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The map label for this gene is phoR [H]

Identifier: 161525184

GI number: 161525184

Start: 2207192

End: 2208511

Strand: Reverse

Name: phoR [H]

Synonym: Bmul_2014

Alternate gene names: 161525184

Gene position: 2208511-2207192 (Counterclockwise)

Preceding gene: 161525185

Following gene: 161525182

Centisome position: 64.04

GC content: 65.23

Gene sequence:

>1320_bases
ATGAACATCATCTGGGCGCGCTTTCTGGTGTCGCTCGTGCTGCTCGTGCTGATCAGCGTACTGGTCGGCGTGTTCGCCGG
CCCGACCGCGGGCTTCGGCTTTGCGGCCGCGATGCTGATCGTGCAGGGCTTTTTCAGTACGTTCCATACGCAGCGTCTCT
GGCGGCTGCTCGATGCGCCGGTGTACGGCGAAGTGCCGAGCGCGCCCGGCATCTGGGGCGAGATCTACTACCGGCTGCAC
AAGCTCGCGAAGCAGTGGCACGCGCAGGTGCGGCAGGTCGAGCAGCAGCATTCGCGCTTCATCCAGGCGATCCAGGCCTC
GCCGAACGGCGTCGCGATGCTCGACGATCACGACCAGATCGAGTGGTGCAACGCGATCGCCGAGGTGCATTTCGGTCTCG
ATGCGAAGCGCGACCTGCGCCAGCACATCACGAACCTCGTCCGTCATCCCGACTTCGTCCGCTATCTGAACGCGCAGCAT
TACGACGAAACGCTCGTGATGCGCGGGATGGGTGACTCGCGGCAGAACGTGCTCGCCGTGCAGGTGTTTCCGTACGGCGA
GAACCGCAAGCTGCTGCTCACGCAGGACATCACCGAGCTCGAGCGCACCGATGCGATGCGCCGCGACTTCGTCGCGAACG
TGTCGCACGAGCTGAAGACGCCGCTCACCGTGCTGTCGGGCTTTCTCGAGACGATGCGCGAACTGCCGCTCGGCGAAGAG
GATCGCGCGCGCTATCTCGAGATGATGGAGCAGCAGGCGTCGCGGATGCGGCACATCGTCACCGATCTGCTGGTGCTCGC
GAAGCTCGAAGGCGAAAGCAAGCCGCCGCTCGATCGCGCGATCGACATGCGCTCGGTGTTCGACCATCTGAAGGAGGACG
CGCACACGCTGTCGAACGGCCATCACGACATCACGTTCTCGATCGACGACACGCTCGGCGTGACGGGCGCGCAGACCGAA
GTGTTCAGCGCGTTCGCGAATCTCGTGACGAACGCGATCCGCTACACGCCGGACGGCGGCAAGATCTGCGTGACGTGGCG
GCGCGAAGGCGCGCAGGGCGTGTTCTCGGTAACCGACAGCGGCTTCGGCATTCCGGCCGCCGACCTGCCGCGGCTGACCG
AGCGCTTCTATCGCGTCGATCGTAGCCGTTCGCGCGATACGGGCGGCACCGGTCTCGGGCTCGCGATCGTCAAGCACGTG
CTGCAGCGGCACGACGCGCATCTATACGTGCAGAGCGAGGAAGGGCGCGGCAGTACGTTCACCGCGCGTTTTCCCGCGTC
GCGGATCATCGCGATTCGTCCGGCCTCGATCGCATCGTGA

Upstream 100 bases:

>100_bases
AGACCGTGCGCGGCAGCGGCTACCGGCTCGCGAAGCACGCGTAACGCCATCGGGCATGCCGGCAACGCGGCATGCCGTTC
ATTCTTTTGGACGCTGAATC

Downstream 100 bases:

>100_bases
GCGCGGCGCGCGCTTGCGGCGCGCGATCGGCATAAGACAACGCAGCCCGAGGGCTGCGTTTTTCATGGGCGACGCGTCGT
GCGTGCTACGCGATCACGAA

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNIIWARFLVSLVLLVLISVLVGVFAGPTAGFGFAAAMLIVQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQH
YDETLVMRGMGDSRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLGEE
DRARYLEMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRSVFDHLKEDAHTLSNGHHDITFSIDDTLGVTGAQTE
VFSAFANLVTNAIRYTPDGGKICVTWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPASRIIAIRPASIAS

Sequences:

>Translated_439_residues
MNIIWARFLVSLVLLVLISVLVGVFAGPTAGFGFAAAMLIVQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQH
YDETLVMRGMGDSRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLGEE
DRARYLEMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRSVFDHLKEDAHTLSNGHHDITFSIDDTLGVTGAQTE
VFSAFANLVTNAIRYTPDGGKICVTWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPASRIIAIRPASIAS
>Mature_439_residues
MNIIWARFLVSLVLLVLISVLVGVFAGPTAGFGFAAAMLIVQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQH
YDETLVMRGMGDSRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLGEE
DRARYLEMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRSVFDHLKEDAHTLSNGHHDITFSIDDTLGVTGAQTE
VFSAFANLVTNAIRYTPDGGKICVTWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPASRIIAIRPASIAS

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=427, Percent_Identity=36.2997658079625, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI145693157, Length=344, Percent_Identity=28.7790697674419, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1788393, Length=259, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI48994928, Length=357, Percent_Identity=25.7703081232493, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1786783, Length=238, Percent_Identity=32.3529411764706, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789149, Length=337, Percent_Identity=29.3768545994065, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790436, Length=301, Percent_Identity=27.2425249169435, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=31.0185185185185, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=27.5555555555556, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082128, Length=245, Percent_Identity=24.4897959183673, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=27.0916334661355, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788713, Length=255, Percent_Identity=24.7058823529412, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=401, Percent_Identity=22.9426433915212, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=257, Percent_Identity=29.1828793774319, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=225, Percent_Identity=28, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=26.2931034482759, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49427; Mature: 49427

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIWARFLVSLVLLVLISVLVGVFAGPTAGFGFAAAMLIVQGFFSTFHTQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQHYDETLVMRGMGDSRQNVLAV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHEECCCCCCCCEEEE
QVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLGEE
EEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCH
DRARYLEMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRSVFDHLKEDAHTLSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
HHDITFSIDDTLGVTGAQTEVFSAFANLVTNAIRYTPDGGKICVTWRREGAQGVFSVTDS
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCEEEECCC
GFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAHLYVQSEEGRGSTF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEE
TARFPASRIIAIRPASIAS
EEECCCCCEEEECCHHCCC
>Mature Secondary Structure
MNIIWARFLVSLVLLVLISVLVGVFAGPTAGFGFAAAMLIVQGFFSTFHTQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQHYDETLVMRGMGDSRQNVLAV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHEECCCCCCCCEEEE
QVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLGEE
EEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCH
DRARYLEMMEQQASRMRHIVTDLLVLAKLEGESKPPLDRAIDMRSVFDHLKEDAHTLSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
HHDITFSIDDTLGVTGAQTEVFSAFANLVTNAIRYTPDGGKICVTWRREGAQGVFSVTDS
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCEEEECCC
GFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAHLYVQSEEGRGSTF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEE
TARFPASRIIAIRPASIAS
EEECCCCCEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]