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The map label for this gene is trpC [H]

Identifier: 161870788

GI number: 161870788

Start: 1921226

End: 1922050

Strand: Direct

Name: trpC [H]

Synonym: NMCC_1870

Alternate gene names: 161870788

Gene position: 1921226-1922050 (Clockwise)

Preceding gene: 161870787

Following gene: 161870789

Centisome position: 89.22

GC content: 56.97

Gene sequence:

>825_bases
ATGCTAATATTCCCCCTTTCCCAGACGAATACGGAACACGACATGACCGACATCCTCAATAAAATCCTTGCCACCAAAGC
ACAGGAAGTTGCCGCCCAAAAAGCCGCCGTCAACGCCGAACACATCCGCGCACTTGCCGCAGAAGCCGCGCCCGTCCGCA
GCTTCATCGATTTGATACGCGGCAAACACCGCCTAAACCTGCCCGCCGTCATTGCCGAAATCAAAAAGGCAAGCCCGAGC
AAAGGCCTGATCCGTCCGGACTTCCGACCGGCCGAGATTGCACGCGCATATGAAAACGCCGGAGCGGCATGTTTGTCCGT
ACTGACCGACGAACCCTATTTCCAAGGTTCGCCCGAATACCTCAAACAGGCGCGCGAAGCCGTATCGCTGCCCGTGCTGC
GCAAAGACTTCATCATCGACGAATATCAGGTTTATCAGGCGCGCGCATGGGGGGCGGATGCCGTCCTGCTGATTGCCGCA
GCACTGGAACAGGAACAATTGGAACGCTTTGAAGCGGTGGCGCACGAATTGGGCATGACCGTCCTGCTCGAGCTGCACGA
TGAAACCGAATTGGAAAAATGCCGCAACCTGACCACGCCGTTGTGGGGCGTAAACAACCGCAACCTGAGGACTTTTGAAG
TCTCCCTCGACCAAACCCTGTCGCTGCTGCCCGCGCTGGAAGGCAAAACCGTCGTTACCGAAAGCGGCATTACGGGTAAG
GCGGATGTGGAATTTATGCGGACGCGCGGTGTGCACACCTTCCTGATCGGCGAAACGTTCATGCGTGCCGCCGATATTGA
GGCGGAAGTGGGCAAACTCTTCTAA

Upstream 100 bases:

>100_bases
TTTGTCAGCAGCACCGGCGGCAGGCTGCACCTGCAATGGTTGCCGCAGACCGTCCTGTCCTATTTCGACAGCTTCCGCAC
AAACAGGCGTTAACGGTTTG

Downstream 100 bases:

>100_bases
ATCCCGATTTCAGACGGCATATTGCCGCCGACCGATCAACACCCTTACCGAGCACGGAACCATCATGCACCGACCGACCG
CCAAACAGATTTTGCACGAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MLIFPLSQTNTEHDMTDILNKILATKAQEVAAQKAAVNAEHIRALAAEAAPVRSFIDLIRGKHRLNLPAVIAEIKKASPS
KGLIRPDFRPAEIARAYENAGAACLSVLTDEPYFQGSPEYLKQAREAVSLPVLRKDFIIDEYQVYQARAWGADAVLLIAA
ALEQEQLERFEAVAHELGMTVLLELHDETELEKCRNLTTPLWGVNNRNLRTFEVSLDQTLSLLPALEGKTVVTESGITGK
ADVEFMRTRGVHTFLIGETFMRAADIEAEVGKLF

Sequences:

>Translated_274_residues
MLIFPLSQTNTEHDMTDILNKILATKAQEVAAQKAAVNAEHIRALAAEAAPVRSFIDLIRGKHRLNLPAVIAEIKKASPS
KGLIRPDFRPAEIARAYENAGAACLSVLTDEPYFQGSPEYLKQAREAVSLPVLRKDFIIDEYQVYQARAWGADAVLLIAA
ALEQEQLERFEAVAHELGMTVLLELHDETELEKCRNLTTPLWGVNNRNLRTFEVSLDQTLSLLPALEGKTVVTESGITGK
ADVEFMRTRGVHTFLIGETFMRAADIEAEVGKLF
>Mature_274_residues
MLIFPLSQTNTEHDMTDILNKILATKAQEVAAQKAAVNAEHIRALAAEAAPVRSFIDLIRGKHRLNLPAVIAEIKKASPS
KGLIRPDFRPAEIARAYENAGAACLSVLTDEPYFQGSPEYLKQAREAVSLPVLRKDFIIDEYQVYQARAWGADAVLLIAA
ALEQEQLERFEAVAHELGMTVLLELHDETELEKCRNLTTPLWGVNNRNLRTFEVSLDQTLSLLPALEGKTVVTESGITGK
ADVEFMRTRGVHTFLIGETFMRAADIEAEVGKLF

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=262, Percent_Identity=41.6030534351145, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=234, Percent_Identity=36.3247863247863, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 30366; Mature: 30366

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIFPLSQTNTEHDMTDILNKILATKAQEVAAQKAAVNAEHIRALAAEAAPVRSFIDLIR
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
GKHRLNLPAVIAEIKKASPSKGLIRPDFRPAEIARAYENAGAACLSVLTDEPYFQGSPEY
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHH
LKQAREAVSLPVLRKDFIIDEYQVYQARAWGADAVLLIAAALEQEQLERFEAVAHELGMT
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VLLELHDETELEKCRNLTTPLWGVNNRNLRTFEVSLDQTLSLLPALEGKTVVTESGITGK
EEEEECCCHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCEEEECCCCCCC
ADVEFMRTRGVHTFLIGETFMRAADIEAEVGKLF
HHHHHHHHCCCEEEEHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MLIFPLSQTNTEHDMTDILNKILATKAQEVAAQKAAVNAEHIRALAAEAAPVRSFIDLIR
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
GKHRLNLPAVIAEIKKASPSKGLIRPDFRPAEIARAYENAGAACLSVLTDEPYFQGSPEY
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHH
LKQAREAVSLPVLRKDFIIDEYQVYQARAWGADAVLLIAAALEQEQLERFEAVAHELGMT
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VLLELHDETELEKCRNLTTPLWGVNNRNLRTFEVSLDQTLSLLPALEGKTVVTESGITGK
EEEEECCCHHHHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCEEEECCCCCCC
ADVEFMRTRGVHTFLIGETFMRAADIEAEVGKLF
HHHHHHHHCCCEEEEHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA