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Identifier: 16519723

GI number: 16519723

Start: 492904

End: 493650

Strand: Reverse

Name: Not Available

Synonym: NGR_a03830

Alternate gene names: 16519723

Gene position: 493650-492904 (Counterclockwise)

Preceding gene: 16519722

Following gene: 16519727

Centisome position: 92.07

GC content: 59.71

Gene sequence:

>747_bases
ATGCAGGGTATGAACATCGCCGTCGTCGGTGGTGCGAGCGGCTTCGGCCTCGAAACGGCAAAGCTCATGGTCCGTGACGG
CGTGTCGAAGATCGTCGTCATCGACATCAATCAGGAGCGTCTTGATGCAGCGAAGGGAGAGCTGGCCGGAAAAGGCACCG
AGATTTTCACGGTCGTCCGCGACATCGCACGGGCAGAAGGCGCGCACGCTTCCTTCGACGCTGCGGTCAAGACCGCAGGG
CGCATCCGCTCGTCAATTTGCGCAGCGATCTATCCGCGCGCACCGCTGCTCGAAATCACCGACGATATGTGGGACGCTGA
AAATGCTATCAACATCAAGGGCACCTATCACATGATGGTGGCGGCGGTGAAGCACATGCAGGGCCACAAGGCCGAGGGCG
AAGTTTCCGGACGCATCGTCAACATTACCTCTGTCGACGCTTTCAAGGCGCACCCGCAGAACGCACACTACGCCGCGACC
AAGGCCGCGGTCGTCAGCTTGACCCGGTCCTTTGCGCATGCGTTCGCCAAGGATCAGGTTCTGATCAACTCCGTCGCGCC
GGCGGGCATGGCGACCGAAAAAGCCAAATCTCTTGGCTTCCTCGGCGAGCTTGCCGCGGCCAATCCGTTGGGCCGGGCTG
CCGAACCAGCAGAAATTGCAGAATTCGTAGTGATGGTCGCGGGCCCGAAGAATACATACATGACCGGTGAACAAGTGATC
GTCTTGGGTGGTTACATCTACGCCTGA

Upstream 100 bases:

>100_bases
GACGTAACCCGCCTGGAAGTGATGCCGACGGGCCAAGTAGTCGGCGGCGCCCAGATGTCCAAACTTTCTCGTTAACTGCG
AACCTTGGAAGGAAAAGATC

Downstream 100 bases:

>100_bases
TGGCGTTCGGGTCGCGCCTGGCCTTCTGGCGCGACCCCATAGGAATCTAGATAGCAAGAAAGTGAAGGCGGAGACGATGG
GAAACGGCTTACAGGAGCGA

Product: short chain dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MQGMNIAVVGGASGFGLETAKLMVRDGVSKIVVIDINQERLDAAKGELAGKGTEIFTVVRDIARAEGAHASFDAAVKTAG
RIRSSICAAIYPRAPLLEITDDMWDAENAINIKGTYHMMVAAVKHMQGHKAEGEVSGRIVNITSVDAFKAHPQNAHYAAT
KAAVVSLTRSFAHAFAKDQVLINSVAPAGMATEKAKSLGFLGELAAANPLGRAAEPAEIAEFVVMVAGPKNTYMTGEQVI
VLGGYIYA

Sequences:

>Translated_248_residues
MQGMNIAVVGGASGFGLETAKLMVRDGVSKIVVIDINQERLDAAKGELAGKGTEIFTVVRDIARAEGAHASFDAAVKTAG
RIRSSICAAIYPRAPLLEITDDMWDAENAINIKGTYHMMVAAVKHMQGHKAEGEVSGRIVNITSVDAFKAHPQNAHYAAT
KAAVVSLTRSFAHAFAKDQVLINSVAPAGMATEKAKSLGFLGELAAANPLGRAAEPAEIAEFVVMVAGPKNTYMTGEQVI
VLGGYIYA
>Mature_248_residues
MQGMNIAVVGGASGFGLETAKLMVRDGVSKIVVIDINQERLDAAKGELAGKGTEIFTVVRDIARAEGAHASFDAAVKTAG
RIRSSICAAIYPRAPLLEITDDMWDAENAINIKGTYHMMVAAVKHMQGHKAEGEVSGRIVNITSVDAFKAHPQNAHYAAT
KAAVVSLTRSFAHAFAKDQVLINSVAPAGMATEKAKSLGFLGELAAANPLGRAAEPAEIAEFVVMVAGPKNTYMTGEQVI
VLGGYIYA

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI32483357, Length=243, Percent_Identity=27.9835390946502, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=31.25, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI15277342, Length=199, Percent_Identity=28.1407035175879, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=23.5537190082645, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI10190704, Length=243, Percent_Identity=28.3950617283951, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI33667109, Length=199, Percent_Identity=24.6231155778894, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI66933014, Length=232, Percent_Identity=27.1551724137931, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=28.6821705426357, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=30.46875, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789208, Length=202, Percent_Identity=29.2079207920792, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=26.4822134387352, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788459, Length=241, Percent_Identity=26.9709543568465, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789378, Length=244, Percent_Identity=24.5901639344262, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI2367365, Length=252, Percent_Identity=28.968253968254, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=30.8, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=28.968253968254, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=27.5590551181102, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=27.5720164609054, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=258, Percent_Identity=25.5813953488372, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=258, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=26.3565891472868, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=259, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=26.0536398467433, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=30.1960784313725, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=24.904214559387, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=27.2030651340996, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=25, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=24.8062015503876, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=258, Percent_Identity=24.4186046511628, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=163, Percent_Identity=27.6073619631902, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=259, Percent_Identity=25.8687258687259, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=259, Percent_Identity=27.027027027027, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=26.615969581749, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639444, Length=242, Percent_Identity=30.9917355371901, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=26.6129032258064, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4EL_RHISN (P55435)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443843.1
- ProteinModelPortal:   P55435
- SMR:   P55435
- GeneID:   962637
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a03830
- HOGENOM:   HBG750976
- ProtClustDB:   CLSK2484863
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: 1.1.1.100

Molecular weight: Translated: 26054; Mature: 26054

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 157-157 BINDING 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGMNIAVVGGASGFGLETAKLMVRDGVSKIVVIDINQERLDAAKGELAGKGTEIFTVVR
CCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCHHHHHHHH
DIARAEGAHASFDAAVKTAGRIRSSICAAIYPRAPLLEITDDMWDAENAINIKGTYHMMV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCCCEEEECCHHHHHH
AAVKHMQGHKAEGEVSGRIVNITSVDAFKAHPQNAHYAATKAAVVSLTRSFAHAFAKDQV
HHHHHHCCCCCCCCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCE
LINSVAPAGMATEKAKSLGFLGELAAANPLGRAAEPAEIAEFVVMVAGPKNTYMTGEQVI
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEEECCCCCEECCCEEE
VLGGYIYA
EECCEEEC
>Mature Secondary Structure
MQGMNIAVVGGASGFGLETAKLMVRDGVSKIVVIDINQERLDAAKGELAGKGTEIFTVVR
CCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCHHHHHHHH
DIARAEGAHASFDAAVKTAGRIRSSICAAIYPRAPLLEITDDMWDAENAINIKGTYHMMV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCCCEEEECCHHHHHH
AAVKHMQGHKAEGEVSGRIVNITSVDAFKAHPQNAHYAATKAAVVSLTRSFAHAFAKDQV
HHHHHHCCCCCCCCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCE
LINSVAPAGMATEKAKSLGFLGELAAANPLGRAAEPAEIAEFVVMVAGPKNTYMTGEQVI
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEEECCCCCEECCCEEE
VLGGYIYA
EECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424