Click here to switch to the map view.

The map label for this gene is upp [H]

Identifier: 16273147

GI number: 16273147

Start: 1297029

End: 1297655

Strand: Reverse

Name: upp [H]

Synonym: HI1228

Alternate gene names: 16273147

Gene position: 1297655-1297029 (Counterclockwise)

Preceding gene: 16273148

Following gene: 16273146

Centisome position: 70.9

GC content: 40.83

Gene sequence:

>627_bases
ATGAAACTGGTTGAAGTAAAACATCCACTTGTAAAACACAAACTAGGTGTGATGCGTGAAGCTGAGATTGATACAAAAAA
ATTCCGTGAACTTGCAACAGAAATCGGTAGCCTATTAACCTATGAAGCAACCTCTGATTTAGAAACTGAAAAAGTAACGA
TCAACGGTTGGAATGGGCCAGTAGAAATCGATCGAATTAAAGGTAAAAAAGTAACGGTTGTGCCAATTTTGCGTGCAGGT
TTAGGAATGATGGATGGTGTACTTGAACACGTACCAAGCGCACGCATCAGCGTAGTGGGGATCTACCGTAATGAAGAAAC
CCTTGAACCAGTTCCTTACTTCCAAAAATTAGCTAGCGATTTAGAAGAGCGACTTTCAATTGTTGTCGATCCGATGCTTG
CAACGGGCGGCTCTATGATTGCCACCCTTGATCTTTTAAAAGCAAAAGGTTGTAAACATATCAAAGTATTAGTGTTAGTC
GCTGCACCAGAAGGAATTAAAGCTCTTGAGGCTGCACACCCTGACATTGAACTTTACTGCGCTTCTATTGATAGCCATTT
AAATGAACAAGGTTACATTATTCCCGGTCTTGGTGACGCGGGCGATAAAATTTTTGGGACAAAATAA

Upstream 100 bases:

>100_bases
CCGTTTCAAGTCAGAATATTTTTATAAACCTCTACCATTTTGTATTTTTTTAATCTAGAATTTGTCAATTTGTTTTTTAA
GAGTCAAAAGGAGAGTAAAA

Downstream 100 bases:

>100_bases
TCCCCAAAACAAGACGGCATTTAAGCCGTCTTTTTTCCGTGCGTTGAAACACAAGAAAAACTGACCGCACTTTTAAGTTA
ATTCAAACAGAGAGTTGAAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKLVEVKHPLVKHKLGVMREAEIDTKKFRELATEIGSLLTYEATSDLETEKVTINGWNGPVEIDRIKGKKVTVVPILRAG
LGMMDGVLEHVPSARISVVGIYRNEETLEPVPYFQKLASDLEERLSIVVDPMLATGGSMIATLDLLKAKGCKHIKVLVLV
AAPEGIKALEAAHPDIELYCASIDSHLNEQGYIIPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKLVEVKHPLVKHKLGVMREAEIDTKKFRELATEIGSLLTYEATSDLETEKVTINGWNGPVEIDRIKGKKVTVVPILRAG
LGMMDGVLEHVPSARISVVGIYRNEETLEPVPYFQKLASDLEERLSIVVDPMLATGGSMIATLDLLKAKGCKHIKVLVLV
AAPEGIKALEAAHPDIELYCASIDSHLNEQGYIIPGLGDAGDKIFGTK
>Mature_208_residues
MKLVEVKHPLVKHKLGVMREAEIDTKKFRELATEIGSLLTYEATSDLETEKVTINGWNGPVEIDRIKGKKVTVVPILRAG
LGMMDGVLEHVPSARISVVGIYRNEETLEPVPYFQKLASDLEERLSIVVDPMLATGGSMIATLDLLKAKGCKHIKVLVLV
AAPEGIKALEAAHPDIELYCASIDSHLNEQGYIIPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=26.7326732673267, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=26.7326732673267, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=83.1730769230769, Blast_Score=362, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.3731343283582, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.3731343283582, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=39.8550724637681, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=26.6009852216749, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=26.6009852216749, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=26.6009852216749, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=26.6009852216749, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22665; Mature: 22665

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVEVKHPLVKHKLGVMREAEIDTKKFRELATEIGSLLTYEATSDLETEKVTINGWNGP
CCEECCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHEEECCCCCCCCCEEEEECCCCC
VEIDRIKGKKVTVVPILRAGLGMMDGVLEHVPSARISVVGIYRNEETLEPVPYFQKLASD
EEEEEECCCEEEEEHHHHHCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
LEERLSIVVDPMLATGGSMIATLDLLKAKGCKHIKVLVLVAAPEGIKALEAAHPDIELYC
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHCCCCCEEEE
ASIDSHLNEQGYIIPGLGDAGDKIFGTK
EEHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKLVEVKHPLVKHKLGVMREAEIDTKKFRELATEIGSLLTYEATSDLETEKVTINGWNGP
CCEECCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHEEECCCCCCCCCEEEEECCCCC
VEIDRIKGKKVTVVPILRAGLGMMDGVLEHVPSARISVVGIYRNEETLEPVPYFQKLASD
EEEEEECCCEEEEEHHHHHCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
LEERLSIVVDPMLATGGSMIATLDLLKAKGCKHIKVLVLVAAPEGIKALEAAHPDIELYC
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHCCCCCEEEE
ASIDSHLNEQGYIIPGLGDAGDKIFGTK
EEHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA