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The map label for this gene is purE [H]

Identifier: 162147509

GI number: 162147509

Start: 1748679

End: 1749164

Strand: Reverse

Name: purE [H]

Synonym: GDI_1725

Alternate gene names: 162147509

Gene position: 1749164-1748679 (Counterclockwise)

Preceding gene: 162147510

Following gene: 162147508

Centisome position: 44.35

GC content: 72.84

Gene sequence:

>486_bases
ATGTCCGCCCCGCTCGTGGGGATCATCATGGGCAGCCAGTCGGACTGGGAAACCATGCGGCATGCCGCCGAGATCCTGGG
CAGGCTGGGCGTCGCGCACGAAGTCCGGATCGTTTCGGCCCATCGCACGCCCGACCGGCTGGCGGACTACGCCCGCACGG
CCGCCGGACGCGGGCTGAAGGTCGTCATCGCCGGCGCCGGGGGGGCGGCGCACCTGCCGGGCATGTGCGCGGCGTGGACC
ATCCTGCCGGTGCTGGGCGTGCCGGTGGAATCGCATGCGCTGAAGGGCATGGACAGCCTGCTGTCCATCGTCCAGATGCC
CGGTGGCGTTCCCGTCGGCACCCTGGCGATCGGCAAGGCCGGGGCCATCAATGCGGCGCTGATGGCATCCTCCATCCTCG
CGCTGGGCGATGCGGCCCTGTCCGCCCGGCTGGCGGCGTGGCGCACGGCGCAGACGGACGCGGTCGCGGACGTCCCGGCC
CGATGA

Upstream 100 bases:

>100_bases
TCCCCGACAATATCGCCTGACCTCCATCCCTGATCCCCGAAAGCCTGCCCGCGTGAGCGATACGCCCCCCCTGCCCGATA
CCGCACCCTCATCCGCCGAC

Downstream 100 bases:

>100_bases
GCGCCCCCTTCCCCGAAGCCCTGCCCGCCGGGGCGGTGCTGGGCATCGTCGGCGGCGGCCAGTTGGGCCGGATGTCGGCC
GTCGCCGCCGCCCAACTGGG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MSAPLVGIIMGSQSDWETMRHAAEILGRLGVAHEVRIVSAHRTPDRLADYARTAAGRGLKVVIAGAGGAAHLPGMCAAWT
ILPVLGVPVESHALKGMDSLLSIVQMPGGVPVGTLAIGKAGAINAALMASSILALGDAALSARLAAWRTAQTDAVADVPA
R

Sequences:

>Translated_161_residues
MSAPLVGIIMGSQSDWETMRHAAEILGRLGVAHEVRIVSAHRTPDRLADYARTAAGRGLKVVIAGAGGAAHLPGMCAAWT
ILPVLGVPVESHALKGMDSLLSIVQMPGGVPVGTLAIGKAGAINAALMASSILALGDAALSARLAAWRTAQTDAVADVPA
R
>Mature_160_residues
SAPLVGIIMGSQSDWETMRHAAEILGRLGVAHEVRIVSAHRTPDRLADYARTAAGRGLKVVIAGAGGAAHLPGMCAAWTI
LPVLGVPVESHALKGMDSLLSIVQMPGGVPVGTLAIGKAGAINAALMASSILALGDAALSARLAAWRTAQTDAVADVPAR

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=64.9350649350649, Blast_Score=166, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324702, Length=155, Percent_Identity=54.1935483870968, Blast_Score=155, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16314; Mature: 16183

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPLVGIIMGSQSDWETMRHAAEILGRLGVAHEVRIVSAHRTPDRLADYARTAAGRGLK
CCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHEEEEEECCCCHHHHHHHHHHHCCCCEE
VVIAGAGGAAHLPGMCAAWTILPVLGVPVESHALKGMDSLLSIVQMPGGVPVGTLAIGKA
EEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCC
GAINAALMASSILALGDAALSARLAAWRTAQTDAVADVPAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SAPLVGIIMGSQSDWETMRHAAEILGRLGVAHEVRIVSAHRTPDRLADYARTAAGRGLK
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHEEEEEECCCCHHHHHHHHHHHCCCCEE
VVIAGAGGAAHLPGMCAAWTILPVLGVPVESHALKGMDSLLSIVQMPGGVPVGTLAIGKA
EEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCC
GAINAALMASSILALGDAALSARLAAWRTAQTDAVADVPAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]