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The map label for this gene is ppx [H]

Identifier: 161525182

GI number: 161525182

Start: 2203245

End: 2204759

Strand: Reverse

Name: ppx [H]

Synonym: Bmul_2012

Alternate gene names: 161525182

Gene position: 2204759-2203245 (Counterclockwise)

Preceding gene: 161525184

Following gene: 161525179

Centisome position: 63.93

GC content: 67.13

Gene sequence:

>1515_bases
ATGGTTACAACTCCCCACTTGCTGGCTGCCGTGGATCTCGGCTCGAACAGCTTCCGGCTGATCGTCGGACGCGTCGAGGA
GACGCCGGCGGGAAGCCAGATCTACCCTGTGGATGCGCTGCGCGAGCCGGTCCGGCTCGCCGCCGGGCTGTCGAGCGACA
AGCTGCTCGACCGCGCGTCTCAGGAGCGCGGCTGGGAGGCGCTCAAGCGGTTCGGCGAGCGTCTGCGCGATTTTCATCCC
GATCACGTGCGTGCGGTCGCGACGAACACGCTGCGCGTCGCGAAGAATGCCGGCGAATTTCTCGTCGAGGCCGAAGCCGC
GCTCGGTTTTCCGATCGAAGTGATCGCAGGCCGCGAAGAGGCGCGCCTGATTTATGCGGGCGCCGCGCACTCGGTGCCCG
CGAGCGCCGGCAAGCGGCTCGTCGTCGACATCGGCGGCGGCTCGACCGAGTTCATCATCGGCTCGCACTACACGCCGCTC
GTGATGGAGAGTCTGTACATCGGTTGCGTGAGCCACAGCCGCGCATTCTTCCCGGCCGGCAACGTCGACGAATACACGAT
GCGGCAGGCCGAACTCGCGGCGAAGCGCGAAATCCAGATCATTTCGAGCGAGTACAAGAAAGCCGGCTGGGATCAGGCGA
TCGGCTCGTCGGGCACGGCGCGCGCGCTCGCCGAACTCGTCGAGGCGAACGGCTTCAACGATCCGGGCATCACGCACGGA
ATCTCGCGCGGCGGTCTCGAGCGGCTCAAGCGCGCGCTGATCAAGGCCGAGAACGTGAACCGGCTGAAGCTGATCGCGCT
GAAGCCCGATCGCGTGCCGGTGCTCGCCGGCGGTCTCGCGATCATGCTGGCCGTGTTCGAGGAACTGGGTGTCGACTATG
TCGACACGACCGACGGCGCGCTGCGCCTCGGCGTGCTCTACGACCTGCTCGGCCGTACGCAGCACGAGGACATGCGCGCG
GTCACCGTCGAAGGATTCACGCGCCGCTACGGCGTCGATCGCGCGCAGGCCGAACGGATCGCCGCGCTCGCGGTGCGCTT
CTACGATCAGCTCGGCGAGCCCGACGACGAGCGGCGCGAAGAGTGCCGGACGTTCCTCGGCTGGGCCGCGGCGCTGCACG
AGATCGGGCTGTCGATCTCGCACAGCGCGTATCACAAGCATTCCGCGTATATCGCGAGCAATGCGGACATGCCCGGTTTC
TCGCGCACCGATCAGGCGCGGCTCGCCGCCTTGGTGCTCGGCCATGCGGGCAAGCTGGGCAAGCTGTCGCAGGCGCGGGA
AGTCGAGTGGCCGCTGCTGTTCTGTCTGCGGCTCGCGGCGCTGCTGTGCCGGCGCCGTACCGACGCCGGGCTGCCCGACA
TTTCGGTCGCGCAGATGAAGAAGGGCGGCTACGAAGTGCGGCTGCCGAGCGCGTGGGTCGAACAGAATCCGCTCACCGAT
TACAGCCTCAGCCAGGAAGCGGCGGAATGGGAGAAGGTCGGCATTCCGTATCGCGTCGTCTATACGGACGCATGA

Upstream 100 bases:

>100_bases
GTGGCGCCCGAAAGCGTTCCACGCTTAAAATGTGCGCTTCGATCGACTGCTTCGCGGGCCGCACGGACGCCGCGAGCGAA
CGCGCACGGAGCCCCTTCTG

Downstream 100 bases:

>100_bases
CGGCCGCGGCGCCGGTGCCGGCGCTGCATACGGCCGCGGCTGCGCCGGCCGCTCAGTCGGACGAGCAGACGATCGCGGTC
AGGAACGGAAACGCCTGCTT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKLLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLVEAEAALGFPIEVIAGREEARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPL
VMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
ISRGGLERLKRALIKAENVNRLKLIALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVEGFTRRYGVDRAQAERIAALAVRFYDQLGEPDDERREECRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVAQMKKGGYEVRLPSAWVEQNPLTD
YSLSQEAAEWEKVGIPYRVVYTDA

Sequences:

>Translated_504_residues
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKLLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLVEAEAALGFPIEVIAGREEARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPL
VMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
ISRGGLERLKRALIKAENVNRLKLIALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVEGFTRRYGVDRAQAERIAALAVRFYDQLGEPDDERREECRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVAQMKKGGYEVRLPSAWVEQNPLTD
YSLSQEAAEWEKVGIPYRVVYTDA
>Mature_504_residues
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKLLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLVEAEAALGFPIEVIAGREEARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPL
VMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
ISRGGLERLKRALIKAENVNRLKLIALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVEGFTRRYGVDRAQAERIAALAVRFYDQLGEPDDERREECRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVAQMKKGGYEVRLPSAWVEQNPLTD
YSLSQEAAEWEKVGIPYRVVYTDA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=496, Percent_Identity=38.3064516129032, Blast_Score=331, Evalue=6e-92,
Organism=Escherichia coli, GI48994966, Length=497, Percent_Identity=37.625754527163, Blast_Score=308, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55112; Mature: 55112

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKLLDRAS
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHH
QERGWEALKRFGERLRDFHPDHVRAVATNTLRVAKNAGEFLVEAEAALGFPIEVIAGREE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCEEEECCCCC
ARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPLVMESLYIGCVSHSRAFFPAG
CEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCC
NVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCHHC
ISRGGLERLKRALIKAENVNRLKLIALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGA
CCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHCCCEEECCCCH
LRLGVLYDLLGRTQHEDMRAVTVEGFTRRYGVDRAQAERIAALAVRFYDQLGEPDDERRE
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
ECRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVLGHAGKLG
HHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
KLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVAQMKKGGYEVRLPSAWVEQNPLTD
CCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCHHHHCCCCCCC
YSLSQEAAEWEKVGIPYRVVYTDA
CCCCHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MVTTPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSSDKLLDRAS
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHH
QERGWEALKRFGERLRDFHPDHVRAVATNTLRVAKNAGEFLVEAEAALGFPIEVIAGREE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCEEEECCCCC
ARLIYAGAAHSVPASAGKRLVVDIGGGSTEFIIGSHYTPLVMESLYIGCVSHSRAFFPAG
CEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCC
NVDEYTMRQAELAAKREIQIISSEYKKAGWDQAIGSSGTARALAELVEANGFNDPGITHG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCHHC
ISRGGLERLKRALIKAENVNRLKLIALKPDRVPVLAGGLAIMLAVFEELGVDYVDTTDGA
CCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHCCCEEECCCCH
LRLGVLYDLLGRTQHEDMRAVTVEGFTRRYGVDRAQAERIAALAVRFYDQLGEPDDERRE
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
ECRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVLGHAGKLG
HHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
KLSQAREVEWPLLFCLRLAALLCRRRTDAGLPDISVAQMKKGGYEVRLPSAWVEQNPLTD
CCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCHHHHCCCCCCC
YSLSQEAAEWEKVGIPYRVVYTDA
CCCCHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]