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The map label for this gene is proA

Identifier: 161702966

GI number: 161702966

Start: 633787

End: 635058

Strand: Direct

Name: proA

Synonym: Bcep18194_A3743

Alternate gene names: 161702966

Gene position: 633787-635058 (Clockwise)

Preceding gene: 78065218

Following gene: 78065220

Centisome position: 17.16

GC content: 67.45

Gene sequence:

>1272_bases
ATGGATATCGATCAGTACATGACCGACCTGGGCCGTCGCGCCCGGCACGCTTCCCGCGCGATGGCGCGCGCCAGCACGGC
CGCGAAGAACGCGGCGCTCGACGCGGTGGCGCGCGCGATCGAACGTGACGCGCAGGTGCTGAAGGACGCGAATGCACGCG
ATGTCGCCCGCGCCCGTGAAAAGGGGCTCGATGCGGCGTTCGTCGATCGCCTGACGCTGTCGGACAAGGCGCTGAATACG
ATGGTCGAAGGCTTGCGCCAGGTGGCGTCGCTGGCCGATCCGATCGGCGAGATCAGCAACCTCAAGTACCGCCCGAGCGG
CATCCAGGTCGGCCAGATGCGTGTGCCGCTCGGCGTGATCGGCATCATCTACGAATCGCGCCCGAACGTGACGATCGACG
CGGCTGCGCTGTGCCTGAAGTCGGGCAATGCGACGATCCTGCGCGGCGGCTCCGAAGCGCTCGAATCGAACACGGCGCTC
GCGAAGCTGATCGGCGAGGGGCTCGAAGCAGCCGGCCTGCCGCAGGATGCGGTGCAGGTCGTCGCGACGGCCGATCGCGC
GGCGGTCGGCAAGCTGATCACGATGACCGAATACGTCGACGTGATCGTGCCGCGCGGCGGCAAGAGCCTGATCGAGCGCC
TGATCAACGAGGCGCGCGTGCCGATGATCAAGCACCTCGACGGCATCTGCCACGTGTACGTCGACGATCGCGCCGATCTC
GCCAAGGCGCTGACTGTCTGCGACAACGCGAAGACGCACCGCTACGGCACCTGCAACACGATGGAGACGCTGCTCGTGTC
GAGCGGTGTCGCGGCGAAGCTGCTGCCGCCGCTCGGCAAGCTGTATCGCGACAAGCAGGTCGAGCTGCGCGTCGATGCGG
CCGCGCGCACGGTGCTCGCCGATGCGGGCGTCGGCCCGCTCGTCGACGCCACCGAGGAAGACTGGCACACCGAGTATCTC
GCGCCGGTGCTCGCGATCAAGGTCGTCGACGGCCTCGACGCCGCGATCGAGCACATCAACCATTACGGCTCGCACCACAC
GGACGCCATCGTCACCGAGGATCACGACCGCGCGATGCGGTTCCTGCGCGAGGTCGATTCGGCGAGCGTGATGGTCAACG
CATCGACGCGCTTCGCGGACGGCTTCGAATTCGGCCTCGGCGCGGAAATCGGCATCTCGAACGACAAGCTGCACGCACGC
GGCCCCGTCGGCCTGGAAGGGCTGACGTCGCTGAAGTACGTCGTGCTCGGACACGGCGAAGGCCGCCAGTAA

Upstream 100 bases:

>100_bases
TTACAATGTTTCGATAGTTGGCGCGGCCCTCCGGCCGCCGCCGCTCACGCCTCCCCACGAATTCATGCCGCCCAGCGCGG
CGCGCTTCTCGAGTCACACG

Downstream 100 bases:

>100_bases
ATAGCGAGGCACACAATCGATGGCGATGCTCTGGGTCAAGACGTTCCATATCGTTCTGATCGCCGCGTGGTTTGCGGGGT
TGTTCTACCTGCCGCGCATC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQVLKDANARDVARAREKGLDAAFVDRLTLSDKALNT
MVEGLRQVASLADPIGEISNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
AKLIGEGLEAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRADL
AKALTVCDNAKTHRYGTCNTMETLLVSSGVAAKLLPPLGKLYRDKQVELRVDAAARTVLADAGVGPLVDATEEDWHTEYL
APVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ

Sequences:

>Translated_423_residues
MDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQVLKDANARDVARAREKGLDAAFVDRLTLSDKALNT
MVEGLRQVASLADPIGEISNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
AKLIGEGLEAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRADL
AKALTVCDNAKTHRYGTCNTMETLLVSSGVAAKLLPPLGKLYRDKQVELRVDAAARTVLADAGVGPLVDATEEDWHTEYL
APVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ
>Mature_423_residues
MDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQVLKDANARDVARAREKGLDAAFVDRLTLSDKALNT
MVEGLRQVASLADPIGEISNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
AKLIGEGLEAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRADL
AKALTVCDNAKTHRYGTCNTMETLLVSSGVAAKLLPPLGKLYRDKQVELRVDAAARTVLADAGVGPLVDATEEDWHTEYL
APVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=38.1067961165049, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=38.1067961165049, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=45.0121654501217, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=34.2925659472422, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=34.2925659472422, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=38.2488479262673, Blast_Score=289, Evalue=7e-79,
Organism=Drosophila melanogaster, GI21357643, Length=416, Percent_Identity=37.7403846153846, Blast_Score=264, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45279; Mature: 45279

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQVLKDANARDVARARE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KGLDAAFVDRLTLSDKALNTMVEGLRQVASLADPIGEISNLKYRPSGIQVGQMRVPLGVI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTALAKLIGEGLEAAGLPQDAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHH
VATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRADL
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCHHHH
AKALTVCDNAKTHRYGTCNTMETLLVSSGVAAKLLPPLGKLYRDKQVELRVDAAARTVLA
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHH
DAGVGPLVDATEEDWHTEYLAPVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEECCC
GRQ
CCC
>Mature Secondary Structure
MDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQVLKDANARDVARARE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KGLDAAFVDRLTLSDKALNTMVEGLRQVASLADPIGEISNLKYRPSGIQVGQMRVPLGVI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTALAKLIGEGLEAAGLPQDAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHH
VATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRADL
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCHHHH
AKALTVCDNAKTHRYGTCNTMETLLVSSGVAAKLLPPLGKLYRDKQVELRVDAAARTVLA
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHH
DAGVGPLVDATEEDWHTEYLAPVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEECCC
GRQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA