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The map label for this gene is apt

Identifier: 16273149

GI number: 16273149

Start: 1299857

End: 1300399

Strand: Reverse

Name: apt

Synonym: HI1230

Alternate gene names: 16273149

Gene position: 1300399-1299857 (Counterclockwise)

Preceding gene: 16273150

Following gene: 16273148

Centisome position: 71.05

GC content: 35.91

Gene sequence:

>543_bases
ATGACTACACAACTTGATTTAATTAAATCTTCTATCAAATCAATTCCTAACTATCCAAAAGAAGGCATTATCTTCCGCGA
CATTACTACCCTTTTAGAAGTTCCAGCAGCTTTTAAAGCAACAATAGATCTTATTGTGGAACAATATCGCGATAAAGGAA
TTACCAAAGTGCTTGGAACTGAATCTCGTGGTTTTATTTTTGGTGCCCCCGTTGCCTTAGCACTAGGTTTACCTTTCGAA
TTAGTACGTAAACCTAAAAAATTACCACGTGAGACTATTTCGCAATCTTATCAATTAGAATATGGTCAAGATACTTTGGA
AATGCACGTTGATGCAATTTCAGAAGGTGACAATGTTTTAATTATTGATGATTTATTAGCAACTGGTGGCACAGTTGAAG
CGACAGTAAAATTAGTGCAACGTTTAGGTGGAGCGGTAAAACACGCTGCATTTGTGATTAATTTACCTGAATTAGGTGGC
GAAAAACGCTTAAATAATTTGGGCGTTGATTGCTATACACTCGTCAATTTTGAAGGTCATTAA

Upstream 100 bases:

>100_bases
CCCCAATTGGGGATTTTTATTTTCCTCTCTTTCTATTTTTTTATGATAGAATGCCAATCTAAAAACGTTTCTTTTTTTAC
CGCACTTTTGAGCATTATTT

Downstream 100 bases:

>100_bases
TTAAGGATTCGATGAGCTATCAAGTCTTAGCCAGAAAATGGCGACCAAAAACATTTGCTGATGTCGTTGGGCAAGAACAT
ATTATCACGGCATTAGCAAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTTQLDLIKSSIKSIPNYPKEGIIFRDITTLLEVPAAFKATIDLIVEQYRDKGITKVLGTESRGFIFGAPVALALGLPFE
LVRKPKKLPRETISQSYQLEYGQDTLEMHVDAISEGDNVLIIDDLLATGGTVEATVKLVQRLGGAVKHAAFVINLPELGG
EKRLNNLGVDCYTLVNFEGH

Sequences:

>Translated_180_residues
MTTQLDLIKSSIKSIPNYPKEGIIFRDITTLLEVPAAFKATIDLIVEQYRDKGITKVLGTESRGFIFGAPVALALGLPFE
LVRKPKKLPRETISQSYQLEYGQDTLEMHVDAISEGDNVLIIDDLLATGGTVEATVKLVQRLGGAVKHAAFVINLPELGG
EKRLNNLGVDCYTLVNFEGH
>Mature_179_residues
TTQLDLIKSSIKSIPNYPKEGIIFRDITTLLEVPAAFKATIDLIVEQYRDKGITKVLGTESRGFIFGAPVALALGLPFEL
VRKPKKLPRETISQSYQLEYGQDTLEMHVDAISEGDNVLIIDDLLATGGTVEATVKLVQRLGGAVKHAAFVINLPELGGE
KRLNNLGVDCYTLVNFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=179, Percent_Identity=39.1061452513966, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI71773201, Length=130, Percent_Identity=43.0769230769231, Blast_Score=112, Evalue=2e-25,
Organism=Escherichia coli, GI1786675, Length=177, Percent_Identity=66.1016949152542, Blast_Score=243, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=41.6184971098266, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=39.3063583815029, Blast_Score=111, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136334, Length=165, Percent_Identity=43.030303030303, Blast_Score=127, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_HAEI8 (Q4QJV7)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_249350.1
- ProteinModelPortal:   Q4QJV7
- SMR:   Q4QJV7
- STRING:   Q4QJV7
- GeneID:   3431190
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI1938
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q4QJV7
- ProtClustDB:   PRK02304
- BioCyc:   HINF281310:NTHI1938-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19710; Mature: 19579

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQLDLIKSSIKSIPNYPKEGIIFRDITTLLEVPAAFKATIDLIVEQYRDKGITKVLGT
CCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCC
ESRGFIFGAPVALALGLPFELVRKPKKLPRETISQSYQLEYGQDTLEMHVDAISEGDNVL
CCCCEEEECHHHHHHCCCHHHHHCCCCCCHHHHCCCEECCCCCHHHHHHHHHHCCCCCEE
IIDDLLATGGTVEATVKLVQRLGGAVKHAAFVINLPELGGEKRLNNLGVDCYTLVNFEGH
EEEHHHHCCCHHHHHHHHHHHHCHHHHHHEEEEECCCCCCHHHHHHCCCEEEEEEEECCC
>Mature Secondary Structure 
TTQLDLIKSSIKSIPNYPKEGIIFRDITTLLEVPAAFKATIDLIVEQYRDKGITKVLGT
CCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCC
ESRGFIFGAPVALALGLPFELVRKPKKLPRETISQSYQLEYGQDTLEMHVDAISEGDNVL
CCCCEEEECHHHHHHCCCHHHHHCCCCCCHHHHCCCEECCCCCHHHHHHHHHHCCCCCEE
IIDDLLATGGTVEATVKLVQRLGGAVKHAAFVINLPELGGEKRLNNLGVDCYTLVNFEGH
EEEHHHHCCCHHHHHHHHHHHHCHHHHHHEEEEECCCCCCHHHHHHCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA