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The map label for this gene is emrA [H]

Identifier: 161524924

GI number: 161524924

Start: 1937267

End: 1938490

Strand: Direct

Name: emrA [H]

Synonym: Bmul_1751

Alternate gene names: 161524924

Gene position: 1937267-1938490 (Clockwise)

Preceding gene: 161524923

Following gene: 161524925

Centisome position: 56.18

GC content: 67.81

Gene sequence:

>1224_bases
ATGAGCGACCCTCAACAAAACGCCGCCAGCGCCCAGCCGCAGAACAACGGCAAGCGCAAACGGATGATGACGCTGCTCGT
CGCGGTCATCGTGATCGCGGCCATCGCATACGGCCTCTACTACTTCCTCGTCGCGCGCTTCCATGAGGAAACCGACGACG
CGTACGTGAACGGCAACGTCGTGCAGATCACGCCGCAGGTCACGGGCACCGTGATCGCGGTCAAGGCCGACGACACGCAG
ACGGTGAAGGCCGGCGATCCGCTCGTCGTGCTCGATCCGGCCGACTCGCAGGTCGCGCTGCAGCAGGCGGAAGCGAACCT
CGCGCAGACCGTGCGCCAGGTGCGCGGCCTGTTCGTCAACGACGATCAGTACCGCGCGCAGGTCGCGCTGCGTCAGTCCG
ACCTGTCGAAGGCGCAGGACGACTTGCGCCGCCGTCTCGCCGTCGCGCAGACGGGCGCGGTGTCGCAGGAAGAAATCTCG
CACGCGCGCGATGCCGTGCGCGCCGCGCAGGCGTCGCTCGACGCCGCGCAGCAGCAGCTCGCGTCGAACCGCGCGCTGAC
CGCGAACACGACGATCGCGTCGCACCCGAACGTGCTCGCCGCAGCCGCGAAGGTGCGCGACGCATACCTCGCGAACGCGC
GCAACACGCTGCCCGCGCCGGTGACCGGCTACGTCGCGAAGCGCTCGGTGCAGGTCGGCCAGCGCGTGTCGCCCGGCACG
CCGCTGATGTCGGTCGTGCCGCTGAACGCGGTGTGGGTCGACGCGAACTTCAAGGAAGTGCAGCTCAAGCACATGCGCAT
CGGCCAGCCGGTCGAACTGACGGCCGACATCTACGGCTCGTCGGTCGTCTATCACGGCAAGGTCGTCGGCTTCTCGGCCG
GCACGGGTTCGGCGTTCTCGCTGCTGCCGGCGCAGAACGCGACCGGCAACTGGATCAAGGTCGTGCAGCGCCTGCCGGTG
CGTATCGAACTCGATCCGAAGGATCTCGACAAGCATCCGCTGCGCATCGGCCTGTCGATGCAGGTCGACGTCAACATCAA
GGACGAACGCGGCGACCAGCTCGTCAACGTGCCGAATACCGTCTACCAGACCGACGTGTTCGCGAAGTACGGCGACGAAG
CCGACGCGGAAATCGCACGCATCATCGCGGAAAACGCGGGCGGCAACGCGCCGGCGCCCGCTGCGGCTGCGGCGAAGCGC
ACCGCCGCGCCGAAGCTGATGTAA

Upstream 100 bases:

>100_bases
GCTCGCGGCGCCCGAGACCGCGAAACAGACCCGACAGGCCGCCAACTGATCCGGCGCCGCCCTACCAAGACACTCGAAAT
AACGGACGGAGAAAATCGCC

Downstream 100 bases:

>100_bases
CCGTTCCGACTCCGGAAAGACAAACGACATGGCACAGGCTCCTGTCTCTCACCCGCCCTTGCAGGGCGGGCAACTCGTGA
TCGGGACGATCGCGGTGTCG

Product: efflux pump membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSDPQQNAASAQPQNNGKRKRMMTLLVAVIVIAAIAYGLYYFLVARFHEETDDAYVNGNVVQITPQVTGTVIAVKADDTQ
TVKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEIS
HARDAVRAAQASLDAAQQQLASNRALTANTTIASHPNVLAAAAKVRDAYLANARNTLPAPVTGYVAKRSVQVGQRVSPGT
PLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVVYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPV
RIELDPKDLDKHPLRIGLSMQVDVNIKDERGDQLVNVPNTVYQTDVFAKYGDEADAEIARIIAENAGGNAPAPAAAAAKR
TAAPKLM

Sequences:

>Translated_407_residues
MSDPQQNAASAQPQNNGKRKRMMTLLVAVIVIAAIAYGLYYFLVARFHEETDDAYVNGNVVQITPQVTGTVIAVKADDTQ
TVKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEIS
HARDAVRAAQASLDAAQQQLASNRALTANTTIASHPNVLAAAAKVRDAYLANARNTLPAPVTGYVAKRSVQVGQRVSPGT
PLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVVYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPV
RIELDPKDLDKHPLRIGLSMQVDVNIKDERGDQLVNVPNTVYQTDVFAKYGDEADAEIARIIAENAGGNAPAPAAAAAKR
TAAPKLM
>Mature_406_residues
SDPQQNAASAQPQNNGKRKRMMTLLVAVIVIAAIAYGLYYFLVARFHEETDDAYVNGNVVQITPQVTGTVIAVKADDTQT
VKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVNDDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEISH
ARDAVRAAQASLDAAQQQLASNRALTANTTIASHPNVLAAAAKVRDAYLANARNTLPAPVTGYVAKRSVQVGQRVSPGTP
LMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVVYHGKVVGFSAGTGSAFSLLPAQNATGNWIKVVQRLPVR
IELDPKDLDKHPLRIGLSMQVDVNIKDERGDQLVNVPNTVYQTDVFAKYGDEADAEIARIIAENAGGNAPAPAAAAAKRT
AAPKLM

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=354, Percent_Identity=53.6723163841808, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788711, Length=378, Percent_Identity=43.9153439153439, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1790519, Length=316, Percent_Identity=31.9620253164557, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87081951, Length=317, Percent_Identity=29.0220820189274, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1789637, Length=318, Percent_Identity=27.6729559748428, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43596; Mature: 43465

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPQQNAASAQPQNNGKRKRMMTLLVAVIVIAAIAYGLYYFLVARFHEETDDAYVNGNV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCE
VQITPQVTGTVIAVKADDTQTVKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVN
EEEECCCCEEEEEEECCCCCEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEEC
DDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEISHARDAVRAAQASLDAAQQQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASNRALTANTTIASHPNVLAAAAKVRDAYLANARNTLPAPVTGYVAKRSVQVGQRVSPGT
HCCCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVVYHGKVVGFSAGTGSAFS
CCEEEEECEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEEEECCCCCEEE
LLPAQNATGNWIKVVQRLPVRIELDPKDLDKHPLRIGLSMQVDVNIKDERGDQLVNVPNT
EECCCCCCCHHHHHHHHCCCEEEECHHCCCCCCEEEEEEEEEEEEECCCCCCEEECCCCH
VYQTDVFAKYGDEADAEIARIIAENAGGNAPAPAAAAAKRTAAPKLM
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDPQQNAASAQPQNNGKRKRMMTLLVAVIVIAAIAYGLYYFLVARFHEETDDAYVNGNV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCE
VQITPQVTGTVIAVKADDTQTVKAGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLFVN
EEEECCCCEEEEEEECCCCCEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEEC
DDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEISHARDAVRAAQASLDAAQQQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASNRALTANTTIASHPNVLAAAAKVRDAYLANARNTLPAPVTGYVAKRSVQVGQRVSPGT
HCCCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVVYHGKVVGFSAGTGSAFS
CCEEEEECEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEEEECCCCCEEE
LLPAQNATGNWIKVVQRLPVRIELDPKDLDKHPLRIGLSMQVDVNIKDERGDQLVNVPNT
EECCCCCCCHHHHHHHHCCCEEEECHHCCCCCCEEEEEEEEEEEEECCCCCCEEECCCCH
VYQTDVFAKYGDEADAEIARIIAENAGGNAPAPAAAAAKRTAAPKLM
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]