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The map label for this gene is y4qG

Identifier: 16519914

GI number: 16519914

Start: 243250

End: 244596

Strand: Direct

Name: y4qG

Synonym: NGR_a01910

Alternate gene names: 16519914

Gene position: 243250-244596 (Clockwise)

Preceding gene: 16519915

Following gene: 16519913

Centisome position: 45.37

GC content: 53.9

Gene sequence:

>1347_bases
ATGTGGCATTGGCATCGGTTTCAAGAGCATGAGGCGCGCCGCTCTGACGCCATCGTCTTGTTGAGGAAAATCATGTCAAA
CGAGAGTAAGTCCAATTCACTCTACGCCTTCGAGAGCCTCGAATCGAACGTGCGATTTTATTCGCGATCGTTCCCCGTGG
TGTTTGAGAAAGCCGCAGGCGCCATTCTGCATGACGAGAGCGGCCGCGAGTTTATCGATTTTCTCTCTGGCTCAGGCGTT
CTTAACTACGGTCACAACGATCCGTATTTTCTTGACGAAGCGACTCAATACCTGAGATCAAATGGAATAATCCACGGGTT
GGACATGGCTACGCCAGCTAAACGAGAGTTTATGGAGTGTTTTGACGCCATAATATTGCGGCCACGTGGTCTGACTTACA
AATTTCAGTTTTGCGGTCCTACCGGCGCTAATGCAGTGGAAGCTGCTTTGAAACTCGCGCGCAAGGCCACTGGACGGCAC
AGCATAGTTTCATTCACTAACGGCTTCCATGGGATGAGCTTGGGTGCGCTCGCGGTTACGGGCAATCGATACTACCGGGA
CGCGGCAGGCTTTCCGCCAGCCGGGGTGGCGTTCATGCCCTATGACGGGTATTGGGGTGCCGATAACGACACTTCGGAAT
ATCTCGATAAGGTGCTCGCTGATGCAAGCAGTGGCGTAGATGTACCTGCGGCAATCATTCTGGAAACCGTGCAAGGCGAA
GGGGGGATCAACGCCGCGCGAAAAGAGTGGCTGCAGTCGATCCAGCGGATTTGCAGAAGCCATGGCATCCTGCTGATTGT
TGACGACATTCAGGCAGGTTGCGGAAGAGCAGGCAATTTCTTCAGTTTCGAGTTTGCGGGTTTGTCGCCAGATGTTGTAG
TCTTGTCGAAGTCTATAAGTGGCTGCGGACTGCCTTTGTCCCTTTTGCTGCTCAAGCCAGAATTAGACGTTTGGCGGCCG
GGCGAACACAATGGGACTTTCAGGGGCAACAATCTTGCGTTCGTGACGGGTGCCGCTGCTTTGCGAAAGTACTGGACGAA
TGATGCGCTGTCTGCCCGTGTCATGGAGACAGGACGCATCATAGCGGAGCGCCTTCGGCAGGTGGCTCAGACCAACCGAG
CTCGTAGCCTCTCCGTACGCGGAAGGGGCATGATGTTGGGGCTCAATTGTGGTACAGGTAAGCTGGCTGAGAGGATCGTC
CGCAAGGCCTTTGAAGAGGGACTTGTGGTAGAGCGATGCGGAGCGGAAGATCAAGTTATCAAGCTTCTACCTCCTTTGAC
AACTGACGAGCAGACGCTTCGACGTGGTCTGGACATCCTGCACAAATCTGTGGCCGCAAGCATCTAA

Upstream 100 bases:

>100_bases
CGCGAATATACTGAAGAAGTGGCACCGACGATACTGCCAGCCTGGGTAGGCGCGTGGGCCTGCATCGCCGTGTAAAACCG
CGGAGCCACGTAAAATTCCG

Downstream 100 bases:

>100_bases
AGCGGATCGCGACTCCGGTTCATGGGCGGGTTAAGCGCGATGCAGCGACGCATCGACTTGTTAGTGGAGGGCGGTGATGA
ATACGACGCTTGTTCTCATT

Product: diaminobutyrate--2-oxoglutarate aminotransferase

Products: L-Glutamate; Succinic semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MWHWHRFQEHEARRSDAIVLLRKIMSNESKSNSLYAFESLESNVRFYSRSFPVVFEKAAGAILHDESGREFIDFLSGSGV
LNYGHNDPYFLDEATQYLRSNGIIHGLDMATPAKREFMECFDAIILRPRGLTYKFQFCGPTGANAVEAALKLARKATGRH
SIVSFTNGFHGMSLGALAVTGNRYYRDAAGFPPAGVAFMPYDGYWGADNDTSEYLDKVLADASSGVDVPAAIILETVQGE
GGINAARKEWLQSIQRICRSHGILLIVDDIQAGCGRAGNFFSFEFAGLSPDVVVLSKSISGCGLPLSLLLLKPELDVWRP
GEHNGTFRGNNLAFVTGAAALRKYWTNDALSARVMETGRIIAERLRQVAQTNRARSLSVRGRGMMLGLNCGTGKLAERIV
RKAFEEGLVVERCGAEDQVIKLLPPLTTDEQTLRRGLDILHKSVAASI

Sequences:

>Translated_448_residues
MWHWHRFQEHEARRSDAIVLLRKIMSNESKSNSLYAFESLESNVRFYSRSFPVVFEKAAGAILHDESGREFIDFLSGSGV
LNYGHNDPYFLDEATQYLRSNGIIHGLDMATPAKREFMECFDAIILRPRGLTYKFQFCGPTGANAVEAALKLARKATGRH
SIVSFTNGFHGMSLGALAVTGNRYYRDAAGFPPAGVAFMPYDGYWGADNDTSEYLDKVLADASSGVDVPAAIILETVQGE
GGINAARKEWLQSIQRICRSHGILLIVDDIQAGCGRAGNFFSFEFAGLSPDVVVLSKSISGCGLPLSLLLLKPELDVWRP
GEHNGTFRGNNLAFVTGAAALRKYWTNDALSARVMETGRIIAERLRQVAQTNRARSLSVRGRGMMLGLNCGTGKLAERIV
RKAFEEGLVVERCGAEDQVIKLLPPLTTDEQTLRRGLDILHKSVAASI
>Mature_448_residues
MWHWHRFQEHEARRSDAIVLLRKIMSNESKSNSLYAFESLESNVRFYSRSFPVVFEKAAGAILHDESGREFIDFLSGSGV
LNYGHNDPYFLDEATQYLRSNGIIHGLDMATPAKREFMECFDAIILRPRGLTYKFQFCGPTGANAVEAALKLARKATGRH
SIVSFTNGFHGMSLGALAVTGNRYYRDAAGFPPAGVAFMPYDGYWGADNDTSEYLDKVLADASSGVDVPAAIILETVQGE
GGINAARKEWLQSIQRICRSHGILLIVDDIQAGCGRAGNFFSFEFAGLSPDVVVLSKSISGCGLPLSLLLLKPELDVWRP
GEHNGTFRGNNLAFVTGAAALRKYWTNDALSARVMETGRIIAERLRQVAQTNRARSLSVRGRGMMLGLNCGTGKLAERIV
RKAFEEGLVVERCGAEDQVIKLLPPLTTDEQTLRRGLDILHKSVAASI

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI4557809, Length=464, Percent_Identity=25.4310344827586, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI284507298, Length=315, Percent_Identity=27.3015873015873, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI13994255, Length=455, Percent_Identity=23.2967032967033, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=22.2222222222222, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI37574042, Length=424, Percent_Identity=23.5849056603774, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI226442709, Length=323, Percent_Identity=24.7678018575851, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=30.5210918114144, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1787560, Length=401, Percent_Identity=32.4189526184539, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI145693181, Length=391, Percent_Identity=28.6445012787724, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789759, Length=401, Percent_Identity=28.927680798005, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=29.925187032419, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786991, Length=435, Percent_Identity=28.0459770114943, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786349, Length=350, Percent_Identity=27.4285714285714, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=408, Percent_Identity=26.2254901960784, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=446, Percent_Identity=27.1300448430493, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=285, Percent_Identity=27.0175438596491, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17541228, Length=442, Percent_Identity=24.4343891402715, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=21.8604651162791, Blast_Score=89, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=440, Percent_Identity=28.8636363636364, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324432, Length=420, Percent_Identity=26.6666666666667, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6321456, Length=432, Percent_Identity=21.2962962962963, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=355, Percent_Identity=24.2253521126761, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357415, Length=427, Percent_Identity=24.5901639344262, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI28574759, Length=443, Percent_Identity=25.5079006772009, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161085790, Length=438, Percent_Identity=26.027397260274, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281366494, Length=401, Percent_Identity=24.6882793017456, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667139, Length=401, Percent_Identity=24.6882793017456, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667143, Length=401, Percent_Identity=24.6882793017456, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=23.943661971831, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4QG_RHISN (P55628)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_444034.1
- ProteinModelPortal:   P55628
- GeneID:   962410
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a01910
- HOGENOM:   HBG725944
- ProtClustDB:   PRK09264
- InterPro:   IPR005814
- InterPro:   IPR004637
- InterPro:   IPR012773
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF7
- TIGRFAMs:   TIGR00709
- TIGRFAMs:   TIGR02407

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.19 [C]

Molecular weight: Translated: 49273; Mature: 49273

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWHWHRFQEHEARRSDAIVLLRKIMSNESKSNSLYAFESLESNVRFYSRSFPVVFEKAAG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCHHHHHCCCCEEECCCCC
AILHDESGREFIDFLSGSGVLNYGHNDPYFLDEATQYLRSNGIIHGLDMATPAKREFMEC
CEEECCCCHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHCCCEEECCCCCCHHHHHHHH
FDAIILRPRGLTYKFQFCGPTGANAVEAALKLARKATGRHSIVSFTNGFHGMSLGALAVT
HHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEE
GNRYYRDAAGFPPAGVAFMPYDGYWGADNDTSEYLDKVLADASSGVDVPAAIILETVQGE
CCCEECCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
GGINAARKEWLQSIQRICRSHGILLIVDDIQAGCGRAGNFFSFEFAGLSPDVVVLSKSIS
CCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCCCCEEEEECCCC
GCGLPLSLLLLKPELDVWRPGEHNGTFRGNNLAFVTGAAALRKYWTNDALSARVMETGRI
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHH
IAERLRQVAQTNRARSLSVRGRGMMLGLNCGTGKLAERIVRKAFEEGLVVERCGAEDQVI
HHHHHHHHHHCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCHH
KLLPPLTTDEQTLRRGLDILHKSVAASI
HHCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MWHWHRFQEHEARRSDAIVLLRKIMSNESKSNSLYAFESLESNVRFYSRSFPVVFEKAAG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCHHHHHCCCCEEECCCCC
AILHDESGREFIDFLSGSGVLNYGHNDPYFLDEATQYLRSNGIIHGLDMATPAKREFMEC
CEEECCCCHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHCCCEEECCCCCCHHHHHHHH
FDAIILRPRGLTYKFQFCGPTGANAVEAALKLARKATGRHSIVSFTNGFHGMSLGALAVT
HHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEE
GNRYYRDAAGFPPAGVAFMPYDGYWGADNDTSEYLDKVLADASSGVDVPAAIILETVQGE
CCCEECCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
GGINAARKEWLQSIQRICRSHGILLIVDDIQAGCGRAGNFFSFEFAGLSPDVVVLSKSIS
CCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCCCCEEEEECCCC
GCGLPLSLLLLKPELDVWRPGEHNGTFRGNNLAFVTGAAALRKYWTNDALSARVMETGRI
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHH
IAERLRQVAQTNRARSLSVRGRGMMLGLNCGTGKLAERIVRKAFEEGLVVERCGAEDQVI
HHHHHHHHHHCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCHH
KLLPPLTTDEQTLRRGLDILHKSVAASI
HHCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-Aminobutanoate; 2-Oxoglutarate [C]

Specific reaction: 4-Aminobutanoate + 2-Oxoglutarate --> L-Glutamate + Succinic semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424