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The map label for this gene is lctP [C]

Identifier: 16273137

GI number: 16273137

Start: 1287584

End: 1289182

Strand: Reverse

Name: lctP [C]

Synonym: HI1218

Alternate gene names: 16273137

Gene position: 1289182-1287584 (Counterclockwise)

Preceding gene: 16273145

Following gene: 16273136

Centisome position: 70.44

GC content: 35.46

Gene sequence:

>1599_bases
ATGCTGTCTTTTATTCTAAGTATTTTTCCTATCGTTTTACTGATTTATCTTATGGTAAAAAGAAACGCGCTACCTTCTTA
TGTTGCCTTACCTTGGGTTGCGACATTAGTTATGGGTGTTCATCTTTTACACTTTAATACAGATATTGTCACTATTAGTG
CAAATGTTGTTTCTGCAATTATTGCGGTACAAACACCTATTACAGTAATTTTTGGTGCGATTCTCTTTAACCGTTTCTCT
GAAATTTCAGGCGCAACAAATATTATGCGAAAATGGCTAGGAAATATTAATCCAAATCCCGTTGCACAATTAATGATTAT
TGGTTGGGCGTTTGCTTTTATGATCGAGGGAGCAAGTGGTTTTGGTACACCAGCGGCAATTGCTGCACCTATTTTAGTGG
GATTAGGTTTTCATCCATTAAAAGTGGCGATGTTGGCACTTATTATGAACTCAGTTCCCGTATCCTTTGGTGCGGTAGGT
ACACCAACTTGGTTTGGTTTTGGTGCTTTAAAATTATCAGAAGATATGATTTTAGAAATTGGGTCTATTACAGCATTTAT
ACACTCCATTGCTGCACTTATTATCCCATTATTAGCACTTCGTATCTTAGTAAATTGGGATGATATTCGTAAAAACATCG
TATTTATCTATATTAGCGTACTGGGTTGCGTAGTACCTTATTTCTTGATTGCTCAAGTCAATTACGAATTTCCATCACTC
GTTGGGGGGGCAATCGGCTTATTTATTTCTGTATGGGCTGCTAATCGCAATATTGGTTTAGCAAAAGTAACAAATACCCT
TGATAATAATGCGGTAAGTGCAGGAGAAGTAGTTAAAGCATTATTTCCGACAGGTTTACTTATTGCATTTTTAATTGTGA
CTCGTATTCATCAATTACCATTCAAAGCAATGATGAATGACGCAACTATTTGGTTCTCAACCACATTAGGTTCGTTAGGA
TTATTTGAAATTAGCAAAGGTTTAATCTTTAGCTTAAAAAATATTTTTGGCTCAAATGTTTCATCAAGCTATAAACTTCT
TTACGTACCCGCATTGATTCCATTTGTCATTACAGTACTAATTGCGATTCCTTTCTTTAAAATTTCCAGTTCAAATGTTA
AACAGATTTTGGTATCAAGTTTACAACAATCTAAAAATCCATTTATTGCCTTAATTGGTGCCTTAGTGATGGTAAACCTA
ATGTTAGTGGGTGGCGAACATTCTATGGTAAAAATTATAGGTAGAACTTTTGCTGAAATTTCTGGTAGTAACTGGACTAT
TTTCTCCTCTTTCTTAGGCGCGATTGGTTCCTTTTTCTCAGGTTCAAATACCGTATCCAACCTAACATTTGGTAGTGTTC
AACTTTCTACCGCAGAAACAACAGGCATTTCTGTCGCACTTGTTCTTGCTTTACAATCTGTTGGTGGGGCAATGGGGAAT
ATGGTATGTATAAATAACATTGTAGCGGTAAGTTCAGTGTTAAATATTTCAAACCAAGAAGGCACAATTATTAAGAAAAC
CATTATACCTATGATCATTTACGGTATCATTGCCGCACTTGGCGCGCTGTTCTTAGTACCTTTATTTTATAATCTATAA

Upstream 100 bases:

>100_bases
TTTTATGAGATATTGATCACATTTTCTTAAAATAGGTATATGCTTTGCATATAAATCCATAAAATAATCACATCTTTTAA
TCTAACTCTGAGGATATTTT

Downstream 100 bases:

>100_bases
AATTTACGCCAAAAATGACCGCACTTTTGCGGTCATTTCCTATTTTAAAGTGCGGTTGATTTTGCGAATGAATTTGTCCA
TTTTGCAAAAACCAAACTTT

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MLSFILSIFPIVLLIYLMVKRNALPSYVALPWVATLVMGVHLLHFNTDIVTISANVVSAIIAVQTPITVIFGAILFNRFS
EISGATNIMRKWLGNINPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILVGLGFHPLKVAMLALIMNSVPVSFGAVG
TPTWFGFGALKLSEDMILEIGSITAFIHSIAALIIPLLALRILVNWDDIRKNIVFIYISVLGCVVPYFLIAQVNYEFPSL
VGGAIGLFISVWAANRNIGLAKVTNTLDNNAVSAGEVVKALFPTGLLIAFLIVTRIHQLPFKAMMNDATIWFSTTLGSLG
LFEISKGLIFSLKNIFGSNVSSSYKLLYVPALIPFVITVLIAIPFFKISSSNVKQILVSSLQQSKNPFIALIGALVMVNL
MLVGGEHSMVKIIGRTFAEISGSNWTIFSSFLGAIGSFFSGSNTVSNLTFGSVQLSTAETTGISVALVLALQSVGGAMGN
MVCINNIVAVSSVLNISNQEGTIIKKTIIPMIIYGIIAALGALFLVPLFYNL

Sequences:

>Translated_532_residues
MLSFILSIFPIVLLIYLMVKRNALPSYVALPWVATLVMGVHLLHFNTDIVTISANVVSAIIAVQTPITVIFGAILFNRFS
EISGATNIMRKWLGNINPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILVGLGFHPLKVAMLALIMNSVPVSFGAVG
TPTWFGFGALKLSEDMILEIGSITAFIHSIAALIIPLLALRILVNWDDIRKNIVFIYISVLGCVVPYFLIAQVNYEFPSL
VGGAIGLFISVWAANRNIGLAKVTNTLDNNAVSAGEVVKALFPTGLLIAFLIVTRIHQLPFKAMMNDATIWFSTTLGSLG
LFEISKGLIFSLKNIFGSNVSSSYKLLYVPALIPFVITVLIAIPFFKISSSNVKQILVSSLQQSKNPFIALIGALVMVNL
MLVGGEHSMVKIIGRTFAEISGSNWTIFSSFLGAIGSFFSGSNTVSNLTFGSVQLSTAETTGISVALVLALQSVGGAMGN
MVCINNIVAVSSVLNISNQEGTIIKKTIIPMIIYGIIAALGALFLVPLFYNL
>Mature_532_residues
MLSFILSIFPIVLLIYLMVKRNALPSYVALPWVATLVMGVHLLHFNTDIVTISANVVSAIIAVQTPITVIFGAILFNRFS
EISGATNIMRKWLGNINPNPVAQLMIIGWAFAFMIEGASGFGTPAAIAAPILVGLGFHPLKVAMLALIMNSVPVSFGAVG
TPTWFGFGALKLSEDMILEIGSITAFIHSIAALIIPLLALRILVNWDDIRKNIVFIYISVLGCVVPYFLIAQVNYEFPSL
VGGAIGLFISVWAANRNIGLAKVTNTLDNNAVSAGEVVKALFPTGLLIAFLIVTRIHQLPFKAMMNDATIWFSTTLGSLG
LFEISKGLIFSLKNIFGSNVSSSYKLLYVPALIPFVITVLIAIPFFKISSSNVKQILVSSLQQSKNPFIALIGALVMVNL
MLVGGEHSMVKIIGRTFAEISGSNWTIFSSFLGAIGSFFSGSNTVSNLTFGSVQLSTAETTGISVALVLALQSVGGAMGN
MVCINNIVAVSSVLNISNQEGTIIKKTIIPMIIYGIIAALGALFLVPLFYNL

Specific function: May play a role in L-lactate transport

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family

Homologues:

Organism=Escherichia coli, GI1790031, Length=549, Percent_Identity=26.0473588342441, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1789347, Length=262, Percent_Identity=26.3358778625954, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1218_HAEIN (Q57251)

Other databases:

- EMBL:   L42023
- PIR:   H64110
- RefSeq:   NP_439374.1
- GeneID:   950748
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1218
- NMPDR:   fig|71421.1.peg.1164
- TIGR:   HI_1218
- HOGENOM:   HBG457300
- OMA:   MNDATTW
- ProtClustDB:   CLSK870639
- BioCyc:   HINF71421:HI_1218-MONOMER
- InterPro:   IPR003804
- TIGRFAMs:   TIGR00795

Pfam domain/function: PF02652 Lactate_perm

EC number: NA

Molecular weight: Translated: 56886; Mature: 56886

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd6cefc8)-; HASH(0xe15aad8)-; HASH(0xe11de5c)-; HASH(0xd76e4f4)-; HASH(0xe144c28)-; HASH(0xd0de41c)-; HASH(0xe2f9408)-; HASH(0xdd548d0)-; HASH(0xcf000e0)-; HASH(0xde7c030)-; HASH(0xc4a2478)-; HASH(0xe34a84c)-; HASH(0xc4ca188)-; HASH(0xb706624)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFILSIFPIVLLIYLMVKRNALPSYVALPWVATLVMGVHLLHFNTDIVTISANVVSAI
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCCEEEEEHHHHHHH
IAVQTPITVIFGAILFNRFSEISGATNIMRKWLGNINPNPVAQLMIIGWAFAFMIEGASG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
FGTPAAIAAPILVGLGFHPLKVAMLALIMNSVPVSFGAVGTPTWFGFGALKLSEDMILEI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCHHEECHHHHHHH
GSITAFIHSIAALIIPLLALRILVNWDDIRKNIVFIYISVLGCVVPYFLIAQVNYEFPSL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VGGAIGLFISVWAANRNIGLAKVTNTLDNNAVSAGEVVKALFPTGLLIAFLIVTRIHQLP
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
FKAMMNDATIWFSTTLGSLGLFEISKGLIFSLKNIFGSNVSSSYKLLYVPALIPFVITVL
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHH
IAIPFFKISSSNVKQILVSSLQQSKNPFIALIGALVMVNLMLVGGEHSMVKIIGRTFAEI
HHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
SGSNWTIFSSFLGAIGSFFSGSNTVSNLTFGSVQLSTAETTGISVALVLALQSVGGAMGN
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHHHCCHHCC
MVCINNIVAVSSVLNISNQEGTIIKKTIIPMIIYGIIAALGALFLVPLFYNL
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MLSFILSIFPIVLLIYLMVKRNALPSYVALPWVATLVMGVHLLHFNTDIVTISANVVSAI
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCCEEEEEHHHHHHH
IAVQTPITVIFGAILFNRFSEISGATNIMRKWLGNINPNPVAQLMIIGWAFAFMIEGASG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
FGTPAAIAAPILVGLGFHPLKVAMLALIMNSVPVSFGAVGTPTWFGFGALKLSEDMILEI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCHHEECHHHHHHH
GSITAFIHSIAALIIPLLALRILVNWDDIRKNIVFIYISVLGCVVPYFLIAQVNYEFPSL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VGGAIGLFISVWAANRNIGLAKVTNTLDNNAVSAGEVVKALFPTGLLIAFLIVTRIHQLP
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
FKAMMNDATIWFSTTLGSLGLFEISKGLIFSLKNIFGSNVSSSYKLLYVPALIPFVITVL
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHH
IAIPFFKISSSNVKQILVSSLQQSKNPFIALIGALVMVNLMLVGGEHSMVKIIGRTFAEI
HHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
SGSNWTIFSSFLGAIGSFFSGSNTVSNLTFGSVQLSTAETTGISVALVLALQSVGGAMGN
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHHHCCHHCC
MVCINNIVAVSSVLNISNQEGTIIKKTIIPMIIYGIIAALGALFLVPLFYNL
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800