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The map label for this gene is uvrB [H]

Identifier: 161870204

GI number: 161870204

Start: 1236912

End: 1239062

Strand: Reverse

Name: uvrB [H]

Synonym: NMCC_1244

Alternate gene names: 161870204

Gene position: 1239062-1236912 (Counterclockwise)

Preceding gene: 161870205

Following gene: 161870199

Centisome position: 57.54

GC content: 54.35

Gene sequence:

>2151_bases
TTGGGTAGCGATTGGGTTTCAGACGGCATACATTCAGGATTTCACCGCCTTATGCCGTCTGAAAGACGTTTCCGACCCAT
CCCTACTACACGCTTTGTCCGCAAACGCATCACAGGCAAGATTATGGAAGTCATTCGATACCCCGATTCCCCCTTCAAAC
TCCACCAACCCTTCCAGCCCGCAGGCGACCAGCCTACCGCTATTGCCGACTTGCTCGAAGGGCTTTCAGACGGCCTTGCC
TACCAAACCCTGCTCGGCGTAACCGGTTCGGGCAAAACCTACACCATGGCGAACGTCATCGCCCAAAGCGGCCGACCCGC
CATCATCATGGCGCACAACAAAACCCTTGCCGCCCAGCTTTATGCCGAAATGCGCGAGTTTTTCCCTGAAAACGCGGTGG
AATATTTCGTCTCCTACTACGACTATTACCAACCCGAAGCCTATGTGCCAAGCCGCGATTTGTTCATCGAAAAAGACAGT
GCGATCAACGAACACATCGAGCAGATGCGCCTTTCCGCCACCAAAAACCTAATGACGCGCAACGACGTGATTATCGTCGC
CACCGTGTCCGCCATTTACGGTATCGGCGACCCGACCGAGTATCAACAAATGGTGTTGTCCGTCAAAGAAGGCGATACCA
TCGAGCAGCGCGACATCATCGCCACGCTCGTTTCCATGCAATACGAACGCGGCGATTTGGACTTCAAACGCGGCAGCTTC
CGCGTGCGCGGCGACGTGATTGACGTGTACCCCGCCGAAAGCTCCGAAAACGCCTTACGCATCAGCCTGTTTGATGACGA
AATCGACCGCCTCGATATGTTCGACCCGCTTTCAGGCAGCCTTATCCAGCGCGTCGGCCGCTACACCGTCTTCCCGTCCA
GCCACTACGTTACCCCGCGCGACACCGTCTTGCGCGCCTGCGAGTCCATCAAAGAAGAATTACGCGAACGCATCGAATTT
TTCGCCCGCGAACAACGCCCCGTCGAACAACAACGCATCGAACAGCGCACCCGTTTCGACCTCGAAATGCTCTACGAAAT
GGGCTTCTGCAAAGGAATCGAAAACTACTCCCGCCACTTTTCCGGCAAAAAAGAAGGCGAACCGCCGCCTACGCTGATGG
ACTACCTGCCCGACAACGCCATCATGTTCATCGACGAAAGCCACGTTACCGTAACCCAAATCGGCGGCATGTACAAAGGC
GACGCATCGCGCAAGCAAAACCTCGTCGACTACGGCTTCCGCCTGCCTTCAGCCCGCGACAACCGCCCGCTCAAATTCCA
CGAATTTGAAAAAGTCATGCCGCAAACCATCTTCGTTTCCGCTACCCCCGCCAAATACGAAGAAGAACACGCCGGACAAG
TGGTCGAACAAGTCGTCCGTCCCACAGGGCTGGTCGACCCCCAAATCATCATCCGCCCCGTCGCCACCCAAGTTGATGAC
TTAATGAGCGAAATCAACGACCGCATCCAAAAAGGCGAACGCATCCTCGTTACCACCCTCACCAAACGTATGGCGGAGCA
ACTCACCGACTATTACAGTGAACTCGGCATCAAAGTGCGCTACCTGCACAGCGACATCGATACCGTCGAGCGCGTTGAAA
TCATTAGAGATTTGCGGCTCGGCCTGTTTGACGTACTCGTCGGCATCAACCTCTTGCGCGAAGGCCTCGACATCCCCGAA
GTCTCCCTTGTTGCCATCCTCGACGCCGACAAAGAAGGCTTCCTGCGCTCCCACCGCAGCCTGATTCAAACCATAGGCCG
CGCCGCGCGCAACGTGAACGGCGTCGCGATTCTGTACGCCGACAAAATCACCGACTCTATGAAAGCCGCCATCGACGAAA
CCGAACGCCGCCGTGAAAAACAAATTAAATTCAACGAAGAACACGGCATCGTGCCGCAACAGATTAAAAAACAGGTCAAA
GACATCATTGACGGCGTGTACCACGAAGAAGACAGCGGCAAAGGCCGTAGACAAGGCAAAAACAAAGTTAAAGTCGGCGA
AATTCACAACGAAGAAGACGCGATTAAAGAAATCGCCAAATTGGAAAAAGCCATGCAACAGGCAGCTAGGGATTTGCAGT
TTGAAGAAGCGTCGGTGTTAAGGGATAGGATTCGGGGGATTAGGGAAGGGTTGTTATTTGGGAGTGAGTAA

Upstream 100 bases:

>100_bases
GGGTTAACAAAAATCAGGACAAGGCGACGAAGCCGCAGACAGTACAAATAGTACGGCAAGGCGAGGCAACGCCGTACTGG
TTTTTGTTAATCCACTATAC

Downstream 100 bases:

>100_bases
TAAAAGCACTTGAAAGTTTAGTTGATGACCACAATGTTCTTAAAAGATTTGGAGAAACAAAAGATGTGGAGAAACATCGT
AACTTGATCAATTACATTCT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 716; Mature: 715

Protein sequence:

>716_residues
MGSDWVSDGIHSGFHRLMPSERRFRPIPTTRFVRKRITGKIMEVIRYPDSPFKLHQPFQPAGDQPTAIADLLEGLSDGLA
YQTLLGVTGSGKTYTMANVIAQSGRPAIIMAHNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDS
AINEHIEQMRLSATKNLMTRNDVIIVATVSAIYGIGDPTEYQQMVLSVKEGDTIEQRDIIATLVSMQYERGDLDFKRGSF
RVRGDVIDVYPAESSENALRISLFDDEIDRLDMFDPLSGSLIQRVGRYTVFPSSHYVTPRDTVLRACESIKEELRERIEF
FAREQRPVEQQRIEQRTRFDLEMLYEMGFCKGIENYSRHFSGKKEGEPPPTLMDYLPDNAIMFIDESHVTVTQIGGMYKG
DASRKQNLVDYGFRLPSARDNRPLKFHEFEKVMPQTIFVSATPAKYEEEHAGQVVEQVVRPTGLVDPQIIIRPVATQVDD
LMSEINDRIQKGERILVTTLTKRMAEQLTDYYSELGIKVRYLHSDIDTVERVEIIRDLRLGLFDVLVGINLLREGLDIPE
VSLVAILDADKEGFLRSHRSLIQTIGRAARNVNGVAILYADKITDSMKAAIDETERRREKQIKFNEEHGIVPQQIKKQVK
DIIDGVYHEEDSGKGRRQGKNKVKVGEIHNEEDAIKEIAKLEKAMQQAARDLQFEEASVLRDRIRGIREGLLFGSE

Sequences:

>Translated_716_residues
MGSDWVSDGIHSGFHRLMPSERRFRPIPTTRFVRKRITGKIMEVIRYPDSPFKLHQPFQPAGDQPTAIADLLEGLSDGLA
YQTLLGVTGSGKTYTMANVIAQSGRPAIIMAHNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDS
AINEHIEQMRLSATKNLMTRNDVIIVATVSAIYGIGDPTEYQQMVLSVKEGDTIEQRDIIATLVSMQYERGDLDFKRGSF
RVRGDVIDVYPAESSENALRISLFDDEIDRLDMFDPLSGSLIQRVGRYTVFPSSHYVTPRDTVLRACESIKEELRERIEF
FAREQRPVEQQRIEQRTRFDLEMLYEMGFCKGIENYSRHFSGKKEGEPPPTLMDYLPDNAIMFIDESHVTVTQIGGMYKG
DASRKQNLVDYGFRLPSARDNRPLKFHEFEKVMPQTIFVSATPAKYEEEHAGQVVEQVVRPTGLVDPQIIIRPVATQVDD
LMSEINDRIQKGERILVTTLTKRMAEQLTDYYSELGIKVRYLHSDIDTVERVEIIRDLRLGLFDVLVGINLLREGLDIPE
VSLVAILDADKEGFLRSHRSLIQTIGRAARNVNGVAILYADKITDSMKAAIDETERRREKQIKFNEEHGIVPQQIKKQVK
DIIDGVYHEEDSGKGRRQGKNKVKVGEIHNEEDAIKEIAKLEKAMQQAARDLQFEEASVLRDRIRGIREGLLFGSE
>Mature_715_residues
GSDWVSDGIHSGFHRLMPSERRFRPIPTTRFVRKRITGKIMEVIRYPDSPFKLHQPFQPAGDQPTAIADLLEGLSDGLAY
QTLLGVTGSGKTYTMANVIAQSGRPAIIMAHNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSA
INEHIEQMRLSATKNLMTRNDVIIVATVSAIYGIGDPTEYQQMVLSVKEGDTIEQRDIIATLVSMQYERGDLDFKRGSFR
VRGDVIDVYPAESSENALRISLFDDEIDRLDMFDPLSGSLIQRVGRYTVFPSSHYVTPRDTVLRACESIKEELRERIEFF
AREQRPVEQQRIEQRTRFDLEMLYEMGFCKGIENYSRHFSGKKEGEPPPTLMDYLPDNAIMFIDESHVTVTQIGGMYKGD
ASRKQNLVDYGFRLPSARDNRPLKFHEFEKVMPQTIFVSATPAKYEEEHAGQVVEQVVRPTGLVDPQIIIRPVATQVDDL
MSEINDRIQKGERILVTTLTKRMAEQLTDYYSELGIKVRYLHSDIDTVERVEIIRDLRLGLFDVLVGINLLREGLDIPEV
SLVAILDADKEGFLRSHRSLIQTIGRAARNVNGVAILYADKITDSMKAAIDETERRREKQIKFNEEHGIVPQQIKKQVKD
IIDGVYHEEDSGKGRRQGKNKVKVGEIHNEEDAIKEIAKLEKAMQQAARDLQFEEASVLRDRIRGIREGLLFGSE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=63.4328358208955, Blast_Score=845, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=306, Percent_Identity=23.202614379085, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 81852; Mature: 81721

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSDWVSDGIHSGFHRLMPSERRFRPIPTTRFVRKRITGKIMEVIRYPDSPFKLHQPFQP
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AGDQPTAIADLLEGLSDGLAYQTLLGVTGSGKTYTMANVIAQSGRPAIIMAHNKTLAAQL
CCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCEEHHHHHHHHCCCCEEEEECCCHHHHHH
YAEMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSAINEHIEQMRLSATKNLMTR
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCC
NDVIIVATVSAIYGIGDPTEYQQMVLSVKEGDTIEQRDIIATLVSMQYERGDLDFKRGSF
CCEEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCE
RVRGDVIDVYPAESSENALRISLFDDEIDRLDMFDPLSGSLIQRVGRYTVFPSSHYVTPR
EEECCEEEEECCCCCCCEEEEEEECCCHHHCCCCCCCCHHHHHHHCCEEECCCCCCCCCH
DTVLRACESIKEELRERIEFFAREQRPVEQQRIEQRTRFDLEMLYEMGFCKGIENYSRHF
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGKKEGEPPPTLMDYLPDNAIMFIDESHVTVTQIGGMYKGDASRKQNLVDYGFRLPSARD
CCCCCCCCCCHHHHHCCCCEEEEEECCCEEEEHHCCCCCCCCHHHHHHHHHCCCCCCCCC
NRPLKFHEFEKVMPQTIFVSATPAKYEEEHAGQVVEQVVRPTGLVDPQIIIRPVATQVDD
CCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LMSEINDRIQKGERILVTTLTKRMAEQLTDYYSELGIKVRYLHSDIDTVERVEIIRDLRL
HHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
GLFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSHRSLIQTIGRAARNVNGVAILYA
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
DKITDSMKAAIDETERRREKQIKFNEEHGIVPQQIKKQVKDIIDGVYHEEDSGKGRRQGK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCC
NKVKVGEIHNEEDAIKEIAKLEKAMQQAARDLQFEEASVLRDRIRGIREGLLFGSE
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GSDWVSDGIHSGFHRLMPSERRFRPIPTTRFVRKRITGKIMEVIRYPDSPFKLHQPFQP
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AGDQPTAIADLLEGLSDGLAYQTLLGVTGSGKTYTMANVIAQSGRPAIIMAHNKTLAAQL
CCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCEEHHHHHHHHCCCCEEEEECCCHHHHHH
YAEMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSAINEHIEQMRLSATKNLMTR
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCC
NDVIIVATVSAIYGIGDPTEYQQMVLSVKEGDTIEQRDIIATLVSMQYERGDLDFKRGSF
CCEEEEEEHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCE
RVRGDVIDVYPAESSENALRISLFDDEIDRLDMFDPLSGSLIQRVGRYTVFPSSHYVTPR
EEECCEEEEECCCCCCCEEEEEEECCCHHHCCCCCCCCHHHHHHHCCEEECCCCCCCCCH
DTVLRACESIKEELRERIEFFAREQRPVEQQRIEQRTRFDLEMLYEMGFCKGIENYSRHF
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGKKEGEPPPTLMDYLPDNAIMFIDESHVTVTQIGGMYKGDASRKQNLVDYGFRLPSARD
CCCCCCCCCCHHHHHCCCCEEEEEECCCEEEEHHCCCCCCCCHHHHHHHHHCCCCCCCCC
NRPLKFHEFEKVMPQTIFVSATPAKYEEEHAGQVVEQVVRPTGLVDPQIIIRPVATQVDD
CCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LMSEINDRIQKGERILVTTLTKRMAEQLTDYYSELGIKVRYLHSDIDTVERVEIIRDLRL
HHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
GLFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSHRSLIQTIGRAARNVNGVAILYA
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
DKITDSMKAAIDETERRREKQIKFNEEHGIVPQQIKKQVKDIIDGVYHEEDSGKGRRQGK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCC
NKVKVGEIHNEEDAIKEIAKLEKAMQQAARDLQFEEASVLRDRIRGIREGLLFGSE
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA