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The map label for this gene is hisH [H]

Identifier: 16273090

GI number: 16273090

Start: 1236913

End: 1238013

Strand: Reverse

Name: hisH [H]

Synonym: HI1166

Alternate gene names: 16273090

Gene position: 1238013-1236913 (Counterclockwise)

Preceding gene: 16273091

Following gene: 16273087

Centisome position: 67.65

GC content: 35.33

Gene sequence:

>1101_bases
ATGCAGTACATCAACATTGCCAATCGTGGCGTAAAATCCTTATCCCCTTATCAAGCAGGCAAACCTATTGAAGAATTGGA
ACGAGAACTTGGTATTTCCAATATCGTTAAACTTGCCTCAAACGAAAACCCATTTGGTTTTCCAGAAAGTGCAAAAAAAG
CAATTTTCGAACAATTAGATAAACTAACTCGTTATCCAGATGCGAATGGCTTTGAATTAAAACAAACTATCGCAAAAAAA
TTTGGCGTTCAACCAAATCAAATTACGCTTGGAAATGGCTCAAATGATTTATTAGAACTTTTTGCTCACACTTTCGCAAC
GGAAGGCGATGAAATCATGTATTCACAATATGCCTTTATTGTGTATCCTTTAGTAACTAAAGCGATTAATGCAATTGTAA
AAGAAATTCCAGCTAAAAATTGGGGGCACGATTTACAAGGATTTTTGACCGCACTTTCTGATAAAACAAAGCTCATTTAC
ATTGCTAATCCCAATAATCCAACGGGTAATTTTTTAACCTCGCAAGAAATTGAAGATTTTTTAGCAGAAGTCCCCGAAAA
TGTAATCGTGGTATTAGATGAAGCCTACACAGAATTTACTAGATCTGAAGAACGAGTGGACTCTTTCAGTTTATTAAAAA
AATATTCAAATTTAATTATTTCACGTTCTCTTTCCAAAGCCTATGGCTTGGCAGGCTTACGCATTGGTTATGCGGTATCT
AATCCCGAAATCGCAGATTTATTAAATCGAGTTCGACAGCCATTTAACTGTAATTCTTTGGCATTAACCGCTGCTGTTGC
CGTAATGAATGACGATAAATTTGTTGAAAAAGTTGCTGAAAATAATCGAATAGAAATGCGACGTTATGAAGACTTTTGTC
AAAAAAATCAATTGGATTATATTCCCTCTAAAGGAAATTTTATAACCATTGATTTCAAACAACCTGCCGCACCAATTTAT
GATGCGTTGTTACGAGAAGGCGTAATCGTTCGCCCAATTGCTGGTTATGGCATGCCGAATCATTTACGTATAAGTATTGG
TTTACCTGAAGAAAACGATAAATTTTTCACCGCACTTTCTAAGGTATTAAAGTTTGCTTAA

Upstream 100 bases:

>100_bases
TCTTCCTCAATAGGAAAAACATTTCCAATGGGCGTATTTACTACGCCCAAATTTATTTAAAAATACATACTAACCCATAT
CAATATTTATAAATACAACT

Downstream 100 bases:

>100_bases
TCTATTATTTAATAATGAAAGGGAAATTTATTATATAAAAAACCCGCTTATTGCGGGTTTTATTTTTCCACTGTTATTAA
GCGTGCTTTGCTGCCACTTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MQYINIANRGVKSLSPYQAGKPIEELERELGISNIVKLASNENPFGFPESAKKAIFEQLDKLTRYPDANGFELKQTIAKK
FGVQPNQITLGNGSNDLLELFAHTFATEGDEIMYSQYAFIVYPLVTKAINAIVKEIPAKNWGHDLQGFLTALSDKTKLIY
IANPNNPTGNFLTSQEIEDFLAEVPENVIVVLDEAYTEFTRSEERVDSFSLLKKYSNLIISRSLSKAYGLAGLRIGYAVS
NPEIADLLNRVRQPFNCNSLALTAAVAVMNDDKFVEKVAENNRIEMRRYEDFCQKNQLDYIPSKGNFITIDFKQPAAPIY
DALLREGVIVRPIAGYGMPNHLRISIGLPEENDKFFTALSKVLKFA

Sequences:

>Translated_366_residues
MQYINIANRGVKSLSPYQAGKPIEELERELGISNIVKLASNENPFGFPESAKKAIFEQLDKLTRYPDANGFELKQTIAKK
FGVQPNQITLGNGSNDLLELFAHTFATEGDEIMYSQYAFIVYPLVTKAINAIVKEIPAKNWGHDLQGFLTALSDKTKLIY
IANPNNPTGNFLTSQEIEDFLAEVPENVIVVLDEAYTEFTRSEERVDSFSLLKKYSNLIISRSLSKAYGLAGLRIGYAVS
NPEIADLLNRVRQPFNCNSLALTAAVAVMNDDKFVEKVAENNRIEMRRYEDFCQKNQLDYIPSKGNFITIDFKQPAAPIY
DALLREGVIVRPIAGYGMPNHLRISIGLPEENDKFFTALSKVLKFA
>Mature_366_residues
MQYINIANRGVKSLSPYQAGKPIEELERELGISNIVKLASNENPFGFPESAKKAIFEQLDKLTRYPDANGFELKQTIAKK
FGVQPNQITLGNGSNDLLELFAHTFATEGDEIMYSQYAFIVYPLVTKAINAIVKEIPAKNWGHDLQGFLTALSDKTKLIY
IANPNNPTGNFLTSQEIEDFLAEVPENVIVVLDEAYTEFTRSEERVDSFSLLKKYSNLIISRSLSKAYGLAGLRIGYAVS
NPEIADLLNRVRQPFNCNSLALTAAVAVMNDDKFVEKVAENNRIEMRRYEDFCQKNQLDYIPSKGNFITIDFKQPAAPIY
DALLREGVIVRPIAGYGMPNHLRISIGLPEENDKFFTALSKVLKFA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=365, Percent_Identity=29.8630136986301, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788627, Length=218, Percent_Identity=27.0642201834862, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=345, Percent_Identity=25.2173913043478, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=345, Percent_Identity=25.5072463768116, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=367, Percent_Identity=27.7929155313352, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41053; Mature: 41053

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYINIANRGVKSLSPYQAGKPIEELERELGISNIVKLASNENPFGFPESAKKAIFEQLD
CCEECCCCCCHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KLTRYPDANGFELKQTIAKKFGVQPNQITLGNGSNDLLELFAHTFATEGDEIMYSQYAFI
HHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
VYPLVTKAINAIVKEIPAKNWGHDLQGFLTALSDKTKLIYIANPNNPTGNFLTSQEIEDF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHH
LAEVPENVIVVLDEAYTEFTRSEERVDSFSLLKKYSNLIISRSLSKAYGLAGLRIGYAVS
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
NPEIADLLNRVRQPFNCNSLALTAAVAVMNDDKFVEKVAENNRIEMRRYEDFCQKNQLDY
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
IPSKGNFITIDFKQPAAPIYDALLREGVIVRPIAGYGMPNHLRISIGLPEENDKFFTALS
CCCCCCEEEEECCCCCHHHHHHHHHCCEEEEEHHCCCCCCEEEEEEECCCCCCHHHHHHH
KVLKFA
HHHHCC
>Mature Secondary Structure
MQYINIANRGVKSLSPYQAGKPIEELERELGISNIVKLASNENPFGFPESAKKAIFEQLD
CCEECCCCCCHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KLTRYPDANGFELKQTIAKKFGVQPNQITLGNGSNDLLELFAHTFATEGDEIMYSQYAFI
HHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
VYPLVTKAINAIVKEIPAKNWGHDLQGFLTALSDKTKLIYIANPNNPTGNFLTSQEIEDF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHH
LAEVPENVIVVLDEAYTEFTRSEERVDSFSLLKKYSNLIISRSLSKAYGLAGLRIGYAVS
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
NPEIADLLNRVRQPFNCNSLALTAAVAVMNDDKFVEKVAENNRIEMRRYEDFCQKNQLDY
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
IPSKGNFITIDFKQPAAPIYDALLREGVIVRPIAGYGMPNHLRISIGLPEENDKFFTALS
CCCCCCEEEEECCCCCHHHHHHHHHCCEEEEEHHCCCCCCEEEEEEECCCCCCHHHHHHH
KVLKFA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA