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The map label for this gene is obgE

Identifier: 161760696

GI number: 161760696

Start: 1193278

End: 1194336

Strand: Direct

Name: obgE

Synonym: Saro_1145

Alternate gene names: 161760696

Gene position: 1193278-1194336 (Clockwise)

Preceding gene: 87199166

Following gene: 87199168

Centisome position: 33.5

GC content: 65.25

Gene sequence:

>1059_bases
ATGCATTTTCTCGATCAGGCCAAGATCTTCATCCGCTCGGGGCAGGGCGGTCCCGGCGCGGTCAGTTTCCGGCGTGAGAA
GTACGTCGAGTACGGCGGACCCGATGGCGGCGACGGCGGCAAGGGCGGCGACATCATCTTCGAGGCCGTAACCGGTCTCA
ACACTCTGATCGACTTCCGCTATGCGCAGCATTTCAAGGCGCAGCGCGGCCATGGAGGCGCGGGCAAGAACCGTACCGGC
GCGGGCGGCAACGACCTTGTCATCAAGGTCCCCGTCGGCACGCAGGTGCTCGACGATGACCGCGAGACGGTGCTGCTCGA
CCTTACCGAAGCGGGCCAGCGCGAAATCCTGCTGCGCGGCGGCGACGGCGGGCGCGGCAATGCATCCTACAAGACGTCGA
CCAATCGCGCCCCGCGCCAGCACGGTCCAGGCTGGCCGGGCGAGGAAATGTACGTCTGGTTGCGTCTGAAGCTTCTGGCG
GACGCCGGCCTTGTCGGCCTGCCCAACGCCGGCAAGTCGACCTTCATCAACCAGATCACCAATACCAAGGCCAAGGTCGG
CGATTACGCGTTCACCACGTTGCGTCCGCAGCTTGGCGTCGTGCGCCACCGCAACCGCGAATTCGTGCTGGCCGACATTC
CGGGCCTGATCGAAGGCGCGGCCGATGGCGCCGGCATCGGCGACCGCTTCCTGGGCCATATCGAGCGTTGCCGCGTGCTC
ATCCACCTTATCGACATTCACAGCGACGTCGATCCGGTCGAGGCCATGCACATCGTCGAGGGCGAACTCGAAGCCTATGG
CGCCGGCCTCGACGAGAAGCCGCGCCTTGTCGCGCTCAACAAGATCGATCTGGTCGACAAGGAACTGGTCAAGGCGTTCC
AGGACGAACTCCTCGAAGGGGGCGCGGACCGTGTGTTTCCGATCTCCGGCGCCACCGGCAAGGGCATGGACGCATTGCTT
GACGCTGTCCTCGAGTATCTCCCCGCCGCCACGGTGACCGAACGCCCGACCGGCGAGGTCGAGGAAGCGGAAGACCAGAA
GCCCTGGTCCCCGATCTGA

Upstream 100 bases:

>100_bases
CGGTTCGAGACACCGGCACTCCATGAACGGGACCAGCAGGCTCGCTTACGGGGCGCGGCGTCCTATTGCATTCGGGCCTG
TCAGTGGACACGTTACCCAG

Downstream 100 bases:

>100_bases
CCGCGTTCCATCCGCCCGTCCCGCGCCTGTCGAGGGACGCGGCGGCCACGCTTGGCGTCATAGACACGACGCCCTGCATA
TCCGACCGGTAACCCTTCAC

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MHFLDQAKIFIRSGQGGPGAVSFRREKYVEYGGPDGGDGGKGGDIIFEAVTGLNTLIDFRYAQHFKAQRGHGGAGKNRTG
AGGNDLVIKVPVGTQVLDDDRETVLLDLTEAGQREILLRGGDGGRGNASYKTSTNRAPRQHGPGWPGEEMYVWLRLKLLA
DAGLVGLPNAGKSTFINQITNTKAKVGDYAFTTLRPQLGVVRHRNREFVLADIPGLIEGAADGAGIGDRFLGHIERCRVL
IHLIDIHSDVDPVEAMHIVEGELEAYGAGLDEKPRLVALNKIDLVDKELVKAFQDELLEGGADRVFPISGATGKGMDALL
DAVLEYLPAATVTERPTGEVEEAEDQKPWSPI

Sequences:

>Translated_352_residues
MHFLDQAKIFIRSGQGGPGAVSFRREKYVEYGGPDGGDGGKGGDIIFEAVTGLNTLIDFRYAQHFKAQRGHGGAGKNRTG
AGGNDLVIKVPVGTQVLDDDRETVLLDLTEAGQREILLRGGDGGRGNASYKTSTNRAPRQHGPGWPGEEMYVWLRLKLLA
DAGLVGLPNAGKSTFINQITNTKAKVGDYAFTTLRPQLGVVRHRNREFVLADIPGLIEGAADGAGIGDRFLGHIERCRVL
IHLIDIHSDVDPVEAMHIVEGELEAYGAGLDEKPRLVALNKIDLVDKELVKAFQDELLEGGADRVFPISGATGKGMDALL
DAVLEYLPAATVTERPTGEVEEAEDQKPWSPI
>Mature_352_residues
MHFLDQAKIFIRSGQGGPGAVSFRREKYVEYGGPDGGDGGKGGDIIFEAVTGLNTLIDFRYAQHFKAQRGHGGAGKNRTG
AGGNDLVIKVPVGTQVLDDDRETVLLDLTEAGQREILLRGGDGGRGNASYKTSTNRAPRQHGPGWPGEEMYVWLRLKLLA
DAGLVGLPNAGKSTFINQITNTKAKVGDYAFTTLRPQLGVVRHRNREFVLADIPGLIEGAADGAGIGDRFLGHIERCRVL
IHLIDIHSDVDPVEAMHIVEGELEAYGAGLDEKPRLVALNKIDLVDKELVKAFQDELLEGGADRVFPISGATGKGMDALL
DAVLEYLPAATVTERPTGEVEEAEDQKPWSPI

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=323, Percent_Identity=39.938080495356, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI111955139, Length=353, Percent_Identity=32.5779036827195, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI111955063, Length=188, Percent_Identity=35.6382978723404, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4758796, Length=189, Percent_Identity=30.1587301587302, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI58761500, Length=128, Percent_Identity=33.59375, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4557537, Length=119, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789574, Length=351, Percent_Identity=51.2820512820513, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=30.46875, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790615, Length=183, Percent_Identity=33.879781420765, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=324, Percent_Identity=37.037037037037, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17552324, Length=305, Percent_Identity=30.8196721311475, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17555344, Length=115, Percent_Identity=34.7826086956522, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509631, Length=130, Percent_Identity=32.3076923076923, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=116, Percent_Identity=34.4827586206897, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=173, Percent_Identity=38.728323699422, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319281, Length=200, Percent_Identity=28, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321612, Length=118, Percent_Identity=33.0508474576271, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI20129375, Length=324, Percent_Identity=37.6543209876543, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24585318, Length=292, Percent_Identity=38.6986301369863, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17981711, Length=115, Percent_Identity=33.9130434782609, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640873, Length=185, Percent_Identity=31.3513513513514, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640877, Length=185, Percent_Identity=31.3513513513514, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640875, Length=185, Percent_Identity=31.3513513513514, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356473, Length=114, Percent_Identity=32.4561403508772, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_NOVAD (Q2G983)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496424.2
- HSSP:   Q5SJ29
- STRING:   Q2G983
- GeneID:   3916442
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1145
- NMPDR:   fig|48935.1.peg.2033
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- PhylomeDB:   Q2G983
- ProtClustDB:   PRK12299
- BioCyc:   NARO279238:SARO_1145-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 37895; Mature: 37895

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFLDQAKIFIRSGQGGPGAVSFRREKYVEYGGPDGGDGGKGGDIIFEAVTGLNTLIDFR
CCCHHCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YAQHFKAQRGHGGAGKNRTGAGGNDLVIKVPVGTQVLDDDRETVLLDLTEAGQREILLRG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCEEEEEECCCCCEEEEEEC
GDGGRGNASYKTSTNRAPRQHGPGWPGEEMYVWLRLKLLADAGLVGLPNAGKSTFINQIT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCEEECCCCCHHHHHHHHH
NTKAKVGDYAFTTLRPQLGVVRHRNREFVLADIPGLIEGAADGAGIGDRFLGHIERCRVL
CCHHHCCCEEEEECCCCHHHHEECCCCEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHH
IHLIDIHSDVDPVEAMHIVEGELEAYGAGLDEKPRLVALNKIDLVDKELVKAFQDELLEG
HHHHHHCCCCCHHHHHHHHHCCHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCC
GADRVFPISGATGKGMDALLDAVLEYLPAATVTERPTGEVEEAEDQKPWSPI
CCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCC
>Mature Secondary Structure
MHFLDQAKIFIRSGQGGPGAVSFRREKYVEYGGPDGGDGGKGGDIIFEAVTGLNTLIDFR
CCCHHCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YAQHFKAQRGHGGAGKNRTGAGGNDLVIKVPVGTQVLDDDRETVLLDLTEAGQREILLRG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCEEEEEECCCCCEEEEEEC
GDGGRGNASYKTSTNRAPRQHGPGWPGEEMYVWLRLKLLADAGLVGLPNAGKSTFINQIT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEHHCCCEEECCCCCHHHHHHHHH
NTKAKVGDYAFTTLRPQLGVVRHRNREFVLADIPGLIEGAADGAGIGDRFLGHIERCRVL
CCHHHCCCEEEEECCCCHHHHEECCCCEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHH
IHLIDIHSDVDPVEAMHIVEGELEAYGAGLDEKPRLVALNKIDLVDKELVKAFQDELLEG
HHHHHHCCCCCHHHHHHHHHCCHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCC
GADRVFPISGATGKGMDALLDAVLEYLPAATVTERPTGEVEEAEDQKPWSPI
CCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA