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The map label for this gene is purK [H]

Identifier: 162147508

GI number: 162147508

Start: 1747534

End: 1748682

Strand: Reverse

Name: purK [H]

Synonym: GDI_1724

Alternate gene names: 162147508

Gene position: 1748682-1747534 (Counterclockwise)

Preceding gene: 162147509

Following gene: 162147506

Centisome position: 44.34

GC content: 69.45

Gene sequence:

>1149_bases
ATGAGCGCCCCCTTCCCCGAAGCCCTGCCCGCCGGGGCGGTGCTGGGCATCGTCGGCGGCGGCCAGTTGGGCCGGATGTC
GGCCGTCGCCGCCGCCCAACTGGGGTTTCGCGCCCACATCCTGACCGACGAGGCCGAGGGACCGGCCGCCCAGGTCGCCC
ACGCCGTCACGGTCGGCGCCTATGACGACCCCGACGTGCTGCGACGCTTCGCCTCGTCCGTCGATGTCGTGACGTTCGAA
TTCGAGAATATCAGCGCCGATGGGCTGGAACTGCTGGCCGGCCTGTGTCCCGTCCGCCCGTCGGGCCGCATCCTGCGCAT
CAGCCAGGATCGCATCGCGGAGAAACGGTTCCTGGCCGGGGCGGGAATTCCCCTGGCCCCGTGGGCCGAAATCCATACGC
CGCAGGATCTCGACACCGCGATCGCGACACTGGGCCTGCCCTTCATCCTGAAGACCACCCGGCTGGGCTATGACGGCAAG
GGGCAGCACCGCGTGCACGCCCCGGACGAGGCCCTGCCGGGCTTCCATGCCCTGGCCCCGCATCCCCTGGTGGCCGAGGC
GATGATCGATTTCGCATGCGAAGTCAGCGTGATGGTCGCGCGCGGGCTGGACGGCACGGCCGTGACCTTCGACGTGACCG
AGAACCGCCACCGGAACGGCATCCTGGATATCAGCCTGGCACCGGCCCGTGTTTCCGCCGACATCGCGGAACAGGCGCGC
GACATCGCCATGCGCGTCGCGACCGCGCTGGACCTGGTCGGCCTGCTGGGCGTGGAAATGTTCGTGGACCGTGACGGCCG
GGTCCTGGTCAATGAAATCGCCCCCCGGCCGCATAATTCCGGCCACTGGACGATGGATGCCTGCCCGGTGGACCAGTTCG
CCATGCATGTCCGCGCCGTGACGGGCTTGCCGCTGCCCCCGGCCGTCCGCCATTCCGACGCGGTGATGAAGAATCTGGTC
GGCCCCGACGACATGGCCCTCTGGCCCGCCATCCTGGCCACCCCGGGCCTGCTGCCCCACCATTACGGCAAGGAAGAGGC
CCGGCCCGGCCGCAAGATGGGCCATGTCAACGTCCTGTTCCCCCATGGCGGCCTGCCGGGCGAATTCGGGGTAAACGCGG
CGCTGGCGCCCTGCCTTCGAAATTCATAG

Upstream 100 bases:

>100_bases
TGGCATCCTCCATCCTCGCGCTGGGCGATGCGGCCCTGTCCGCCCGGCTGGCGGCGTGGCGCACGGCGCAGACGGACGCG
GTCGCGGACGTCCCGGCCCG

Downstream 100 bases:

>100_bases
ATGAATTTCGGAGATCAGCAGGCCGCCAAGACTTTAGGCGTCCTCGCCACCCGACAGGGCGCGGATCTTCCGGTGCAGGG
TTGACCGGCTGATCCCCAGT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSAPFPEALPAGAVLGIVGGGQLGRMSAVAAAQLGFRAHILTDEAEGPAAQVAHAVTVGAYDDPDVLRRFASSVDVVTFE
FENISADGLELLAGLCPVRPSGRILRISQDRIAEKRFLAGAGIPLAPWAEIHTPQDLDTAIATLGLPFILKTTRLGYDGK
GQHRVHAPDEALPGFHALAPHPLVAEAMIDFACEVSVMVARGLDGTAVTFDVTENRHRNGILDISLAPARVSADIAEQAR
DIAMRVATALDLVGLLGVEMFVDRDGRVLVNEIAPRPHNSGHWTMDACPVDQFAMHVRAVTGLPLPPAVRHSDAVMKNLV
GPDDMALWPAILATPGLLPHHYGKEEARPGRKMGHVNVLFPHGGLPGEFGVNAALAPCLRNS

Sequences:

>Translated_382_residues
MSAPFPEALPAGAVLGIVGGGQLGRMSAVAAAQLGFRAHILTDEAEGPAAQVAHAVTVGAYDDPDVLRRFASSVDVVTFE
FENISADGLELLAGLCPVRPSGRILRISQDRIAEKRFLAGAGIPLAPWAEIHTPQDLDTAIATLGLPFILKTTRLGYDGK
GQHRVHAPDEALPGFHALAPHPLVAEAMIDFACEVSVMVARGLDGTAVTFDVTENRHRNGILDISLAPARVSADIAEQAR
DIAMRVATALDLVGLLGVEMFVDRDGRVLVNEIAPRPHNSGHWTMDACPVDQFAMHVRAVTGLPLPPAVRHSDAVMKNLV
GPDDMALWPAILATPGLLPHHYGKEEARPGRKMGHVNVLFPHGGLPGEFGVNAALAPCLRNS
>Mature_381_residues
SAPFPEALPAGAVLGIVGGGQLGRMSAVAAAQLGFRAHILTDEAEGPAAQVAHAVTVGAYDDPDVLRRFASSVDVVTFEF
ENISADGLELLAGLCPVRPSGRILRISQDRIAEKRFLAGAGIPLAPWAEIHTPQDLDTAIATLGLPFILKTTRLGYDGKG
QHRVHAPDEALPGFHALAPHPLVAEAMIDFACEVSVMVARGLDGTAVTFDVTENRHRNGILDISLAPARVSADIAEQARD
IAMRVATALDLVGLLGVEMFVDRDGRVLVNEIAPRPHNSGHWTMDACPVDQFAMHVRAVTGLPLPPAVRHSDAVMKNLVG
PDDMALWPAILATPGLLPHHYGKEEARPGRKMGHVNVLFPHGGLPGEFGVNAALAPCLRNS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=343, Percent_Identity=34.402332361516, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1788155, Length=307, Percent_Identity=29.9674267100977, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=364, Percent_Identity=34.8901098901099, Blast_Score=216, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40450; Mature: 40319

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPFPEALPAGAVLGIVGGGQLGRMSAVAAAQLGFRAHILTDEAEGPAAQVAHAVTVGA
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHEEEECC
YDDPDVLRRFASSVDVVTFEFENISADGLELLAGLCPVRPSGRILRISQDRIAEKRFLAG
CCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHC
AGIPLAPWAEIHTPQDLDTAIATLGLPFILKTTRLGYDGKGQHRVHAPDEALPGFHALAP
CCCCCCCCHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCHHHCCCCHHCCC
HPLVAEAMIDFACEVSVMVARGLDGTAVTFDVTENRHRNGILDISLAPARVSADIAEQAR
CCHHHHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHH
DIAMRVATALDLVGLLGVEMFVDRDGRVLVNEIAPRPHNSGHWTMDACPVDQFAMHVRAV
HHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHH
TGLPLPPAVRHSDAVMKNLVGPDDMALWPAILATPGLLPHHYGKEEARPGRKMGHVNVLF
CCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCEEEEE
PHGGLPGEFGVNAALAPCLRNS
CCCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
SAPFPEALPAGAVLGIVGGGQLGRMSAVAAAQLGFRAHILTDEAEGPAAQVAHAVTVGA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHEEEECC
YDDPDVLRRFASSVDVVTFEFENISADGLELLAGLCPVRPSGRILRISQDRIAEKRFLAG
CCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHC
AGIPLAPWAEIHTPQDLDTAIATLGLPFILKTTRLGYDGKGQHRVHAPDEALPGFHALAP
CCCCCCCCHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCHHHCCCCHHCCC
HPLVAEAMIDFACEVSVMVARGLDGTAVTFDVTENRHRNGILDISLAPARVSADIAEQAR
CCHHHHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHH
DIAMRVATALDLVGLLGVEMFVDRDGRVLVNEIAPRPHNSGHWTMDACPVDQFAMHVRAV
HHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHH
TGLPLPPAVRHSDAVMKNLVGPDDMALWPAILATPGLLPHHYGKEEARPGRKMGHVNVLF
CCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCEEEEE
PHGGLPGEFGVNAALAPCLRNS
CCCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]