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The map label for this gene is dnaX

Identifier: 16273148

GI number: 16273148

Start: 1297779

End: 1299845

Strand: Reverse

Name: dnaX

Synonym: HI1229

Alternate gene names: 16273148

Gene position: 1299845-1297779 (Counterclockwise)

Preceding gene: 16273149

Following gene: 16273147

Centisome position: 71.02

GC content: 37.78

Gene sequence:

>2067_bases
ATGAGCTATCAAGTCTTAGCCAGAAAATGGCGACCAAAAACATTTGCTGATGTCGTTGGGCAAGAACATATTATCACGGC
ATTAGCAAATGGATTAAAAGATAATCGACTACATCACGCTTACCTCTTTTCAGGCACGCGTGGTGTAGGAAAAACCTCTA
TTGCTAGATTATTCGCAAAAGGATTAAATTGTGTTCACGGTGTAACGGCAACGCCTTGTGGCGAATGTGAAAATTGTAAA
GCTATTGAGCAAGGCAATTTTATTGATTTAATTGAAATTGATGCGGCGTCTCGCACAAAAGTTGAAGACACGCGTGAATT
ATTGGATAACGTGCAATATAAACCAGTTGTGGGCAGATTTAAGGTTTACTTAATCGATGAAGTCCATATGCTATCTCGTC
ATTCATTTAATGCGTTGCTCAAGACTTTAGAAGAACCGCCCGAATATGTAAAATTTTTACTCGCAACAACGGATCCACAA
AAACTACCTGTAACTATTCTTTCTCGCTGTTTACAATTTCATCTTAAAGCATTAGATGAAACTCAAATCTCCCAGCATCT
TGCCCATATTTTGACGCAAGAAAATATTCCTTTTGAAGATCCTGCATTAGTTAAACTTGCAAAAGCGGCGCAAGGAAGTA
TTCGTGATAGCTTAAGTTTAACGGATCAAGCCATTGCAATGGGCGACCGACAAGTTACAAATAATGTTGTAAGCAATATG
TTAGGGTTGCTTGATGATAACTATTCTGTTGATATTTTATACGCCTTACATCAAGGCAATGGCGAACTCTTAATGCGAAC
ACTACAAAGAGTTGCTGATGCGGCAGGCGATTGGGATAAATTACTTGGCGAATGTGCAGAAAAATTACATCAAATTGCGC
TTATGCAACTTCTTCCACAAAAATCTTCAGATAACAATGAACATTTTTCATTTTTAGCCAAACATATCTCTCCAGAAAAT
GTTCAGTTTTTTTATCAAGTCATTGTTTCTGGTAGAAAAGATTTATCAAATGCACCAAATCGTCGTATTGGTGCAGAGAT
GACATTATTGAGGGCATTGGCATTCCACCCAAAGTTCCTTACGGCAGTACCAAAGGCTAACACCACTATTACTCCACCGC
CATCAACGCCAAGTGCGGTTGAAAATACGGGTAATTATGTCGATGTGCCAGTACTGTCGCAAAGTATCAAATCTGCTTAT
TCTCAAGCAAAACCAAATAAAACGAGCATTCCAAATTTGGCAAGCCTTTCGGCTTTAGATGCGCTTGAACATTTAACACA
ACTGGAAAACCAAGAACGTCAAGAACACAAAGCTGAATCATTAGCTGTAGTAAGTGAAACCTTACATCACATCCAAGAAC
TAGACGAAGAAAAATCTCATAAAAAAATGACCGCACTTCCCGTGCGAGAAATGACTGAGCCGAAGCCCAAGCACATAGAA
AAGCCAACATTACCATCAAATGCCGCACAGGCTCCACAAAAAAATAGCACAGAAGAAAATTCAAGTGATGATAATGTAGA
AATTGCTCAAGATGAGCAAGAAATCTTGAGTGCTGACACCTATCGTTGGGAATGGAGCAATCCAGAACTTGCTAAAGCCG
ATACAGGCGTTTGTCCTTCTGATATAAAACAGGCGATTTTAAAAGATATTACGCCTGAATTACGTTTAAAAATCATTACC
CAAACTCAACAACAAGATCAGTGGGCAGATATAGTTGAGCGTTCTGGCTTAACAGGATTTAGCAAAGAATTAGCATTAAA
TTGTTTCTTACAAAGCAAAACCGATGATGAAATCAATCTTGGACTACATTCAGAAAAATCCCATTTACGCCAAGACAGAA
GTATAAAAAATTTAGCTGAAGCATTAAGCAAATTACAAGGTAAAGATATTCGATTAACAATTAATCTTGATGATAGCAAT
GTCACGACGCCAATTGAATATCGCCGCAATATTTATCAAGCATTGCGGGAAAAAGCTCAAAATGAGTTGCAAAAAGATAG
TAAATTACAAATTCTACTTAATGAGTTTGATGCAAAATTAGATGTAGAGAGTATTCGACCAGTTTAA

Upstream 100 bases:

>100_bases
TGATTAATTTACCTGAATTAGGTGGCGAAAAACGCTTAAATAATTTGGGCGTTGATTGCTATACACTCGTCAATTTTGAA
GGTCATTAATTAAGGATTCG

Downstream 100 bases:

>100_bases
AGACAATATTGTATTGAAAACTCCCGTTTCAAGTCAGAATATTTTTATAAACCTCTACCATTTTGTATTTTTTTAATCTA
GAATTTGTCAATTTGTTTTT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MSYQVLARKWRPKTFADVVGQEHIITALANGLKDNRLHHAYLFSGTRGVGKTSIARLFAKGLNCVHGVTATPCGECENCK
AIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVVGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPVTILSRCLQFHLKALDETQISQHLAHILTQENIPFEDPALVKLAKAAQGSIRDSLSLTDQAIAMGDRQVTNNVVSNM
LGLLDDNYSVDILYALHQGNGELLMRTLQRVADAAGDWDKLLGECAEKLHQIALMQLLPQKSSDNNEHFSFLAKHISPEN
VQFFYQVIVSGRKDLSNAPNRRIGAEMTLLRALAFHPKFLTAVPKANTTITPPPSTPSAVENTGNYVDVPVLSQSIKSAY
SQAKPNKTSIPNLASLSALDALEHLTQLENQERQEHKAESLAVVSETLHHIQELDEEKSHKKMTALPVREMTEPKPKHIE
KPTLPSNAAQAPQKNSTEENSSDDNVEIAQDEQEILSADTYRWEWSNPELAKADTGVCPSDIKQAILKDITPELRLKIIT
QTQQQDQWADIVERSGLTGFSKELALNCFLQSKTDDEINLGLHSEKSHLRQDRSIKNLAEALSKLQGKDIRLTINLDDSN
VTTPIEYRRNIYQALREKAQNELQKDSKLQILLNEFDAKLDVESIRPV

Sequences:

>Translated_688_residues
MSYQVLARKWRPKTFADVVGQEHIITALANGLKDNRLHHAYLFSGTRGVGKTSIARLFAKGLNCVHGVTATPCGECENCK
AIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVVGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPVTILSRCLQFHLKALDETQISQHLAHILTQENIPFEDPALVKLAKAAQGSIRDSLSLTDQAIAMGDRQVTNNVVSNM
LGLLDDNYSVDILYALHQGNGELLMRTLQRVADAAGDWDKLLGECAEKLHQIALMQLLPQKSSDNNEHFSFLAKHISPEN
VQFFYQVIVSGRKDLSNAPNRRIGAEMTLLRALAFHPKFLTAVPKANTTITPPPSTPSAVENTGNYVDVPVLSQSIKSAY
SQAKPNKTSIPNLASLSALDALEHLTQLENQERQEHKAESLAVVSETLHHIQELDEEKSHKKMTALPVREMTEPKPKHIE
KPTLPSNAAQAPQKNSTEENSSDDNVEIAQDEQEILSADTYRWEWSNPELAKADTGVCPSDIKQAILKDITPELRLKIIT
QTQQQDQWADIVERSGLTGFSKELALNCFLQSKTDDEINLGLHSEKSHLRQDRSIKNLAEALSKLQGKDIRLTINLDDSN
VTTPIEYRRNIYQALREKAQNELQKDSKLQILLNEFDAKLDVESIRPV
>Mature_687_residues
SYQVLARKWRPKTFADVVGQEHIITALANGLKDNRLHHAYLFSGTRGVGKTSIARLFAKGLNCVHGVTATPCGECENCKA
IEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVVGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQK
LPVTILSRCLQFHLKALDETQISQHLAHILTQENIPFEDPALVKLAKAAQGSIRDSLSLTDQAIAMGDRQVTNNVVSNML
GLLDDNYSVDILYALHQGNGELLMRTLQRVADAAGDWDKLLGECAEKLHQIALMQLLPQKSSDNNEHFSFLAKHISPENV
QFFYQVIVSGRKDLSNAPNRRIGAEMTLLRALAFHPKFLTAVPKANTTITPPPSTPSAVENTGNYVDVPVLSQSIKSAYS
QAKPNKTSIPNLASLSALDALEHLTQLENQERQEHKAESLAVVSETLHHIQELDEEKSHKKMTALPVREMTEPKPKHIEK
PTLPSNAAQAPQKNSTEENSSDDNVEIAQDEQEILSADTYRWEWSNPELAKADTGVCPSDIKQAILKDITPELRLKIITQ
TQQQDQWADIVERSGLTGFSKELALNCFLQSKTDDEINLGLHSEKSHLRQDRSIKNLAEALSKLQGKDIRLTINLDDSNV
TTPIEYRRNIYQALREKAQNELQKDSKLQILLNEFDAKLDVESIRPV

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=275, Percent_Identity=22.9090909090909, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI31881687, Length=275, Percent_Identity=22.9090909090909, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI6677723, Length=236, Percent_Identity=23.728813559322, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI194306571, Length=239, Percent_Identity=23.4309623430962, Blast_Score=66, Evalue=9e-11,
Organism=Homo sapiens, GI194306567, Length=239, Percent_Identity=23.4309623430962, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1786676, Length=363, Percent_Identity=66.6666666666667, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1787341, Length=165, Percent_Identity=29.0909090909091, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=222, Percent_Identity=27.4774774774775, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=266, Percent_Identity=25.9398496240602, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324039, Length=241, Percent_Identity=23.2365145228216, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI18859927, Length=283, Percent_Identity=24.3816254416961, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO3X_HAEIN (P43746)

Other databases:

- EMBL:   L42023
- PIR:   F64111
- RefSeq:   NP_439385.1
- ProteinModelPortal:   P43746
- GeneID:   950174
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1229
- NMPDR:   fig|71421.1.peg.1175
- TIGR:   HI_1229
- HOGENOM:   HBG729459
- OMA:   FFYQVIV
- ProtClustDB:   PRK07994
- BioCyc:   HINF71421:HI_1229-MONOMER
- BRENDA:   2.7.7.7
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029
- SMART:   SM00382
- TIGRFAMs:   TIGR02397

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5; SSF48019 Pol_clamp_load_C

EC number: =2.7.7.7

Molecular weight: Translated: 77043; Mature: 76912

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPKTFADVVGQEHIITALANGLKDNRLHHAYLFSGTRGVGKTSIARLFAK
CCHHHHHHHCCCCHHHHHHCHHHHHHHHHHCHHCCCCEEEEEECCCCCCCHHHHHHHHHH
GLNCVHGVTATPCGECENCKAIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVVGRF
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPVTILSRCLQFHLKALDE
EEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
TQISQHLAHILTQENIPFEDPALVKLAKAAQGSIRDSLSLTDQAIAMGDRQVTNNVVSNM
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGLLDDNYSVDILYALHQGNGELLMRTLQRVADAAGDWDKLLGECAEKLHQIALMQLLPQ
HHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
KSSDNNEHFSFLAKHISPENVQFFYQVIVSGRKDLSNAPNRRIGAEMTLLRALAFHPKFL
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCHHH
TAVPKANTTITPPPSTPSAVENTGNYVDVPVLSQSIKSAYSQAKPNKTSIPNLASLSALD
HHCCCCCCEECCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
ALEHLTQLENQERQEHKAESLAVVSETLHHIQELDEEKSHKKMTALPVREMTEPKPKHIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
KPTLPSNAAQAPQKNSTEENSSDDNVEIAQDEQEILSADTYRWEWSNPELAKADTGVCPS
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHCCCCEEEECCCCCCCCCCCCCCHH
DIKQAILKDITPELRLKIITQTQQQDQWADIVERSGLTGFSKELALNCFLQSKTDDEINL
HHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEC
GLHSEKSHLRQDRSIKNLAEALSKLQGKDIRLTINLDDSNVTTPIEYRRNIYQALREKAQ
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
NELQKDSKLQILLNEFDAKLDVESIRPV
HHHHCCCHHHHHHHHHCCCCCHHHCCCC
>Mature Secondary Structure 
SYQVLARKWRPKTFADVVGQEHIITALANGLKDNRLHHAYLFSGTRGVGKTSIARLFAK
CHHHHHHHCCCCHHHHHHCHHHHHHHHHHCHHCCCCEEEEEECCCCCCCHHHHHHHHHH
GLNCVHGVTATPCGECENCKAIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVVGRF
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPVTILSRCLQFHLKALDE
EEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
TQISQHLAHILTQENIPFEDPALVKLAKAAQGSIRDSLSLTDQAIAMGDRQVTNNVVSNM
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
LGLLDDNYSVDILYALHQGNGELLMRTLQRVADAAGDWDKLLGECAEKLHQIALMQLLPQ
HHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
KSSDNNEHFSFLAKHISPENVQFFYQVIVSGRKDLSNAPNRRIGAEMTLLRALAFHPKFL
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCHHH
TAVPKANTTITPPPSTPSAVENTGNYVDVPVLSQSIKSAYSQAKPNKTSIPNLASLSALD
HHCCCCCCEECCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
ALEHLTQLENQERQEHKAESLAVVSETLHHIQELDEEKSHKKMTALPVREMTEPKPKHIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
KPTLPSNAAQAPQKNSTEENSSDDNVEIAQDEQEILSADTYRWEWSNPELAKADTGVCPS
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHCCCCEEEECCCCCCCCCCCCCCHH
DIKQAILKDITPELRLKIITQTQQQDQWADIVERSGLTGFSKELALNCFLQSKTDDEINL
HHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEC
GLHSEKSHLRQDRSIKNLAEALSKLQGKDIRLTINLDDSNVTTPIEYRRNIYQALREKAQ
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
NELQKDSKLQILLNEFDAKLDVESIRPV
HHHHCCCHHHHHHHHHCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800