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The map label for this gene is recQ [H]

Identifier: 161870789

GI number: 161870789

Start: 1922232

End: 1924415

Strand: Direct

Name: recQ [H]

Synonym: NMCC_1871

Alternate gene names: 161870789

Gene position: 1922232-1924415 (Clockwise)

Preceding gene: 161870788

Following gene: 161870794

Centisome position: 89.26

GC content: 56.96

Gene sequence:

>2184_bases
ATGCCGACGGGCGGGGGCAAGTCTTTGTGTTACCAGATTCCGGCGCTGATGCGCGAAGGCGTGGCAGTTGTCGTATCGCC
GCTGATTGCGTTGATGAACGACCAAGTGGCCAGTCTGCATGTGGCCGGGATTGAAGCGGCGGCAGTCAACAGCAGCACAT
CGGCAGATGAGGCGCGCGAGATTGCCGACAAGCTTGCCCAAGGCCGTCTGAAACTGCTTTATGTCGCGCCGGAACGCTTG
GTTACCGACCGCTTTTTGCGTTTTCTCGACCAACAAACCGTCAGCCTGTTTGCCATTGACGAGGCGCATTGCGTCAGCCA
ATGGGGACACGATTTCCGCCCTGAATATCAACAGCTCGGCATCCTTGCCGAACGCTATCCGAACGTCCCGCGCATCGCCC
TGACCGCTACCGCCGATGCCGCCACGCGCGCCGACATCAAGCATTATCTGCACTTGGACAATGCGCCCGAATTTGTCTCC
AGCTTCGACCGTCCGAATATTTATTATCAGGTTATCGAAAAAAACAACGGCAAAAAACAATTGCTGGATTTCATCCGCAA
AGAAATGACGGGGCAAAGCGGCATTGTGTATTGCCTAAGCCGCAAAAAGGTGGAAGATGTGGCGCAGTTTTTGCGTGAAA
ACGGATTAAACGCGATTCCGTATCATGCTGGTTTGAGCATGGACGTGCGCGAGGAAAACCAACGCCGCTTTACGCATGAA
GACAATATTATCGTGGTGGCGACCGTGGCGTTCGGCATGGGCATAGACAAACCCGACGTGCGCTTTGTCGCCCATCTCGA
TATGCCCCAGAGTGTCGAACATTTCTATCAGGAATCGGGGCGTGCCGGCCGGGACGGGCTGCCTGCCGTGAGCTGGCTGT
GTTACGGTTTGAACGATTGGGTGTTGCTGCGCGAACGGATTGCCGAAGGCAACAGCGACGAGGTGCAAAAGCAAATCGAA
ATGCAAAAACTCGATGCCATGCTTTCCGTCTGCGAAACCGCCGCCTGCCGCCGCGTACTGCTGCTCAAACATTTCGGCGA
AGCATCCGAACCATGCGGCCATTGCGACAACTGCCTGCATCCGCCCGTACGGTTTGACGGCACGGTGTTGGTGCAAAAAT
TACTCAGCTGCGTGTACCGCGCCGGACAACGTTTTGCCGCCGGTTACATCACCAACCTTTTACGAGGTAAAAGCGACGAT
TGGATACGCGGCAACCGGCACGAACAACTGTCCACATTCGGCATCGGTACGGAGTTGTCCGACAAAGAATGGCGCAGCGT
CATCCGCCAGTGTATCAGCCTCGGCTACCTCACCGTCAACATTACCCGATATCAGGCATTGCAACTGACCGAAGCCGCCA
AAAAAGTCCTCAAAGGCGAAACCGAAGTGATGCTGCGTCCGCTCAAGCGCGACAAGCCCGCCGCCCGCACCCTCAAAGAC
AACTGGCTGCGTACCGAACGCGAAGAACGCCTGTGGCAGGCATTGCGCGTTTGGCGTATGAAACAGGCAGAAGCCGAAGT
CATCCCCGCCTATATGATTTTCGGCGACAAAACCCTGCGCGACCTTGTCGAAAAAATGCCGCAAGACCTCAACGGACTGC
ACGACATCTACGGTTTGGGCGAAGCCAAAATCGACCGTTTCGGACACGGCATCCTCGAAGTCTGCCGCAACACCGCCGAC
TTTAGCCACAATGCCGTCATCCGCCCGCAAACCGAACGCGAACAACAACTGCGTCAAAAACTCGAAGCCTGGCGGTATGA
ACAGGCAAGGGCGGAAAACTGCGCCCTGCATGCCGTCCTCTCCGACGAAAGCCTTGCCGATATGCTTGCCGATACGCCCG
AAACCGAAACCGACCTCGAAGGCGTACACGGCTTGGGCAGCGTACGCGCCGCCAAATACGGACGGGACATCCTCGCCGTC
TGCCGTCCGTTTTCAGACGGCATCGATGAAGCCGCCAAACACAAACGCCGCCTGATGCGCGCCCTGATTCAATGGTGCAA
CGAAACGGCAAAACACGAACAGTCCGAACCCTACCGCATTCTCAGCAAAGCCGCCCTGCGCGCCATTGCCGCCAAACAGC
CGGAAGGCTTGGCGGAGCTTGCCGCCGTATACGGCGTAGGCGAAGAAAAAGCCGCACGTTACGGTGCGGCGGTGTTGGCG
GTATTGGAACGAAATGCCGTCTGA

Upstream 100 bases:

>100_bases
CAAACAGATTTTGCACGAAGTATTCGGTTATCCCGAATTTCGCGGCAAGCAGGAGTCTATCGTCAATGCTTTGGCCGGCG
GCGAGAGTTTGATGGTGCTG

Downstream 100 bases:

>100_bases
AGCCCGTTACCAAGTTTCAGACGGCATTGCCTCTATTTAAAAATTCCTGTTTTTATAGTGGATTAACAAAAATCAGGACA
AGGCGGCGAAGCCGCAGACA

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MPTGGGKSLCYQIPALMREGVAVVVSPLIALMNDQVASLHVAGIEAAAVNSSTSADEAREIADKLAQGRLKLLYVAPERL
VTDRFLRFLDQQTVSLFAIDEAHCVSQWGHDFRPEYQQLGILAERYPNVPRIALTATADAATRADIKHYLHLDNAPEFVS
SFDRPNIYYQVIEKNNGKKQLLDFIRKEMTGQSGIVYCLSRKKVEDVAQFLRENGLNAIPYHAGLSMDVREENQRRFTHE
DNIIVVATVAFGMGIDKPDVRFVAHLDMPQSVEHFYQESGRAGRDGLPAVSWLCYGLNDWVLLRERIAEGNSDEVQKQIE
MQKLDAMLSVCETAACRRVLLLKHFGEASEPCGHCDNCLHPPVRFDGTVLVQKLLSCVYRAGQRFAAGYITNLLRGKSDD
WIRGNRHEQLSTFGIGTELSDKEWRSVIRQCISLGYLTVNITRYQALQLTEAAKKVLKGETEVMLRPLKRDKPAARTLKD
NWLRTEREERLWQALRVWRMKQAEAEVIPAYMIFGDKTLRDLVEKMPQDLNGLHDIYGLGEAKIDRFGHGILEVCRNTAD
FSHNAVIRPQTEREQQLRQKLEAWRYEQARAENCALHAVLSDESLADMLADTPETETDLEGVHGLGSVRAAKYGRDILAV
CRPFSDGIDEAAKHKRRLMRALIQWCNETAKHEQSEPYRILSKAALRAIAAKQPEGLAELAAVYGVGEEKAARYGAAVLA
VLERNAV

Sequences:

>Translated_727_residues
MPTGGGKSLCYQIPALMREGVAVVVSPLIALMNDQVASLHVAGIEAAAVNSSTSADEAREIADKLAQGRLKLLYVAPERL
VTDRFLRFLDQQTVSLFAIDEAHCVSQWGHDFRPEYQQLGILAERYPNVPRIALTATADAATRADIKHYLHLDNAPEFVS
SFDRPNIYYQVIEKNNGKKQLLDFIRKEMTGQSGIVYCLSRKKVEDVAQFLRENGLNAIPYHAGLSMDVREENQRRFTHE
DNIIVVATVAFGMGIDKPDVRFVAHLDMPQSVEHFYQESGRAGRDGLPAVSWLCYGLNDWVLLRERIAEGNSDEVQKQIE
MQKLDAMLSVCETAACRRVLLLKHFGEASEPCGHCDNCLHPPVRFDGTVLVQKLLSCVYRAGQRFAAGYITNLLRGKSDD
WIRGNRHEQLSTFGIGTELSDKEWRSVIRQCISLGYLTVNITRYQALQLTEAAKKVLKGETEVMLRPLKRDKPAARTLKD
NWLRTEREERLWQALRVWRMKQAEAEVIPAYMIFGDKTLRDLVEKMPQDLNGLHDIYGLGEAKIDRFGHGILEVCRNTAD
FSHNAVIRPQTEREQQLRQKLEAWRYEQARAENCALHAVLSDESLADMLADTPETETDLEGVHGLGSVRAAKYGRDILAV
CRPFSDGIDEAAKHKRRLMRALIQWCNETAKHEQSEPYRILSKAALRAIAAKQPEGLAELAAVYGVGEEKAARYGAAVLA
VLERNAV
>Mature_726_residues
PTGGGKSLCYQIPALMREGVAVVVSPLIALMNDQVASLHVAGIEAAAVNSSTSADEAREIADKLAQGRLKLLYVAPERLV
TDRFLRFLDQQTVSLFAIDEAHCVSQWGHDFRPEYQQLGILAERYPNVPRIALTATADAATRADIKHYLHLDNAPEFVSS
FDRPNIYYQVIEKNNGKKQLLDFIRKEMTGQSGIVYCLSRKKVEDVAQFLRENGLNAIPYHAGLSMDVREENQRRFTHED
NIIVVATVAFGMGIDKPDVRFVAHLDMPQSVEHFYQESGRAGRDGLPAVSWLCYGLNDWVLLRERIAEGNSDEVQKQIEM
QKLDAMLSVCETAACRRVLLLKHFGEASEPCGHCDNCLHPPVRFDGTVLVQKLLSCVYRAGQRFAAGYITNLLRGKSDDW
IRGNRHEQLSTFGIGTELSDKEWRSVIRQCISLGYLTVNITRYQALQLTEAAKKVLKGETEVMLRPLKRDKPAARTLKDN
WLRTEREERLWQALRVWRMKQAEAEVIPAYMIFGDKTLRDLVEKMPQDLNGLHDIYGLGEAKIDRFGHGILEVCRNTADF
SHNAVIRPQTEREQQLRQKLEAWRYEQARAENCALHAVLSDESLADMLADTPETETDLEGVHGLGSVRAAKYGRDILAVC
RPFSDGIDEAAKHKRRLMRALIQWCNETAKHEQSEPYRILSKAALRAIAAKQPEGLAELAAVYGVGEEKAARYGAAVLAV
LERNAV

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=610, Percent_Identity=33.4426229508197, Blast_Score=302, Evalue=6e-82,
Organism=Homo sapiens, GI14591902, Length=373, Percent_Identity=42.8954423592493, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI14591904, Length=373, Percent_Identity=42.8954423592493, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI148612816, Length=386, Percent_Identity=39.8963730569948, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI110735439, Length=477, Percent_Identity=35.2201257861635, Blast_Score=262, Evalue=9e-70,
Organism=Homo sapiens, GI169218196, Length=477, Percent_Identity=35.2201257861635, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI51242947, Length=356, Percent_Identity=40.1685393258427, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI51242943, Length=356, Percent_Identity=40.1685393258427, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI284005309, Length=312, Percent_Identity=37.5, Blast_Score=179, Evalue=1e-44,
Organism=Escherichia coli, GI48994977, Length=565, Percent_Identity=46.5486725663717, Blast_Score=511, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI25145561, Length=497, Percent_Identity=38.430583501006, Blast_Score=314, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI71987997, Length=373, Percent_Identity=41.5549597855228, Blast_Score=293, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI71987993, Length=373, Percent_Identity=41.5549597855228, Blast_Score=292, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI32564293, Length=468, Percent_Identity=35.6837606837607, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17552866, Length=402, Percent_Identity=39.0547263681592, Blast_Score=260, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6323844, Length=492, Percent_Identity=34.7560975609756, Blast_Score=296, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24646066, Length=679, Percent_Identity=33.1369661266568, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24664226, Length=392, Percent_Identity=40.5612244897959, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24664230, Length=392, Percent_Identity=40.5612244897959, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI62472181, Length=392, Percent_Identity=40.5612244897959, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI21358123, Length=376, Percent_Identity=35.1063829787234, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81804; Mature: 81673

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTGGGKSLCYQIPALMREGVAVVVSPLIALMNDQVASLHVAGIEAAAVNSSTSADEARE
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHEEEECCHHHHCCCCCCHHHHHH
IADKLAQGRLKLLYVAPERLVTDRFLRFLDQQTVSLFAIDEAHCVSQWGHDFRPEYQQLG
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHCCCCCCCCHHHHH
ILAERYPNVPRIALTATADAATRADIKHYLHLDNAPEFVSSFDRPNIYYQVIEKNNGKKQ
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEEECCCCHHH
LLDFIRKEMTGQSGIVYCLSRKKVEDVAQFLRENGLNAIPYHAGLSMDVREENQRRFTHE
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCC
DNIIVVATVAFGMGIDKPDVRFVAHLDMPQSVEHFYQESGRAGRDGLPAVSWLCYGLNDW
CCEEEEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHH
VLLRERIAEGNSDEVQKQIEMQKLDAMLSVCETAACRRVLLLKHFGEASEPCGHCDNCLH
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCC
PPVRFDGTVLVQKLLSCVYRAGQRFAAGYITNLLRGKSDDWIRGNRHEQLSTFGIGTELS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCC
DKEWRSVIRQCISLGYLTVNITRYQALQLTEAAKKVLKGETEVMLRPLKRDKPAARTLKD
CHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHH
NWLRTEREERLWQALRVWRMKQAEAEVIPAYMIFGDKTLRDLVEKMPQDLNGLHDIYGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHCCHHHHHHHHHHCCC
EAKIDRFGHGILEVCRNTADFSHNAVIRPQTEREQQLRQKLEAWRYEQARAENCALHAVL
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
SDESLADMLADTPETETDLEGVHGLGSVRAAKYGRDILAVCRPFSDGIDEAAKHKRRLMR
CCHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHCHHHHHHHCCHHCCHHHHHHHHHHHHH
ALIQWCNETAKHEQSEPYRILSKAALRAIAAKQPEGLAELAAVYGVGEEKAARYGAAVLA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
VLERNAV
HHHHCCC
>Mature Secondary Structure 
PTGGGKSLCYQIPALMREGVAVVVSPLIALMNDQVASLHVAGIEAAAVNSSTSADEARE
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHEEEECCHHHHCCCCCCHHHHHH
IADKLAQGRLKLLYVAPERLVTDRFLRFLDQQTVSLFAIDEAHCVSQWGHDFRPEYQQLG
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHCCCCCCCCHHHHH
ILAERYPNVPRIALTATADAATRADIKHYLHLDNAPEFVSSFDRPNIYYQVIEKNNGKKQ
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEEECCCCHHH
LLDFIRKEMTGQSGIVYCLSRKKVEDVAQFLRENGLNAIPYHAGLSMDVREENQRRFTHE
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCC
DNIIVVATVAFGMGIDKPDVRFVAHLDMPQSVEHFYQESGRAGRDGLPAVSWLCYGLNDW
CCEEEEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHH
VLLRERIAEGNSDEVQKQIEMQKLDAMLSVCETAACRRVLLLKHFGEASEPCGHCDNCLH
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCC
PPVRFDGTVLVQKLLSCVYRAGQRFAAGYITNLLRGKSDDWIRGNRHEQLSTFGIGTELS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCC
DKEWRSVIRQCISLGYLTVNITRYQALQLTEAAKKVLKGETEVMLRPLKRDKPAARTLKD
CHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHH
NWLRTEREERLWQALRVWRMKQAEAEVIPAYMIFGDKTLRDLVEKMPQDLNGLHDIYGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHCCHHHHHHHHHHCCC
EAKIDRFGHGILEVCRNTADFSHNAVIRPQTEREQQLRQKLEAWRYEQARAENCALHAVL
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
SDESLADMLADTPETETDLEGVHGLGSVRAAKYGRDILAVCRPFSDGIDEAAKHKRRLMR
CCHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHCHHHHHHHCCHHCCHHHHHHHHHHHHH
ALIQWCNETAKHEQSEPYRILSKAALRAIAAKQPEGLAELAAVYGVGEEKAARYGAAVLA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
VLERNAV
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]