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The map label for this gene is msrA [H]

Identifier: 162149389

GI number: 162149389

Start: 3703038

End: 3703742

Strand: Direct

Name: msrA [H]

Synonym: GDI_3623

Alternate gene names: 162149389

Gene position: 3703038-3703742 (Clockwise)

Preceding gene: 162149388

Following gene: 162149391

Centisome position: 93.89

GC content: 65.96

Gene sequence:

>705_bases
ATGACACGGTCAGGACTACTCGGCATCTCGCTCATTGCCATGGGGGCGCTCGGCACGGCGTGCCATGCCGCGGACGCGCC
GCTCGCCACGCGTCTGCCGCCGCCGGCAGCCGCCGAAGCGCCCGCGACGACCCATCGTGCCACCGCCGTCTTCGCCGGAG
GATGTTTCTGGGGCGTCCAGAGTGTCTTCCAGCACATACGCGGCGTGACCGCGACGCGCGCGGGATATGACGGCGGAACG
AAGGACACCGCCGAATACGAGACCGTCAGCGGCGGCGATACGGGGCACGCGGAATCGGTCGCGGTCGAATACGACCCGAC
GCAGGTCGGTTACGGCACGCTGATGCAGATCTTCTTCTCGGTCGCACTGGACCCTACGCAGGTGAACAGGCAATTTCCGG
ATGTCGGCAGCCAGTATCGCTCCGCCCTGTTCACCCGCACGCCGGAGCAGGCGACGGCGGCGCGCGCCTATATCCGGCAG
CTGAATGCCGCGCATGTCTTCGCGCGCCCGATCGCAACGCAGATCGTTCCGGATCATGGCTTCTATCCGGCCGAGGAGTA
TCACCAGAATTTCGCGGCCCGCCATCCGGAAGATTCCTACATCGCAACGTATGACGCCCCTCGGATCGAGGCGCTGAAGA
TGGTATACGGCGCACAGTATCGCGATGACCCGATCCTGACGCTTGCCGCGCCCGGCGGACCGTAA

Upstream 100 bases:

>100_bases
CTCCGCTCCGGTGCTCGGGAACACACGCCGGGCGCGGCCTATCGGGCCGCTCTCGCTCACCAGCTCACATTTTCGGTCAG
GCTCTGAGAGGACCAAAACC

Downstream 100 bases:

>100_bases
GGGCGGGGGCGGCAGCAACAGGAGCAAGAGTGACGGAAGCCGAATGGAGTCACTGGATGGCGGCCGCCCAGCAGGGCGAC
GCCAATGCCTATCGGCTTGT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTRSGLLGISLIAMGALGTACHAADAPLATRLPPPAAAEAPATTHRATAVFAGGCFWGVQSVFQHIRGVTATRAGYDGGT
KDTAEYETVSGGDTGHAESVAVEYDPTQVGYGTLMQIFFSVALDPTQVNRQFPDVGSQYRSALFTRTPEQATAARAYIRQ
LNAAHVFARPIATQIVPDHGFYPAEEYHQNFAARHPEDSYIATYDAPRIEALKMVYGAQYRDDPILTLAAPGGP

Sequences:

>Translated_234_residues
MTRSGLLGISLIAMGALGTACHAADAPLATRLPPPAAAEAPATTHRATAVFAGGCFWGVQSVFQHIRGVTATRAGYDGGT
KDTAEYETVSGGDTGHAESVAVEYDPTQVGYGTLMQIFFSVALDPTQVNRQFPDVGSQYRSALFTRTPEQATAARAYIRQ
LNAAHVFARPIATQIVPDHGFYPAEEYHQNFAARHPEDSYIATYDAPRIEALKMVYGAQYRDDPILTLAAPGGP
>Mature_233_residues
TRSGLLGISLIAMGALGTACHAADAPLATRLPPPAAAEAPATTHRATAVFAGGCFWGVQSVFQHIRGVTATRAGYDGGTK
DTAEYETVSGGDTGHAESVAVEYDPTQVGYGTLMQIFFSVALDPTQVNRQFPDVGSQYRSALFTRTPEQATAARAYIRQL
NAAHVFARPIATQIVPDHGFYPAEEYHQNFAARHPEDSYIATYDAPRIEALKMVYGAQYRDDPILTLAAPGGP

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=151, Percent_Identity=38.4105960264901, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI208609995, Length=151, Percent_Identity=38.4105960264901, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=38.3177570093458, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790665, Length=151, Percent_Identity=45.6953642384106, Blast_Score=125, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320881, Length=155, Percent_Identity=35.4838709677419, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664627, Length=168, Percent_Identity=31.547619047619, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664631, Length=168, Percent_Identity=30.952380952381, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45553131, Length=149, Percent_Identity=32.2147651006711, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24976; Mature: 24845

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSGLLGISLIAMGALGTACHAADAPLATRLPPPAAAEAPATTHRATAVFAGGCFWGVQ
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHEEEECHHHHHHH
SVFQHIRGVTATRAGYDGGTKDTAEYETVSGGDTGHAESVAVEYDPTQVGYGTLMQIFFS
HHHHHHCCCHHHCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHH
VALDPTQVNRQFPDVGSQYRSALFTRTPEQATAARAYIRQLNAAHVFARPIATQIVPDHG
HHCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FYPAEEYHQNFAARHPEDSYIATYDAPRIEALKMVYGAQYRDDPILTLAAPGGP
CCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
TRSGLLGISLIAMGALGTACHAADAPLATRLPPPAAAEAPATTHRATAVFAGGCFWGVQ
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHEEEECHHHHHHH
SVFQHIRGVTATRAGYDGGTKDTAEYETVSGGDTGHAESVAVEYDPTQVGYGTLMQIFFS
HHHHHHCCCHHHCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHH
VALDPTQVNRQFPDVGSQYRSALFTRTPEQATAARAYIRQLNAAHVFARPIATQIVPDHG
HHCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FYPAEEYHQNFAARHPEDSYIATYDAPRIEALKMVYGAQYRDDPILTLAAPGGP
CCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]