGAGCGATGTTCA

Downstream 100 bases:

>100_bases
TTTTTGCCATGTGAGCTATCCAGTCTGATGTTGCGGAGCCGGTGCTGACAGTGAGCGCCGCAGCTACCCACTGAGCAGCC
TCCAGCGCACTTTCATGAAC

Product: peroxiredoxin

Products: NA

Alternate protein names: Thioredoxin reductase

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MPVKKRVPFVAFRTRVRDETIGGPNPYRWEVRTTEDYFSGKRVVLFSLPGAFTPTCSTQQLPDFERLYDEFGKVGIEAVY
CLSVNDAFVMNAWGKALGLEKVRLIPDGSGEFTRKMGMLVAKDNLGFGMRSWRYAAVVNDSVVEQWFEEEGFSDNCESDP
YWASSPQNILETLRTFDTARLGRVPIKF

Sequences:

>Translated_188_residues
MPVKKRVPFVAFRTRVRDETIGGPNPYRWEVRTTEDYFSGKRVVLFSLPGAFTPTCSTQQLPDFERLYDEFGKVGIEAVY
CLSVNDAFVMNAWGKALGLEKVRLIPDGSGEFTRKMGMLVAKDNLGFGMRSWRYAAVVNDSVVEQWFEEEGFSDNCESDP
YWASSPQNILETLRTFDTARLGRVPIKF
>Mature_187_residues
PVKKRVPFVAFRTRVRDETIGGPNPYRWEVRTTEDYFSGKRVVLFSLPGAFTPTCSTQQLPDFERLYDEFGKVGIEAVYC
LSVNDAFVMNAWGKALGLEKVRLIPDGSGEFTRKMGMLVAKDNLGFGMRSWRYAAVVNDSVVEQWFEEEGFSDNCESDPY
WASSPQNILETLRTFDTARLGRVPIKF

Specific function: Unknown

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI6912238, Length=134, Percent_Identity=41.044776119403, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI78706776, Length=128, Percent_Identity=43.75, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI78709078, Length=128, Percent_Identity=43.75, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4VD_RHISN (Q53212)

Other databases:

- EMBL:   Z68203
- EMBL:   U00090
- RefSeq:   NP_444105.1
- ProteinModelPortal:   Q53212
- SMR:   Q53212
- GeneID:   962155
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a01200
- HOGENOM:   HBG493509
- ProtClustDB:   CLSK864408
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 21433; Mature: 21301

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKKRVPFVAFRTRVRDETIGGPNPYRWEVRTTEDYFSGKRVVLFSLPGAFTPTCSTQQ
CCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECHHHHCCCEEEEEECCCCCCCCCCCCC
LPDFERLYDEFGKVGIEAVYCLSVNDAFVMNAWGKALGLEKVRLIPDGSGEFTRKMGMLV
CCCHHHHHHHHCCCCEEEEEEEECCCEEEECCHHHHCCCCEEEEEECCCCHHHHHHCCEE
AKDNLGFGMRSWRYAAVVNDSVVEQWFEEEGFSDNCESDPYWASSPQNILETLRTFDTAR
EECCCCCCCCCEEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LGRVPIKF
HCCCCCCC
>Mature Secondary Structure 
PVKKRVPFVAFRTRVRDETIGGPNPYRWEVRTTEDYFSGKRVVLFSLPGAFTPTCSTQQ
CCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECHHHHCCCEEEEEECCCCCCCCCCCCC
LPDFERLYDEFGKVGIEAVYCLSVNDAFVMNAWGKALGLEKVRLIPDGSGEFTRKMGMLV
CCCHHHHHHHHCCCCEEEEEEEECCCEEEECCHHHHCCCCEEEEEECCCCHHHHHHCCEE
AKDNLGFGMRSWRYAAVVNDSVVEQWFEEEGFSDNCESDPYWASSPQNILETLRTFDTAR
EECCCCCCCCCEEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LGRVPIKF
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424