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The map label for this gene is nuoD [H]

Identifier: 161870820

GI number: 161870820

Start: 1952371

End: 1953627

Strand: Reverse

Name: nuoD [H]

Synonym: NMCC_1902

Alternate gene names: 161870820

Gene position: 1953627-1952371 (Counterclockwise)

Preceding gene: 161870821

Following gene: 161870819

Centisome position: 90.72

GC content: 54.49

Gene sequence:

>1257_bases
GTGGCCAATAAATTAAGAAACTACACCATCAACTTCGGCCCGCAACACCCTGCGGCGCACGGCGTATTGCGTATGATTTT
GGAGTTGGAAGGCGAAACCATCGTCCGTGCCGACCCGCATATCGGTCTCCTGCATCGCGGCACCGAAAAACTGGCGGAAA
CCAAAACCTATCTGCAAGCCCTGCCTTATATGGACAGGCTGGACTACGTTTCCATGATGGTCAACGAGCAGGCATACTGC
TTGGCGGTAGAAAAACTCGCCGGAATTGATGTACCTATCCGCGCCCAATACATCCGCGTGATGTTCGCCGAAGTAACGCG
CATCCTCAATCACTTGATGGGCATCGGTTCGCACGCATTCGACATCGGCGCGATGACCGCCATCCTCTACGCCTTCCGCG
ACCGCGAAGAGCTGATGGACTTGTACGAAGCCGTGTCCGGCGCGCGTATGCACGCCGCCTACTTCCGTCCCGGCGGCGTT
TACCGCGACCTGCCCGACTTCATGCCCAAATACGAGAGCAGCAAATTCCGCAATGCCAAAGTATTGAAGCAGCTCAACGA
ATCCCGCGAAGGCACCATGCTCGACTTTATCGATGCCTTCTGCGAACGCTTCCCCAAAAATATCGACACACTCGAAACCC
TCCTGACCGACAACCGTATTTGGAAACAGCGTACCGTCGGCATCGGCGTTGTCACTCCTGAGCGCGCCATGCAAAAAGGC
TTTACCGGCGTGATGTTGCGCGGTTCGGGTGTGGAATGGGACGTGCGTAAGAAACAGCCTTACGAAATGTACGACAAAAT
GGATTTCGACATCCCTGTCGGCGTGAACGGCGACTGCTACGACCGCTACCTCTGCCGTATGGAAGAAATGCGTCAATCCG
TACGCATCATCAAACAATGTTCCGAGTGGTTGCGTGTCAATCCGGGTCCGGTCATTACCACAAACCACAAATTCGCTCCG
CCCAAACGTACCGAAATGAAAACAGGTATGGAAGACCTGATTCACCATTTCAAACTCTTTACCGAGGGTATGCACGTTCC
CGAGGGCGAGACCTACACCGCTGTCGAACACCCGAAAGGCGAGTTCGGCGTTTACATCATTTCAGACGGCGCGAACAAAC
CCTACCGCCTGAAAATCCGCGCACCCGGCTTCGCCCACCTGCAAGGTATGGACGAAATGGCAAAAGGCCACATGCTGGCT
GATGTGGTGGCGATTATCGGCACGCAGGATATTGTGTTTGGCGAAGTAGACAGATAA

Upstream 100 bases:

>100_bases
GAAATGCGTTACGACGAAGAGCAAAAACGCGTGATTTACCAACCTGTTACCATTGAGCCGCGCGAGATCACGCCGCGTAT
CGTCCGTGAGGAGAACTACG

Downstream 100 bases:

>100_bases
AGCTGTAAAAAAGCAGCCTGCACTTTTCAGACTGCCTGAAAAAATTATTAGGAATAAAAAGCATGAATTTTTGGCATATG
CAGATGCATCCAACCGATGA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MANKLRNYTINFGPQHPAAHGVLRMILELEGETIVRADPHIGLLHRGTEKLAETKTYLQALPYMDRLDYVSMMVNEQAYC
LAVEKLAGIDVPIRAQYIRVMFAEVTRILNHLMGIGSHAFDIGAMTAILYAFRDREELMDLYEAVSGARMHAAYFRPGGV
YRDLPDFMPKYESSKFRNAKVLKQLNESREGTMLDFIDAFCERFPKNIDTLETLLTDNRIWKQRTVGIGVVTPERAMQKG
FTGVMLRGSGVEWDVRKKQPYEMYDKMDFDIPVGVNGDCYDRYLCRMEEMRQSVRIIKQCSEWLRVNPGPVITTNHKFAP
PKRTEMKTGMEDLIHHFKLFTEGMHVPEGETYTAVEHPKGEFGVYIISDGANKPYRLKIRAPGFAHLQGMDEMAKGHMLA
DVVAIIGTQDIVFGEVDR

Sequences:

>Translated_418_residues
MANKLRNYTINFGPQHPAAHGVLRMILELEGETIVRADPHIGLLHRGTEKLAETKTYLQALPYMDRLDYVSMMVNEQAYC
LAVEKLAGIDVPIRAQYIRVMFAEVTRILNHLMGIGSHAFDIGAMTAILYAFRDREELMDLYEAVSGARMHAAYFRPGGV
YRDLPDFMPKYESSKFRNAKVLKQLNESREGTMLDFIDAFCERFPKNIDTLETLLTDNRIWKQRTVGIGVVTPERAMQKG
FTGVMLRGSGVEWDVRKKQPYEMYDKMDFDIPVGVNGDCYDRYLCRMEEMRQSVRIIKQCSEWLRVNPGPVITTNHKFAP
PKRTEMKTGMEDLIHHFKLFTEGMHVPEGETYTAVEHPKGEFGVYIISDGANKPYRLKIRAPGFAHLQGMDEMAKGHMLA
DVVAIIGTQDIVFGEVDR
>Mature_417_residues
ANKLRNYTINFGPQHPAAHGVLRMILELEGETIVRADPHIGLLHRGTEKLAETKTYLQALPYMDRLDYVSMMVNEQAYCL
AVEKLAGIDVPIRAQYIRVMFAEVTRILNHLMGIGSHAFDIGAMTAILYAFRDREELMDLYEAVSGARMHAAYFRPGGVY
RDLPDFMPKYESSKFRNAKVLKQLNESREGTMLDFIDAFCERFPKNIDTLETLLTDNRIWKQRTVGIGVVTPERAMQKGF
TGVMLRGSGVEWDVRKKQPYEMYDKMDFDIPVGVNGDCYDRYLCRMEEMRQSVRIIKQCSEWLRVNPGPVITTNHKFAPP
KRTEMKTGMEDLIHHFKLFTEGMHVPEGETYTAVEHPKGEFGVYIISDGANKPYRLKIRAPGFAHLQGMDEMAKGHMLAD
VVAIIGTQDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=62.56038647343, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=61.5196078431373, Blast_Score=521, Evalue=1e-148,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.780487804878, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1789076, Length=414, Percent_Identity=25.6038647342995, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1788832, Length=410, Percent_Identity=25.609756097561, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17555284, Length=416, Percent_Identity=58.1730769230769, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17568379, Length=416, Percent_Identity=57.6923076923077, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24638644, Length=416, Percent_Identity=61.2980769230769, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI221459469, Length=414, Percent_Identity=57.487922705314, Blast_Score=488, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47773; Mature: 47642

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKLRNYTINFGPQHPAAHGVLRMILELEGETIVRADPHIGLLHRGTEKLAETKTYLQA
CCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHCCHHHHHHHHHHHHH
LPYMDRLDYVSMMVNEQAYCLAVEKLAGIDVPIRAQYIRVMFAEVTRILNHLMGIGSHAF
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DIGAMTAILYAFRDREELMDLYEAVSGARMHAAYFRPGGVYRDLPDFMPKYESSKFRNAK
HHHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCHHHH
VLKQLNESREGTMLDFIDAFCERFPKNIDTLETLLTDNRIWKQRTVGIGVVTPERAMQKG
HHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCEEEEECHHHHHHCC
FTGVMLRGSGVEWDVRKKQPYEMYDKMDFDIPVGVNGDCYDRYLCRMEEMRQSVRIIKQC
CCEEEEECCCCCEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SEWLRVNPGPVITTNHKFAPPKRTEMKTGMEDLIHHFKLFTEGMHVPEGETYTAVEHPKG
HHHHCCCCCCEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
EFGVYIISDGANKPYRLKIRAPGFAHLQGMDEMAKGHMLADVVAIIGTQDIVFGEVDR
CEEEEEEECCCCCCEEEEEECCCCHHHCCHHHHHHCHHHHHHHHHHCCCCEEECCCCC
>Mature Secondary Structure 
ANKLRNYTINFGPQHPAAHGVLRMILELEGETIVRADPHIGLLHRGTEKLAETKTYLQA
CCCCCCCEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHCCHHHHHHHHHHHHH
LPYMDRLDYVSMMVNEQAYCLAVEKLAGIDVPIRAQYIRVMFAEVTRILNHLMGIGSHAF
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DIGAMTAILYAFRDREELMDLYEAVSGARMHAAYFRPGGVYRDLPDFMPKYESSKFRNAK
HHHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCHHHH
VLKQLNESREGTMLDFIDAFCERFPKNIDTLETLLTDNRIWKQRTVGIGVVTPERAMQKG
HHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCEEEEECHHHHHHCC
FTGVMLRGSGVEWDVRKKQPYEMYDKMDFDIPVGVNGDCYDRYLCRMEEMRQSVRIIKQC
CCEEEEECCCCCEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SEWLRVNPGPVITTNHKFAPPKRTEMKTGMEDLIHHFKLFTEGMHVPEGETYTAVEHPKG
HHHHCCCCCCEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
EFGVYIISDGANKPYRLKIRAPGFAHLQGMDEMAKGHMLADVVAIIGTQDIVFGEVDR
CEEEEEEECCCCCCEEEEEECCCCHHHCCHHHHHHCHHHHHHHHHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA