Click here to switch to the map view.

The map label for this gene is serC

Identifier: 16273091

GI number: 16273091

Start: 1238101

End: 1239189

Strand: Reverse

Name: serC

Synonym: HI1167

Alternate gene names: 16273091

Gene position: 1239189-1238101 (Counterclockwise)

Preceding gene: 16273099

Following gene: 16273090

Centisome position: 67.71

GC content: 38.93

Gene sequence:

>1089_bases
ATGTCACAAGTCTTTAATTTTAGCGCAGGCCCTGCGATGATTTTCCCAGAAGTGTTGCAAAAAGCACAAAATGAACTTAT
AAACTGGCTCAATCAAGGTGTTTCTGTAATGGAAGTAAGCCATCGCGGAAAGTATTTTATGGAACTCGTTACCCAAGCGG
AAAAAGATCTACGTGAGGTTTACAATATTCCTGATAACTATCGTACACTTTTCTTACAAGGTGGTGCTCGCGGTCAATTT
GCCACCATTCCGATGAACTTAATCGGTAAAAAAGGCAAAGCCCTTTATTTAAATAGTGGGCATTGGTCAGCTACAGCGGC
AAAAGAAGCAAGAAATTTTGCAGAAATTGATGAAATCACTATCGTAGAAAATGGCGAACAGACTCGAATTACCGATCTTG
ATTTTAGCCATATCGCTGATCAATATGACTACGTTCATTATTGCCCGAATGAAACCATCAGTGGTGTGGAGATTTTTGAT
GTGCCAAATGTGGGCAATGCCGTATTGGTCGCGGATATGTCTTCAAATATTCTTTCACGTCAAATCGATATCAGTAAATT
TGGGGTAATTTATGCTGGTGCGCAAAAAAATCTTGGCCCTGCGGGCATTACATTAGTCATTATTCGTGATGATTTAATCG
GTAATGCACGTAAAGAAACCCCATCTATTTGGAATTATGCAACTCAACGTGATGCAGATTCAATGATCAACACGCCCCCA
ACTTTTGCGTGGTATTTATGTTCCCTCGTATTTAAACATCTTAAAGAAATAGGCGGCTTAGAAATAATCGAAAAACGTAA
TGCACTAAAAGCACAAACCCTTTATGATTATATTGATTCGAGCAAACTTTATCGCAATGTGGTAGCAAAAGAAAACCGCT
CAACAATGAATGTCACTTTCATCACAGGTAATCCTGAATTAGATGCAAAATTTGTCGCAGAGTCTACTGCTGCTGGCTTG
CAAGCCTTGAAAGGTCATAAGGTTTTAGGTGGAATGCGCGCATCTATTTATAACGCAATGTCGCAAAATGGTGTTGAGGC
ACTCATTTCATTTATGAAAAAATTTGAAACTGAAAATCTTCCTCAATAG

Upstream 100 bases:

>100_bases
GATAGAAAGAATTTTTTTGATTTCAGTAAAAAGCATTGATTATCGATTTTTGTAGTGATAAAAAAGACATCATTATTTTC
ATAAAAAGCAAGGAAATACA

Downstream 100 bases:

>100_bases
GAAAAACATTTCCAATGGGCGTATTTACTACGCCCAAATTTATTTAAAAATACATACTAACCCATATCAATATTTATAAA
TACAACTATGCAGTACATCA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSQVFNFSAGPAMIFPEVLQKAQNELINWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRTLFLQGGARGQF
ATIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFD
VPNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPP
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTAAGL
QALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENLPQ

Sequences:

>Translated_362_residues
MSQVFNFSAGPAMIFPEVLQKAQNELINWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRTLFLQGGARGQF
ATIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFD
VPNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPP
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTAAGL
QALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENLPQ
>Mature_361_residues
SQVFNFSAGPAMIFPEVLQKAQNELINWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRTLFLQGGARGQFA
TIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDV
PNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPPT
FAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTAAGLQ
ALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENLPQ

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=360, Percent_Identity=45.5555555555556, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI10863955, Length=355, Percent_Identity=41.6901408450704, Blast_Score=274, Evalue=8e-74,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=53.2033426183844, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17506897, Length=357, Percent_Identity=42.5770308123249, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=38.7012987012987, Blast_Score=242, Evalue=6e-65,
Organism=Drosophila melanogaster, GI21356589, Length=362, Percent_Identity=45.0276243093923, Blast_Score=301, Evalue=7e-82,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_HAEIN (P44336)

Other databases:

- EMBL:   L42023
- PIR:   E64187
- RefSeq:   NP_439325.1
- ProteinModelPortal:   P44336
- SMR:   P44336
- GeneID:   949636
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1167
- NMPDR:   fig|71421.1.peg.1120
- TIGR:   HI_1167
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   HINF71421:HI_1167-MONOMER
- BRENDA:   2.6.1.52
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40313; Mature: 40182

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 152-152 BINDING 172-172 BINDING 195-195

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVFNFSAGPAMIFPEVLQKAQNELINWLNQGVSVMEVSHRGKYFMELVTQAEKDLREV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHH
YNIPDNYRTLFLQGGARGQFATIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEIT
HCCCCCCEEEEEECCCCCCEEECCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEE
IVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDVPNVGNAVLVADMSSNILSR
EEECCCCCEEECCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCCHHHHH
QIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPP
HCCHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHCCCCC
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTF
HHHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
ITGNPELDAKFVAESTAAGLQALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENL
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
PQ
CC
>Mature Secondary Structure 
SQVFNFSAGPAMIFPEVLQKAQNELINWLNQGVSVMEVSHRGKYFMELVTQAEKDLREV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHH
YNIPDNYRTLFLQGGARGQFATIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEIT
HCCCCCCEEEEEECCCCCCEEECCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEE
IVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDVPNVGNAVLVADMSSNILSR
EEECCCCCEEECCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCCHHHHH
QIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPP
HCCHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHCCCCC
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTF
HHHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
ITGNPELDAKFVAESTAAGLQALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENL
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
PQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800